Clinical trials: Healthcare-Associated Infections
Infection, Hospital
Passive Disinfection Cap Compliance Study
Insertion and maintenance of central venous catheter (CVC) lines are common hospital procedures in patients, including those being treated for cancer.
- Trial name
- NCT03391960
- Testing
- Passive disinfection device
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Solventum US LLC
Hip Fractures (ICD-10 72.01-72.2)
Pre- and Postoperative Chest Therapy With Positive Expiratory Pressure (PEP) to Prevent Hospital-acquired Pneumonia
The goal of this clinical trial is to investigate whether pre- and postoperative treatment with systematic PEP therapy can prevent hospital-acquired pneumonia in patients with hip frac-ture.
- Trial name
- NCT07189260
- Testing
- positive expiratory pressure
- Where
- 2 sites in Denmark
- Volunteers
- 566 people
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Multidrug-resistant Colonization
Studies of the Human Microbiome in Clinical Center Patients
Background: The intestines, mouth, and skin all contain billions of bacteria and some fungi. Every person s body contains microorganisms like these. They normally do not make people sick.
- Trial name
- NCT01933620
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pneumonia
A Peri-intubation Oral Intervention to Reduce Oral Flora and VAP
The purpose of this study is determine if a single, early dose of chlorhexidine applied within 12 hours after endotracheal tube insertion will reduce the bacteria in the oral cavity and the incidence of pneumonia in trauma…
- Trial name
- NCT00248300
- Testing
- Chlorhexidine
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- Virginia Commonwealth University
Ventilator Associated Pneumonia ( VAP)
Pre-clinical Diagnosis Using Integrated Microbial and Host Response Signatures to Improve Outcomes From Ventilator-associated Pneumonia in Critically Ill Children
Ventilator-associated pneumonia (VAP), defined as pneumonia occurring 48 hours after initiation of invasive mechanical ventilation, is insidious in onset and severe in consequence.
- Trial name
- VAP-Dx (NCT07026656)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Cambridge
Pneumonia, Ventilator-Associated, Pneumonia
Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria
Secondary infections remain a major cause of mortality in critically ill patients, mainly because of high prevalence of multidrug-resistant microorganisms.
- Conditions
- Pneumonia, Ventilator-Associated, Pneumonia, Bloodstream Infection, Sepsis
- Trial name
- NCT04839653
- Testing
- Oral Paste(0,5 g) containing 10 mg of polymyxin B, 10 mg of gentamycin and 150 mg of amphotericine B or 500 000 U of nistatin q6h, Suspension (10 ml) containing 100 mg of polymyxin B, 80 mg of gentamycin, 350 mg of amphotericine B or 8000000 U of nistation and 500 mg of vancomycin q6h, Intravenous Antibacterial Agent - a 3-day course of systemic cefotaxime 1 g q6h or ceftriaxone 1 g qd
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- MEDSI Clinical Hospital 1, ICU
Nosocomial Pneumonia, Ventilator Associated Pneumonia
Characteristics of Lower Respiratory Tract Escherichia Coli Isolates in Mechanically Ventilated Intensive Care Patients
Prospective, multicenter observational study to collect Escherichia coli (E. coli) isolates originating from mechanically ventilated intensive care unit (ICU) patients; in order to characterize phenotype and genotype of E.
- Conditions
- Nosocomial Pneumonia, Ventilator Associated Pneumonia, Escherichia Coli Infections, Escherichia Coli Pneumonia
- Trial name
- COLOCOLI (NCT03303937)
- Volunteers
- 289 people
- Sponsor
- Hôpital Louis Mourier
Pneumonia, Ventilator-Associated
Aerosolized Antibiotics in the Treatment of Ventilator Associated Pneumonia
The purpose of this study is to determine if administering inhaled antibiotics directly into the lungs in conjunction with intravenous (IV) antibiotics leads to better outcomes and decreased recurrence of ventilator associated…
- Trial name
- AAINTVAP (NCT02478710)
- Testing
- Aerosolized Tobramycin or Vancomycin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wright State University
Ventilator Associated Pneumonia ( VAP)
Combined Use of a Respiratory Multiplex PCR and Algorithm-based Therapy to Improve Early Optimization of Antibiotic Therapy in Critically Ill Patients With Ventilator-associated Pneumonia
Assess the impact of a strategy combining respiratory mPCR and algorithm-based therapy developed using local epidemiology on the early optimization of initial antibiotic therapy for ventilator-associated pneumonia (VAP)…
- Trial name
- SMART-VAP (NCT07403474)
- Testing
- strategy combining respiratory mPCR and algorithm-based therapy developed using local epidemiology
- Where
- 2 sites in France
- Volunteers
- 124 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
MRSA, VRE
Benefits of Universal Glove and Gowning
This study will test if doctors, nurses and other people who take care of patients in hospitals wearing gloves and gown for all contact with patients in an intensive care unit (ICU) will: Decrease the chance of patients getting…
- Trial name
- BUGG (NCT01318213)
- Where
- United States
- Volunteers
- 19,856 people
- Sponsor
- University of Maryland, Baltimore
Ventilator Associated Pneumonia
Frequency of Ventilator Associated Pneumonia (VAP) in Mechanically Ventilated Patients Using the AnapnoGuard System
Ventilator Associated Pneumonia (VAP) is a common complication experienced by mechanically ventilated patients and within the framework of Respiratory Intensive Care Units.
