Clinical trials: Head Trauma Injury
Mild Concussion, Healthy Volunteers
A New Generation of Magnetoencephalographs for High Speed Functional Brain Imaging
The goal is to perform a first evaluation of the capabilities of a new generation of non-invasive magnetoencephalography whole head device using optically pumped magnetometers using Helium 4 as the sensitive element (OPM He4) to…
- Trial name
- DEMAGUS (NCT06244472)
- Testing
- Experiment 1: visual and auditory attention task, Experiment 2: language production and rest tasks, Experiment 3: visuo-motor task
- Where
- 2 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Traumatic Brain Injury
Assessment of the Feasibility of a Systematic Multidimensional Evaluation of the Outcome of Traumatic Brain Injury Patients and Their Relatives.
The main objective is to assess the feasibility of collecting and implementing a multidimensional evaluation in a sample of patients with a mild to severe traumatic brain injury (TBI) and their relatives, evaluated at 6 months…
- Trial name
- MUST² (NCT06194071)
- Testing
- Completion of questionnaires and on-site visits during an 18 months follow-up after TBI
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Nantes University Hospital
Brain Disorders - Alzheimer's Disease, Dementia, Parkinson's Disease, Traumatic Brain Injury
Impact of a Biophoton Therapy on Patients With Brain Disorders
Previous clinical studies revealed that the newly developed biophoton therapy has been safe and effective in treating patients with Alzheimer's disease, dementia, stroke, traumatic brain injury, or Parkinson's disease.
- Trial name
- Alzheimer (NCT06147999)
- Testing
- Biophotonizer - a Biophoton Generator
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- First Institute of All Medicines
Gait Disorders, Neurologic, Cerebral Palsy
Feasibility of the Overground Bodyweight Supporting Walking System Andago
The overall aim of this project is to investigate the clinical utility of the Andago System, a CE certified mobile bodyweight supporting walking robot, in children with neuromotor disorders.
- Conditions
- Gait Disorders, Neurologic, Cerebral Palsy, Stroke, Traumatic Brain Injury
- Trial name
- NCT03787199
- Testing
- Andago, Treadmill
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University Children's Hospital, Zurich
Mild Cognitive Impairment, Acquired Brain Injury
Long-term Tablet-computer Based Casual Puzzle Video Game Intervention in Healthy Older and Cognitively Impaired Persons
This study aims at investigating the effects of tablet-based puzzle video games on cognitive function and emotional well-being. This study extends preliminary findings of studies looking at short-term benefits of playing puzzle…
- Conditions
- Mild Cognitive Impairment, Acquired Brain Injury, Cognitive Impairment, Healthy
- Trial name
- NCT03139799
- Testing
- Experimental - Puzzle Video Game Intervention, Control - Tablet Newspaper Reading Intervention
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Bern
Transcranial Direct Current Stimulation, Post-Concussion Syndrome
Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome
Globally, 10 million new traumatic brain injury (TBI) cases are estimated annually, with mild traumatic brain injury (mTBI) accounting for 75-90% of all TBI cases.
- Conditions
- Transcranial Direct Current Stimulation, Post-Concussion Syndrome, Functional Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy
- Trial name
- NCT06376500
- Testing
- tDCS with cognitive training programme
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Chronic Brain Injury
SPIRIT Club Chronic Brain Injury Exercise Platform
Many physical fitness centers and online exercise programs are not designed to support people with intellectual and developmental disabilities.
- Trial name
- SPIRITClubCBI (NCT07169370)
- Testing
- SPIRIT Club CBI Pathway
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Ohio State University
Acute Subdural Hematoma, Acquired Brain Injury
A Comparative Analysis of Prognostic Factors for Functional Outcomes in Patients With Acute Subdural Hematoma
Acute subdural hematoma (ASDH) is the most common intracranial traumatic lesion that requires surgical intervention. Although there is extensive published research on acute subdural, there remains uncertainty regarding mortality…
- Trial name
- NCT06364059
- Testing
- Decompressive craniectomy with evacuation of subdural hematoma
- Where
- Czechia
- Volunteers
- 175 people
- Sponsor
- Charles University, Czech Republic
Traumatic Brain Injury, Injury of Body Region
Neuroimaging & Plasma Markers for Predicting Outcomes After Mild Traumatic Brain Injury
This exploratory study aims to identify the most promising biomarkers that alone or in combination might predict development of mood disorders [i.e., major depression (MD], cognitive disorders [i.e., executive function deficits…
- Trial name
- NCT02891941
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Bicep Tendon Rupture
Evaluation of Clinical and Radiographic Findings in Patients Treated Surgically for Biceps Long Head Injury
This is an interventional, single-center study with clinical and radiographic evaluation, at follow-up of at least 2 years, of patients treated surgically with arthroscopy-assisted distal biceps tendon repair at the Rizzoli…
- Trial name
- Artro-Bic (NCT06483256)
- Testing
- radiographic control
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Ortopedico Rizzoli
Traumatic Brain Injury
Geri-TBI: A Prospective Multi-center Evaluation of Geriatric Patients With Traumatic Brain Injury
This multicenter prospective observational study is designed to prospectively record data on patients who are managed per institutional standard of care.
