Clinical trials: Healing Fracture of Bone
Unstable Intertrochanteric Fracture, Pertrochanteric Fracture of Femur, Closed
The Effect of Teriparatide on Bone Union in Unstable Intertrochanteric Fracture Patients Treated With PFNA
Phase III, prospective, randomized, parallel, double blind, placebo-controlled study to determine whether Teriparatide can accelerate bone healing in unstable intertrochanteric fracture patients treated with Proximal Femoral Nail…
- Trial name
- NCT03133195
- Testing
- Teriparatide, Calcium supplement, Vitamin D
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Bone Fractures
Kefir Peptides for Bone Fracture Healing
This study is designed to evaluate the effects of kefir-derived peptides on bone healing in patients with upper limb fractures. Kefir peptides are natural protein fragments that may promote bone formation and reduce inflammation.
- Trial name
- KPs-Fracture (NCT07166458)
- Testing
- Kefir Peptide, Standard Care (in control arm)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Jen-Chieh Lai
Fracture of Distal Femur
Plating of Distal Femur Fractures by Far Cortical Locking Using MotionLoc Screws
The objective of this study is to document callus formation and healing of fractures stabilized with locking plates utilizing modern MotionLoc screws that provide controlled axial micro-motion to actively promote fracture healing.
- Trial name
- NCT01667887
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Legacy Biomechanics Laboratory
Pelvic Fracture
Use of Teriparatide to Accelerate Fracture Healing
The purpose of this study is to compare the effect of the drug teriparatide to the effect of placebo on pelvic fracture healing.
- Trial name
- NCT00594906
- Testing
- Teriparatide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Osteopenia, Osteoporosis
Calcium-Rich Food Versus Calcium Carbonate for Bone Health
This study will compare adherence, tolerability, safety, and treatment satisfaction between a calcium-rich food and a traditional calcium carbonate supplement in women ages 40 to 90 who are at increased risk for osteoporosis.
- Conditions
- Osteopenia, Osteoporosis, Bone Health in Perimenopausal Women, Menopause Related Conditions
- Trial name
- NCT07763509
- Testing
- 500 mg calcium from milk-derived minerals, Calcium Carbonate 500 MG
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Cornell University
Distal Femur Fracture
Far Cortical Locking Versus Standard Constructs for Distal Femur Fractures
To determine if Far Cortical Locking screws increase fracture healing rates at 3 months in Closed Distal Femur Fractures in adults when compared to Standard screw constructs.
- Trial name
- FCL (NCT01766648)
- Testing
- Far Cortical locking screw fixation, Standard screw fixation
- Where
- Canada
- Volunteers
- 167 people
- Sponsor
- University of British Columbia
Distal Fibular Fracture, Bimalleolar Fracture
Comparison of Biodegradable & Metal Plates for Fixing Ankle Fracture
A randomised, prospective clinical investigation to compare post-operative fracture healing and complication rate after the fixation of ankle fractures using the Inion OTPS FreedomPlateTM Biodegradable Fixation System versus…
- Conditions
- Distal Fibular Fracture, Bimalleolar Fracture, Trimalleolar Fracture
- Trial name
- NCT00864877
- Testing
- biodegradable fixation system (Inion OTPS FreedomPlateTM)
- Where
- United Kingdom
- Sponsor
- Inion Oy
Tibial Fractures
Multiregion BHA in Open Tibia Fractures
This clinical study is being conducted to demonstrate the safety and effectiveness of the Bone Healing Accelerant (BHA) product when applied to tibia (leg bone) fractures with an external wound or skin break (also called open…
- Trial name
- NCT04056429
- Testing
- BHA
- Sponsor
- Carmell Therapeutics Corporation
Rotator Cuff Tears, Micro Fracture
The Effect of Microfracture Procedure on Rotator Cuff Tendon Healing
Patients with complaints of shoulder pain or limitation of motion and had rotator cuff rupture diagnosed with magnetic resonance imaging will be analyzed and the patients with surgical indication will be included in a randomized…
- Trial name
- NCT04421417
- Testing
- Microfracture + Standard Arthroscopic Rotator Cuff Repair, Standard Arthroscopic Rotator Cuff Repair
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Göker Utku değer
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Femoral Fractures
Supracondylar Distal Femur Fractures and Abaloparatide
Supracondylar femur fractures in the geriatric population present a unique challenge to the orthopaedic surgeon both in terms of fixation, healing, and final extremity axial alignment.
