Clinical trials: Health Prevention
Mortality, Oral Health
De-adoption of Oral Chlorhexidine Prophylaxis and Implementation of an Oral Care Bundle (CHORAL)
The objective of the CHORAL study is to evaluate the de-adoption of oral chlorhexidine and the introduction of a bundle of oral care practices on selected outcomes in critically ill mechanically ventilated adults.
- Conditions
- Mortality, Oral Health, Dryness, Mouth, Pain, Orofacial
- Trial name
- CHORAL (NCT03382730)
- Testing
- Chlorhexidine Mouth Rinse, Chlorhexidine Mouth Rinse De-Adoption
- Where
- 5 sites in Canada
- Volunteers
- 3,260 people
- Sponsor
- University of Toronto
Periodontal Diseases, Pregnancy
The 4th Month Oral Consultation at Pregnant Women
Epidemiological studies have suggested that maternal periodontitis affects the fetal-placental unit, with an increased risk of adverse pregnancy outcome.
- Trial name
- C4M (NCT03132207)
- Testing
- Non interventionel study
- Where
- 2 sites in France
- Volunteers
- 622 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Venous Thromboembolism, Clinical Decision Support Systems
Smart Technology Facilitated Venous Thromboembolism Prophylaxis Based on Bundled Evidence-based Prevention Strategies
Venous thromboembolism (VTE) is the third leading cause of cardiovascular disease deaths globally, and its incidence is increasing over the years.
- Conditions
- Venous Thromboembolism, Clinical Decision Support Systems, Digital Health
- Trial name
- SmaVTE-BEST (NCT06353373)
- Testing
- Application of the modified DeVTEcare system
- Volunteers
- 15,626 people
- Sponsor
- Navy General Hospital, Beijing
Preventative Medicine
The Effectiveness of Mental Health First Aid Intervention Among Undergraduate Students in Switzerland
Mental Health First Aid (MHFA) is an educational training program which has been proven effective at increasing knowledge, improving attitudes and reducing the stigma of mental illness among individuals/the general population.
- Trial name
- NCT06035770
- Testing
- Mental Health First Aid (educational training program)
- Where
- Switzerland
- Volunteers
- 107 people
- Sponsor
- Institut et Haute Ecole de la Santé la Source
Cardiovascular Diseases, Hypercholesterolemia
The ZWOlle Transmural Integrated Care for CArdiovaScular Risk Management Study
Cardiovascular disease (CVD) contributes importantly to mortality and morbidity. Prevention of CVD by lifestyle change and medication is important and needs full attention.
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Hypertension
- Trial name
- ZWOT-CASE (NCT03428061)
- Testing
- Integrated care for cardiovascular risk management
- Where
- Netherlands
- Volunteers
- 740 people
- Sponsor
- UMC Utrecht
Adolescent Drinking, Adolescent Substance Use
Optimizing and Advancing SBIRT in Schools
The goal of this clinical trial is to establish whether brief interventions for alcohol use can be delivered in schools for both indicated prevention and selected prevention, determine if an expanded workforce is an effective…
- Conditions
- Adolescent Drinking, Adolescent Substance Use, Risk Behavior, Health
- Trial name
- OASIS (NCT06206161)
- Testing
- Indicated Prevention, Clinical Staff, Selective Prevention, Expanded Paraprofessional Workforce
- Where
- United States
- Volunteers
- 21,000 people
- Sponsor
- Massachusetts General Hospital
Pre-Exposure Prophylaxis
Leveraging Electronic Health Record Data in a Risk Prediction Model to Increase HIV PrEP Intake in Primary Care
Kaiser Permanente Northern California (KPNC) has been a national leader in implementation of HIV preexposure prophylaxis (PrEP), a daily antiretroviral pill that is more than 99% effective in preventing HIV acquisition.
