Clinical trials: Headache Disorder
Cervicogenic Headache
Effects of SNAGS Along With Thoracic Postural Correction Techniques in Patients With Chronic Cervicogenic Headache
The aim of this study is to find out the effects of Mulligan SNAGs along with thoracic postural correction techniques on patients with chronic cervicogenic headache.
- Trial name
- NCT04993950
- Testing
- sustained natural apophyseal glides, SNAGS with thoracic postural correction techniques
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Migraine
Ictal and Interictal Inflammatory Markers in Migraine
The purpose of this study is to evaluate blood levels of several proteins that may be altered in the inflammation associated with migraine headaches.
- Trial name
- NCT01138150
- Testing
- Treximet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
Temporomandibular Disorder (TMD)
Marine Lipids Ease Painful TMD
The ADAPT study is a single-site, Phase 2b, randomized, quadruple-masked, placebo-controlled trial evaluating an omega-3 dietary supplement enriched with specialized pro-resolving mediator (SPM) precursors in adults with chronic…
- Trial name
- ADAPT (NCT07437313)
- Testing
- SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Migraine
Safety, Efficacy and Pharmacokinetics of ALD403
The purpose of this study is to assess the safety, pharmacokinetics and efficacy of a single dose of ALD403 in the prevention of migraine headache in frequent episodic migraineurs for 24 weeks.
- Trial name
- NCT01772524
- Testing
- ALD403
- Where
- 26 sites in United States
- Volunteers
- 163 people
- Sponsor
- Alder Biopharmaceuticals, Inc.
Migraine
Efficacy and Safety of Subcutaneous Administration of TEV-48125 for the Preventive Treatment of Chronic Migraine
To evaluate the efficacy and safety of subcutaneous (SC) administration of TEV-48125 [monthly TEV-48125 225 mg (loading dose only: 675 mg) and TEV-48125 675 mg once over a period of 3 months] compared with placebo for preventive…
- Trial name
- NCT03303079
- Testing
- TEV-48125
- Where
- Japan
- Volunteers
- 571 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Tension-type Headache
Muscle Soreness and Stiffness in Patients With Chronic or Frequent Episodic Tension Type Headache.
The aim is to investigate muscle soreness and stiffness in patients with Chronic or Frequent Episodic Tension Type Headache before and after treatment with amitriptyline - and to compare the results with healthy individuals.
- Trial name
- NCT02746250
- Testing
- Amitriptyline
- Where
- Denmark
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Comparison of Occipital Nerve and Sphenopalatine Ganglion Blockade
Migraine is a chronic disorder that causes disability. Episodic migraine can be managed by prophylactic medical treatment or interventional pain procedures.
- Trial name
- NCT06243874
- Testing
- greater occipital nerve block, transnasal sphenopalatine ganglion block
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ankara University
Migraine Without Aura, Migraine With Aura
Impact of a Nurse for Migraine Management: the IMPACT Project
Headache disorders are prevalent, disabling, under recognized, under diagnosed and under treated. Migraine has a prevalence of 10% in men and 25% in women in Canada.
- Conditions
- Migraine Without Aura, Migraine With Aura, Chronic Migraine
- Trial name
- IMPACT (NCT01804517)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Notre-Dame Hospital, Montreal, Quebec, Canada
Migraine, Chronic Migraine Headache
The Nordic Chronic Migraine Trial of CGRP Monoclonal Antibody and Onabotulinumtoxin A Dual Therapy Compared to CGRP mAbs Monotherapy
Migraine is characterized by attacks of throbbing, moderate or severe headache, often associated with nausea, vomiting, and/or sensitivity to light and/or sound.
- Trial name
- NorMig (NCT07040813)
- Testing
- CGRP mAbs and onabotulinumtoxin A
- Where
- 6 sites in Norway
- Volunteers
- 450 people
- Sponsor
- Oslo University Hospital
Migraine, Acute Treatment of Migraine
Nerivio Efficacy by Time of Treatment Onset
This is a Post-marketing study investigating the impact of treatment time onset with Nerivio on the efficacy of Remote Electrical Neuromodulation (REN) for the acute treatment of migraine.
