Clinical trials: Headache (Migraine)
Migraine, Chronic Headache
Does Topiramate Adjust the Excitability of the Brain in Migraine Sufferers?
The purpose of the study is to determine by the use of non-invasive magnetic stimulation if the medication Topiramate adjusts the excitability of the migraine sufferer's brain.
- Trial name
- NCT00286923
- Testing
- Topiramate
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Emerald City Headache Organization
Migraine, Obesity
Behavioral Weight Loss as a Treatment for Migraine in Obese Women
This study involves a randomized controlled trial to test the efficacy of behavioral weight loss as a treatment for migraine in obese females aged 18 to 50 years.
- Trial name
- NCT01197196
- Testing
- Behavioral Weight Loss Intervention, Migraine Education
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- The Miriam Hospital
Migraine, Headache Disorders
Natural Language Processing for Headache Medicine
Headache disorders are diagnosed by clinical history taking and applying the criteria provided within the International Classification of Headache Disorders Third Edition (ICHD-3).
- Trial name
- NCT05377437
- Testing
- Natural Language Processing
- Where
- 2 sites in Belgium
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Migraine
Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine
Subjects enrolled at 2 investigative sites will complete 3 visits. Following Visit 1, during a 1-month Baseline Period, subjects will treat with their usual medication and document any warning signs (Prodrome pre-headache) that a…
- Trial name
- NCT00846495
- Testing
- topiramate, frovatriptan
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Clinvest
Migraine Disorders
Effects of the Visual Stimulation on the Motor and Visual Cortex in Migraneurs With and Without Aura
The aim of this study is to investigate the motor and visual cortex excitability in response to visual stimulation of migraineurs with and without aura compared to healthy individuals.
- Trial name
- NCT02564822
- Testing
- Visual Stimulation
- Where
- Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Cyclic Vomiting Syndrome
Staccato Granisetron® (AZ 010) for the Treatment of Cyclic Vomiting Syndrome
This is a multicenter, randomized, double-blind, parallel group, placebo-controlled, efficacy and safety study of adult outpatients diagnosed with CVS and experiencing recurring episodes of stereotypical vomiting.
- Trial name
- NCT04645953
- Testing
- 3mg AZ-010, 1mg AZ010
- Where
- 18 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Migraine
Pain Control in Episodic and Chronic Migraine
The phenomenon of offset analgesia (OA) refers to a disproportionately large decrease in perceived pain following a slight reduction in the intensity of a noxious heat stimulus.
- Trial name
- NCT06599905
- Testing
- Episodic Migraine (EM), Chronic Migraine (CM)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine
Effects of Prayer on Pain Thresholds and Scores of Anxiety and Depression in Participants With and Without Migraine
This study comprised two separate assessor-blinded randomized crossover experiments, one in participants with migraine and one in participants without migraine.
- Trial name
- NCT07143461
- Testing
- Prayer Condition, Reading Condition
- Where
- Brazil
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Headache Disorders, Dizziness
Headache Ear Auditory Dizziness Sinus (HEADS) Registry
The Headache, Ear, Auditory, Dizziness, Sinus (HEADS) Registry is a study over time of individuals living in the United States who experience sinus, vestibular, auditory, and headache symptoms.
- Conditions
- Headache Disorders, Dizziness, Vestibular Diseases, Sinus Disease
- Trial name
- HEADS (NCT07754266)
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Association of Migraine Disorders
Migraine
A Research Study of Greater Occipital Nerve Block as a Treatment for Acute Migraine Attacks
Several observational studies have shown improvement in episodic migraine with the use of greater occipital nerve block as an acute therapy, and a recent placebo controlled trial did not show a decrease in frequency of episodic…
- Trial name
- NCT03159000
- Testing
- Saline, lidocaine/bupivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Migraine Disorders, Muscle Tenderness
Muscle Tenderness and Hardness in Migraine Patients
The aim of the study is to examine symptomatology, quantitative sensory test (QST) parameters, muscle tenderness and muscle hardness in migraine patients interictally and compare with healthy controls
- Conditions
- Migraine Disorders, Muscle Tenderness, Headache Disorders, Primary, Nervous System Diseases
- Trial name
- NCT03626805
- Where
- Denmark
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine Without Aura, Unilateral Headache
Acupuncture for Migraine Prophylaxis
Hypothesis: Acupuncture obtains an abiding effect on migraine prophylaxis Design: A open-label randomized controlled trial. 249 participants will be included.
- Trial name
- AMP (NCT01687660)
- Testing
- acupuncture
- Where
- China
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Li ying
Headache, Migraine
EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model
The purpose of this study is to determine whether EP-4 receptor antagonist can prevent the headache expected during a Prostaglandin E2 infusion.
- Trial name
- NCT00957983
- Testing
- BGC20-1531
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Medication Overuse Headache
Orbitofrontal Cortex (OFC) Influence on Addictive Medication Overuse Headache (MOH) Deriving From Migraine
Medication Overuse Headache (MOH) is an illness affecting about 1,5 % of the general population. It is characterized by chronic headache occurring for at least 15 days a month, by a use of antimigraine drugs during at least 3…
- Trial name
- MOH-PET (NCT00833209)
- Testing
- PET (withdrawal), Imaging
- Where
- 2 sites in France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Migraine
The Effect of Glyceryl Trinitate and Diamox on Cerebral Haemodynamics.
After infusion / injection of Glyceryl trinitrate and Diamox it is wished to study the effect of drugs on the cerebral haemodynamics such as Cerebral blod flow and cerebral blod volume.
- Trial name
- NCT00363571
- Testing
- GTN, Diamox
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine Headaches, Nausea
Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the ED: A RCT
Haloperidol is known to be a safe alternative medication to control difficult pain, and has been shown effective when compared to placebo for controlling headaches.
- Conditions
- Migraine Headaches, Nausea, Restlessness
- Trial name
- NCT02098499
- Testing
- Haloperidol, Metoclopramide 10mg, Diphenhydramine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, Portsmouth
Migraine
Ascending Single Doses of Erenumab (AMG 334) in Healthy Adults and Migraine Patients
The primary purpose of this study is to determine whether erenumab is safe and well tolerated in healthy adults and migraine patients.
- Trial name
- NCT01688739
- Testing
- Erenumab
- Where
- Belgium
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Amgen
Migraine, Tension Type Headache
Effectiveness of a Cognitive and Physical Intervention to Reduce Head and Muscle Pain in a Large Population
This study is an interventional trial to evaluate the effectiveness of a cognitive and physical program (Intervention), in reducing the frequency of head and neck pain in the population of an extensive territory of Italy.
- Conditions
- Migraine, Tension Type Headache, Cervical Pain
- Trial name
- NCT01050972
- Testing
- Behavioral: Cognitive, Relaxation, Exercise Therapy
- Where
- Italy
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Migraine
Prophylactic Treatment With Atorvastatin for Chronic Migraine (ChronicStatinMig)
The main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be…
- Trial name
- NCT06485336
- Testing
- Atorvastatin 40mg
- Where
- 6 sites in Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Migraine
Nasal Cavity Cooling for the Symptomatic Relief of Migraine Headache - a Pilot Study
The aim of the study is to evaluate the effect of self-administered intranasal cooling for the symptomatic relief of migraine headache and associated symptoms in an "at home setting".
- Trial name
- NCT04660864
- Testing
- Nasal cavity cooling device.
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Lund University