- Trial name
- NCT04626141
- Testing
- Abaloparatide
- Where
- United States
- Sponsor
- Daniel Horwitz
Bone Fracture
Fracture Healing Assessed by HR-pQCT After Administration of Calcium and Vitamin D
This study is designed as a single-blind RCT in 80 postmenopausal women to compare the effect of immediate administration of daily calcium supplementation (1000 mg calcium) or two daily dosages of calcium + vitamin D (1000 mg…
- Trial name
- NCT02889237
- Testing
- Calcium, Calcium + low dose vitamin D, Calcium + high dose vitamin D
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- VieCuri Medical Centre
Non Displaced Atypical Femoral Fractures
Effect of Teriparatide on Fracture Healing in Patients With Incomplete Atypical Femur Fractures
Atypical femur (thigh bone) fractures (AFFs) are uncommon low-trauma fractures which often occur without warning, are highly debilitating, and are slow to heal.
- Trial name
- NCT01896011
- Testing
- Teriparatide 20 mcg
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- University Health Network, Toronto
Fracture Humerus of Shaft
Scandinavian Humeral Diaphyseal Fracture Trial
This pragmatic multicenter randomized controlled trial (RCT) includes adult participants with an acute humeral shaft fracture to compare surgical fixation of humeral shaft fracture to non-surgical treatment with early…
- Trial name
- SHAFT (NCT04574336)
- Testing
- Surgical treatment, Non-surgical treatment
- Where
- 22 sites in Denmark, Finland and 2 more
- Volunteers
- 287 people
- Sponsor
- Kolding Sygehus
Fractures, Bone
855303-RNA Biomarker Validation
The purpose of this study is to test the accuracy of using RNA in blood as a way to forecast new fracture healing outcome.
- Trial name
- 855303-RNAVal (NCT06872775)
- Testing
- Blood draws to assess RNA expression levels
- Where
- 7 sites in United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
Inflamation, Healing
Evaluation of Irisin Levels in Adult Forearm Fracture Surgery Under Infraclavicular Block and General Anesthesia
This randomized prospective study evaluates the effect of general anesthesia versus infraclavicular nerve block on perioperative serum irisin levels in adults undergoing forearm fracture surgery.
- Conditions
- Inflamation, Healing, Angiogenesis
- Trial name
- NCT07324681
- Testing
- General Anesthesia (GA), Infraclavicular Brachial Plexus Blocks
- Volunteers
- 90 people
- Sponsor
- Ankara City Hospital Bilkent
Hip Fracture
A Proof-of-Concept Study Investigating the Safety and Efficacy of ZT-031 on Hip Fracture Healing in Men and Postmenopausal Women
The purpose of this research study is to test if an experimental drug called ZT-031 can help men over 30 years or post-menopausal women over 55 years of age with certain types of hip fracture to heal better or faster following…
- Trial name
- SHIFT (NCT00787358)
- Testing
- ZT-031
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Zelos Therapeutics
Tibial Fractures
Mobile Monitoring of Fracture Healing
The objective of this study is to develop methods for using forces measured on circular external fixators to predict the state of individual patient's healing of severe tibial fractures and defects.
- Trial name
- NCT02534259
- Testing
- Force monitoring of external fixator struts
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Milton S. Hershey Medical Center
Tibial Plateau Fracture
Personalized Weight-Bearing With Smart Crutch Tips After Surgery for Tibial Plateau Fractures
This study will compare two approaches to rehabilitation after surgery for a fracture of the upper part of the shinbone that involves the knee joint (tibial plateau fracture).
- Trial name
- NCT07897149
- Testing
- Crutch Tip Biofeedback System, Individualized FEA-Guided Postoperative Weight-Bearing, Usual-Care Postoperative Weight-Bearing
- Volunteers
- 86 people
- Sponsor
- Comeback Mobility Inc
Fracture Healing
Midterm Follow up of Pediatric Pelvic Fracture Management at Assiut University Hospital
Midterm radiographic and function follow up of pediatric pelvic fractures managed at Assiut University Hospital ( AUH) with a minimum of 3 years Analysis of all recorded cases of pediatric Pelvic Fracture in AUH trauma unit from…
- Trial name
- NCT06591585
- Testing
- Fracture Healing
- Volunteers
- 65 people
- Sponsor
- Assiut University