Clinical trials: Head and Neck Tumours
Head and Neck Cancer
A Study Using Cone Beam CT for Head and Neck Cancer
Cone beam CT (computed tomography) is a developing technology which allows CT images to be obtained while a patient is on the radiation treatment table.(A CT scan uses x-rays to produce detailed pictures of structures in the…
- Trial name
- NCT01661062
- Testing
- Cone Beam Computed Tomography (CT) Scan
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan Rogel Cancer Center
Cancer Survivor, Head and Neck Cancer
Impact of Secondary Lymphedema on Symptoms, Functional Status, and Quality of Life After Treatment in Patients With Head and Neck Cancer
RATIONALE: Collecting information about the impact of lymphedema on symptoms, functional status, and quality of life after treatment in patients with head and neck cancer may help doctors learn more about the disease and plan the…
- Conditions
- Cancer Survivor, Head and Neck Cancer, Lymphedema
- Trial name
- NCT01098669
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- Vanderbilt University
Oral Cavity Squamous Cell Carcinoma
Durvalumab With or Without Tremelimumab in Resectable Locally Advanced Squamous Cell Carcinoma of the Oral Cavity
This is a randomized, open-label, prospective, pilot phase I/II study with focus on translational research and on the evaluation of the biological changes that are observed in sequential tumor tissue acquisition in patients with…
- Trial name
- DUTRELASCO (NCT03784066)
- Testing
- Durvalumab, Durvalumab + Tremelimumab
- Where
- Belgium
- Volunteers
- 21 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Esophageal Squamous Cell Carcinoma
The Prognostic Value of Tertiary Lymphatic Structure in Esophageal Squamous Cell Carcinoma
Retrospective analysis of the presence and maturity of tertiary lymphoid structures in pathological sections of patients with esophageal squamous cell carcinoma after surgical treatment.
- Trial name
- NCT06241066
- Testing
- no-Intervention
- Where
- China
- Volunteers
- 359 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Head and Neck Squamous Cell Carcinoma
Specific Methylation Profiles in HNSCC
In the study, N-20190047, the investigators aim to define specific methylation patterns in a group of patients with head and neck squamous cell carcinomas.
- Trial name
- NCT04567056
- Testing
- Blood sample
- Where
- Denmark
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Oral Mucositis, Head and Neck Cancer
Dose Ranging Study to Assess the Safety and Efficacy of SCV-07 for the Delay to Onset of Severe Oral Mucositis in Patients Receiving Chemoradiation Therapy for Head and Neck Cancer
Oral Mucositis (OM) is a painful and debilitating side effect of many of the drug or radiation regiments used to treat cancer. This study examines the investigational drug SCV-07 and it's possible application in treating Oral…
- Trial name
- SCV-07 OM (NCT00756951)
- Testing
- SCV-07
- Where
- 19 sites in United States
- Volunteers
- 59 people
- Sponsor
- SciClone Pharmaceuticals
Solid Tumor Malignancies, Testicular Cancer
Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS)
The purpose of this study is to assess the safety and effectiveness of a drug called Pedmark® sodium thiosulfate (STS) in reducing hearing impairment with standard of care cisplatin therapy.
- Conditions
- Solid Tumor Malignancies, Testicular Cancer, Head and Neck Cancer, Thoracic Cancer
- Trial name
- NCT07407582
- Testing
- Pedmark® STS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Arizona
Oesophageal Cancer
Does the Incremental Shuttle Walk Test Predict the Development of a Hospital Acquired Pneumonia in Patients Undergoing Elective Oesophagectomy: A Prospective Cohort Study
The purpose of this study was to assess the predictive value of the incremental shuttle walk test on rates of hospital acquired pneumonia for patients undergoing oesophagectomy.
- Trial name
- NCT04440124
- Testing
- Incremental shuttle walk test
- Where
- United Kingdom
- Volunteers
- 121 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Melanoma, Urothelial Carcinoma
A RC198 Study in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors
Safety study of RC198 in Subjects with Solid Tumors.
- Conditions
- Melanoma, Urothelial Carcinoma, Renal Cell Carcinoma, Non-small Cell Lung Cancer
- Trial name
- NCT05867303
- Testing
- RC198 Injection
- Where
- 5 sites in Australia, China
- Volunteers
- 48 people
- Sponsor
- RemeGen Co., Ltd.
Esophageal Cancer
Adjuvant Radiotherapy for Patients With Esophageal Squamous Cell Carcinoma After R0 Resection
This retrospective study is exploring the treatment effect and toxicity of adjuvant radiotherapy in patients diagnosed with esophageal squamous cell carcinoma after R0 resection.
- Trial name
- NCT05460403
- Testing
- Adjuvant Radiotherapy
- Where
- China
- Volunteers
- 3,591 people
- Sponsor
- Chinese Academy of Medical Sciences
Head and Neck Cancer, Oral Complications of Radiation Therapy
Iseganan Hydrochloride in Preventing Oral Mucositis in Patients Who Are Undergoing Radiation Therapy for Head and Neck Cancer
RATIONALE: Iseganan hydrochloride may be effective in preventing or lessening oral mucositis in patients who are receiving radiation therapy for head and neck cancer.
