Clinical trials: Health-Related Quality-of-Life
Alcohol Dependence, Alcohol Use Disorder
Extended-release Naltrexone and Care Management for Alcohol Dependent Frequent Emergency Department Users
Our primary aim is to assess the feasibility of initiating treatment in the ED with extended-release naltrexone (XR-NTX) plus care management (CM) vs.
- Trial name
- NCT02445339
- Testing
- XR-NTX+CM (Extended-Release Naltrexone plus Care Management)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Pyruvate Kinase Deficiency, Congenital Non-Spherocytic Hemolytic Anemia
Pyruvate Kinase Deficiency Natural History Study
The purpose of this study is to describe the range and incidence of symptoms, treatments, and complications related to pyruvate kinase deficiency (PKD).
- Trial name
- PKD NHS (NCT02053480)
- Where
- 30 sites in United States, Canada and 4 more
- Volunteers
- 254 people
- Sponsor
- Boston Children's Hospital
PIK3CA-related Overgrowth Spectrum
Health-related Quality of Life, Symptom Severity, and Pain Among Patients With PIK3CA-related Overgrowth Spectrum: A Mixed-methods Observational Study
This was a mixed-methods observational study that incorporated both qualitative interviews and longitudinal quantitative data collection through an online survey (initial, 2 months, and 4 months).
- Trial name
- NCT05294289
- Testing
- Alpelisib
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Novartis Pharmaceuticals
Acute Leukemia
Patient Activation, Counseling and Exercise - Acute Leukemia (PACE-AL)
The purpose of this study is to test a new preventive and restorative intervention for patients with acute leukaemia undergoing consolidation chemotherapy, to measure and delineate the patients' treatment related symptom burden…
- Trial name
- PACE-AL (NCT01404520)
- Testing
- Exercise based multimodal intervention
- Where
- 2 sites in Denmark
- Volunteers
- 70 people
- Sponsor
- Universitetshospitalernes Center for Sygepleje
Irritable Bowel Syndrome
Evaluation of Patient Education in Irritable Bowel Syndrome
About 10% of the population in western countries suffer from abdominal pain and change of bowel habits - known as the irritable bowel syndrome.
- Trial name
- NCT00305968
- Testing
- patient education
- Where
- Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
IBS - Irritable Bowel Syndrome
Assessment of Psychological Symptoms and Health Related Quality of Life in Patients With Irritable Bowel Syndrome
To evaluate the relation between the clinical presentations and the psychiatric co-morbidities with the quality of life in patients with irritable bowel syndrome.
- Trial name
- NCT05480059
- Testing
- A questionnaire
- Volunteers
- 80 people
- Sponsor
- Assiut University
Congenital Heart Disease
Quality of Life and Neurodevelopment Assessment of Children With Congenital Heart Disease Aged 2 to 4 Years
Congenital heart diseases (CHD) are the firt cause of congenital malformations (8 for 1000 births). Since the 90's, great advances in prenatal diagnosis, pediatric cardiac surgery, intensive care, and cardiac catheterization have…
- Trial name
- QoLCHD (NCT04812210)
- Where
- France
- Volunteers
- 248 people
- Sponsor
- University Hospital, Montpellier
Stroke
Quality of Life After Stroke Using a Telemedicine-based Stroke Network
To study the effect of a telemedicine model of stroke care on patient-based outcomes.
- Trial name
- STROKE TeleQOL (NCT02447094)
- Testing
- Alteplase
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Thomas Jefferson University
End Stage Renal Disease, Hemodialysis-Induced Symptom
Integrated Patient Care Intradialysis Programme in Hemodialysis Through a Virtual Health Platform
There is wide evidence regarding the weak points of end-stage Chronic kidney disease (CKD) patients in hemodialysis, and they include three intervention aspects: exercise, nutrition and psychological support.
- Conditions
- End Stage Renal Disease, Hemodialysis-Induced Symptom, Chronic Kidney Diseases
- Trial name
- GoodRENal (NCT04823286)
- Testing
- Virtual reality health platform during hemodialysis
- Where
- 8 sites in Belgium, Greece and 2 more
- Volunteers
- 41 people
- Sponsor
- Cardenal Herrera University
Tension-Type Headache, Trigger Points
Trigger Point Dry Needling for Chronic Tension-Type Headache
In this double-blind randomized trial, we aimed to explore the effectiveness of trigger point dry needling in patients with chronic tension type headache (CTTH) in reduction of headache frequency, intensity, duration, and…
- Trial name
- NCT03500861
- Testing
- Dry Needling
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Eastern Mediterranean University
Partially Edentulous Patients
Comparison of Patient Satisfaction Between Conventional and Digital Removable Partial Dentures
Study type: cross over within subject clinical trial Primary aim: To compare patient satisfaction among three different RPDs: conventional cast Co-Cr, 3D-printed Co-Cr, and PEEK RPDs.
