Clinical trials: Healthcare-Associated Infections
Oncology, Critical Illness
Indwelling Device-associated Biofilms
Healthcare associated infections linked to the use of indwelling medical devices increase hospital morbidity, mortality and the Intensive Care treatment costs.
- Conditions
- Oncology, Critical Illness, Sepsis, Hospital Infection
- Trial name
- BiofilmICU (NCT04328818)
- Testing
- indwelling device biofilm identification
- Where
- Romania
- Volunteers
- 150 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Infections, Critical Illness
Ventilator-Associated Pneumonia in Critically Ill COVID-19 vs. Non-COVID-19 Patients
The COVID-19 pandemic has led to an increased incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, in a context of high prevalence of multidrug-resistant organisms (MDROs) there is a lack of…
- Conditions
- Infections, Critical Illness, Superinfection, Organ Failure, Multiple
- Trial name
- NCT05972980
- Testing
- COVID-19
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Nosocomial Infection, Necrotizing Enterocolitis
Effect of Oral Probiotic Supplementation on The Rate of Hospital Acquired Infection and Necrotizing Enterocolitis in Preterm Very Low Birth Weight Infants
The purpose of this study is to determine whether oral probiotic supplementation could reduce the incidence of nosocomial infections in preterm infants.
- Trial name
- NCT01340469
- Testing
- probiotics
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Nosocomial Infection
Achromobacter Xylosoxidans (ACHX) Infections
Data extraction from bacteriological laboratory of Martinique University hospital to determine the frequency and the distribution of nosocomial infections due to Achromobacter xylosoxidans (ACHX), an emerging multi-resistant…
- Trial name
- ACHX (NCT03429283)
- Testing
- descriptive retrospective epidemiological study
- Where
- Martinique
- Volunteers
- 120 people
- Sponsor
- University Hospital Center of Martinique
Pneumonia, Bacterial Pneumonia
An Effectiveness, Safety, and Microbiology Study of Doripenem in Patients With Nosocomial (Hospital-acquired) Pneumonia
The purpose of this study is to evaluate the effectiveness and safety of doripenem monohydrate in the treatment of patients with nosocomial (hospital-acquired) pneumonia.
- Conditions
- Pneumonia, Bacterial Pneumonia, Ventilator-Associated Pneumonia, Infections, Nosocomial
- Trial name
- NCT00502801
- Testing
- doripenem
- Where
- 40 sites in United States, Argentina and 7 more
- Volunteers
- 185 people
- Sponsor
- PriCara, Unit of Ortho-McNeil, Inc.
Cross Infection, Prevalence
The Prevalence of Healthcare-associated Infection in Medical Intensive Care Units in Tunisia
We aimed to determine the prevalence of HAI in medical Tunisian ICUs. Secondary endpoints were to identify the predominant infecting microorganisms and evaluate independent risk factors of HAIs.
- Conditions
- Cross Infection, Prevalence, Epidemiology, Critical Care
- Trial name
- NOSOREA2 (NCT05547646)
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Abderrahmane Mami Hospital
Pneumonia, Ventilator-Associated
Effect of Aerosolised Colistin in Ventilator Associated Pneumonia
the management of Ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR) gram-negative bacilli (GNB) represent a real therapeutic dilemma in intensive care unit (ICU).
- Trial name
- NCT02683603
- Testing
- AS colistin and "imipenem", IV colistin " and "imipenem" ., AS colimycin (colistin)
- Where
- Tunisia
- Volunteers
- 133 people
- Sponsor
- Tunis University
Covid19, Personal Protective Equipment
Rational Use of Personal Protective Equipment During COVID-19 Pandemic
This study aims to improve the personal protective equipment (PPE) used while treating patients with COVID-19, to protect staff and avoid cross-infection of patients.
- Trial name
- RUPERT (NCT04712045)
- Testing
- New PPE, Old PPE
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Nosocomial Infection
Prevention and Control of Healthcare-Associated Infections
Bundling infection control interventions should decrease incidence of Healthcare-Associated Infections in General Medical Wards at Siriraj Hospital, Bangkok, Thailand
- Trial name
- NCT00917319
- Testing
- Bundling Infection Control Interventions
- Where
- Thailand
- Volunteers
- 2,000 people
- Sponsor
- Mahidol University
Acute Lower Respiratory Tract Infection, Pneumonia
Fast Identification of Pathogen in the Setting of Hospital-acquired Pneumonia Using Ion Mobility Spectrometry
With this study the investigators want to determine, if a fast identification of germs, causing hospital-acquired infections of the lower respiratory tract, is possible through the use of MCC-IMS technology - a method that allows…
- Trial name
- NCT01624181
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University of Göttingen
Nosocomial Infection, Diarrhea, Infantile
Effect and Tolerability of Lactobacillus Rhamnosus GG LA801 for the Preventive Nutritional Care of Nosocomial Diarrhea in Children
One of the most common infections acquired in hospital, also known as nosocomial infections, is intestinal infections. These infections can lead to the development of nosocomial diarrhea which can have serious consequences in…
- Trial name
- EPISODE (NCT04628819)
- Where
- 2 sites in France
- Volunteers
- 61 people
- Sponsor
- PiLeJe
Pneumonia, Pneumonia, Ventilator-Associated
PROUD Study: A Prospective Study on the Usage Patterns of Doripenem in the Asia Pacific Region
The purpose of this study is to understand the utilization patterns of doripenem in Asia Pacific, including the profile of the patients treated with carbapenems.