- Trial name
- NCT06976723
- Testing
- Nerivio
- Where
- United States
- Volunteers
- 55,261 people
- Sponsor
- Theranica
Migraine Without Aura
Study the Effect of Acupuncture on Migraine Patient Without Aura Via Functional Magnetic Resonance Imaging.
This study recruits 30 subjects into three groups, including two experimental groups and one control group. The two experimental groups receive acupuncture treatment for 4 weeks and two times functional magnetic resonance imaging…
- Trial name
- NCT04636359
- Testing
- Acupuncture stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing University of Chinese Medicine
Migraine Headache
Treatment of Multiple Attacks of Acute Migraine (0462-025)
A study to evaluate rizatriptan for the treatment of multiple attacks of acute migraine compared to placebo.
- Trial name
- NCT00899379
- Testing
- rizatriptan benzoate
- Volunteers
- 473 people
- Sponsor
- Organon and Co
Migraine
Pharmacokinetics & Safety of Cambia® in Migraine With or Without Aura in 12-17 Year Olds
Study Objectives: 1. The primary objective is to characterize the pharmacokinetics of a single oral administration of 50 mg Cambia in pediatric subjects, ages 12-17 years with a diagnosis of episodic migraine with or without…
- Trial name
- NCT02287376
- Testing
- Diclofenac Potassium for Oral Solution
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Depomed
Migraine
A Research Study To Compare Two Kinds Of Daily Headache
Chronic daily headache has been classified into several categories. One category is of sudden onset and is called New Daily Persistent Headache (NDPH).
- Trial name
- NCT00335803
- Where
- United States
- Sponsor
- Thomas Jefferson University
Migraine
Bioavailability of Variably Aged MK-0974 Tablets (MK-0974-038)(COMPLETED)
This study will evaluate the comparative bioavailability of three capsule formulations of MK-0974.
- Trial name
- NCT01209741
- Testing
- telcagepant potassium, MK-0974 5Mo5C, MK-0974 12Mo5C
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Migraine, Pain
Anesthetic Blockades and Migraine
Greater occipital nerve (GON) anesthetic blockades are widely used for the treatment of headaches, yet its efficacy in migraine has hardly been assessed with controlled studies.
- Trial name
- NCT02188394
- Testing
- Anesthetic blockades with bupivacaine, Isotonic saline injection
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- César Fernández-de-las-Peñas
Cervicogenic Headache
Comparison of the Effects of Mechanical Traction and Manual Traction on Cervicogenic Headache
52 people between the ages of 18-45 who were diagnosed with cervicogenic headache by the physician who applied to the Physical Medicine and Rehabilitation Department of Bursa VM Medical Park Hospital will be included in the…
- Trial name
- NCT05397977
- Testing
- mechanical traction group, manuel traction group
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Istinye University
Headache Disorders, Secondary, Brain Diseases
Hypersensitivity to Amylin in Post-Traumatic Headache
Pramlintide is a peptide analogue of human amylin which is a vasoactive substance involved in the pathogenesis of headache. This study investigates whether pramlintide induces migraine-like headache in people with persistent…
- Conditions
- Headache Disorders, Secondary, Brain Diseases, Headache Disorders, Nervous System Diseases
- Trial name
- NCT07340775
- Testing
- Amylin
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Hydrocephalus
Study of Ultrasound of the Eye for Children With Suspected Shunt Failure
The purpose of the study is to determine whether an ultrasound of the eye can be used as a radiation-free alternative to X-ray to identify children with risk of shunt failure in the Emergency Department.
- Trial name
- NCT00743457
- Testing
- Ocular Ultrasound
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Oregon Health and Science University
Migraine Disorder, Episodic Migraine
Neurophysiological and Biomolecular Effects of Atogepant in Episodic Migraine
The investigators aim to assess and compare neurophysiological and biochemical changes induced by a 3-month treatment with atogepant (60 mg daily) in patients with high-frequency episodic migraine (8-14 monthly migraine days).
- Trial name
- ATOM (NCT06882122)
- Testing
- Atogepant 60 mg
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
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