Clinical trials: Headache Disorder
Migraine
Chordate System Prophylactic Migraine Clinical Investigation
The purpose of this pilot study is to evaluate the performance of the Chordate System, in terms of the prophylactic effect and tolerability of treatment in patients diagnosed with migraine.
- Trial name
- NCT02243865
- Testing
- Chordate System S200 + CT100 (active treatment)
- Where
- 4 sites in Sweden
- Volunteers
- 87 people
- Sponsor
- Chordate Medical
Migraine
A Dose-Finding Study of MK0974 in Acute Migraine (MK0974-004)
The purpose of this study is to investigate the efficacy and safety of an MK 0974 for migraine headache and to identify an appropriate dose range for further study.
- Trial name
- NCT00246337
- Testing
- MK0974, Rizatriptan
- Volunteers
- 420 people
- Sponsor
- Merck Sharp & Dohme LLC
Binocular Vision Disorder, Convergence Insufficiency
Neurolens Headache Study
To understand the benefits of the neurolens Measurement Device and neurolens treatment as it pertains to treating symptoms related to Chronic Headaches.
- Conditions
- Binocular Vision Disorder, Convergence Insufficiency, Headache, Computer Vision Syndrome
- Trial name
- NCT05070767
- Testing
- Neurolens spectacle lens
- Where
- 10 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Neurolens Inc.
Migraine
A Pharmacokinetic Study of MK-1602 in the Treatment of Acute Migraine (MK-1602-007)
The purpose of this study is to characterize the pharmacokinetics of MK-1602 in the treatment of acute migraine, including the influence of demographic and other variables on MK-1602 pharmacokinetics, and to evaluate the…
- Trial name
- NCT01657370
- Testing
- MK-1602, Rescue medication
- Volunteers
- 195 people
- Sponsor
- Allergan
Migraine, Headache
Bioequivalence Study to Compare Ibuprofen/ Paracetamol Tablets (200mg Ibuprofen/ 500mg Paracetamol) Versus Nuromol® Tablets (200mg Ibuprofen/ 500mg Paracetamol)
Randomized, two-way, two-period, single oral dose, open-label, crossover, bioequivalence study to compare Ibuprofen/ Paracetamol tablets (200mg Ibuprofen/ 500mg Paracetamol) versus Nuromol® tablets (200mg Ibuprofen/ 500mg…
- Conditions
- Migraine, Headache, Backache
- Trial name
- NCT06180070
- Testing
- Ibuprofen/ Paracetamol tablets, Nuromol® tablets
- Where
- Jordan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Migraine
Acute Treatment of Migraine With e-TNS
The main objective of this study is to assess the efficacy of the Cefaly® device as an acute treatment of migraine attack in adult patients.
- Trial name
- ACME (NCT02590939)
- Testing
- CEFALY Active
- Where
- 3 sites in United States
- Volunteers
- 106 people
- Sponsor
- Cefaly Technology
Migraine Disorders
A Functional MRI Study on Erenumab Treatment Effects in Episodic Migraine Patients
The purpose of this study is to investigate the effects of erenumab on central sensitization and brain networks connectivity of migraine patients
- Trial name
- RESET BRAIN (NCT03977649)
- Testing
- erenumab
- Where
- 5 sites in Italy
- Volunteers
- 62 people
- Sponsor
- Novartis Pharmaceuticals
Migraine
Efficacy and Safety of 2 Dose Regimens of TEV-48125 Versus Placebo for the Preventive Treatment of Episodic Migraine
The study is being conducted to evaluate two doses of TEV-48125 in adult patients with episodic migraine
- Trial name
- NCT02629861
- Testing
- Fremanezumab
- Where
- 275 sites in United States, Canada and 7 more
- Volunteers
- 875 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine
An Observational Study to Assess Change in Disease Activity When Ubrogepant Tablets Are Combined With Atogepant Tablets to Treat Migraine in Adult Participants
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound.
- Trial name
- COURAGE II (NCT05653986)
- Where
- United States
- Volunteers
- 391 people
- Sponsor
- AbbVie
Migraine
A Study of the Effect of a Disease-Specific Migraine Smart Phone Application (App) on Participant Care
The purpose of this study is to determine whether using a smart phone application to foster communication between study participants and their doctor will impact care.