- Conditions
- Pneumonia, Pneumonia, Ventilator-Associated, Urinary Tract Infections
- Trial name
- NCT00986102
- Testing
- doripenem
- Where
- 16 sites in Hong Kong, Indonesia and 3 more
- Volunteers
- 216 people
- Sponsor
- Janssen Research & Development, LLC
Healthcare-Associated Infections (HAIs), Carbapenem-Resistant Enterobacteriaceae Colonization
Correlation Between Carbapenemase-Producing Enterobacterales Load, Environmental Contamination, and Transmission in Critical Care Units
Carbapenemase-producing Enterobacterales (CPE) are multidrug-resistant bacteria that can colonize the gastrointestinal tract of hospitalized patients and spread within intensive care units (ICUs).
- Conditions
- Healthcare-Associated Infections (HAIs), Carbapenem-Resistant Enterobacteriaceae Colonization, Antimicrobial Resistance (AMR)
- Trial name
- CPE-Load ICU S (NCT07685132)
- Where
- Argentina
- Volunteers
- 60 people
- Sponsor
- Hospital Italiano de Buenos Aires
Ventilator Associated Pneumonia
Prognostic Biomarkers in Predicting Mortality in Respiratory Patients With Ventilator-Associated Pneumonia
The aim of this study is to evaluate prognostic efficiency RDW and NLR for mortality prediction in respiratory patients with VAP.
- Trial name
- NCT04739748
- Testing
- complete blood picture
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Assiut University
Healthcare-Associated Pneumonia
Hospital-acquired Pneumonia Prevention: Intervention, Evaluation & Research
The purpose of this study is to determine the effectiveness of a universal, standardized oral care protocol on prevention of non-ventilated hospital-acquired pneumonia (NV-HAP) in the acute care setting.
- Trial name
- HAPPIER-1 (NCT04915898)
- Testing
- Oral Hygiene - teeth brushing
- Where
- United States
- Volunteers
- 8,709 people
- Sponsor
- Orlando Health, Inc.
Healthcare-Associated Pneumonia, Sepsis
Trial of Antimicrobial Restraint in Presumed Pneumonia
The objective of this cluster-randomized crossover study is to determine the effect of delaying antimicrobial initiation until objective microbiologic data is obtained in patients with presumed ICU-acquired pneumonia without…
- Trial name
- TARPP (NCT04438187)
- Testing
- antimicrobial initiation
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- University of Kansas Medical Center
Nosocomial Infections
ED Residents MBP During CVC Placement: Sim Lab Based Training
1. Baseline performance in maximal barrier precaution technique of Emergency Medicine (EM) residents, certified in CVC placement, is poor 2.
- Trial name
- EM CVC MBP (NCT00791583)
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- St. Luke's-Roosevelt Hospital Center
Ventilator Associated Pneumonia
Common Canister Protocol for Inhaler Administration in Mechanically Ventilated Patients
Many hospitals employ a common canister inhaler protocol in patients that do not require mechanical ventilator support. Common canister refers to a single inhaler paired with standardized cleaning methods for use on more than one…
- Trial name
- NCT01935388
- Testing
- Common canister
- Where
- United States
- Volunteers
- 354 people
- Sponsor
- Barnes-Jewish Hospital
Chlorhexidine, Ventilator Associated Pneumonia
Different Oral Colonization of Gram-negative Bacteria in ICU Patients When Using Chlorhexidine at 0.12% Versus Chlorhexidine at 2.0%
This study will assess the utility of different chlorhexidine mouthwash concentrations on ICU patients to decolonize their oral cavities from gram-negative bacteria, since this is a non-desirable condition that leads to higher…
- Trial name
- NCT03442023
- Testing
- Chlorhexidine gluconate at 2%, Chlorhexidine gluconate at 0.12%
- Where
- Mexico
- Volunteers
- 74 people
- Sponsor
- Universidad de Guanajuato
VAP - Ventilator Associated Pneumonia
Bacteriophage Cocktail Therapy for Multidrug-Resistant Gram-Negative Ventilator-Associated Pneumonia
The purpose of this study is to systematically evaluate the efficacy and safety of bacteriophage cocktail therapy in patients with ventilator-associated pneumonia caused by Gram-negative bacterial infections.
- Trial name
- NCT07202234
- Testing
- Phage cocktail administered via nebulization, Nebulized normal saline inhalation therapy
- Volunteers
- 248 people
- Sponsor
- Chinese PLA General Hospital