Clinical trials: Head and Neck Tumors
Neoplasms, Non-small-cell Lung Cancer
A Study to Learn About How Different Amounts of the Study Medicine PF-07826390 Act in the Body of People With Cancer When Taken Alone or With Other Anti-cancer Medicines.
The purpose of this study is to learn about the: safety (the effect of the study medicine on the participant's body), effects of the study medicine alone or in combination with sasanlimab - the best amount of the study medicine.
- Conditions
- Neoplasms, Non-small-cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck, Renal Cell Carcinoma
- Trial name
- NCT06546553
- Testing
- PF-07826390, sasanlimab, SOC (anti-PD-1 + platinum -based chemo)
- Where
- 8 sites in United States
- Volunteers
- 10 people
- Sponsor
- Pfizer
Head and Neck Neoplasms, Hearing Disorder
Hearing Loss and the Effects of Statin Drugs in People With Head and Neck Squamous Cell Carcinoma Treated With Cisplatin Chemoradiation
Background: Cisplatin is a chemotherapy drug. It is used to treat head and neck squamous cell carcinoma (HNSCC) and other cancers. It can cause hearing loss for some people.
- Conditions
- Head and Neck Neoplasms, Hearing Disorder, Hyperlipidemia
- Trial name
- NCT03225157
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Stage I Oral Cavity Squamous Cell Carcinoma, Stage II Oral Cavity Squamous Cell Carcinoma
Photodynamic Therapy With HPPH Compared to Standard of Care Surgery in Treating Patients With Oral Cavity Cancer
This randomized phase II clinical trial studies how well photodynamic therapy with HPPH works compared to standard of care surgery in treating patients with oral cavity cancer.
- Trial name
- NCT03090412
- Testing
- HPPH, Laboratory Biomarker Analysis, Photodynamic Therapy
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Roswell Park Cancer Institute
Oropharyngeal Carcinoma, HPV Positive Oropharyngeal Squamous Cell Carcinoma
Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma
This is a phase II clinical trial. The purpose of this study is to determine the feasibility of deescalating chemoradiation treatment based on mid-treatment tumor response determined by rapid nodal shrinkage and clearance of…
- Trial name
- NCT03215719
- Testing
- Standard Radiation Treatment, Dose-Deescalated Treatment, Cisplatinum
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Esophageal Neoplasms
Study Comparing Radiochemotherapy With Folfox 4 Regimen or 5FU-Cisplatin in Patients With Inoperable Esophageal Cancer
The primary objectives of this study are to assess the feasibility (completion of full treatment) in both arms and to assess endoscopic complete response rate in both arms.
- Trial name
- NCT00160030
- Testing
- FOLFOX 4, 5-FU / Cisplatin
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Sanofi
Head and Neck Carcinoma
Effects of Human Papillomavirus Diagnosis on Relationships of Patients With Head and Neck Cancer
This trial studies the effects of human papillomavirus diagnosis on the relationships of patients with head and neck cancer. Determining the effects of human papillomavirus diagnosis on relationships may determine whether human…
- Trial name
- NCT04666428
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Thomas Jefferson University
Esophageal Cancer, Recurrence
Predicting Early Tumor Recurrence in Patients With Esophageal Squamous Cell Carcinoma
The prognosis of patients with esophageal squamous cell carcinoma (ESCC) who develop post-operative early tumor recurrence is often relatively poor.
- Conditions
- Esophageal Cancer, Recurrence, DNA Methylation
- Trial name
- NCT06476067
- Testing
- Surgery
- Where
- 2 sites in Japan
- Volunteers
- 150 people
- Sponsor
- City of Hope Medical Center
Head and Neck Cancer
Ferumoxytol - Iron Oxide Nanoparticle Magnetic Resonance Dynamic Contrast Enhanced MRI
The goal of this clinical research study is to learn if ferumoxytol, when given at the time of a magnetic resonance imaging (MRI), can help researchers learn more about the spread of certain kinds of cancers.
- Trial name
- NCT01895829
- Testing
- Magnetic Resonance Imaging (MRI), Ferumoxytol
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- M.D. Anderson Cancer Center
Squamous Cell Carcinoma of the Head and Neck
Neoadjuvant Treatment of Locally Advanced HNSCC With Pertuzumab Combined With Lenvatinib.
A single-arm, single-center clinical trial evaluating efficacy (Phase #)
- Trial name
- NCT07550972
- Testing
- A single-arm, single-center clinical trial evaluating efficacy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang Provincial People's Hospital
Healthy, Head and Neck Cancer
Rehabilitation Assessment and Progress Tracking System Based on Video Images for Dysphagic Patients
The current cervical range of motion (CROM) and tongue movement measurement methods are not reliable between observers, which is not practical in real-world usage.
- Trial name
- NCT05141539
- Testing
- Rehabilitation assessment software, VFSS and FOIS
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Mahidol University
Cancer, Thyroid Cancer
Pharmaceutical Management in Targeted Radioligand Therapy
Targeted Radionuclide Therapy (TRT) is a treatment modality used in nuclear medicine to target cancer cells while preserving surrounding healthy tissues.
