Clinical trials: Healthcare-Associated Infections
Pneumonia, Ventilator-Associated, Pneumonia, Bacterial
Impact of a Strategy Based on Bacterial DNA Detection to Optimize Antibiotics in Patients With Hospital-acquired Pneumonia
VAPERO is a randomized, unblinded, controlled study to measure the impact of a strategy based on the Unyvero® multiplex PCR test on the adjustment of antimicrobial therapy in patients suspected with ventilator-associated or…
- Trial name
- VAPERO (NCT03711331)
- Testing
- FilmArray® Pneumonia panel plus, Standard care
- Where
- France
- Volunteers
- 161 people
- Sponsor
- University Hospital, Lille
Clostridium Difficile Infection, Health Care Associated Infection
Natural History of Clostridioides Difficile Infection
Aim: To investigate if host factors, such as composition and diversity of intestinal microbiota and/or genetic determinants, are associated with a higher risk of recurrence of Clostridioides difficile infection (CDI).
- Conditions
- Clostridium Difficile Infection, Health Care Associated Infection, Nosocomial Infection
- Trial name
- NCT04801862
- Where
- 15 sites in Spain
- Volunteers
- 750 people
- Sponsor
- Hospital Universitario de Valme
Nosocomial Infection, Pneumonia
Pilot Study of the Utility of Empiric Antibiotic Therapy for Suspected ICU-Acquired Infection
Infection developing in the intensive care unit is a common complication of critical illness, but notoriously difficult to diagnose.
- Conditions
- Nosocomial Infection, Pneumonia, Systemic Inflammatory Response Syndrome, Critical Illness
- Trial name
- NCT00438269
- Testing
- Site-specific empiric regimens included: Meropenem, Piperacillin/tazobactam, Ciprofloxacin and cefazolin +/- metronidazole
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Canadian Critical Care Trials Group
Poor Performance Status, Neurologic Deficits
Saving Brain in Uganda and Burkina Faso
The study will estimate the effect of peer-counseling for exclusive breast feeding (EBF) in the first 6 months of life on cognition and other determinants of human capital formation including behavioral and emotional status…
- Conditions
- Poor Performance Status, Neurologic Deficits, Mixed Behavior and Emotional Disorder, Malnutrition
- Trial name
- NCT01882335
- Testing
- Peer support for exclusive breastfeeding
- Where
- Uganda
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Makerere University
Infection Wound, Gastrointestinal Complication
Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery
This international, multicentre, pragmatic, double-blind, placebo-controlled, randomised trial of TxA versus placebo will enrol 3,300 patients throughout Australia and internationally.
- Conditions
- Infection Wound, Gastrointestinal Complication, Anesthesia, Bleeding
- Trial name
- TRIGS (NCT04192435)
- Testing
- Tranexamic Acid
- Where
- Australia
- Volunteers
- 3,300 people
- Sponsor
- Bayside Health
Infection, Hospital
Organosilane for Surface Cleaning in Intensive Care Units
The purpose of this study is to evaluate if surface disinfection with organosilane associated with traditional cleaning reduces the incidence of healthcare-associated infections (HAIs) in intensive care units when compared with…
- Trial name
- ORG-CLEAN (NCT05673226)
- Testing
- Surface disinfection with Organosilane
- Where
- 14 sites in Brazil
- Volunteers
- 10,301 people
- Sponsor
- Hospital Israelita Albert Einstein
Hospital-Acquired Pneumonia, Ventilator-Associated Pneumonia
Clinical Efficacy of Intravenous Iclaprim Versus Vancomycin in the Treatment of Hospital-Acquired, Ventilator-Associated, or Health-Care-Associated Pneumonia
The purpose of this study is to compare the clinical cure rates of two dosing regimens of iclaprim with vancomycin (every 12 hours [q12h]) in the treatment of patients with hospital-acquired pneumonia (HAP), ventilator-associated…
- Conditions
- Hospital-Acquired Pneumonia, Ventilator-Associated Pneumonia, Health-Care-Associated Pneumonia
- Trial name
- NCT00543608
- Testing
- iclaprim, vancomycin
- Volunteers
- 135 people
- Sponsor
- Arpida AG
Human Microbiome
Human Microbiome and Healthcare Associated Infections - Nursing Home Dwelling Older Veterans
The purpose of the research is to find out the effect of commonly used topical antibiotics on the bacteria that live in the nose, throat and on the skin of older adults.
- Trial name
- NCT04218799
- Testing
- Intranasal Mupirocin and Topical Chlorhexidine
- Where
- 2 sites in United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Ventilator Associated Pneumonia
Air-impingement Manipulation to Clear Subglottic Secretion Compared With Drainage Tube in Prolonged Intubated Patients
This is a randomized controlled trial compared two methods to drainage subglottic secretion in prolonged intubated patients.After enrolled, patients are randomized assigned to intermittent subglottic secretion drainage group and…
- Trial name
- NCT02032849
- Testing
- Manual air-impingement operation, subglottic secretion drainage
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing Chao Yang Hospital
Microbial Colonization, Infection, Bacterial
Microorganisms on Reusable Tourniquets
The purpose of this study was to compare microbial contamination on the surface of reusable stasis after indefinite use, 2 weeks and 4 weeks.