- Trial name
- NCT05171010
- Testing
- no study-based therapeutic interventions
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Methodist Health System
Acquired Brain Injury
Effect of Methylphenidate on Ecologic Function in Paediatric Acquired Brain Injury Population
The purpose of this study is to investigate the influence of Methylphenidate in pediatric acquired brain injury population, regarding ecologic (every day) function.
- Trial name
- NCT02227056
- Testing
- Methylphenidate
- Where
- Israel
- Volunteers
- 34 people
- Sponsor
- Loewenstein Hospital
Cerebral Palsy, Traumatic Brain Injury
Hybrid Approach to Pediatric Rehabilitation
Children and youth recovering from acquired injuries typically receive therapy via in-patient or outpatient rehabilitation (OPR).
- Conditions
- Cerebral Palsy, Traumatic Brain Injury, Orthopedic Disorder
- Trial name
- NCT06547762
- Testing
- Hybrid approach (in-person and remote) to pediatric rehabilitation: A look beyond the COVID-19 crisis
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Alyn Pediatric & Adolescent Rehabilitation Hospital
Brain Injuries
Tablet-based Application for Cognitive Therapy
Cognitive impairments such as deficits in attention, executive functions, perception, language, speech, arithmetics, and memory are very common symptoms after acquired brain injury, which can be caused by neurological diseases…
- Trial name
- TACTIC (NCT06462703)
- Testing
- Tablet-based neurorehabilitation with myReha
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Klinikum Floridsdorf
Cerebral Palsy Infantile, Acquired Brain Injury
Augmented Reality Training for Cerebral Palsy
Rehabilitation programmes for children and adolescents with CP or ABI are not easily accessible, which hinders the development of their physical and cognitive abilities.
- Trial name
- TERAPACE (NCT06944613)
- Testing
- Augmented reality-based programme/Microsoft Hololens version 2
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Esquirol
Traumatic Brain Injury (TBI) Patients
Early Neuromodulation in Traumatic Brain Injury
The two goals of the proposed study are: (1) To determine how brain activity changes with cognitive recovery over time from acute to chronic phases of traumatic brain injury (TBI).
- Trial name
- NCT06871124
- Testing
- transcranial electrical stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Traumatic Brain Injury
Phase 2 a Study to Assess Safety and Pharmacokinetics of VAS203 in Patients With Traumatic Brain Injury
In the exploratory multi-center Phase 2 a study safety, tolerability, pharmacodynamics and pharmacokinetics of the Nitric Oxide Synthase inhibitor VAS203 is assessed in patients with moderate and severe traumatic brain injury.
- Trial name
- NOSTRA (NCT02012582)
- Testing
- VAS203, Saline
- Where
- 6 sites in Austria, France and 3 more
- Volunteers
- 32 people
- Sponsor
- veriNOS operations GmbH
Traumatic Brain Injury
Clinical Randomisation of an Antifibrinolytic in Significant Head Injury
The CRASH-3 trial will provide reliable evidence about the effect of tranexamic acid on mortality and disability in patients with traumatic brain injury.
- Trial name
- CRASH-3 (NCT01402882)
- Testing
- Tranexamic Acid
- Where
- Georgia
- Volunteers
- 12,737 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Premature Birth, Brain Injury
Melatonin As A Novel Neuroprotectant In Preterm Infants- Dosage Study
Preterm babies are at risk of brain injury. Melatonin, a naturally occurring hormone, may reduce this risk. The unborn baby receives melatonin from the mother but following premature delivery there maybe a period of prolonged…
- Trial name
- MIND (NCT00649961)
- Testing
- Melatonin injection
- Where
- 2 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- Imperial College London
Hemianopsia, Homonymous, Brain Injury
Biofeedback for Hemianopia Vision Rehabilitation
Patients with brain injury secondary to stroke, surgery, or trauma frequently suffer from homonymous hemianopia, defined as vision loss in one hemifield secondary to retro- chiasmal lesion.
- Conditions
- Hemianopsia, Homonymous, Brain Injury, Stroke, Brain Tumor
- Trial name
- NCT05397873
- Testing
- Biofeedback training
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University Health Network, Toronto