- Trial name
- NCT01126320
- Testing
- AnapnoGuard 100,, routine mechanical ventilator
- Where
- Israel
- Volunteers
- 161 people
- Sponsor
- Hospitech Respiration
Carbapenem-Resistant Enterobacteriaceae Infection
Efficacy and Safety of Colistimethate Sodium for Injection in The Treatment of Carbapenem-Resistant Enterobacteriaceae Infection
Colistin can be used to treat the infection caused by carbapenem-resistant enterobacteriaceae(CRE). In China, patients diagnosed with Hospital-acquired-pneumonia (HAP)or bloodstream infection caused by CRE are recruited, and…
- Trial name
- NCT06051513
- Testing
- treatment with or without colistin
- Where
- 15 sites in China
- Volunteers
- 404 people
- Sponsor
- Southeast University, China
Pathogenic Bacteria in the Oropharynx, Ventilator-associated Pneumonia
Chlorhexidine vs Lactobacillus Plantarum for Oral Care in Intubated ICU Patients
Critically ill patients often need ventilatory support through a plastic tube connected to a ventilator. Those patients have a altered microbiological flora in the mouth, oropharynx as well as throughout the intestine.
- Trial name
- NCT01105819
- Testing
- Lactobacillus plantarum 299 for oral care, Chlorhexidine for standard oral care
- Where
- 3 sites in Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Nosocomial Pneumonia
High-dose Inhaled NO Therapy for the pREvenvention of NP After Cardiac Surgery Under CPB
The primary aim of this single-center, prospective, randomized, controlled, study is to test the hypothesis that inhalation of NO 200 ppm prevents the development of nosocomial pneumonia in patients at risk after cardiac surgery…
- Trial name
- NCT06261827
- Testing
- 200-ppm NO
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Pneumonia, Ventilator-Associated, Hospital-acquired Pneumonia
Comprehensive Molecular Diagnosis and Management of Hospital- and Ventilator-associated Pneumonia in Norway
HVAPNOR consists of Three work packages: 1. Prospective observational study of Hospital (HAP) - and ventilator-Associated pneumonia (VAP) at 5 hospitals in Norway.
- Conditions
- Pneumonia, Ventilator-Associated, Hospital-acquired Pneumonia, Infectious Disease, Infection, Hospital
- Trial name
- HVAPNOR (NCT04381247)
- Testing
- Molecular diagnostics in HAP and VAP
- Where
- Norway
- Volunteers
- 550 people
- Sponsor
- Vestre Viken Hospital Trust
Intubated Patient Requiring a Gastric Tube
Impact of the Choice of Gastric Tube Placement Sites on the Incidence of Ventilator Associated Pneumonia
In intensive care, many gastric tubes are inserted on a regular basis. There are different practices in terms of the location of the gastric tube.
- Trial name
- SONG (NCT05915663)
- Testing
- nasogastric tube and orogastric tube, orogastric tube and nasogastric tube
- Where
- 16 sites in France
- Volunteers
- 2,400 people
- Sponsor
- Centre Hospitalier le Mans
Clostridium Difficile Infection, VRE Infection
Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives
Throughout project, the investigators design, evaluate and disseminate infection control and antibiotic stewardship (ABS) measures aimed at reducing the incidence of Clostridium difficile infection (CDI).
- Conditions
- Clostridium Difficile Infection, VRE Infection, Nosocomial Infection, MRGN Bacteria
- Trial name
- ABSOLUTE (NCT03250104)
- Testing
- Infection Control, Antibiotic Stewardship
- Where
- Germany
- Volunteers
- 80,000 people
- Sponsor
- University Hospital of Cologne
Hospital-acquired Pneumonia
Feasibility Study of Contemporary Diagnostics for Patients With Suspected Hospital-Acquired Pneumonia.
Hospital-Acquired Pneumonia (HAP) is a severe lung infection that develops while a patient is in hospital. We aim to design a trial to see if modern diagnostic investigations can safely improve outcomes for patients suspected of…
- Trial name
- HAP-FAST (NCT05483309)
- Testing
- CT scan, FilmArray Pneumonia Panel
- Where
- 3 sites in United Kingdom
- Volunteers
- 220 people
- Sponsor
- University of Liverpool
Nosocomial Infections, Pneumonia, Ventilator-Associated
A Efficacy and Safety Study of Nasal Prongs With Proprietary Surface Coating Aiming to Reduce Bacterial Colonization
The study is a first step in establishing the safety and efficacy of the CytaCoat technology when applied to a medical device such as a nasal prong and the clinical data generated will serve as a basis for continuous studies in…
- Trial name
- NCT02756351
- Testing
- CytaCoat Nasal Prong, Inspiration Healthcare Inspire nCPAP Nasal Prong
- Where
- Sweden
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- CytaCoat AB
Ventilator Associated Pneumonia ( VAP)
Role of Inhaled Polymyxin as an Adjunct to Intravenous Therapy in Multidrug Resistant Ventilator-associated Pneumonia in Stroke Patients
This study investigates whether adjunctive inhaled colistin enhances clinical recovery and microbiological clearance in multidrug resistant ventilator-associated pneumonia in stroke patients
- Trial name
- NCT07865871
- Testing
- Inhaled colistin, Saline
- Volunteers
- 78 people
- Sponsor
- Ain Shams University