Clinical trials: Headache Disorders
Migraine Disorders, Brain, Healthy Adult Participants
Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With Migraine
Researchers want to find out how a substance in the body called CGRP affects balance. CGRP (calcitonin gene-related peptide) is a small protein involved in migraine. Several approved migraine medicines work by blocking it.
- Conditions
- Migraine Disorders, Brain, Healthy Adult Participants, Vestibulo-Ocular Reflex
- Trial name
- VOR-GRIP (NCT07826910)
- Testing
- Atogepant 60 mg
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Konrad Peter Weber
Migraine, Neuropathic Pain
Feasibility and Effectiveness of a Specific App to Delivery Mindfulness Sessions
A standardized behavioural approach based on mindfulness delivered mainly by a specific APP on android will be developed and applied for patients with chronic pain conditions, as migraine and neuropathic pain.
- Trial name
- BE_BI_MIND_APP (NCT05101837)
- Testing
- Home program
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Tension-Type Headache
Prophylactic Effect of Memantine in Chronic Tension-Type Headache
The purpose of this study is to test whether memantine has a prophylactic effect on chronic tension-type headaches.
- Trial name
- NCT00315666
- Testing
- memantine
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Danish Headache Center
Pediatric, Headache
A Study of Family-based Cognitive-behavioral Therapy for Chronic Pediatric Headache and Anxiety
The primary aim of this proposal is to refine the intervention under investigation (i.e., family-based CBT) and evaluate the feasibility and acceptability of the intervention and methods (e.g., recruitment, assessments).
- Conditions
- Pediatric, Headache, Anxiety
- Trial name
- NCT01182051
- Testing
- CBT or relaxation training
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Chronic Headaches
Bion for Occipital Nerve Stimulation
This is a prospective, single-centre, cross-over study designed to evaluate the safety and efficacy of using the bion, an implantable medical device, for the treatment of chronic headaches.
- Trial name
- NCT00205829
- Testing
- battery-powered bion(R) microstimulator system
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Boston Scientific Corporation
Chronic Headache, Chronic Headache Disorder
The Impact of Greater Occipital Nerve and Stellate Ganglion Block Treatments on Sleep in Chronic Headache Management
This study aims to evaluate the effect of Greater Occipital Nerve and Stellate Ganglion block treatments on sleep in patients with chronic headaches.
- Conditions
- Chronic Headache, Chronic Headache Disorder, Migraine
- Trial name
- NCT06646081
- Testing
- Greater Occipital Nerve Block, Stellate Ganglion Block
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Ankara Etlik City Hospital
Migraine
A Research Study of Greater Occipital Nerve Block as a Treatment for Acute Migraine Attacks
Several observational studies have shown improvement in episodic migraine with the use of greater occipital nerve block as an acute therapy, and a recent placebo controlled trial did not show a decrease in frequency of episodic…
- Trial name
- NCT03159000
- Testing
- Saline, lidocaine/bupivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Migraine, Migraine in Adolescence
Mindfulness-Based Intervention for Adolescents With Chronic Migraine
The goal of this study is to assess feasibility and acceptability of a mindfulness-based intervention adapted for adolescents with migraine to inform a future randomized trial assessing effects of the intervention on…
- Trial name
- NCT06414109
- Testing
- BREATHE-Migraine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Colorado, Denver
Headache (Migraine)
Work-related Burden Changes, Quantified with HEADWORK, Among Individuals Treated with Migraine Preventive Therapies.
Migraine is one of the leading causes of disability worldwide among the population under 50. It's economic indirect burden is mostly determined by reduction of work productivity both by absenteeism and presenteeism.
- Trial name
- NCT06812299
- Where
- 3 sites in Italy
- Volunteers
- 175 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine Disorders
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches
This is a 60 week study including a double-blind phase followed by an open-label phase.
