Clinical trials: Healthcare-Associated Infections
Ventilator-associated Pneumonia
Impact of Direct Antimicrobial Susceptibility Testing on Respiratory Sample of Intensive Care Patient With Suspected VAP
Inappropriate antibiotic therapy in ventilator-associated pneumonia (VAP) is associated with increased mortality. The international guidelines recommend using broad spectrum antimicrobials especially in patients who received…
- Trial name
- AB-DIRECT2 (NCT02897466)
- Testing
- Direct Antimicrobial Susceptibility Testing
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Aspiration, Aspiration Pneumonia
Early Antibiotics After Aspiration in ICU Patients
The purpose of this study is to evaluate the use of early antibiotics in ICU patients who appear to have aspirated, to help determine whether this improves outcomes by reducing the later incidence of pneumonia and other negative…
- Trial name
- NCT05079620
- Testing
- Ceftriaxone, Amoxicillin clavulanic acid, Cefepime
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- UConn Health
Tracheal and Oropharyngeal Colonization by Gram-negative Pathogens
Oral Care and Gram-negative Pathogen in Children
Critical care nursing interventions related to oral care can reduce the microorganisms in the oropharynx available for translocation to other sites.
- Trial name
- NCT01410682
- Testing
- 0,12% digluconate chlorhexidine, toothbrushing
- Volunteers
- 74 people
- Sponsor
- Federal University of São Paulo
Community-acquired Pneumonia, Hospital-acquired Pneumonia
Use of Presepsin as a Marker for Immunotherapy Administration in Pneumonia
The current study is an exploratory, phase IIa randomized clinical trial (RCT) aiming to evaluate if early presepsin increase coupled with early initiation of anakinra as an adjunct therapy to the standard-of-care treatment may…
- Trial name
- INSPIRE (NCT05785442)
- Testing
- Anakinra Prefilled Syringe
- Where
- 5 sites in Greece
- Volunteers
- 60 people
- Sponsor
- Hellenic Institute for the Study of Sepsis
Endotracheal Intubation During Surgery, Hospital Acquired Infections
BIP ETT Clinical Tolerability, Safety and Performance Study
The objective of the study is to determine Bactiguard coated BIP Endotracheal tube´s tolerability, safety and performance and compare it to a standard un-coated Endotracheal tube.
- Trial name
- BIPETT (NCT01682486)
- Testing
- BIP ETT (Bactiguard), Standard ETT
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Bactiguard AB
Ventilator Associated Pneumonia, Multi-antibiotic Resistance
Ventilator Associated Pneumonia by Multi-Drug Resistant Organism
Ventilator-associated pneumonia (VAP) is an infection of the pulmonary parenchyma in patients exposed to invasive mechanical ventilation for at least 48 h and is part of ICU-acquired pneumonia.
- Trial name
- VAP-MDR (NCT05549427)
- Testing
- Ventilation
- Where
- Oman
- Volunteers
- 319 people
- Sponsor
- Sultan Qaboos University
Ventilator Associated Pneumonia
Ventilator Associated Pneumonia in Taper Guard Versus Normal Tube in ICU Patients
Ventilator associated pneumonia ( VAP) adds burden to the care of the intensive care patients as they may cause the death of the patient or prolong the intensive care stay or complicate the illness in other ways.
- Trial name
- NCT01501227
- Testing
- Taper Guard Endotracheal Tube, Conventional endotracheal tube
- Where
- Malaysia
- Volunteers
- 100 people
- Sponsor
- University of Malaya
Ventilator-associated Pneumonia
Effectiveness of Different Educational Strategies on the KAP, Psychological and Clinical Outcomes
A randomized controlled triple blinded clinical trial with repeated measurements. The reporting of this study complies with the CONSORT (Consolidated Standards of Reporting Trials) statement for trials of non-pharmacological…
- Trial name
- NCT02838160
- Testing
- Routine Care, Routine care Plus the designed booklet, Routine care Plus the designed booklet Plus participation in oral presentations
- Volunteers
- 160 people
- Sponsor
- Baqiyatallah Medical Sciences University
Cross Infection, Staphylococcal Infections
Prophylaxis With Intranasal Mupirocin for Prevention of S. Aureus Infections
In order to evaluate the effect of eliminating nasal carriage by mupirocin prophylaxis on subsequent Staphylococcus aureus infection, a prospective randomized trial was performed particularly including patients with predisposing…
- Trial name
- NCT00156377
- Testing
- Mupirocin
- Where
- Germany
- Volunteers
- 1,200 people
- Sponsor
- University Hospital Muenster
Multi Drug Resistant Infections, Pneumnia
Traditional Chinese Medicine in Multidrug-Resistant Bacterial Pneumonia
This is a multicenter prospective observational cohort study involving hospitalized adult patients with multidrug-resistant bacterial pneumonia.
- Trial name
- MDRBP-TCM (NCT07726095)
- Where
- China
- Volunteers
- 652 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Respiratory Distress Syndrome, Adult, Pneumonia
Comparison Study of High Frequency Percussive Ventilation With Conventional Ventilation
This study is designed to exam the effects of early management with high frequency percussive ventilation (HFPV) on patients with lung injury.
