Clinical trials: Head and Neck Tumours
Oesophageal Cancer
Do Changes in ctDNA Predict Response for Patients With Oesophageal Cancer Receiving Durvalumab
Patients with cancer are increasingly being treated with drugs designed to modulate the response of their immune system, broadly to boost their body's defences against cancer.
- Trial name
- CALIBRATION (NCT03653052)
- Testing
- Durvalumab
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Simon C Pacey, MD
Head and Neck Cancer
Molecular Imaging-based Dose Escalation in HPV Negative Patients With Locally Advanced SCC of the Oropharynx
Phase I study to assess the feasibility (i.e. early toxicity) of Molecular Imaging-based Dose Escalation in HPV Negative Patients With Locally Advanced SCC of the Oropharynx.
- Trial name
- NCT02336711
- Testing
- dose escalation
- Where
- 2 sites in Belgium
- Volunteers
- 10 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Oral Leukoplakia
Analyzing Handprint Patterns to Predict Oral Cancer Risks: A Comparative Study
Aims: To evaluate the qualitative and quantitative parameters of finger and palmar dermatoglyphic patterns in patients with oral premalignant and malignant lesions OBJECTIVES: 1.
- Trial name
- QQA-FPD-PMML (NCT06256809)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King Khalid University
Earache
Interest of Pregabalin (Lyrica) on the Treatment of Reflex Earache in Head and Neck Cancer.
Referred otalgia is one of the symptoms of oropharynx and hypopharynx cancer. It can be primary (otodynia) or secondary (referred otalgia and projected pain).
- Trial name
- LYRORL (NCT02924675)
- Testing
- Pregabalin
- Where
- France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Lille
Head and Neck Squamous Cell Carcinoma
Radiotherapy With Pembrolizumab in Metastatic Head and Neck Squamous Cell Carcinoma (HNSCC)
Randomized phase II study of immune stimulation with Pembrolizumab and radiotherapy in second line therapy of metastatic head and neck squamous cell carcinoma.
- Trial name
- NCT03386357
- Testing
- A (pembrolizumab+RT), B (pembrolizumab)
- Where
- 7 sites in Germany
- Volunteers
- 115 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Metastatic Thyroid Papillary Carcinoma, Metastatic Thyroid Follicular Carcinoma
Durvalumab Plus Tremelimumab for the Treatment of Patients With Progressive, Refractory Advanced Thyroid Carcinoma -The DUTHY Trial
This is a prospective, multi-centre, open label, stratified, exploratory phase II study evaluating the efficacy and safety of durvalumab plus tremelimumab in different cohorts of patients with thyroid cancers.
- Conditions
- Metastatic Thyroid Papillary Carcinoma, Metastatic Thyroid Follicular Carcinoma, Metastatic Thyroid Cancer
- Trial name
- DUTHY (NCT03753919)
- Testing
- Durvalumab, Tremelimumab
- Where
- 15 sites in Spain
- Volunteers
- 79 people
- Sponsor
- Grupo Espanol de Tumores Neuroendocrinos
Head and Neck Cancer, Radiotherapy, Conformal (IMRT)
SGRT in Head and Neck Cancer Radiotherapy
This study is a prospective, randomized, open-label, single-center exploratory trial. A total of 40 newly diagnosed, untreated head and neck cancer patients （stage I-IVa, AJCC 8th edition） will be enrolled and randomly assigned…
- Trial name
- NCT07726407
- Testing
- SGRT-guided radiotherapy with open thermoplastic mask immobilization, Closed head-neck-shoulder thermoplastic mask with laser alignment
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Esophageal Squamous Cell Carcinoma, Chemoradiotherapy
Whole-course Immunonutrition Combined With Chemoradiotherapy±ICIs for Local Advanced Patients With Inoperable Esophageal Squamous Cell Carcinoma
Chemoradiotherapy has been a standard modality for inoperable locally advance esophageal carcinoma. The goal of this randomized control study is to compare the feasibility, and survival benefits of whole-course immunonutrition…
- Conditions
- Esophageal Squamous Cell Carcinoma, Chemoradiotherapy, Immunonutrition, Inoperable
- Trial name
- NCT05833594
- Testing
- Whole-course Immunonutrition Combined With Chemoradiotherapy±ICIs
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Anhui Provincial Hospital
Esophageal Cancer
UICC Classification of Esophageal Cancer
Background. The aim of our study was to investigate the ability of the Seventh edition of the classification by the International Union Against Cancer (UICC) to identify patients at higher risk and to predict the overall survival…
- Trial name
- NCT01770275
- Where
- Germany
- Volunteers
- 605 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Head and Neck Neoplasm, Gastrostomy
Endoscopic Direct-PEG Placement in Patients Unable to Undergo Pull-PEG Procedure
Placement of a feeding tube through a gastrostomy can be performed endoscopically or radiologically. While percutaneous endoscopic gastrostomy (PEG) tube placement is most frequently performed using a "pull" technique, this…
- Conditions
- Head and Neck Neoplasm, Gastrostomy, Esophageal Stenosis and Obstruction
- Trial name
- PEG (NCT04151030)
- Testing
- PEG placement
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Kansas City Veteran Affairs Medical Center
Esophageal Cancer, Esophageal Neoplasms
Rehabilitation and Recovery for Persons With Esophageal or Gastric Cancer
This study aims to develop and evaluate a model for systematic and evidence-based cancer rehabilitation for people with esophageal and gastric cancer to provide conditions for a better quality of life and fewer cancer-related…
- Conditions
- Esophageal Cancer, Esophageal Neoplasms, Gastric Cancer, Stomach Neoplasm
- Trial name
- NCT05698992
- Testing
- evidence-based individualized rehabilitation
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Cancer, Neoplasms
A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers
This study will investigate OC-001 as monotherapy, and in combination with, Avelumab, in various cancer types
- Conditions
- Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer
- Trial name
- NCT04260802
- Testing
- OC-001, Drug: OC-001 in Combination with Avelumab
- Where
- 5 sites in Canada
- Volunteers
- 73 people
- Sponsor
- Ocellaris Pharma, Inc.
