Clinical trials: Healthcare-Associated Infections
Corona Virus Infection, Pneumonia, Ventilator-Associated
Mucolytics in Patients on Invasive Mechanical Ventilation Due to Severe Acute Respiratory Syndrome Coronavirus 2
It is planned to include patients over 18 years of age of both sexes, admitted to the Intensive Care Unit of Clinical Hospital Centre Split for respiratory insufficiency caused by severe acute respiratory syndrome coronavirus 2…
- Trial name
- NCT04755972
- Testing
- Inhalation of N-acetylcysteine, Inhalation of 5% sodium chloride, Inhalation of 8,4% sodium bicarbonate
- Where
- Croatia
- Volunteers
- 175 people
- Sponsor
- Clinical Hospital Center, Split
Nosocomial Infections
Nosocomial Respiratory Virus Infection
Hospital-acquired Viral Respiratory Infections (HAVRI) are associated with substantial burden on health care systems. The prevention and control of these viral infections rely on multiple measures such as hand hygiene or wearing…
- Trial name
- NOSOVIRUS (NCT06643039)
- Testing
- Nasopharyngeal swab, Questionnaire
- Where
- 6 sites in France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Nosocomial Infection
Neutrophil CD64 for Early Diagnosis of Nosocomial Infection in Preterm Newborns
Diagnosis of late-onset sepsis is difficult in the absence of specific clinical signs and biological markers in the infection initial phase .The aim of this study is to determine the performance of a new infection marker …
- Trial name
- NEOCD64 (NCT01951781)
- Testing
- blood sample
- Where
- France
- Volunteers
- 153 people
- Sponsor
- University Hospital, Montpellier
Ventilator-Associated Pneumonia, Severe Pneumonia
Fiberoptic Bronchoscopy in Severe Ventilator-associated Pneumonia
This randomized controlled trial evaluated the clinical effect of fiberoptic bronchoscopy in the management of adult patients with severe ventilator-associated pneumonia (VAP).
- Conditions
- Ventilator-Associated Pneumonia, Severe Pneumonia, Critical Illness
- Trial name
- NCT07149909
- Testing
- Other (Conventional Therapy), Fiberoptic Bronchoscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Benha University
Ventilator Associated Pneumonia
Antimicrobial Stewardship Program and Ventilator Associated Pneumonia
Antibiotic Stewardship Programs (ASPs) help clinicians improve the quality of patient care and improve patient safety through increased infection cure rates, reduced treatment failures; however, there are different techniques…
- Trial name
- NCT04097899
- Testing
- implementation of antimicrobial stewardship comprehensive care bundle program on ventilator associated pneumonia patients
- Volunteers
- 25 people
- Sponsor
- Zagazig University
Sepsis, Ventilator Associated Pneumonia
Intravenous Clarithromycin in Septic Syndrome
The aim of this clinical trial is to clarify the clinical efficacy of clarithromycin as immunotherapy for the management of septic syndrome by ventilator-associated pneumonia.
- Trial name
- NCT00297674
- Testing
- Intravenous Clarithromycin
- Where
- 3 sites in Greece
- Volunteers
- 200 people
- Sponsor
- University of Athens
Hospital Infections
Efficacy of Combination Therapy With Minocycline for Treatment of Stenotrophomonas Maltophilia Infections
The objective of the study is to evaluate the efficacy of minocycline for treatment Stenotrophomonas maltophilia infection. The hypothesis of study is the combination therapy with minocycline would be better than the monotherapy…
- Trial name
- NCT05575427
- Testing
- Minocycline, Levofloxacin or Cotrimoxazole
- Where
- Thailand
- Volunteers
- 112 people
- Sponsor
- Mahidol University
Pneumonia
Doripenem in the Treatment of Hospital-Acquired Pneumonia
The purpose of this study is to compare the safety and effectiveness of doripenem in patients with hospital-acquired pneumonia (HAP).
- Trial name
- NCT00211003
- Testing
- doripenem
- Volunteers
- 240 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Pneumonia Hospital Acquired
The Applicability of Different Scoring Systems and Use of Steroids in the Treatment of Hospital Acquired Pneumonia
Cross sectional randomized clinical trial study will be done at Respiratory intensive care unit and Chest department at Assiut University Hospitals on All patients who developed hospital acquired pneumonia including ventilator…
- Trial name
- NCT03121690
- Testing
- Prednisone
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Assiut University
Community Acquired Pneumonia
A Registry Study on Hospitalized Patients With Community-acquired Pneumonia in Real-life of China
The purpose of this study is to evaluate the disease burden of hospitalized patients with CAP and HCAP in real life of China
- Trial name
- CAP-China (NCT02492425)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Capital Medical University
Cross Infection, Carbapenem Resistant Bacterial Infection
Epidemiological Features of Emergent Highly Resistant Bacteria in Tunisian Intensive Care Units
Investigate the epidemiology, risk factors and impact on clinical practice of healthcare-associated infections with emergent highly drug-resistant (eHDR) pathogens, particularly carbapenem resistant enterobacteriaceae and…
- Conditions
- Cross Infection, Carbapenem Resistant Bacterial Infection, Vancomycin-Resistant Enterococcal Infection, Critical Illness
- Trial name
- NOSOREA3 (NCT06392568)
- Testing
- epidemiological records
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- Abderrahmane Mami Hospital
Airway Clearance Impairment
Comparisons of Two Airway Clearance Techniques
The goal of this clinical trial is to compare the effectiveness of two airway clearance techniques for patients with ventilator associated pneumonia.