- Trial name
- NCT03559088
- Testing
- Migraine App
- Where
- 16 sites in United States
- Volunteers
- 120 people
- Sponsor
- Eli Lilly and Company
Migraine
A Study of the Pulmonary Safety and Pharmacokinetics of Zolmitriptan Inhalation Powder
This study is an open-label, parallel group study to evaluate acute pulmonary safety and Pharmacokinetics (PK) of two doses, separated by 2 hours, of CVT-427 zolmitriptan inhalation powder in three groups of adults: those with…
- Trial name
- NCT02905227
- Testing
- CVT-427 (zolmitriptan inhalation powder)
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acorda Therapeutics
Headache, Tension-Type Headache
Placebo and Active Controlled, Double Dummy Study to Compare Efficacy of Aspirin and Ibuprofen in Treatment of Episodic Tension-type Headache
The purpose of this study is to determine the efficacy and tolerability of 500 mg and 1000 mg Aspirin® (study medication) by comparing it to placebo (the control group without active substance) or 200 mg or 400 mg Ibuprofen…
- Conditions
- Headache, Tension-Type Headache, Tension-Type Headache (Episodic)
- Trial name
- NCT01464983
- Testing
- Acetylsalicylic acid (Aspirin, BAYE4465), Ibuprofen
- Where
- 11 sites in United Kingdom
- Volunteers
- 1,115 people
- Sponsor
- Bayer
Cluster Headache
Effect of Ketamine Intranasal Spray in Treatment of Chronic Cluster Headache
Ketamine has been used clinically IV in a very safe manner by a very small number of clinicians, to treat migraines and CH, and various other rarer pain disorders, including mixed headache and neuropathic pain clinical syndromes.
- Trial name
- NCT04179266
- Testing
- Ketamine
- Where
- Denmark
- Volunteers
- 23 people
- Sponsor
- CCH Pharmaceuticals
Pain Disorders
Crossover, Single Dose Randomized, Bioequivalence of Ketoprofen Lysine Salt Immediate Release vs Oral Solution
Objectives: The objective of the study was to investigate the bioequivalence between two formulations containing ketoprofen lysine salt (KLS) when administered as single oral doses in two consecutive study periods to healthy male…
- Trial name
- NCT02350296
- Testing
- KSL 40 mg, OKi® 80 mg
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dompé Farmaceutici S.p.A
Migraine, Headaches
Efficacy and Safety of 20 mg Sumatriptan Powder Delivered Intranasally With the Bi-directional Device Compared With 100 mg Sumatriptan Tablets in Adults With Acute Migraine With or Without Aura
This study is being conducted to determine if OPTINOSE SUMATRIPTAN delivered nasally (through the nose) using the OPTINOSE SUMATRIPTAN DEVICE can reduce the pain associated with migraine headaches in 30 minutes after use.
- Trial name
- COMPASS (NCT01667679)
- Where
- 13 sites in United States
- Volunteers
- 275 people
- Sponsor
- Avanir Pharmaceuticals
Episodic Cluster Headache
A Study to Evaluate the Efficacy and Safety of TEV-48125 (Fremanezumab) for the Prevention of Episodic Cluster Headache (ECH)
This is a 13-week, multicenter, randomized, double-blind, double-dummy, placebo-controlled, parallel-group study to compare the efficacy and safety of 2 dose regimens of TEV-48125 (Fremanezumab) versus placebo in adult…
- Trial name
- NCT02945046
- Testing
- Fremanezumab
- Where
- 82 sites in United States, Australia and 10 more
- Volunteers
- 169 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine Headache
Automated Variable Pattern Insufflator Device (AVPI) for the Acute Treatment of Migraine
Randomized, sham-controlled, double-blind study for acute migraine attacks. Randomized to active treatment and sham treatment arms for the first treatment. Optional second active treatment.
- Trial name
- NCT04584762
- Testing
- Automated Variable Pressure Insufflation
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- Nocira, LLC
Migraine
Eptinezumab as Preventive Treatment of Migraine in Adults With Migraine
This study evaluates the efficacy of eptinezumab to prevent migraine in participants with chronic migraine.
- Trial name
- Sunrise (NCT04921384)
- Testing
- Eptinezumab
- Where
- 87 sites in China, Georgia and 6 more
- Volunteers
- 981 people
- Sponsor
- H. Lundbeck A/S
Cluster Headache
A Study to Explore the Long-Term Safety and Efficacy of Fremanezumab (TEV-48125) for the Prevention of Cluster Headache
This is a 68-week study to evaluate the long-term safety and efficacy of fremanezumab in participants with cluster headache (CH).
- Trial name
- ENFORCE (NCT03107052)
- Testing
- Fremanezumab
- Where
- 83 sites in United States, Australia and 10 more
- Volunteers
- 275 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine Headache
A Study of LY2951742 in Participants With Migraine
To assess the efficacy and safety of LY2951742 in the prevention of migraine headache in migraineurs with or without aura during 3 months of treatment.
- Trial name
- NCT01625988
- Testing
- LY2951742
- Where
- 37 sites in United States
- Volunteers
- 218 people
- Sponsor
- Eli Lilly and Company