Clinical trials: Headaches Chronic
Traumatic Encephalopathies, Chronic, Concussion, Mild
Use of Adipose-Derived Stem/Stromal Cells in Concussion and Traumatic Brain Injuries
Concussion is the most common type of brain injury throughout life. Study is seeking improvement of long-term residua following adolescent and adult post-traumatic injuries often associated with contact sports and accidental…
- Conditions
- Traumatic Encephalopathies, Chronic, Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- C-TBI (NCT02959294)
- Testing
- Microcannula Harvest Adipose, Centricyte 1000, Sterile Normal Saline IV deployment AD-cSVF
- Where
- United States
- Sponsor
- Robert W. Alexander, MD, FICS
Brain Injuries, Traumatic, Concussion, Brain
rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head
The objective of this study is to investigate the treatment effect of repetitive transcranial magnetic stimulation in patients with a history of both persistent post-traumatic headache and post-concussion symptoms.
- Conditions
- Brain Injuries, Traumatic, Concussion, Brain, Headaches Chronic, Headache
- Trial name
- TOPiCS-rTMS (NCT03691272)
- Testing
- rTMS - Real Air Film Coil
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Emotions, Corticosteroids
Mapping Emotional Dynamics During Corticosteroid Treatment
Rationale: Synthetic glucocorticoids can result in neuropsychiatric adverse effects in a minority of patients. Although, not all patients experience severe adverse effects, more subtle emotional disturbances are often…
- Trial name
- NCT05391295
- Testing
- Short daily questionnaire
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Leiden University Medical Center
Pediatric, Headache
A Study of Family-based Cognitive-behavioral Therapy for Chronic Pediatric Headache and Anxiety
The primary aim of this proposal is to refine the intervention under investigation (i.e., family-based CBT) and evaluate the feasibility and acceptability of the intervention and methods (e.g., recruitment, assessments).
- Conditions
- Pediatric, Headache, Anxiety
- Trial name
- NCT01182051
- Testing
- CBT or relaxation training
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Chronic Tension-Type Headache
Immune-Pineal Axis Function in Chronic Tension-Type Headache
The purpose of this study is to determine whether electroacupuncture is effective in the treatment of chronic tension-type headache, measured by Headache Impact Test, Visual Analogue Scale and biomarkers.
- Trial name
- NCT01954277
- Testing
- Electroacupuncture
- Where
- Brazil
- Volunteers
- 34 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Migraine
Study of EVO756 in Adults With Migraine
This study will evaluate the efficacy and safety of EVO756 against placebo in adults with migraine.
- Trial name
- NCT07616128
- Testing
- EVO756, Dose 1, EVO756, Dose 2
- Where
- 35 sites in United States, Canada and 1 more
- Volunteers
- 330 people
- Sponsor
- Evommune, Inc.
Headache
Acceptance and Commitment Therapy vs Medical Treatment as Usual Wait-list Control for Primary Headache Sufferers
Research to date suggests that individuals with headache use avoidance as a way to manage their pain. Despite the wide use of avoidance as a coping mechanism of headache triggers, very little empirical evidence exist to support…
- Trial name
- ALGEA (NCT02734992)
- Testing
- ACT+ MTAU, Waitlist Control +MTAU
- Where
- Cyprus
- Volunteers
- 100 people
- Sponsor
- University of Cyprus
Migraine
A Dose-finding Trial With Lu-AG09222 in Adults With Migraine Who Have Not Been Helped by Prior Preventive Treatments
The purpose of this trial is to determine which doses of Lu AG09222 are recommended to help prevent migraines. People who join this trial have already tried 1 to 4 other available medications to prevent their migraines, but these…
- Trial name
- PROCEED (NCT06323928)
- Testing
- Lu AG09222
- Where
- 120 sites in United States, Bulgaria and 12 more
- Volunteers
- 874 people
- Sponsor
- H. Lundbeck A/S
Magnetic Therapy, Rhinosinusitis
Effect of Electromagnetic Therapy on Patients With Chronic Rhinosinusitis.
This study aimed to evaluate the efficacy of Pulsed electromagnetic field (PEMF) for Chronic sinusitis in a randomized, double-blind, placebo-controlled trial.
- Conditions
- Magnetic Therapy, Rhinosinusitis, Headache, Fatigue
- Trial name
- NCT05865613
- Testing
- Pulsed electromagnetic field
- Where
- Egypt
- Volunteers
- 37 people
- Sponsor
- Cairo University
Chronic Headache
Combined Biofeedback With Virtual Reality in the Treatment of Pediatric Headache
The objective of the study is to examine the effect of combined treatments (biofeedback with virtual reality) for pediatric chronic headache.