- Trial name
- TRI-RBD (NCT07228988)
- Testing
- Conventional cast Cr-Co RPDs, 3D Printed Cr-Co RPDS, Milled PEEK RPDs
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- King Abdulaziz University
Skeletal Class III Malocclusion
Efficacy of RME and Facemask Therapy for Class III Malocclusion
This multicenter randomized controlled trial compares the efficacy of Rapid Maxillary Expansion (RME) combined with facemask (FM) protraction versus FM protraction alone in treating growing children with skeletal Class III…
- Trial name
- NCT07053683
- Testing
- Combined RME and Facemask Therapy, Facemask Therapy Alone
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Wuhan Integrated Traditional Chinese and Western Medicine Hospital
Adolescent Idiopathic Scoliosis
Memory and Scoliosis Spinal Exercises
This is a behavioral observational study aimed at evaluating the impact that spinal exercises exert on memory of young people. It consists of a short self-administered questionnaire which will be given to adolescents with…
- Trial name
- NCT05969301
- Testing
- Specific spinal exercises for idiopathic scoliosis
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- International Institute of Behavioral Medicines
Depression - Major Depressive Disorder, Anxiety
Impact of Behavioral Activation on Depression and Quality of Life in Patients with Colon Cancer
The purpose of this randomized clinical trial is to study anxiety and depression symptoms at diagnosis in patients with colon cancer. Previous studies have shown that so-called.
- Conditions
- Depression - Major Depressive Disorder, Anxiety, Colon Cancer
- Trial name
- BAdepCa (NCT06745700)
- Testing
- Brief Behavioural Activation, Care as usual
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Region Västmanland
Disease Alzheimer
Health Related Quality of Life Effects of Off-the-shelf Computer Gaming in Alzheimer and Related Disorders Populations
Interactive games (virtual reality) have recently been the center of interest and scientific discussion in the field of cognitive and functional rehabilitation.
- Trial name
- NCT01416012
- Testing
- Physical Therapy (standard), Balance and Gait training in Individualized sessions, Kinect
- Where
- 3 sites in Australia, France and 1 more
- Volunteers
- 31 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Menopause, Hot Flashes
Acupuncture for Hot Flushes in Menopause
In a pragmatic study investigate whether Traditional Chinese Medicine acupuncture-care decreases the frequency of hot flushes and increases health related quality of life among postmenopausal women.
- Trial name
- ACUFLASH (NCT00284492)
- Testing
- Traditional chinese medicine type acupuncture, Self Care
- Where
- Norway
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Colorectal Neoplasms, Prostatic Neoplasms
Determinants of Quality Of Life in AGEd Cancer Patients
Patients face multiple stresses and challenges in the aftermath of cancer diagnosis. Despite needs perceived by elderly patients might differ from those of younger patients, there is a paucity of published data assessing the…
- Trial name
- DEQOLAGE (NCT02672657)
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson's Disease
Multimodal Exercise Program on Parkinson's Disease Patients With Depression
Depression symptoms are common in Parkinson's Disease, it affects health-related quality of life. The evidence showed that exercise improved depression and HRQOL in PD patients.
- Trial name
- NCT03752346
- Testing
- exercise group
- Volunteers
- 98 people
- Sponsor
- Chang Gung Memorial Hospital
Pediatric Cancer, Adolescent and Young Adult Cancer
Improving Communication Between AYA Oncology Patients and Clinicians: A Patient-Centered Intervention
The overarching goal is to develop and demonstrate proof-of-concept of ReSPECT (Reproductive and Sexual Health Patient Education and Communication Tool), a multi-modal communication intervention to improve adolescent and young…
- Trial name
- NCT06982066
- Testing
- ReSPECT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Connecticut Children's Medical Center
Early Childhood Caries, Dental Caries in Children
Treatment of Early Childhood Caries Using Silver Diammine Fluoride and Sodium Fluoride Tricalciumphosphate and the Effects on Oral Health Related Quality of Life
There is still a need for the assessment of different minimal intervention strategies and treatments focusing on the prevention and arrest of carious lesions of primary molars The evidence-based clinical practice guideline on…
- Conditions
- Early Childhood Caries, Dental Caries in Children, Dental Caries Extending Into Dentin, Dental Caries
- Trial name
- NCT05772039
- Testing
- Topical application of 38% Silver Diammine Fluoride Solution, Topical application of 5% Sodium Fluoride with functional Tricalcium phosphate Varnish
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Universiti Sains Malaysia
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