Clinical trials: Headache (Migraine)
Migraine
Tampa Kinesiophobia Scale Modified for Headache
Tampa Kinesiophobia Scale is a scale that has been validated and reliable in individuals with low back pain in the Turkish population and evaluates fear of movement due to the risk of triggering pain.
- Trial name
- Kinesiophobia (NCT06857357)
- Testing
- Questionnaires
- Where
- 14 sites in Cyprus, Turkey (Türkiye)
- Volunteers
- 329 people
- Sponsor
- Bozok University
Migraine Disorders
Optimized tDCS for the Treatment of Migraine
The aim of this study is to establish an optimized protocol of tDCS that normalize the lack of habituation and efficiency of inhibitory cortical circuits in migraine patients and determine tDCS polarity and the best cortical…
- Trial name
- NCT02562222
- Testing
- anodal tDCS on M1, cathodal tDCS on M1, anodal tDCS on V1
- Where
- Brazil
- Volunteers
- 14 people
- Sponsor
- Universidade Federal de Pernambuco
Headache
eNeura SpringTMS Post-Market Observational US Study of Migraine
A multi-center, prospective, non-randomized, single arm, open label, post-market, observational study to evaluate the use of the eneura, springtms system in reduction of migraine headache symptoms.
- Trial name
- ESPOUSE (NCT02357381)
- Testing
- eNeura SpringTMS
- Where
- 7 sites in United States
- Volunteers
- 263 people
- Sponsor
- eNeura, Inc.
Headache, Migraine
Comparison of a Drug and Placebo in the Prevention of Migraine Headaches
The purpose of this study is to determine whether ethosuximide works better than placebo in the prevention of episodic migraine among veterans.
- Trial name
- NCT01122381
- Testing
- ethosuximide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- US Department of Veterans Affairs
Chronic Migraine
NINDS CRC Chronic Migraine Treatment Trial
The purpose of this study is to compare the reduction in the number of severe headache days at six months in people with chronic migraine treated with topiramate and propranolol versus those treated with topiramate and a placebo.
- Trial name
- CMTT (NCT00772031)
- Testing
- propranolol LA, topiramate
- Where
- 39 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Anne Lindblad
Vestibular Migraine, Migraine Disorders
4-Aminopyridine, Atenolol, or Placebo in Patients With Vestibular Migraine
This phase 2 randomized study will be used to test the efficacy of 4-aminopyridine (4AP) or atenolol to reduce severity and frequency of vestibular and headache symptoms of vestibular migriane sufferers.
- Conditions
- Vestibular Migraine, Migraine Disorders, Vestibular Diseases
- Trial name
- NCT03578354
- Testing
- 4-aminopyridine, Atenolol
- Where
- United States
- Sponsor
- Massachusetts Eye and Ear Infirmary
Migraine Disorders, Muscle Tenderness
Muscle Tenderness and Hardness in Migraine Patients
The aim of the study is to examine symptomatology, quantitative sensory test (QST) parameters, muscle tenderness and muscle hardness in migraine patients interictally and compare with healthy controls
- Conditions
- Migraine Disorders, Muscle Tenderness, Headache Disorders, Primary, Nervous System Diseases
- Trial name
- NCT03626805
- Where
- Denmark
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine, Hemicrania
Home Detox in Medication Overuse Headache (MOH) During Covid-19 Emergency
Medication Overuse Headache (MOH) is a disabling condition that affects the 2% of migraine population. Medication overuse (MO) makes this condition very difficult to treat.
- Trial name
- MOHC (NCT04410536)
- Testing
- Symptomatic drugs, Bridge therapy, Mindfulness program
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Migraine
Trial on Metoclopramide and Ketoprofen in Acute Migraine of Childhood
This is a Randomized double blind trial with the aim to estimate the effectiveness of 3 therapeutic regimes per os on migraine pain: metoclopramide 0,15 mg/kg + placebo metoclopramide 0,15 mg/Kg + ketoprofen 1 mg/kg ketoprofen 1…
- Trial name
- NCT00557544
- Testing
- metoclopramide, ketoprofen
- Where
- Italy
- Sponsor
- IRCCS Burlo Garofolo
Migraine Headache
Bioavailability of DHE Administered by I123 POD Device, IV Injection, and Migranal Nasal Spray in Healthy Adults
A Phase I clinical trial to compare the bioavailability of dihydroergotamine mesylate (DHE) following a single dose administration of INP104 (DHE administered by I123 Precision Olfactory Delivery (POD) Device Nasal Spray) to that…
- Trial name
- NCT03401346
- Testing
- INP104, Dihydroergotamine Mesylate (DHE), Migranal Nasal Spray
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Impel Pharmaceuticals
Chronic Migraine, Headache
Osteopathic Manipulative Techniques for the Treatment of Chronic Migraine Headaches
This study evaluates a standardized osteopathic manipulative therapy (OMT) as a treatment for chronic migraine headaches. It will determine the feasibility of enrolling patients in standardized osteopathic manipulative therapy…
- Trial name
- SMART-CM (NCT04520425)
- Testing
- Osteopathic manipulative therapy
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Headache, Migraine
The Effect of PACAP27 on the Extra- and Intracerebral Arteries Assessed by Magnetic Resonance Angiography (MRA) on Healthy Volunteers
Studying Pituitary adenylate cyclase-activating peptide 27 (PACAP27) effects on extra- and intracerebral arteries assessed by MRA on healthy volunteers.