- Trial name
- VR (NCT00897780)
- Testing
- Biofeedback with virtual reality
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Traumatic Brain Injury, Chronic Pain
Structured Treatment of Pain (STOP) Study
This study seeks to compare two different behavioral treatments for pain in Veterans with a history of TBI. Both treatments involve educating the Veteran about pain, discussing the impact of pain, and different ways to manage it…
- Trial name
- STOP (NCT01768650)
- Testing
- Self-Management #1, Self-Management #2
- Where
- 4 sites in United States
- Volunteers
- 231 people
- Sponsor
- University of Washington
Chronic Migraine Headache
The Neuroanatomical and Psychological Correlates of Suggestibility in Patients With Non-Responsive Chronic Migraine
Chronic migraine is a disabling neurovascular disorder and one of the leading causes of years lived with disability worldwide. Population-based studies report a worrying level of resistance to currently available treatments in…
- Trial name
- SIGMA (NCT07617441)
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto per la Ricerca e l'Innovazione Biomedica
Headache (Migraine), Migraine
Molecular Phenotyping of Migraine Patients According to Sex and Age Through CGRP Quantification
Patients will be asked to visit the study center 2 times, the first time for clinical assessment and a second time for sample collection. Healthy controls will only be asked to visit the study center for sample collection.
- Conditions
- Headache (Migraine), Migraine, Migraine Headache, Migraine with Aura
- Trial name
- FAST (NCT06674772)
- Testing
- Saliva test
- Where
- Spain
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Refractory Chronic Cluster Headache
Ketamine + Magnesium for Chronic Cluster Headache (KETALGIA)
Chronic cluster headache (CCH) is a rare primary headache disorder, defined by episodic attacks that occur for more than one year with no remission period or with remission periods lasting < 3 months (ICHD-3 criteria).
- Trial name
- KETALGIA (NCT04814381)
- Testing
- Ketamine + Magnesium sulfate (drug combination)
- Where
- 14 sites in France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chinese Medicine, Stable Coronary Heart Disease
Xuefu-Zhuyu Capsule for the Treatment of "Qizhi Xueyu Zheng" (Qi Stagnation and Blood Stasis Syndrome)
"Xuefu-Zhuyu capsule" (XFZY) is made from a classic Fangji "Xuefu-Zhuyu Decoction" in an ancient Chinese medical book "Yi Lin Gai Cuo" by Chinese physician Wang Qingren, which is the most representative formula for the treatment…
- Conditions
- Chinese Medicine, Stable Coronary Heart Disease, Chronic Insomnia, Headache
- Trial name
- NCT04218487
- Testing
- Xuefu-Zhuyu Capsule, conventional therapy
- Where
- 12 sites in China
- Volunteers
- 720 people
- Sponsor
- Zhong Wang
Cluster Headache, Chronic Disease
Continuous Positive Airway Pressure as a Potential New Treatment for Cluster Headache
Cluster headache is also called suicide headache due to excruciating nocturnal attacks. There are few treatment options available. Inhalation of oxygen has shown to abort the attacks.
- Trial name
- CPAP (NCT03397563)
- Testing
- Continuous Positive Airway Pressure
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Idiopathic Intracranial Hypertension (IIH)
Eptinezumab for Chronic Headache in Idiopathic Intracranial Hypertension
The goal of this clinical trial is to learn if eptinezumab can reduce headache frequency and headache-related disability in adults with idiopathic intracranial hypertension (IIH) and chronic headache.
- Trial name
- PRIMA (NCT07645833)
- Testing
- Eptinezumab
- Volunteers
- 96 people
- Sponsor
- Rigmor Højland Jensen
Chronic Pain, Headache
Placebo Impacts Sleep and Pain Modulation in Chronic Pain
The goal of this free-choice parallel design clinical trial is to examine the potential beneficial effects of using open-label placebo (OLP) in improving chronic pain related outcomes and sleep quality in people with…
- Trial name
- NCT06225817
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Maryland, Baltimore
Migraine Disorders, Refractory Migraine
EMBRACE Study: Enduring Migraine Benefit From Responsive Artery Coil Embolization
This single-site, open-label pilot study evaluates the safety, feasibility, and potential durability of the TEMMA procedure (Targeted Embolization for Migraine Management), an endovascular treatment strategy targeting meningeal…
- Conditions
- Migraine Disorders, Refractory Migraine, Chronic Migraine
- Trial name
- EMBRACE (NCT07313800)
- Testing
- TEMMA Endovascular Treatment
- Where
- United States
- Sponsor
- Cortex Neurovascular
Migraine
(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist
To compare Botox-treated and Botox-untreated symptomatic tissues (defined as areas where the head hurts and the pain is felt) of chronic migraine (CM) patients using molecular studies.
- Trial name
- NCT03381261
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital