Clinical trials: Healthcare Associated Infections
Antibiotic-Associated Diarrhea, Clostridium Difficile-Associated Diarrhea
Efficacy and Safety Study in the Prevention of Antibiotic-Associated Diarrhea (AAD) and Clostridium Difficile-Associated Diarrhea (CDAD) in Hospitalized Adult Patients Exposed to Nosocomial Infection
The purpose of this study is to evaluate the efficacy and safety of Bio-K+ CL-1285 in the prevention of Antibiotic-Associated Diarrhea (AAD) and Clostridum difficile-Associated Diarrhea (CDAD) in hospitalized patients exposed to…
- Trial name
- NCT00958308
- Testing
- BIO-K+ CL-1285®
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Bio-K Plus International Inc.
Cross Infection, Carbapenem Resistant Bacterial Infection
Epidemiological Features of Emergent Highly Resistant Bacteria in Tunisian Intensive Care Units
Investigate the epidemiology, risk factors and impact on clinical practice of healthcare-associated infections with emergent highly drug-resistant (eHDR) pathogens, particularly carbapenem resistant enterobacteriaceae and…
- Conditions
- Cross Infection, Carbapenem Resistant Bacterial Infection, Vancomycin-Resistant Enterococcal Infection, Critical Illness
- Trial name
- NOSOREA3 (NCT06392568)
- Testing
- epidemiological records
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- Abderrahmane Mami Hospital
Hospital Infection
Application of Standardized Cleaning and Disinfection Mode of HFT Surface in Hospital Infection Prevention and Control
The scientific, feasible and effective mode of standardized cleaning and disinfection of ICU high-frequency contact surfaces is discussed and verified.
- Trial name
- NCT04920240
- Testing
- cleaning and disinfection mode for surfaces with high frequency contact, Routine procedure
- Where
- China
- Volunteers
- 432 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Clostridium Difficile Infection, VRE Infection
Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives
Throughout project, the investigators design, evaluate and disseminate infection control and antibiotic stewardship (ABS) measures aimed at reducing the incidence of Clostridium difficile infection (CDI).
- Conditions
- Clostridium Difficile Infection, VRE Infection, Nosocomial Infection, MRGN Bacteria
- Trial name
- ABSOLUTE (NCT03250104)
- Testing
- Infection Control, Antibiotic Stewardship
- Where
- Germany
- Volunteers
- 80,000 people
- Sponsor
- University Hospital of Cologne
Ventilated-acquired Pneumonia
Tracheal Dosage of Amylase : a New Surrogate for Microaspirations in Ventilated ICU Patients
Microaspirations of the oropharyngeal ± gastric contents through the endotracheal tube cuff contribute to the constitution of VAP.
- Trial name
- NCT01267565
- Testing
- dosage of amylase
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Université Victor Segalen Bordeaux 2
Mechanical Ventilation Complication
Effect of Intermittent Versus Continuous Subglottic Secretion Drainage on Tracheal Mucosa Damages
Endotracheal tubes with subglottic secretion drainage (incorporating a suction port above the cuff) have been shown to reduce the incidence of ventilator-associated pneumonia.
- Trial name
- ASPIRE (NCT01555229)
- Testing
- Intermittent subglottic secretion drainage, Continuous subglottic secretion drainage
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Ventilator Associated Pneumonia ( VAP)
Clinical Outcomes of Inhaled Amikacin in Ventilator Associated Pneumonia
Article: Clinical Outcomes of Inhaled Amikacin in Ventilator-Associated Pneumonia: A group randomized controlled,add-on trial English:Patients in intensive care units often need ventilators to breathe.
- Trial name
- RCT (NCT07369336)
- Testing
- Amikacin (Inhalation), Standard-of-Care Intravenous Antibiotics
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Postgraduate Medical Institute, Lahore
Severe COVID-19
COVID-19 and VA-LRTI: Second Versus First Wave of the Pandemic
Multicenter observational retrospective cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients from the first and the second wave of the pandemic.
- Trial name
- CoVAPid2 (NCT05256511)
- Where
- France
- Sponsor
- University Hospital, Lille
Mechanical Ventilation Complication
National Approach to Standardize and Improve Mechanical Ventilation
This is a pre-post implementation cohort study. This is a data driven quality improvement project which aims to improve the care of mechanically ventilated patients through the implementation of a bundle of evidence based…
- Trial name
- NASAM (NCT03790150)
- Testing
- Evidence-based practices
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 27,966 people
- Sponsor
- King Abdullah International Medical Research Center
Crossing Infections, Drug Resistance, Microbial
Evaluation of Cost of Nosocomial Infection
This study will investigate the cost and impact of Healthcare Associated Infection (HAI) to patients, the health service and the wider community.