- Conditions
- Microbial Colonization, Infection, Bacterial, HAI, Nurse's Role
- Trial name
- NCT06566495
- Testing
- collection of microbiological material from reusable tourniquets
- Where
- Poland
- Volunteers
- 53 people
- Sponsor
- Medical University of Gdansk
Fluid Overload Pulmonary Edema, Fluid Overload
Lung Ultrasound-guided Fluid Therapy in Pediatric Intensive Care Unit Patients
A randomized clinical trial to evaluate the effect of using pulmonary ultrasound to guide fluid therapy on distinct variables.
- Conditions
- Fluid Overload Pulmonary Edema, Fluid Overload, Pneumonia, Ventilator-Associated, Fluid Overload Without Edema
- Trial name
- NCT04215692
- Testing
- Pulmonary ultrasound
- Where
- Mexico
- Volunteers
- 68 people
- Sponsor
- Instituto Mexicano del Seguro Social
Pneumonia, Ventilator Associated
Pilot Study of Lateral Rotation Interventions for Efficacy and Safety in ICU Care
Intensive care unit (ICU) patients on respirators are at high risk for preventable pulmonary complications (PPC). Turning these patients from side to side may reduce PPC, but carries the burden of decreases in blood pressure and…
- Trial name
- NCT00542321
- Testing
- Manual turn, kinetic therapy bed
- Volunteers
- 16 people
- Sponsor
- The University of Texas Health Science Center, Houston
Coronavirus Infections, Healthcare Associated Infection
NO Prevention of COVID-19 for Healthcare Providers
Thousands of healthcare workers have been infected with SARS-CoV-2 and contracted COVID-19 despite their best efforts to prevent contamination. No proven vaccine is available to protect healthcare workers against SARS-CoV-2.
- Trial name
- NOpreventCOVID (NCT04312243)
- Testing
- Inhaled nitric oxide gas
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hospital-acquired Pneumonia
Efficacy and Safety of Colistimethate Sodium Injection Vial to Treat Hospital-acquired Pneumonia in Adults
1. To evaluate the clinical and microbiological efficacy and safety of Colistimethate sodium Injection Vial to treat adults with hospital-acquired pneumonia . 2.
- Trial name
- NCT01940731
- Testing
- Colistimethate sodium
- Where
- 5 sites in China
- Volunteers
- 60 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Ventilator Acquired Pneumonia
Direct E-test on Bronchoalveolar Lavage From Patients With Ventilator-acquired Pneumonia
Background: Ventilator-acquired pneumonia (VAP) is the most prevalent nosocomial infection in intensive care units (ICUs). Early microbiological diagnosis and initial administration of appropriate antimicrobial therapy are…
- Trial name
- NCT01042353
- Testing
- E test, standard culture method
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Université Victor Segalen Bordeaux 2
Ventilator Associated Pneumonia (VAP)
Pulmonary Infections and Barotrauma Associated With MV IN PICU
This study aims to determine the incidence, risk factors and outcome of ventilation associated common complication in the PICUs at Assiut University Children Hospital in Egypt.
- Trial name
- NCT05792501
- Testing
- Mechanical ventilation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Gangrenous Appendicitis
Prophylaxis With Single Versus Five Dose of Antibiotic Therapy as Treatment of Patients With Gangrenous Acute Appendicitis
A prospective, randomized controlled clinical trial was conducted at the Hospital Universitario de Santander to test the effectiveness of providing a single 1-dose therapy of antibiotic prophylaxis versus a 5-day antibiotic…
- Trial name
- NCT01115153
- Testing
- prophylaxis, therapy
- Where
- Colombia
- Volunteers
- 150 people
- Sponsor
- Universidad Industrial de Santander
Pneumonia, Bacterial
Study Evaluating Safety and Efficacy of Tigecycline Versus Imipenem/Cilastatin Subjects With Hospital-Acquired Pneumonia
This study will compare the safety and efficacy of a tigecycline regimen versus an imipenem/cilastatin regimen for the treatment of subjects who are hospitalized with hospital-acquired pneumonia (HAP).
- Trial name
- NCT00707239
- Testing
- tigecycline, imipenem/cilastatin
- Where
- 40 sites in United States, Argentina and 12 more
- Volunteers
- 108 people
- Sponsor
- Pfizer
Ventilator-Induced Lung Injury, Ventilatory Failure
"Lung Barometric Measurements in Normal And in Respiratory Distressed Lungs"
Little is known about how lung mechanics are affected during the very early phase after starting mechanical ventilation. Since the conventional method of measuring esophageal pressure is complicated, hard to interpret and…
- Conditions
- Ventilator-Induced Lung Injury, Ventilatory Failure, Ventilator Lung, Ventilation Therapy; Complications
- Trial name
- LUNAR (NCT04484727)
- Testing
- PEEP-step method
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Göteborg University
Ventilator-Associated Pneumonia
The Population Pharmacokinetics of Imipenem in Patients With Ventilator-associated Pneumonia
This is prospective, randomized and crossover design to assess the pharmacokinetic and pharmacodynamics of three regimen. 0.5-hr infusion of imipenem 0.5 g every 6 hrs 2-hr infusion of imipenem 0.5 g every 6 hrs 2-hr infusion of…
- Trial name
- NCT01489124
- Testing
- Imipenem
- Where
- Thailand
- Volunteers
- 9 people
- Sponsor
- Sutep Jaruratanasirikul