Clinical trials: Head Trauma
Mild Traumatic Brain Injury, Concussion Post Syndrome
Treatment for Patients With Chronic Post-Concussion Symptoms
The current project will examine the effect of a brief psychological intervention on post-concussion symptoms, neurocognitive function, cerebral blood flow (CBF), and psychophysiological and salivary cortisol markers of autonomic…
- Trial name
- NCT03759808
- Testing
- Psychological Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Rotator Cuff Tear Surgical Repair
Clinical Trial to Compare Clinical and Functional Results of the Augmentation of Supraspinatus Tears With the Long Head of the Biceps Brachii Tendon
The goal of this clinical trial is to reduce the risk for re-tear in rotator cuff surgeries and improve clinical results in a working age population.
- Trial name
- NCT07657689
- Testing
- Augmented supraspinatus repair, Convencional Supraspinatus tear repair
- Volunteers
- 90 people
- Sponsor
- HOSPITAL FRATERNIDAD MUPRESPA HABANA
Acquired Brain Injury (Including Stroke)
Implementation of a Home-based Computerized Cognitive Rehabilitation Program for Patients With ABI
Rationale: Patients with acquired brain injury (ABI) may suffer from persistent cognitive deficits and/or subjective cognitive complaints, especially in the domains of attention and working memory.
- Trial name
- CoRe@Home (NCT06749197)
- Testing
- Rehacom
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- Erasmus Medical Center
Traumatic Brain Injury
Predict Severe Traumatic Brain Injury
Severe traumatic brain injury (TBI) is associated with a 20-30% mortality rate and significant disability among most survivors. The Centers for Disease Control and Prevention (CDC) estimate that 2% of the U.S.
- Trial name
- NCT06966713
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Chicago
Post-Concussion Syndrome
Concussion Symptom Treatment and Education Program (C-STEP) in Post-Concussion Syndrome
This prospective randomized intervention study aims to determine if the Concussion Symptom Treatment Program (C-STEP), a cognitive behavioral therapy, improves outcomes for children with post-concussion syndrome.
- Trial name
- NCT04111991
- Testing
- Usual Care, C-STEP (Cognitive Behavioral Therapy)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Sean Rose
Intubation; Difficult, Cervical Spine Injury
Head Motion in Pediatric Patients Endotracheally Intubated With Video Laryngoscopy Versus Direct Laryngoscopy
The purpose of this study is to evaluate if intubation with video laryngoscopy (VL) will result in less head motion and therefore less cervical motion when compared with direct laryngoscopy (DL).
- Trial name
- NCT02405390
- Testing
- Video Laryngoscopy, Direct Laryngoscopy, Storz C-Mac® laryngoscope
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Traumatic Brain Injury
Brain Injury Assessment Study at Hennepin County Medical Center
The goals of this study are to develop an objective, multi-modal classification scheme and outcome measures for traumatic brain injury based on several measures: (1) blood-based biomarkers (indicates which cell types are…
- Trial name
- BASH (NCT02706574)
- Volunteers
- 774 people, healthy volunteers welcome
- Sponsor
- CentraCare
Corneal Abrasion
The Debridement To Treat The Traumatic Corneal Abrasion
Patients who signed informed consent to participate in the study will receive corneal epithelial deplasia. The patient was instructed to follow up closely in the following year, and the recurrence of the patient was collected…
- Trial name
- NCT05534217
- Testing
- corneal debridement of corneal abrasion
- Where
- China
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Traumatic Brain Injury, Post-Concussion Syndrome
Cognitive Effects of Hyperbaric Oxygen Therapy (HBOT) After a Traumatic Brain Injury
This is a retrospective, single-center observational study evaluating the cognitive effects of hyperbaric oxygen therapy (HBOT) in adults who sustained a traumatic brain injury (TBI).
- Trial name
- NCT07883668
- Testing
- Hyperbaric Oxygen Therapy - HBOT
- Volunteers
- 1,000 people
- Sponsor
- Assaf-Harofeh Medical Center
PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder
Ketamine Treatment for PTSD and MDD in TBI
The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI).
