Clinical trials: Head and Neck Tumours
Oropharyngeal Carcinoma
Patient Reported Outcome Post Radiation Therapy or Chemoradiotherapy Patient Care in Patients With Oropharyngeal Cancer
This study examines patient reported outcomes post radiation therapy or chemoradiotherapy patient care in patients with oropharyngeal cancer.
- Trial name
- NCT04874493
- Testing
- Electronic Health Record Review, Questionnaire Administration
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- M.D. Anderson Cancer Center
Oral Cavity SCC
Trial of Nivolumab as a Novel Neoadjuvant Pre-Surgical Therapy for Locally Advanced Oral Cavity Cancer
The purpose of this study is to look at the effectiveness of nivolumab in patients with oral cavity cancer (OCC) who are about to undergo surgery.
- Trial name
- NCT03021993
- Testing
- Nivolumab
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Medical University of South Carolina
Esophageal Squamous Cell Carcinoma
Camrelizumab Combined With Neoadjuvant Concurrent Chemoradiotherapy for Resectable Locally Advanced ESCC（NICE-RT）
NICE-RT study is a "safety run-in" and phase II trial evaluating the safety and efficacy of Camrelizumab combined with Nab-paclitaxel and Carboplatin and Radiotherapy in patients with resectable locally advanced esophageal…
- Trial name
- NCT05650216
- Testing
- Chemotherapy (nab-paclitaxel AUC=2 and carboplatin 80mg/m2)，Immunotherapy (camrelizumab 200mg)、Radiotherapy(primary lesion and adjacent lymph nodes 41.4Gy， distant lymph node 0.5Gy*4)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Chest Hospital
Thyroid Cancer
To Perform a Post-market Study of the Performance of the Idylla ThyroidPrint Assay Using Clinical Samples in Predicting the Nature of Indeterminate Thyroid Nodules (ITNs) Across Multiple Centers.
To perform a post-market study of the performance of the Idylla™ ThyroidPrint® Assay using clinical samples in predicting the nature of indeterminate thyroid nodules (ITNs) across multiple centers.
- Trial name
- NCT06849284
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Cornwall Hospitals Trust
HPV, Throat Cancer
A Study of Reduced Radiation Therapy and Standard-of-Care Chemotherapy in People With HPV-Positive Throat Cancer
The purpose of this study is to find out if lower doses of radiation may help reduce the side effects of radiation therapy in combination with standard-of-care chemotherapy in people with HPV-positive throat cancer.
- Conditions
- HPV, Throat Cancer, Oropharyngeal Carcinoma, Oropharyngeal Cancer
- Trial name
- NCT05491512
- Testing
- 18 F-FMISO PET/CT, Radiation, Cisplatin
- Where
- 7 sites in United States
- Volunteers
- 121 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cancer of the Esophagus, Gastric Cardia Carcinoma
TaxXel: Taxotere and Xeloda in Esophageal Cancer
This is an open label, non-randomised, multicentre phase 1-2 study with a fixed dose of Taxotere in combination with Xeloda which is dose escalated during the first phase of the study (modified Fibonacci design) and fixed during…
- Trial name
- TaxXel (NCT00821912)
- Testing
- Docetaxel, Capecitabine
- Where
- 10 sites in Norway, Sweden
- Volunteers
- 93 people
- Sponsor
- Karolinska University Hospital
Anal Cancer, Anxiety Disorder
Psychological and Emotional Impact in Patients Undergoing Treatment For Metastatic Cancer Either in a Clinical Trial or as Standard Off-Trial Therapy
RATIONALE: Gathering information from patients who received treatment for metastatic cancer while participating in a phase II or phase III randomized clinical trial and from patients receiving standard treatment off-trial may…
- Conditions
- Anal Cancer, Anxiety Disorder, Breast Cancer, Depression
- Trial name
- NCT00896467
- Testing
- questionnaire administration, psychosocial assessment and care, quality-of-life assessment
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Oscar Lambret
Lung Cancer, Gastric Cancer
CEA-Targeted CAR-T Therapy in CEA-Positive Advanced Solid Tumors
This study is a single-arm, open-label, dose-escalating + dose-expansion clinical study, aiming to evaluate the safety and efficacy of CEA-targeted CAR-T cell preparations, and to preliminarily observe the study drug in…
- Conditions
- Lung Cancer, Gastric Cancer, Colon Cancer, Rectal Cancer
- Trial name
- NCT07179692
- Testing
- CEA-targeted CAR-T cells
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Oral Squamous Cell Carcinoma, Locally Advanced Head and Neck Carcinoma
Neoadjuvant Immunochemotherapy for LAOSCC
To evaluate the prognostic efficacy of neoadjuvant immunochemotherapy with tislelizumab, albumin paclitaxel and cisplatin followed by radical surgery and adjuvant therapy compared with standard therapy for patients with locally…
- Trial name
- NCT06258811
- Testing
- albumin paclitaxel, cispatin, tislelizumab
- Where
- China
- Volunteers
- 134 people
- Sponsor
- Lai-ping Zhong
Esophageal Cancer
Endoscopic Assisted Calcium Electroporation in Esophageal Cancer
In this pilot study, patients with non-curable esophageal cancer will be treated with endoscopic assisted calcium electroporation (CaEP).