- Conditions
- Head and Neck Cancer, Oral Complications of Radiation Therapy, Radiation Toxicity
- Trial name
- NCT00022373
- Testing
- iseganan HCl oral solution, management of therapy complications
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms
Neoadjuvant Chemoimmunotherapy (Camrelizumab + Paclitaxel + Carboplatin) for Resectable HNSCC
This phase II study evaluates the efficacy and safety of neoadjuvant chemoimmunotherapy consisting of camrelizumab (PD-1 inhibitor), paclitaxel, and carboplatin in patients with resectable locally advanced (Stage III-IVA)…
- Conditions
- Squamous Cell Carcinoma of Head and Neck, Laryngeal Neoplasms, Oral Cavity Neoplasm
- Trial name
- NeoCamre-HN (NCT07400094)
- Testing
- Camrelizumab, Paclitaxel, carboplatin
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- National Medical Research Radiological Centre of the Ministry of Health of Russia
Head and Neck Cancer
Prospective PROM and PREM Analysis Demonstrating Specification Advantage and Language Barriers
Importance: Patient reported outcome and experience measures (PROM and PREM) constitute a cornerstone of the collective efforts to improve and personalize healthcare systems.
- Trial name
- NCT06457594
- Testing
- Questionnaire
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Unresectable Esophageal Squamous Cell Carcinoma, Locally Advanced Esophageal Squamous Cell Carcinoma
AK104 Alone or in Combination With Chemotherapy in the First-line Treatment of ESCC
This is a two-arm, open, multicenter clinical study to evaluate the efficacy and safety of AK104 alone or in combination with cisplatin and paclitaxel in the treatment of advanced esophageal squamous carcinoma without systemic…
- Conditions
- Unresectable Esophageal Squamous Cell Carcinoma, Locally Advanced Esophageal Squamous Cell Carcinoma, Metastatic Esophageal Squamous Cell Carcinoma
- Trial name
- NCT05522894
- Testing
- AK104, Cisplatin, Paclitaxel
- Volunteers
- 80 people
- Sponsor
- Chinese Academy of Medical Sciences
Esophageal Cancer
S0356 Oxaliplatin, 5-FU, Radiation Therapy (RT), Surgery for Pts With Stage II or III Cancer of Esophagus or Gastroesophageal (GE) Junction
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin and fluorouracil, work in different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00086996
- Testing
- fluorouracil, oxaliplatin, conventional surgery
- Where
- 143 sites in United States
- Volunteers
- 98 people
- Sponsor
- SWOG Cancer Research Network
Nasopharyngeal Carcinoma
Therapeutic Gain by Induction-concurrent Chemoradiotherapy and/or Accelerated Fractionation for Nasopharyngeal Carcinoma
The objectives of this clinical study are threefold: 1. To compare the benefits in cancer control and survival obtained from adding induction-concurrent chemotherapy to radiation with those from adding concurrent-adjuvant…
- Trial name
- NCT00379262
- Testing
- Capecitabine, Adjuvant chemotherapy using PF (5-Fluorouracil ), Induction chemotherapy using PF (5-Fluorouracil)
- Where
- 7 sites in China
- Volunteers
- 803 people
- Sponsor
- Hong Kong Nasopharyngeal Cancer Study Group Limited
Non Small Cell Lung Cancer, Triple Negative Breast Cancer
CAB-ROR2-ADC Safety and Efficacy Study in Patients With TNBC or Head & Neck Cancer (Ph1) and NSCLC or Melanoma (Ph2)
The objective of this study is to assess safety and efficacy of CAB-ROR2-ADC in solid tumors
- Conditions
- Non Small Cell Lung Cancer, Triple Negative Breast Cancer, Melanoma, Head and Neck Cancer
- Trial name
- NCT03504488
- Testing
- CAB-ROR2-ADC, PD-1 inhibitor
- Where
- 59 sites in United States, Greece and 4 more
- Volunteers
- 132 people
- Sponsor
- BioAtla, Inc.
Squamous Cell Carcinoma of Head and Neck
Single-Arm Exploratory Study of PD-L1 Antibody Plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma
This single-arm exploratory study plans to enroll 69 locally advanced head and neck squamous cell carcinoma (LA-HNSCC) patients.
- Trial name
- NCT07055841
- Testing
- Adebrelimab, TP regimen, Surgery or radiotherapy
- Where
- China
- Volunteers
- 69 people
- Sponsor
- Xiuping Ding
Head and Neck Cancer, Fibula Flap
Risk for Subsequent Osteoradionecrosis in A Transferred Fibula Flap in Head and Neck Cancer Patients Undergoing Segmental Mandibulectomy: a Cohort Study
A retrospective analysis of 329 patients at one single institution between January 2014 and December 2019 who underwent free fibula flap reconstruction was conducted.
- Conditions
- Head and Neck Cancer, Fibula Flap, Osteoradionecrosis, Mandibulectomy
- Trial name
- NCT06428994
- Testing
- Radiotherapy
- Where
- Taiwan
- Volunteers
- 580 people
- Sponsor
- Chang Gung Memorial Hospital
Head and Neck Cancer, Dysphagia
Clinical Impact of Respiratory-Swallow Training on Refractory Dysphagia in Oropharyngeal Head and Neck Cancer
Veterans following treatment of head and neck cancer can be left with lasting swallowing impairment that may require diet alterations, need for feeding tubes, and risk of pneumonia.
- Trial name
- NCT03377270
- Testing
- Respiratory Swallow Training
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- VA Office of Research and Development
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