- Conditions
- PTSD, Post Traumatic Stress Disorder, Major Depressive Disorder, Traumatic Brain Injury
- Trial name
- NCT06228391
- Testing
- IV ketamine, Midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Traumatic Brain Injury
Cranial Ultrasound for Point of Care Intracranial Pathology Detection in Pediatrics
To improve patient selection for head CT, a safe and high sensitivity screening neuroimaging modality is needed. Currently many clinicians must make treatment decisions based solely on the patients clinical exam, which has low…
- Trial name
- CUPID-Peds (NCT06697808)
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Wake Forest University Health Sciences
Mild Traumatic Brain Injury
Deployment Related Mild Traumatic Brain Injury (mTBI)
The study will provide evidence on the long term outcomes of mTBI in service members returning from Afghanistan and Iraq. In addition, the study will provide evidence on mTBI incidence, and symptom patterns.
- Trial name
- NCT01847040
- Where
- 2 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Defense and Veterans Brain Injury Center
Concussion
Care for Post-Concussive Symptoms
The proposed study is a pilot randomized trial of a stepped collaborative care intervention designed to decrease post-concussive symptoms and improve post-injury functioning among sports-injured youth aged 11-17.
- Trial name
- CARE4PCS (NCT02268240)
- Testing
- Stepped Care
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Seattle Children's Hospital
Traumatic Brain INjury
Biomarkers in Prehospital Prediction of Need for Neurosurgical Observation or Intervention in TBI Patients
The PreTBI II study aims to investigate the diagnostic potential of prehospital S100B and GFAP measurements in prediction of need for neurosurgical observation and/or intervention in moderate TBI patients, to rule-in high-risk…
- Trial name
- PreTBI II (NCT03028376)
- Testing
- Blood sampling
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- University of Aarhus
Post-Traumatic Headache
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1
The acute and subacute sensations that occur on the scalp with injection of different concentrations of bupivacaine for grater occipital nerve blockade will be compared.
- Trial name
- NCT06069791
- Testing
- Bupivacaine Injection
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Epilepsy, Brain Injuries
Hybrid Device DIALYTRODE for Multimodal Neuro-monitoring of Patients With Brain Injury and Status Epilepticus
This clinical trial evaluates the safety and diagnostic performance of a newly developed combined catheter that will be implanted into the brain of patients with severe brain injury for short time (up to 28 days) monitoring of…
- Trial name
- NCT03163485
- Testing
- Dialytrode, Standard treatment
- Where
- 2 sites in Germany
- Sponsor
- University of Erlangen-Nürnberg Medical School
Traumatic Brain Injury
Blood Biomarkers of Injury and Outcome in Traumatic Brain Injury
Blood samples will be drawn on traumatic brain injury patients who are participating in the ProTECT III study.
- Trial name
- BIO-ProTECT (NCT01730443)
- Where
- 37 sites in United States
- Volunteers
- 576 people
- Sponsor
- Emory University
Orbital Fractures
The Accuracy of Reconstruction of Orbital Walls Fracture Using Prebent Mesh Versus Patient Specific Implant
under GA, incision to access to orbital walls. Then insertion of prebent titanium mesh or customized titanium implant and fixation with miniscrews, examination of ocular motility using forced duction test followed by closure of…
- Trial name
- NCT06294535
- Testing
- reconstruction of orbital walls
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tanta University
Acute Brain Injuries, Mechanical Ventilation
Retrospective Study on Ventilator Weaning Outcomes in Patients With Acute Brain Injury
Invasive mechanical ventilation (IMV) is a life-saving supportive therapy for patients with acute brain injury, which accounted for nearly one-fifth of all mechanically ventilated patients in the intensive care unit (ICU).
- Trial name
- NCT07496125
- Where
- China
- Sponsor
- Southeast University, China
Brain Injuries, Attention Disorder
Effects of Neurofeedback Training on Attentional Deficits in Patients With Acquired Brain Injury
The goal of this study is to investigate new neuromodulation therapies for attention deficits following acquired brain injury. Brain damage can affect various domains, including motor and cognitive functions.
- Trial name
- NeMoRe (NCT06863025)
- Testing
- Neurofeedback training, Standard cognitive therapy
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Hospitales Nisa