- Trial name
- ECONI (NCT03253640)
- Testing
- Exposure
- Where
- 2 sites in United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Glasgow Caledonian University
Influenza, Influenza Prophylaxis
Oseltamivir and Baloxavir Marboxil for Prophylaxis Against Influenza Under a Hospital-based Setting
This study aims to randomly assign close contacts of hospitalized influenza virus patients to receive baloxavir marboxil prophylaxis, oseltamivir prophylaxis or no antiviral prophylaxis and monitor the incidence of clinical…
- Conditions
- Influenza, Influenza Prophylaxis, Nosocomial Infection
- Trial name
- NCT06762587
- Testing
- Baloxavir Marboxil, Oseltamivir
- Where
- China
- Volunteers
- 372 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Ventilator-Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) in Intensive Care Unit (ICU)
Ventilator-associated pneumonia (VAP) is very common in the intensive care unit (ICU), affecting 9 to 40% of ICU patients and mortality rates range from 20 to 50% and may reach more than 70% when the infection is caused by…
- Trial name
- NCT00935285
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- University of Thessaly
Ventilator Associated Pneumonia ( VAP)
VAP Identification by AI
Ventilator-associated pneumonia (VAP) is the most frequent infection in the intensive care setting. For VAP there is currently no reliable diagnostic criteria.
- Trial name
- AI-VAP (NCT06917521)
- Where
- Switzerland
- Volunteers
- 76 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Nosocomial Pneumonia (NP), Ventilator-associated Pneumonia (VAP)
A Study Comparing Ceftazidime-Avibactam Versus Meropenem in Hospitalized Adults With Nosocomial Pneumonia
The purpose of the study is to evaluate the effects of Ceftazidime-Avibactam compared to Meropenem for treating hospitalized adults with nosocomial pneumonia including ventilator-associated pneumonia
- Trial name
- NCT01808092
- Testing
- ceftazidim-avibactam (CAZ-AVI, experimental product), meropenem (active comparator)
- Where
- 123 sites in Argentina, Brazil and 24 more
- Volunteers
- 969 people
- Sponsor
- Pfizer
Community-associated Infections, Health-care Acquired Infections
Optimal Antibiotic Treatment of Moderate to Severe Bacterial Infections
Severe bacterial infections are associated with mortality of about 30%. Patients with moderate to severe bacterial infections given early and appropriate empirical antibiotic treatment are at a lesser risk for a fatal outcome…
- Conditions
- Community-associated Infections, Health-care Acquired Infections, Nosocomial Infections
- Trial name
- CDSS (NCT01338116)
- Testing
- antibiotic treatment of by TREAT/PCR
- Where
- Israel
- Volunteers
- 600 people
- Sponsor
- Rabin Medical Center
Nosocomial Infections
Potential Nosocomial Infection Prevention Via Modification of Anesthesia Intraoperative Aseptic Practice
We hypothesized that by improving hand hygiene compliance in the operative environment, we would reduce horizontal transmission of pathogenic bacteria to surgical patients.
- Trial name
- NCT00617006
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Healthcare-Associated Pneumonia
Hospital-acquired Pneumonia Prevention: Intervention, Evaluation & Research
The purpose of this study is to determine the effectiveness of a universal, standardized oral care protocol on prevention of non-ventilated hospital-acquired pneumonia (NV-HAP) in the acute care setting.
- Trial name
- HAPPIER-1 (NCT04915898)
- Testing
- Oral Hygiene - teeth brushing
- Where
- United States
- Volunteers
- 8,709 people
- Sponsor
- Orlando Health, Inc.
Pneumonia, Ventilator-Associated, Pneumonia, Hospital Acquired
FilmArray Pneumonia Panel for Antimicrobial Treatment of HAP/VAP in Intensive Care Units
Microbiologic diagnosis of pneumonia is often limited by a long turnaround time of cultures. This randomized trial aims to evaluate the impact of BioFire FilmArray Pneumonia panel on (1) the proportion of appropriate/optimal…
- Conditions
- Pneumonia, Ventilator-Associated, Pneumonia, Hospital Acquired, Critically Ill
- Trial name
- FilmArray (NCT05214716)
- Testing
- FilmArray Pneumonia panel
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Kyungmin Huh
Pneumonia, Ventilator-Associated, Respiratory Tract Infections
Predicting Ventilator-associated Lower Respiratory Tract Infection Outcomes Using Sequenced-based Early Microbiological Response
We are using a tool called QtNGS (quantitative targeted amplicon-based next-generation sequencing ) to measure the abundance of local pathogens in patients with ventilator-associated lower respiratory tract infections.
- Conditions
- Pneumonia, Ventilator-Associated, Respiratory Tract Infections, Prognosis
- Trial name
- NCT06467864
- Testing
- bronchoscope
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Complicated Intra-abdominal Infection, Hosptial Acquired Pneumonia
A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria.
A Phase 3 comparative study to determine the efficacy, safety and tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) versus Meropenem (MER) ± Colistin (COL) for the treatment of serious infections due to Gram…
- Conditions
- Complicated Intra-abdominal Infection, Hosptial Acquired Pneumonia, Ventilator Associated Pneumonia
- Trial name
- REVISIT (NCT03329092)
- Testing
- ATM-AVI, MTZ, MER
- Where
- 157 sites in United States, Argentina and 19 more
- Volunteers
- 422 people
- Sponsor
- Pfizer