- Trial name
- NCT04958044
- Testing
- Calcium Gluconate
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Michael Patrick Achiam
Head and Neck Cancer
Post-operative Radiotherapy With Cisplatin Alone or in Combination With Iressa in Upper Aerodigestive Tract Carcinomas
This trial will be an open multicentric randomized phase II study comparing post-operative radiotherapy + cisplatin associated or not with Iressa in upper aerodigestive tract carcinomas.
- Trial name
- NCT00169221
- Testing
- Iressa (Gefitinib), chemoradiotherapy with cisplatin
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Groupe Oncologie Radiotherapie Tete et Cou
Cancer of Head and Neck
Evaluation of an Active Swallowing Rehabilitation on Quality of Life of Patients Treated by Radiotherapy for Head and Neck Cancer
Toxicity and mainly dysphagia have increased in head and neck cancers as chemoradiation indications have risen over the last decade, leading to a significant loss of quality of life for patients.
- Trial name
- RORC (NCT02892487)
- Testing
- Swallowing therapy
- Where
- 21 sites in France
- Volunteers
- 183 people
- Sponsor
- Rennes University Hospital
Stage I Papillary Thyroid Cancer, Stage II Papillary Thyroid Cancer
Central Neck Dissection in Patients With Clinical Node Negative Thyroid Cancer
This phase II trial studies how well thyroid gland removal with or without central lymph node dissection works in treating patients with thyroid cancer or suspected thyroid cancer that has not spread to the lymph nodes…
- Conditions
- Stage I Papillary Thyroid Cancer, Stage II Papillary Thyroid Cancer, Stage III Papillary Thyroid Cancer
- Trial name
- NCT02138214
- Testing
- Thyroidectomy, entral lymph node dissection (CLND), Quality-of-life assessment
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Wisconsin, Madison
Head and Neck Carcinoma
Tongue-out Radiation Therapy (TORT) for the Mitigation of Radiotherapy-related Toxicities in Patients With Head and Neck Cancer
Our institution recently began incorporating a novel "tongue-out" radiation therapy (TORT) technique for patients with head and neck tumors at particular subsites (oropharynx, larynx, hypopharynx). Protruding the tongue, i.e.
- Trial name
- NCT07227792
- Testing
- Tongue-out radiation therapy (TORT)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Yvonne Mowery
Papillary Thyroid Cancer, Papillary Thyroid Microcarcinoma
Treatment of Papillary Thyroid Carcinoma With Radiofrequency Ablation
Investigators intend to evaluate the efficiency of Radiofrequency ablation (RFA) therapy to treat papillary thyroid carcinoma.
- Trial name
- NCT04129411
- Testing
- RFA
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Head and Neck Squamous Cell Carcinoma
TumorGraft- Guided Therapy for Improved Outcomes in Head and Neck Squamous Cell Cancer- A Feasibility Study
Primary objectives: 1. Evaluate the feasibility of rapidly accruing 30 participants with recurrent metastatic head and neck squamous cell carcinoma for the development of patient derived xenographs (PDX) from fresh, real time…
- Trial name
- Xenograft (NCT02752932)
- Testing
- Drug testing on PDX per Investigator's choice (upto 4)
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Melanoma, Head and Neck Squamous Cell Carcinoma
Oncolytic Adenovirus TILT-123 and Avelumab for Treatment of Solid Tumors Refractory to or Progressing After Anti-PD(L)1
This is a phase 1, dose-escalation trial evaluating the safety of oncolytic adenovirus TILT-123 in combination with avelumab in patients with advanced solid tumors refractory to or progressing after anti-PD(L)1.
- Trial name
- AVENTIL (NCT05222932)
- Testing
- TILT-123, Avelumab
- Where
- 2 sites in United States, Finland
- Volunteers
- 15 people
- Sponsor
- TILT Biotherapeutics Ltd.
Esophagus Squamous Cell Carcinoma
Palbociclib Combined With Afatinib for Advanced Squamous Carcinoma of Esophagus or Gastroesophageal Junction
This is a prospective, multicenter, exploratory study. Patients with advanced esophageal or gastro-esophageal junction squamous carcinoma who had progressed on first-line chemotherapy combined with immune checkpoint inhibitors…
- Trial name
- NCT05865132
- Testing
- Palbociclib, Afatinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- AIPING ZHOU
Cancer of Head and Neck
Prognostic Value of 18FDG PET/CT Textural Indices in HNSCC
Head and neck (HN) cancer is the sixth most common malignancy worldwide, with around 800,000 new cases and 320,000 deaths in 2015.
- Trial name
- ImpactTextureO (NCT03378193)
- Where
- France
- Volunteers
- 284 people
- Sponsor
- University Hospital, Brest
Nasopharyngeal Carcinoma
The Influence of Anxiety and Depression on Survival in Nasopharyngeal Carcinoma Patients
This is a prospective, observational cohort study aimed to explore the influence of anxiety and depression to long term survival in nasopharyngeal carcinoma patients.
- Trial name
- NCT03290001
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Sun Yat-sen University
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