- Trial name
- NCT03560024
- Testing
- PACAP27
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
ZAP, US. Zomig for Appropriate for Primary Care
The purpose of this study is to determine how useful and effective the use of ZOMIG-ZMT™ (zolmitriptan) 5.0 mg and ZOMIG® Nasal Spray (zolmitriptan) 5.0 mg is for patients, in treating migraine over a period of 6 months
- Trial name
- NCT00637286
- Testing
- Zolmitriptan
- Volunteers
- 120 people
- Sponsor
- AstraZeneca
Migraine
A Pragmatic Trial of Machine Prescription for Migraine
The purpose of this study is to estimate the ability of ML models to predict the effect of migraine preventives. This will be achieved by first identifying sociodemographic, headache and comorbidity features of migraine patients.
- Trial name
- MigPred (NCT06893874)
- Testing
- Preventive migraine treatment
- Where
- Norway
- Volunteers
- 169 people
- Sponsor
- Norwegian University of Science and Technology
Chronic Migraine, Headache
KETOMIGRAINE: Ketogenic Diet in Drug-resistant Chronic Migraineurs
Our protocol, named "KETOMIGRAINE", is based on the prescription of a Ketogenic Diet (KD) to twenty subjects with diagnosis of Chronic Migraine (CM), resistant to oral preventive treatments and non-responders to monoclonal…
- Trial name
- NCT05313503
- Testing
- ketogenic diet
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Headache
Management of Headache Disorders: A Clinical Trial Screening for Prognostic Patient Characteristics
The management of headache disorders is too often based upon trial and error or on personal beliefs and opinions. Seldom it is based on scientific arguments.
- Trial name
- NCT00298142
- Testing
- Usual Care provided by a medical doctor (GP or Neurologist), Usual care plus Physio-/ Manual Therapy
- Where
- 14 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- Vrije Universiteit Brussel
Migraine
Auditory Functions in Patients With Migraine
Migraine is a neurological disease associated with an altered cortical excitability level . The prevalence of migraine is10.5% of adults in Assiut governorate, and is more frequent in women and in individuals with higher…
- Trial name
- NCT04575623
- Testing
- Duration Pattern test (DPT) /Dichotic Digits Test (DDT) /Auditory fusion test-revised (ART-R)/, Dual band pure tone audiometer (Orbiter 992). -Impedance audiometer (AT 235h). -Sound treated booth (industrial acoustic company IAC model 1602-A-t) -Panasonic stereo CD player SA-AK 240.
- Volunteers
- 120 people
- Sponsor
- Assiut University
Chronic Migraine
Hypothalamus Connectivity in Chronic and Episodic Migraine
The purpose is to compare, using functional magnetic resonance imagery in resting-state, the connectivity of the hypothalamus in 2 groups of migraineurs.
- Trial name
- HYPOTHAMIG (NCT02328976)
- Testing
- functional Magnetic Resonance Imaging (fMRI)
- Where
- France
- Volunteers
- 53 people
- Sponsor
- University Hospital, Toulouse
Chronic Migraine, Headaches
A Retrospective Study to Evaluate the Effectiveness and Benefit of onabotulinumtoxinA in Patients With Chronic Migraines
This study will evaluate the effectiveness and benefit of treatment with onabotulinumtoxinA in Chronic Migraine patients who have received a minimum of 7 treatment cycles.
- Trial name
- NCT01749410
- Testing
- onabotulinumtoxinA
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Allergan
Cerebral Microangiopathy, CADASIL
Impact of tDCS on Cerebral Autoregulation
The aim of the study is to investigate whether there is a polarity-specific influence of tDCS on cerebral vasomotor reactivity monitored by transcranial doppler sonography.
- Conditions
- Cerebral Microangiopathy, CADASIL, Migraine With Aura, ICA Stenosis
- Trial name
- NCT01865604
- Testing
- Anodal tDCS, Cathodal tDCS
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
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