Clinical trials: Headache Disorders, Primary
Inflammation, Migraine
Identification of Inflammatory Markers in Migraine Patients
Migraine is prevalent in 10-12% of the population. It involves the development of a cranial perivascular neurogenic inflammation. Recent information suggests that migraine might be a risk factor to stroke.
- Conditions
- Inflammation, Migraine, Headache
- Trial name
- NCT00969995
- Where
- Israel
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Migraine
Bioavailability Study to Compare OPTINOSE SUMATRIPTAN With IMITREX® in Healthy Subjects
The purpose of this study is: To compare the single-dose pharmacokinetics (PK) of intranasal administration of 20 mg OPTINOSE SUMATRIPTAN with 20 mg IMITREX® (sumatriptan) Nasal Spray, 100 mg IMITREX® (sumatriptan) Oral Tablet…
- Trial name
- NCT01507610
- Testing
- Sumatriptan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Optinose US Inc.
Primary Headache Disorders, Tension Headache
Pericranial and General Sensitivity in Patients With Primary Headache
Primary headaches such as migraine and tension type headache are among the most common neurological disorders and frequently cause significant disability and reduced quality of life.
- Conditions
- Primary Headache Disorders, Tension Headache, Tension-type Headache, Migraine
- Trial name
- HEAD-TMD (NCT07514208)
- Testing
- Pericranial Tenderness Assessment, Pressure Pain Threshold Assessment, Temporomandibular Disorder Assessment
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitat Internacional de Catalunya
Migraine
Safety and Pharmacokinetics (PK) Study of Single Ascending Doses of CVT-427 (Zolmitriptan Inhalation Powder) In Healthy Adults
This study is the first study in humans with CVT-427 (zolmitriptan inhalation powder) and is designed to evaluate the safety, tolerability, and PK of single ascending doses of CVT-427 in adult healthy volunteers.
- Trial name
- NCT02609945
- Testing
- zolmitriptan, CVT-427 (zolmitriptan inhalation powder),
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Acorda Therapeutics
Migraine Disorders, Migraine Variant
Vestibular System in Migrainous Vertigo Patients
Do migrainous vertigo patients have more pathology in their vestibular system than migraine patients without vertigo? The aim of this study is to compare the vestibular system of migraine patients with and without vertigo in the…
- Conditions
- Migraine Disorders, Migraine Variant, Episodic Recurrent Vertigo
- Trial name
- NCT00901953
- Where
- Norway
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Headache, Migraine
Psychological Assessment and Treatment of Chronic Benign Headache
Subjects with chronic migraine or tension headaches will receive 12 sessions of biofeedback or relaxation training after fulfilling screening, intake interviews, \& psychological testing requirements.
- Conditions
- Headache, Migraine, Tension Headache, Stress Headache
- Trial name
- NCT00018811
- Testing
- Relaxation training & thermal biofeedback, Surface EMG biofeedback
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
PMS, Menstrual Cramp
A Randomized Placebo-Controlled Study to Evaluate the Effects of a Gummy and Capsule Supplement on Symptoms of Premenstrual Syndrome
This virtual, randomized, placebo-controlled clinical trial evaluates the effectiveness of a PMS capsule and PMS gummy in alleviating premenstrual syndrome symptoms over 12 weeks.
- Conditions
- PMS, Menstrual Cramp, Mood Change
- Trial name
- NCT06763809
- Testing
- PMS Capsule, PMS Gummy
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Semaine Health
Headache, Migraine
Natriuretic Peptide's Headache Inducing Characteristics and Effects on the Cerebral Blood Flow
To investigate headache score and accompanying symptoms during and after infusion of the natriuretic peptides.
- Trial name
- NCT01637662
- Testing
- Natriuretic peptides
- Where
- Denmark
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine With Aura, Migraine Without Aura
A Phase I Study to Study the PK and Safety of Single Doses of STS101, DHE Injection and Nasal Spray in Healthy Subjects
Single-center, single-dose, open-label, 2-part, 3-period crossover (in each part), pharmacokinetic and safety study.
