Clinical trials: Head and Neck Neoplasms
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma
TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer
This phase Ib trial tests the safety, side effects and best dose of tumor membrane vesicle (TMV) vaccine therapy alone and in combination with pembrolizumab and evaluates how well it works in treating patients with head and neck…
- Conditions
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Metastatic Head and Neck Squamous Cell Carcinoma, Metastatic Hypopharyngeal Squamous Cell Carcinoma, Metastatic Laryngeal Squamous Cell Carcinoma
- Trial name
- NCT06868433
- Testing
- Autologous Tumor Membrane Vesicles Vaccine, Biospecimen Collection, Computed Tomography
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Head and Neck Cancer, HPV
Response-Adaptive Treatment in Untreated Locoregional HPV-Negative Head and Neck Cancer
The purpose of this study is to assess the objective response rate following neoadjuvant therapy with volrustomig, paclitaxel, and carboplatin in previously untreated human papillomavirus (HPV)-negative locally advanced head and…
- Trial name
- NCT07065630
- Testing
- Volrustomig, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Chicago
Squamous Cell Cancer of Head and Neck (SCCHN)
Phase II Study of Daily Adaptive Radiotherapy for Submandibular Gland-sparing in Head and Neck Cancer
This is a randomized, single centre, single blinded prospective study comparing the standard of care imaging guided radiation therapy and daily adaptive radiotherapy (ART) for submandibular gland-sparing in head and neck cancer
- Trial name
- RTL-DART (NCT07348887)
- Testing
- Daily adaptive radiation therapy, Image guided radiation therapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Head & Neck Cancer, Head & Neck Squamous Cell Carcinoma
Impact of Early Response to First-line Anti-PD-1 Monotherapy in Patients With Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Carcinoma, Assessed by 18F-FDG PET/CT
This study aims to evaluate the role of early response assessment by 18F-FDG PET/CT in patients with recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma with PD-L1 CPS >1 treated with pembrolizumab…
- Trial name
- PEMBRO-PET (NCT07448727)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Rome Tor Vergata
Head and Neck Cancer, Radiotherapy
Optical Coherence Tomography in Patients With Radiotherapy for Head and Neck Cancer
The purpose of this study is to determine whether any eventual skin damage caused by radiation therapy can be detected and monitored at a subclinical level via optical coherence tomography (OCT).
- Trial name
- ROOCT (NCT04610645)
- Testing
- OCT, Dermatoscope
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Krankenhaus Barmherzige Schwestern Linz
Head and Neck Cancer
A Single-center Phase II Study to Investigate the Immune Maintenance Therapy Pattern in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Achieved MPR After Neoadjuvant Immunotherapy Combined With Chemotherapy
Head and neck cancer is the malignant tumor with the highest morbidity and mortality, of which 60% present with locally advanced disease at initial diagnosis, and the 5-year survival rate of standard treatment is less than 30%.
- Trial name
- NCT06208826
- Testing
- Toripalimab, Radiation Therapy, Cisplatin
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Radiation-Induced Xerostomia, Head and Neck Cancer
Pilot Study of Radiation-Induced Xerostomia Treatment With Allogeneic Mesenchymal Stromal Stem Cells
This pilot interventional study evaluates the safety and preliminary efficacy of treatment with allogeneic mesenchymal stromal stem cells (MSCs) derived from umbilical cord tissue in patients with radiation-induced xerostomia…
- Trial name
- NCT07431645
- Testing
- Allogeneic Mesenchymal Stromal Cells (MSC)
- Where
- Slovenia
- Volunteers
- 10 people
- Sponsor
- Institute of Oncology Ljubljana
Breast Cancer, Sarcoma
Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial
This is a phase II single-arm, Phase 2a, randomized, double-blinded, placebo-controlled pilot clinical trial determining efficacy of riluzole in preventing cognitive dysfunction in subjects with cancer, who are receiving…
- Conditions
- Breast Cancer, Sarcoma, Gastric (Stomach) Cancer, Lung Cancer
- Trial name
- NCT07447050
- Testing
- Riluzole
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of California, Irvine
Head and Neck Cancer, Radiotherapy
Iparomlimab and Tuvonralimab Plus Hypofractionated Radiotherapy and Chemotherapy for HAHNSCC
Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at a locally advanced stage, where cisplatin-based chemoradiotherapy is standard but still results in high recurrence rates.
- Conditions
- Head and Neck Cancer, Radiotherapy, Anti-PD-1/CTLA-4 Antibody
- Trial name
- NCT07447570
- Testing
- Iparomlimab and Tuvonralimab injection, Hypofractionated Radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Squamous Cell Carcinoma of the Head and Neck
Randomized Phase II Study of DCE-MRI-based Dose Escalation for Poor-prognosis and Neck Cancer
This study aims to improve locoregional control of poor prognosis Head and Neck Cancer (HNC) patients by selectively escalating the radiotherapy dose to subvolumes of tumor likely to be resistant to standard Radiation Therapy…
- Trial name
- NCT02031250
- Testing
- Cisplatin, Carboplatin, IMRT (Intensity-Modulated Radiation Therapy)
- Where
- 2 sites in United States
- Volunteers
- 106 people
- Sponsor
- University of Michigan Rogel Cancer Center
Head and Neck Cancer
Trial Comparing Different Follow-up Strategies
There is an ongoing debate about the optimal duration, frequency and extent of follow-up (FU) after treatment with curative intent (aimed at complete cure) in patients with head and neck cancer (HNC).