- Conditions
- Respiratory Distress Syndrome, Adult, Pneumonia, Mechanical Ventilation
- Trial name
- NCT00308022
- Testing
- High Frequency Percussive Ventilation
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Ventilator Associated Pneumonia, Respiratory Infection
Aerosolized Antibiotics and Respiratory Tract Infection in Patients on Mechanical Ventilation
The purpose of this study was to determine the effect of aerosolized antibiotics on respiratory infection in mechanically ventilated patients.We hypothesize that aerosolized antibiotics , which achieve high drug concentrations in…
- Conditions
- Ventilator Associated Pneumonia, Respiratory Infection, Tracheobronchitis
- Trial name
- NCT00396578
- Testing
- aerosolized vancomycin or gentamicin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Ventilator Associated Pneumonia, Aspiration
Ventilator Aspiration With PneuX (PneuX vs Standard Care Feasibility RCT)
This is a single centre, open-label, feasibility randomised controlled trial. The study aims to assess the feasibility of conducting an RCT to compare the PneuX ETT with standard care in hospitalised patients requiring mechanical…
- Conditions
- Ventilator Associated Pneumonia, Aspiration, Infections, Ventilator Lung
- Trial name
- VAP-X (NCT05410106)
- Testing
- PneuX Endotracheal Tube, Standard care (Taperguard, Covidien)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cardiff and Vale University Health Board
Urinary Tract Infection, Acute Pyelonephritis
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults
This is an open-label, randomized, multi-center, interventional, active-controlled Phase 4 study to evaluate the efficacy and safety of CAZ-AVI versus BAT in the treatment of infected participants with selected infection types…
- Conditions
- Urinary Tract Infection, Acute Pyelonephritis, Hospital Acquired Pneumonia, Ventilator-associated Pneumonia
- Trial name
- NCT04882085
- Testing
- Zavicefta, Ceftazidime-Avibactam, Best Available Treatment
- Where
- 37 sites in China
- Volunteers
- 60 people
- Sponsor
- Pfizer
Pneumonia, Ventilator-associated, Pneumonia, Staphylococcal
Prevention of S. Aureus Pneumonia Study in Mechanically Ventilated Subjects Who Are Heavily Colonized With S. Aureus.
The purpose of this study is the prevention of Staphylococcus aureus pneumonia in mechanically ventilated subjects heavily colonized with S. aureus.
- Trial name
- NCT02940626
- Testing
- ASN100
- Where
- 93 sites in United States, Austria and 14 more
- Volunteers
- 155 people
- Sponsor
- Arsanis, Inc.
Ventilator Associated Pneumonia
PK of BV100 in Patients VABP Suspected or Confirmed to Be Due to CRAB
A multicenter Phase 2 study to evaluate the pharmacokinetics, efficacy, and safety of intravenous BV100 combined with Polymyxin B in adult patients with VABP suspected or confirmed to be due to CRAB
- Trial name
- NCT05685615
- Testing
- BV100 plus Polymyxin B, BAT
- Where
- 16 sites in Georgia, Greece and 1 more
- Volunteers
- 39 people
- Sponsor
- BioVersys AG
Crossing Infections, Drug Resistance, Microbial
Evaluation of Cost of Nosocomial Infection
This study will investigate the cost and impact of Healthcare Associated Infection (HAI) to patients, the health service and the wider community.
- Trial name
- ECONI (NCT03253640)
- Testing
- Exposure
- Where
- 2 sites in United Kingdom
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Glasgow Caledonian University
Critical Illness, Sepsis
Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients
Introduction- Hospital acquired infections (HAI) are a major cause of morbidity and mortality and increase health care costs. Critically ill patients are particularly susceptible to these infections and have an even higher…
- Conditions
- Critical Illness, Sepsis, Septic Shock, Ventilator Associated Pneumonia
- Trial name
- SuDDICU (NCT02389036)
- Testing
- SDD Oral Paste, SDD Gastric Suspension, Intravenous Antibiotic
- Where
- 3 sites in Australia, Canada and 1 more
- Volunteers
- 20,010 people
- Sponsor
- The George Institute
Complicated Skin and Structure Infection, Nosocomial Pneumonia
Cost Study of Linezolid Versus Vancomycin Among Previously Hospitalized Patients
This is a retrospective, observational, non-interventional drug study using de-identified data from two administrative claims datasets. The study design and analysis will reflect the perspective of the commercially insured.
- Trial name
- NCT01363271
- Testing
- Linezolid, Vancomycin
- Volunteers
- 7,260 people
- Sponsor
- Pfizer
Healthcare-Associated Pneumonia, Ventilator-Associated Pneumonia
Safety and Efficacy Study of Ceftolozane/Tazobactam to Treat Ventilated Nosocomial Pneumonia (MK-7625A-008)
This is a phase 3, multicenter, prospective, randomized study of intravenous (IV) ceftolozane/tazobactam versus IV meropenem in the treatment of adult participants with either ventilator-associated bacterial pneumonia (VABP) or…
- Conditions
- Healthcare-Associated Pneumonia, Ventilator-Associated Pneumonia, Lung Diseases
- Trial name
- ASPECT-NP (NCT02070757)
- Testing
- Ceftolozane/tazobactam, Meropenem
- Volunteers
- 726 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)