- Trial name
- NCT05991869
- Testing
- Point-of-care decision support intervention
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Substance-Related Disorders
Disrupting SRFOH to Improve Substance Use and Mental Health Outcomes for Parents in Rural Regions
The study will evaluate the effectiveness of the Just Care for Families program in preventing Oregon Department of Human Services (ODHS)-involved parents in rural communities from escalating opioid and/or methamphetamine use and…
- Trial name
- NCT06560866
- Testing
- Just Care for Families
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Hypertension
Mobilizing Community Hypertension Access Pilot
The Live Healthy Chicago (LHC) Community Pilot is a prospective, community-based study evaluating the feasibility, effectiveness, and economic impact of a pharmacist-led hypertension management program delivered in trusted…
- Trial name
- NCT07547345
- Testing
- Community-Based Multidisciplinary Hypertension Management Program
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
Ischemic Heart Disease
Effectiveness New Health Care Organization Model in Primary Care for Chronic Cardiovascular Disease Patients Based
The purpose of this study is to determine whether a multifactorial primary care intervention based on chronic models can improve the level of control and reduce the number of hospital admissions in patients with ischemic heart…
- Trial name
- PROPRESE (NCT01826929)
- Testing
- Therapeutic education
- Where
- 3 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Schizophrenia, Schizoaffective Disorder
Smoking Relapse Prevention in Schizophrenia
This study seeks to determine if continued treatment with bupropion and nicotine replacement therapy (NRT) can reduce the smoking relapse rate in patients with schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Smokers
- Trial name
- NCT00320697
- Testing
- bupropion + nicotine patch + nicotine gum or lozenges
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- North Suffolk Mental Health Association
Migraine, Sleep Disorder (Disorder)
Sleep, Stress and Migraine - an Observational and Training Study
The MiSleepS study investigates how sleep disturbances and stress are linked to migraine attacks. Participants wear a device called a WHOOP band, which tracks sleep and body signals, and answer brief daily questions via a…
- Conditions
- Migraine, Sleep Disorder (Disorder), Stress, Migraine in Adults
- Trial name
- MiSleepS (NCT07573488)
- Testing
- Profile-based behavioral sleep and stress management
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Susanne Wegener
Alcohol Use Disorder, Suicide Prevention
Adapting a Telehealth Intervention for Suicide Prevention Among Patients With Alcohol Use Disorder in Tanzania
Together, alcohol use and suicide account for approximately 4 million deaths per year, with a considerable burden on low and middle-income countries.
- Trial name
- IDEAS-AUD (NCT07475988)
- Testing
- IDEAS-AUD
- Volunteers
- 30 people
- Sponsor
- Duke University
Diabetes Mellitus, Type 2, Heart Failure
Randomised Trial of Health Coaching in Secondary Prevention of Diabetes and Heart Disease
A randomised trial with individual patients as units of observation will be carried out. Health coaching is used to modify health behaviour and thus improve disease control and health status, as well as use of health care…
- Conditions
- Diabetes Mellitus, Type 2, Heart Failure, Coronary Disease
- Trial name
- TerVa (NCT00552903)
- Testing
- Health coaching
- Where
- Finland
- Volunteers
- 1,500 people
- Sponsor
- Paijat-Hame Hospital District
Coronary Artery Disease, Cardiac Rehabilitation
Electronic Cardiac Rehabilitation (eCardiacRehab) Feasibility Study
In Norway, more than 11,000 patients undergo percutaneous coronary intervention (PCI) annually. However, a very recent study utilizing registry data show a national average of cardiac rehabilitation (CR) participation of only…
- Conditions
- Coronary Artery Disease, Cardiac Rehabilitation, Ethics, Continuity of Patient Care
- Trial name
- eCardiacRehab (NCT06759805)
- Testing
- eCardiacRehab
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Haukeland University Hospital
Colorectal Cancer
¡Salud! Por la Vida (SPLV) A Colorectal Screening Promotion Program
The overall goal of this educational program was to increase colorectal cancer screening (CRCS) in men and women who attend Federally Qualified Health Centers (FQHC) in Puerto Rico.
- Trial name
- SPLV (NCT05502666)
- Testing
- ¡Salud! Por la Vida
- Where
- Puerto Rico
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- University of Puerto Rico
HIV, Pre-exposure Prophylaxis
Life Steps for PrEP for Youth
This is a formative study, designed to provide information required to tailor Life-Steps for Pre-Exposure Prophylaxis (PrEP), an evidence-based cognitive behavioral adherence intervention, to enhance PrEP uptake and adherence in…
- Conditions
- HIV, Pre-exposure Prophylaxis, Medication Adherence
- Trial name
- LSPY (NCT03805451)
- Testing
- Life Steps for PrEP for Youth
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fenway Community Health
Cardiovascular Risk Factors, Cardiovascular Diseases
Cardiovascular Risk Factors in Mexican Women
Cardiovascular disease is a major cause of morbidity and mortality among women. Cardiovascular risk in women is influenced not only by traditional risk factors, but also by sex-specific factors and social determinants of health.
- Trial name
- REFARCAM Mx (NCT07863674)
- Where
- 3 sites in Mexico
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Medicaweb, S.A.C.V.
Anxiety, Depression Disorder
Screening and Monitoring of Mental Health in Educational Settings: Programme for Detection, Psychoeducation and Self-help
Adolescence is a critical developmental stage during which many mental health problems first emerge. However, a large proportion of these issues go undetected and untreated.
- Conditions
- Anxiety, Depression Disorder, Bullying, Addiction
- Trial name
- SENSE (NCT07818603)
- Testing
- program for the detection, referral, and psychoeducation in adolescents
- Where
- Spain
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Cardiovascular Disease Prevention, Cardiometabolic Diseases
Preventative Screening and Health Coaching in a Food Insecure Population
The goal of this longitudinal study is to investigate the role of virtual health coaching on mitigation of cardiometabolic disease risk in an underserved, food insecure population.
- Conditions
- Cardiovascular Disease Prevention, Cardiometabolic Diseases, Cardiovascular Risk Factor, Cardiovascular Risk Score
- Trial name
- HEALTHCOACH (NCT06907524)
- Testing
- Longitudinal, Individualized Health Coaching
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
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