Esophageal Cancer, Gastric (Stomach) Cancer
Timing of Comprehensive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal or Gastric Adenocarcinoma
Purpose of the Study: This clinical study investigates whether a shorter or longer duration of systemic therapy before local treatment (surgery or radiation) results in better disease control in patients with esophageal or…
- Conditions
- Esophageal Cancer, Gastric (Stomach) Cancer, Gastric Adenocarcinoma, Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma
- Trial name
- OMEC-5 (NCT07000253)
- Testing
- Chemotherapy, Targeted Systemic Therapy, Immunotherapy
- Where
- 5 sites in Netherlands, Norway and 1 more
- Volunteers
- 290 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Head and Neck Cancer
PD-L1 ImagiNg to prediCt Durvalumab Treatment Response in HNSCC
Non-invasive imaging of tumor PD-L1 expression with 89Zr-labeled durvalumab PET/CT predicts response to durvalumab.
- Trial name
- PINCH (NCT03829007)
- Testing
- PD-L1 imaging, Durvalumab
- Where
- 4 sites in Netherlands
- Volunteers
- 33 people
- Sponsor
- Radboud University Medical Center
Metastatic Solid Tumor, Advanced Solid Tumor
A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors
The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.
- Trial name
- NCT06657144
- Testing
- CHS-114, Toripalimab, 5 Fluorouracil
- Where
- 30 sites in United States, Taiwan
- Volunteers
- 154 people
- Sponsor
- Coherus Oncology, Inc.
Thyroid Cancer, Non-Cancer Thyroid Disease
Scientific Protocol for the Study of Thyroid Cancer and Other Thyroid Disease in Ukraine Following the Chernobyl Accident
The nuclear power plant accident at Chornobyl released large quantities of Iodine-131 and other radioisotopes of iodine in the atmosphere, contaminating thousands of square kilometers and exposing millions of people.
- Conditions
- Thyroid Cancer, Non-Cancer Thyroid Disease, Non Thyroid Cancer
- Trial name
- NCT00341094
- Where
- Ukraine
- Volunteers
- 23,143 people
- Sponsor
- National Cancer Institute (NCI)
Parathyroid Neoplasms
Using X-Ray Dye to Locate Hidden Parathyroid Tumors
Occasionally tumors of the parathyroid gland cannot be detected by standard x-ray diagnostic procedures (CT scans, MRIs, and ultrasounds). In order for the tumor to be removed surgically it must first be localized.
- Trial name
- NCT00001394
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Smoking, Head and Neck Neoplasms
Efficacy of Smoking Cessation Intervention for Head and Neck Cancer Patients
The purpose of this study is to determine whether a brief smoking ENT-resident-based intervention increased smoking cessation in patients with Head and Neck cancer attending a Lebanese university hospital, as compared with usual…
- Trial name
- NCT03786172
- Testing
- Smoking cessation Intervention, Usual care
- Where
- 2 sites in Lebanon
- Volunteers
- 100 people
- Sponsor
- Saint-Joseph University
Esophageal Cancer
Pemetrexed, Cisplatin, and Radiation Therapy in Treating Patients With Esophageal or Gastroesophageal Junction Cancer
RATIONALE: Pemetrexed may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by…
- Trial name
- NCT00701857
- Testing
- cisplatin, Pemetrexed, radiation therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arizona
Parathyroid Carcinoma, Hypercalcemia
An Intra-individual Titration Study of KRN1493 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Intractable Primary Hyperparathyroidism
This is an intra-individual titration study of KRN1493 to evaluate the safety and efficacy of KRN1493 for the treatment of hypercalcemia in patients with parathyroid carcinoma or intractable primary hyperparathyroidism (PHPT).
- Conditions
- Parathyroid Carcinoma, Hypercalcemia, Primary Hyperparathyroidism
- Trial name
- NCT01460030
- Testing
- Cinacalcet HCl
- Where
- Japan
- Sponsor
- Kyowa Kirin Co., Ltd.
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