- Conditions
- Cancer, Thyroid Cancer, Metastatic Prostate Cancer, Neuroendocrine Tumor Carcinoid
- Trial name
- PharmTRT (NCT07389512)
- Where
- 3 sites in France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Head and Neck Neoplasms, Carcinoma, Squamous Cell
Postoperative Concurrent Chemoradiation for Head and Neck Cancer With Multiple Minor Risk
The purpose of this study is to determine the treatment outcome of postoperative concurrent chemoradiation for head and neck squamous cell carcinoma with multiple minor risks.
- Trial name
- NCT00937612
- Testing
- Radiotherapy
- Where
- 3 sites in Taiwan
- Volunteers
- 10 people
- Sponsor
- Chang Gung Memorial Hospital
Nasopharyngeal Carcinoma
Reduced-dose Radiotherapy for Low-risk Stage III Patients With Nasopharyngeal Carcinoma
To study the 2-year PFS (progression-free survival) of patients with stage III nasopharyngeal carcinoma of pretreatment EBV DNA<4000 copy/ml treated with induction chemotherapy followed by two different doses of…
- Trial name
- NCT03668730
- Testing
- Intensity-modulated radiation therapy, Paclitaxel liposome, Cisplatin
- Where
- China
- Volunteers
- 215 people
- Sponsor
- Sun Yat-sen University
Esophageal Cancer
Dose Escalated Adaptive RadioTherapy in Definitive Chemo-radiotherapy for Esophageal Cancer
In Denmark, 1000 new cases of esophageal and gastro-esophageal junction cancer occur every year. Surgery is the primary treatment for patients with localized disease who are considered medically and technically operable.
- Trial name
- DART (NCT04086901)
- Testing
- Radiotherapy dose escalation
- Where
- 3 sites in Denmark
- Volunteers
- 3 people
- Sponsor
- University of Aarhus
Head and Neck Cancer
Impact of Applying a Bandage Skin Hydrogel on the Pains of the Head and Neck in Patients With Cancer of Head and Neck Treated With Radiotherapy
The investigators hope to get by reduced and delayed acute radiodermatitis following the application of dressings to skin hydrogel Hydrosorb®, a reduction in head and neck pains and improved quality of life of patients with head…
- Trial name
- IPAC (NCT01520701)
- Testing
- bandage skin Hydrotac®, Ialuset®
- Where
- 7 sites in France
- Volunteers
- 130 people
- Sponsor
- Centre Francois Baclesse
Head and Neck Cancer
Multiparametric Photoacoustic Imaging in the Course of Radiation Therapy of Malignant Head and Neck Tumors
Multispectral photoacoustic imaging enables the measurement of the optical absorption of various tissue components or exogenous contrast agents in vivo.
- Trial name
- NCT04437030
- Testing
- MSOT Acuity Echo device
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital Heidelberg
Laryngeal Carcinoma
The Relationship Between The Differential Expression Of FosB Protein In Laryngeal Cancer Tissues And Clinical Prognosis
To determine whether there is statisstical difference in FosB (FBJ murine osteosarcoma viral oncogene homolog B) protein expression between laryngeal cancer tissue and adjacent tissue through immunohistochemistry methods.
- Trial name
- NCT06836765
- Testing
- the expression negative in laryngeal cancer tissue, the expression positive in laryngeal cancer tissue
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yang ji
Head and Neck Cancer
"QUAD SHOT" Radiotherapy With Pembrolizumab in Patients With Recurrent Head & Neck Cancer
The purpose of this study is to test the safety of palliative "QUAD SHOT" radiotherapy combined with pembrolizumab and evaluate the effects of the combination treatment patients with recurrent cancer of head and neck.
- Trial name
- QUADSHOT (NCT04373642)
- Testing
- Pebrolizumab + QUADSHOT Radiotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Oklahoma
Cancer of Head and Neck
Evaluation of Cetuximab (ERBITUX) and Concurrent Carboplatin, Paclitaxel & Radiotherapy in the Management of Patients With Advanced Locoregional Squamous Cell Carcinomas of the Head and Neck (GCC 0442)
The purpose of this study is to evaluate the response of the tumor to the treatment regimen that will be used in this study. This study will also test the safety of cetuximab (C225), given with chemotherapy and radiation therapy.
- Trial name
- NCT00343083
- Testing
- Erbitux, Paclitaxel & Carboplatin, Radiation
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Maryland, Baltimore
Cancer T1-N0 or T2-N0 of the Oral Cavity
Sentinel. Ambulatory. Oral Cavity. Oropharynx (S.A.C.O)
This is a single-center pilot study of open-label, non-randomized interventional research based on the outpatient management of 30 patients with T1-N0 or T2-N0 cancer in the oral cavity or oropharynx.
- Trial name
- SACO (NCT03545256)
- Testing
- outpatient surgery for T1-N0 or T2-N0 cancers of the oral cavity or oropharynx with lymph node search
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
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