- Trial name
- DeintensiF (NCT05388136)
- Testing
- Conventional follow up schedule with imaging, Deintensified follow up schedule without imaging
- Where
- 3 sites in Switzerland
- Volunteers
- 30 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Head and Neck Cancer
Cisplatin With or Without Monoclonal Antibody Therapy in Treating Patients With Metastatic or Recurrent Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies can locate cancer cells and either kill them or deliver tumor-killing substances to…
- Trial name
- NCT00003809
- Testing
- cetuximab, cisplatin
- Where
- 76 sites in United States, Puerto Rico and 1 more
- Sponsor
- Eastern Cooperative Oncology Group
Radiation-Induced Xerostomia, Head and Neck Cancer
Trial of Acupuncture for Radiation-Induced Xerostomia in Head and Neck Cancer
This study is being done to find out what effects, good and/or bad, acupuncture has on participants and their xerostomia caused by radiation therapy for the treatment of the cancer.
- Conditions
- Radiation-Induced Xerostomia, Head and Neck Cancer, Radiation Toxicity, Oral Complications of Chemotherapy and Head/Neck Radiation
- Trial name
- ACUPUNCTURE (NCT02589938)
- Testing
- Standard Oral Hygiene, Standard Oral Hygiene + True Acupuncture
- Where
- 36 sites in United States
- Volunteers
- 258 people
- Sponsor
- Wake Forest University Health Sciences
Head and Neck Carcinoma
Pain Management for Head and Neck Cancer Survivors
This clinical trial improves an existing pain management program and tests its effect on head and neck cancer survivors. This trial aims to find a better program to improve pain-related physical functioning, mood, and quality of…
- Trial name
- NCT05115825
- Testing
- Behavioral Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- OHSU Knight Cancer Institute
Smoking Cessation, Smoking Reduction
Preoperative Smoking Cessation in Patients Undergoing Surgery
Background: At present, effectively implementing smoking cessation programs in the health care system constitutes a major challenge. A unique opportunity to initiate smoking cessation focuses on smokers scheduled for surgery.
- Conditions
- Smoking Cessation, Smoking Reduction, Surgery--Complications, Surgery
- Trial name
- PORTICO (NCT05192837)
- Testing
- Intensive preoperative smoking cessation counselling
- Where
- Switzerland
- Volunteers
- 251 people
- Sponsor
- Luzerner Kantonsspital
Head and Neck Squamous Cell Carcinoma
Predicting Immunotherapy Efficacy in Head and Neck Squamous Cell Cancer
This study will investigate the clinical validity and clinical utility of the OncoPrism-HNSCC (Head and Neck Squamous Cell Carcinoma) test.
- Trial name
- PREDAPT-HNSCC2 (NCT05296135)
- Testing
- OncoPrism-HNSCC™
- Where
- United States
- Sponsor
- Cofactor Genomics, Inc.
Head and Neck Cancer, Local Recurrent Tumor
Local Injection Methylene Blue Combined With Radiation in HNSCC Patients
The goal of this clinical trial is to investigate the effectiveness of Methylene Blue (MB) as a radiosensitizer in treating head and neck squamous cell carcinoma (HNSCC) that has recurred locally and is resistant to radiation…
- Trial name
- NCT07435415
- Testing
- Methylene Blue (50 mg/10ml)
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- China Medical University Hospital
Breast Cancer, Head and Neck Cancers
Food-related Quality of Life in Patients With Cancer
Food plays a fundamental role in quality of life. In patients with cancer psychological burden and treatment-related side effects can impact appetite, taste perception and pleasure of eating, making nutritional management more…
- Conditions
- Breast Cancer, Head and Neck Cancers, Gynecologic Cancer, Gastrointestinal Cancer
- Trial name
- QVA-Mod (NCT07437326)
- Testing
- Self-reported questionnaires, Salivary and sensory tests
- Where
- 3 sites in France
- Volunteers
- 180 people
- Sponsor
- Hospices Civils de Lyon
Oral Squamous Cell Carcinoma
"Ultra-High Frequency intraOral UltraSonography of the TONgue" (HOUSTON)
Oral diseases are currently diagnosed by means of clinical examination and supported by surgical biopsy procedures. In particular, daily oral medicine practice is lacking the use of a routine diagnostic support to the…
- Trial name
- HOUSTON (NCT06336941)
- Testing
- Ultrasound
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- University of Pisa
Head and Neck Squamous Cell Carcinoma
Camrelizumab Combined With EGFR Monoclonal Antibody or Chemotherapy for Perioperative Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma
This is a prospective, randomized, controlled, multicenter, non-inferiority clinical study designed to evaluate the efficacy and safety of camrelizumab combined with EGFR monoclonal antibody or chemotherapy as perioperative…
- Trial name
- NCT07432087
- Testing
- Camrelizumab and Cetuximab, Camrelizumab and Chemotherapy
- Volunteers
- 246 people
- Sponsor
- Yue He, MD