- Conditions
- Migraine With Aura, Migraine Without Aura, Migraine
- Trial name
- NCT03874832
- Testing
- Dihydroergotamine
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Satsuma Pharmaceuticals, Inc.
Migraine, Pediatric Migraine
PEDİATRİC MİGRAİNE PATİENTS İN FİNDİNGS
Migraine is a common neurological disease in the pediatric population. However, studies investigating the clinical symptoms associated with the different phases of migraine attacks (prodrome, aura, postdrome), particularly in…
- Trial name
- NCT07593287
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mersin University
Migraine
The Impact of Migraine on Canadians' Productivity: A Real-World Pharmacy-Based Study
This is a cross-sectional, real-world observational, community pharmacy-based study in which adults treated with a triptan for their migraine will self-report productivity and activity impairment using a web-based portal or…
- Trial name
- NCT05556564
- Testing
- observational study
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- PeriPharm
Migraine, Headaches
Effect on Migraine Frequency of Combined Anti-oxidant Therapy: The MIGRANT Study.
Migraine affects 15% of Western Australians and is a leading cause of suffering and disability in our community (1,2). Research suggests that inflammation of the brain's coverings (meninges) by nerve cell inflammation and the…
- Trial name
- MIGRANT (NCT02629536)
- Testing
- N-acetyl cysteine 600 mg, VitE 250 IU, VitC 500 mg tablet
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Notre Dame Australia
Migraine, Laughter
The Effect of Laughter Therapy in Women
Migraine: An episodic disorder consisting of severe headache, usually with photophobia (sensitivity to light), phonophobia (sensitivity to sound), and/or nausea (occasionally vomiting). Migraine is predominantly a female disease.
- Trial name
- NCT05804812
- Testing
- laughter therapy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Sinop University
Migraine Disorders
A Study of Lasmiditan in Participants With Migraine
The purpose of this study is to measure how much of the drug gets into the blood stream and how long it takes the body to get rid of it during an acute migraine attack and also during the time between acute migraine attacks.
- Trial name
- NCT03247790
- Testing
- Lasmiditan
- Where
- 3 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Migraine
A Study Of The Safety, Tolerability, And Pharmacokinetics Of Multiple Doses Of PF-05180999 In Healthy Adults
PF-05180999 is a novel phosphodiesterase-2 (PDE2) inhibitor. The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of multiple doses of PF-05180999 administered twice daily over 14 days.
- Trial name
- NCT01981486
- Testing
- PF-05180999 Tablets
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
Migraine, Headache
The Role of CGRPand Nociceptin in Migraine
The release of the neuropeptide calcitonin gene-related peptide (CGRP) is thought to play a causative role in migraine. Nociceptin immunoreactivity and ORL-1 mRNA have been detected in human trigeminal ganglia where it was…
- Trial name
- NCT00155129
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Migraine
Bioequivalence of the Tablet and Liquid-Filled Capsule Forms of MK0974 (0974-042)
This study will demonstrate the definitive bioequivalence of a solid dose formulation of MK0974 to the liquid filled capsule formulation of MK0974.
- Trial name
- NCT00966030
- Testing
- MK0974 tablet, Comparator: MK0974 liquid filled capsule
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Headache Migraine
Investigating the Impact of Acupuncture on the Quality of Life of Primitive Headaches Patients
Primary headache is one of the most common neurological diseases in modern society, which seriously affects the patient's quality of life.
- Trial name
- NCT06398353
- Testing
- Real acupuncture
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Migraine
Diary-based Study on the Course of Hormone-withdrawal Migraines
Single centered diary-based study to identify course and characteristics of hormone withdrawal headaches/migraines in users of combined hormonal contraceptives Objectives of the Research Project: to identify the course and…
- Trial name
- NCT04012593
- Testing
- Diary
- Where
- Switzerland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Migraine Disorders
Education on Migraine in Pregnant Women
Patient education is one type of low-cost intervention that can be easily applied but there are not specific studies about it in pregnant women with migraine.
- Trial name
- MIGREMB (NCT06054399)
- Testing
- educational program
- Where
- Chile
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Clinica Alemana de Santiago