- Trial name
- NCT06032871
- Testing
- high frequency chest wall oscillation, Chest physiotherapy
- Where
- 2 sites in Taiwan
- Volunteers
- 30 people
- Sponsor
- Hui-Ling Lin
Evidence-based Practices, Nursing Education
Effect of Selected Evidence-based Practices and Related Nurses' Education on the Incidence and Severity of Ventilator-associated Pneumonia
Background: Invasive mechanical ventilation (MV) is used as a cornerstone in the treatment plan of intensive care units (ICUs) patients to provide adequate tissue oxygenation to support the body during the treatment course.
- Conditions
- Evidence-based Practices, Nursing Education, Incidence, Ventilator-associated Pneumonia
- Trial name
- NCT05877105
- Testing
- Ventilator-associated pneumonia prevention Evidence-based practices (VAPPEBP) which consists of ten items bundle
- Where
- Egypt
- Volunteers
- 99 people
- Sponsor
- Cairo University
Ventilator-Associated Pneumonia
Impact of the Duration of Antibiotics on Clinical Events in Patients With Pseudomonas Aeruginosa Ventilator-associated Pneumonia (iDIAPASON)
Ventilator-associated pneumonia (VAP) accounts for 25% of infections in intensive care units (Réseau RAISIN 2012). A short duration (8 days; SD) vs.
- Trial name
- iDIAPASON (NCT02634411)
- Testing
- 8 days of effective antibiotic treatment, 15 days of effective antibiotic treatment
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure
Silver-Coated Endotracheal Tube to Reduce Ventilator Associated Pneumonia (VAP)
The purpose of this study is to determine if the use of a silver-coated endotracheal tube (ETT) can reduce the incidence and/or delay the time of onset of VAP when compared to a non silver-coated ETT in patients who have been…
- Trial name
- NASCENT (NCT00148642)
- Testing
- silver salts coated endotracheal tube, uncoated endotracheal tube
- Where
- 5 sites in United States
- Volunteers
- 2,003 people
- Sponsor
- C. R. Bard
Ventilator-Associated Pneumonia
To Compare Endotracheal Tube (ET) With Subglottic Suction Drainage and Standard ET in the Incidence of VAP
Ventilator Associated Pneumonia (VAP) is associated with increased hospitalisation, increased health care cost and high morbidity and mortality. The incidence of VAP increases with duration of mechanical ventilation.
- Trial name
- NCT03101202
- Testing
- SSD tube
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Bloodstream Infections
RCT Cefiderocol vs BAT for Treatment of Gram Negative BSI
The purpose of this study is to determine whether a new antibiotic, Cefiderocol which works against a wide variety of gram negative bacteria, is equally effective as the antibiotics that are currently used as current standard of…
- Trial name
- GAMECHANGER (NCT03869437)
- Testing
- Cefiderocol, Best Available Therapy
- Where
- 19 sites in Australia, Malaysia and 4 more
- Volunteers
- 513 people
- Sponsor
- The University of Queensland
VAP - Ventilator Associated Pneumonia
Ventilator-associated Pneumonia (VAP) Diagnostic Stewardship Trial
This is a prospective pilot/feasibility trial of a bundled diagnostic stewardship intervention at the level of the microbiologic testing pathway in ventilator-associated pneumonia (VAP).
- Trial name
- NCT05176353
- Testing
- VAP diagnostic stewardship bundle
- Where
- United States
- Volunteers
- 4,892 people
- Sponsor
- University of Michigan
Health Care Associated Infection, Skin
Effect Of Bath Wıth Chlorexıdıne On Protectıon Of Skın Integrıty And Preventıon Of Hospıtal Infectıon
The study was designed in a randomized controlled experimental design type to determine the effect of a 2% chlorhexidine bath applied in the pediatric intensive care unit on protecting skin integrity and preventing…
- Trial name
- NCT05844683
- Testing
- 2% chlorhexidine digluconate solution, usual baths
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Okan University
Ventilator-associated Pneumonia
Ventilator-associated Pneumonia (VAP) and Humidification System
The purpose of this study is to determine which humidification system is more effective in preventing pneumonia in mechanically ventilated patients.
- Trial name
- NCT01546974
- Testing
- HME filter Twin Star 55, Drager Medical, Germany, Heated humidification
- Where
- Brazil
- Volunteers
- 306 people
- Sponsor
- Hospital Sao Domingos