- Trial name
- NCT00168428
- Testing
- Botulinum Toxin Type A
- Where
- 6 sites in United States, Canada and 4 more
- Volunteers
- 705 people
- Sponsor
- Allergan
Migraine
Melatonin for Migraine Prevention
The circadian system with its centre in the hypothalamus is involved in migraine pathophysiology. Whether it plays a pivotal role is not clarified.
- Trial name
- MMP (NCT00849511)
- Testing
- melatonin
- Where
- 2 sites in Norway
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nordlandssykehuset HF
Headache, Cephalgia
Effect of Osteopathic Manipulative Treatment for Patients With Chronic Headache
Participants with chronic or recurrent headache, unrelated to any known pathology or disease, will be randomly assigned to one of four interventions: Osteopathic manipulation of the body other than the head, osteopathic…
- Conditions
- Headache, Cephalgia, Migraine
- Trial name
- OMTHA (NCT01332864)
- Testing
- Osteopathic Manipulative Treatment (OMT), Light touch
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Western University of Health Sciences
Headache, Migraine
Psychological Assessment and Treatment of Chronic Benign Headache
Subjects with chronic migraine or tension headaches will receive 12 sessions of biofeedback or relaxation training after fulfilling screening, intake interviews, \& psychological testing requirements.
- Conditions
- Headache, Migraine, Tension Headache, Stress Headache
- Trial name
- NCT00018811
- Testing
- Relaxation training & thermal biofeedback, Surface EMG biofeedback
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Migraine
Fremanezumab Managed Access Program for Pediatric Patients
This is a Managed Access Program (MAP) based on a licensed physician's unsolicited request on a compassionate basis. Specifically, this MAP is for male and female pediatric patients 6 to 17 years with a diagnosis of either…
- Trial name
- NCT03539393
- Testing
- Fremanezumab
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
Migraine Disorders, Migraine Headache
The Efficacy and Safety of Intra-oral Topical Ketoprofen for the Treatment of Acute Migraine
The purpose of this study is to evaluate the efficacy and safety of intra-oral topical ketoprofen for the treatment of acute migraine.
- Conditions
- Migraine Disorders, Migraine Headache, Migraine, Acute Migraine
- Trial name
- NCT01228552
- Testing
- Topical, intra-oral ketoprofen gel
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Behar, Caren, M.D.
Concussion, Intermediate
Magnesium and Riboflavin Treatment for Post-Concussion Headache
This clinical trial will try to determine if the supplements magnesium and riboflavin will reduce the pain and duration of headaches in persons diagnosed with a concussion.
- Trial name
- NCT06260072
- Testing
- magnesium and riboflavin supplement
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Virginia
Headache, Migraine
Adolescent Lifestyle Medicine Headache Study
The goal of this pilot clinical trial is to assess the implementation of a 7-week Lifestyle Medicine intervention for adolescents with headache.
- Trial name
- NCT07373275
- Testing
- Lifestyle Medicine Group Medical Visits
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- MaineHealth
Refractory Migraine, Headache
Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment
The goal of this clinical trial is to test whether injecting lidocaine into two blood vessels of the brain can help treat chronic headaches (migraines)
- Trial name
- LIGHT 2 (NCT07361549)
- Testing
- Lidocaine (drug), Saline
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Daniel A Tonetti, MD
Stroke (CVA) or TIA, Headache, Migraine
Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache
Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months.
- Conditions
- Stroke (CVA) or TIA, Headache, Migraine, Botulinum Toxins, Type A, Cerebral Venous Sinus Thrombosis
- Trial name
- NCT04580238
- Testing
- Botox 200 UNT Injection, Non Botox based Standard of Care Treatments for Headache/Migraine
- Where
- Canada
- Sponsor
- University of Alberta
Migraine Headache
Pilot Study of BOTOX for Migraine Headaches
The purposes of this study are to assess whether subjects treated with BOTOX will: 1. have a decrease in the frequency and intensity of migraine headaches 2. experience improvements in quality of life 3.
- Trial name
- NCT00850421
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- HealthPartners Institute