Clinical trials: Health of the Human Microbiome
Rheumatoid Arthritis, Parkinson Disease
Deciphering the Impact of Exposures From the Gut Microbiome-derived Molecular Complex in Human Health and Disease
The ExpoBiome project will analyze the impact of fasting on patients with Parkinsons's Disease (PD) or rheumatoid arthritis (RA) on a clinical level as well as the effect of fasting on their immune system and gut microbiota.
- Conditions
- Rheumatoid Arthritis, Parkinson Disease, Healthy
- Trial name
- ExpoBiome (NCT04847011)
- Testing
- Fasting
- Where
- 2 sites in Germany
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- Andreas Michalsen
Microbial Colonization, Atopic Dermatitis
Nationwide Research on the Rewilding of Kindergarten Yards
Biodiversity is essential for nature and human well-being. Land use has reduced biodiversity in cities that is associated with altered commensal microbiota and a rising burden of immunological disorders among urban children.
- Conditions
- Microbial Colonization, Atopic Dermatitis, Asthma in Children, Allergy
- Trial name
- Vahvistu (NCT06390878)
- Testing
- Biodiversity, Playground equipment
- Where
- 2 sites in Finland
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Natural Resources Institute Finland
Inflammatory Response
The Effects of Agro-ecological Farming Systems on Human Health
As concerns regarding the effects of agriculture on human and environmental health mount, a growing number of farmers are seeking ways to improve health from the ground up.
- Trial name
- AGROHEALTH (NCT05575258)
- Testing
- 44-Day Diet Conventionally Sourced - YELLOW Diet, 44-Day Diet Agro-Ecologically Sourced - GREEN Diet
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Utah State University
Human Microbiome
Effects of Triphala and VSL#3 Probiotic Supplementation on Stool Microbiome Profiles and Inflammation
Normal aging can lead to loss of gut microbial biodiversity which is linked to inflammaging and immunosenescence or the loss of immunocompetence.
- Trial name
- TRIPH2017 (NCT03907501)
- Testing
- Synbiotic, Probiotic
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Healthy Adult Participants
Safety and Efficacy of a Prebiotic Blend in Healthy Humans
The GRASP Trial is a 30-day, randomized, double-blind, placebo-controlled study (Protocol No.: GW-2025-02) designed to evaluate the safety and tolerability of a novel multi-fiber prebiotic blend in healthy adult volunteers (age…
- Trial name
- GRASP (NCT07514741)
- Testing
- Fiber Blend 1 (Low Dose), Fiber Blend 2 (High Dose)
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- LOAM Science
Overweight and Obesity
The Alberta FYBER (Feed Your Gut Bacteria morE fibeR) Study
Too much body-fat has been linked to a low-grade inflammation throughout the body. This inflammation is thought to then cause different diseases, like heart disease and diabetes.
- Trial name
- NCT02322112
- Testing
- Microcrystalline Cellulose Supplementation, Acacia Gum Supplementation, Resistant Starch Type 4 Supplementation
- Where
- Canada
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Healthy Infants
HMOs on Infant Gut Microbiota Modulation and Development of the Immune System in Healthy Infants
The goal of this clinical trial is to learn how a mixture of human milk oligosaccharides impacts the development of the infant microbiota, the immune maturation and how the interaction between the microbiota and immune maturation…
- Trial name
- BELIEF (NCT06631937)
- Testing
- Human Milk Oligosaccharides
- Where
- 2 sites in Denmark
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University of Aarhus