Clinical trials: Healthy (Controls)
Obesity, Morbid Obesity
Obesity-related Inflammation in Patients Prior to and After Bariatric Surgery
This study investigates the chronic long-term health condition of obesity and its effect on neutrophil function and the inflammatory response
- Trial name
- NCT03283644
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
HIV Infections, Malaria
Drug Interaction Study Between Antimalarial and Anti-HIV Medications
The purpose of this study is to find out whether taking certain anti-HIV medicines with certain antimalarial medicines affects the amount of the medicines in the blood.
- Trial name
- NCT00266058
- Testing
- Lopinavir/Ritonavir, Efavirenz, Artemether/lumefantrine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Hypohidrotic Ectodermal Dysplasia
Characterization of Sweat Gland Function in Patients With Recessively Inherited Hypohidrotic Ectodermal Dysplasia
Hypohidrotic ectodermal dysplasia (HED) is a complex genetic disorder characterized by lack of sweat glands, sparse hair, and missing or malformed teeth.
- Trial name
- NCT01109290
- Where
- Germany
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University Hospital Erlangen
Eating Disorders
Comparing Neural Responses to Food Images in EDNOS Patients and Healthy Controls Using fMRI
Currently, there is not a robust, testable neural model available that sufficiently explains the development and maintenance of anorexia nervosa (AN) a severe, often fatal, adolescent-onset eating disorder.
- Trial name
- ANfMRI (NCT01882023)
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Arginine Vasopressin Deficiency, Diabetes Insipidus
Effect of Intranasal Oxytocin on Emotion Recognition and Acute Psycho-Social Stress-induced Cortisol Increase in Patients With Central Diabetes Insipidus and Healthy Controls
This study aims to investigate the potential beneficial effects of intranasal oxytocin compared to placebo on emotion recognition and acute psychosocial stress in patients with arginine vasopressin deficiency compared to matched…
- Trial name
- OxyMOTION (NCT06676774)
- Testing
- Oxytocin nasal spray
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder
Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 2
In Study 2, investigators will recruit individuals with schizophrenia (SZ) and or schizoaffective disorder (SZA) and healthy controls (HC) using optimized behavioral tasks to replicate the behavioral findings from Study 1 and to…
- Conditions
- SCHIZOPHRENIA 1 (Disorder), Schizo Affective Disorder, Healthy Adult
- Trial name
- CNTRACS 2 (NCT07875790)
- Testing
- Motion Perception Task, Sine Wave Speech Task, Volatility Task
- Where
- 5 sites in United States
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Psychosis, Healthy
Is Cognitive Training Neuroprotective in Early Psychosis?
The purpose of this study is to perform longitudinal high-resolution 7T MRI and Prisma 3T MRI in participants with first-episode psychosis (FEP) enrolled in our ongoing randomized controlled clinical trial (RCT) of cognitive…
- Trial name
- NCT03049800
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Multiple Sclerosis, Healthy Controls
Multiple Sclerosis: Associated Cardiometabolic Risks and Impact of Exercise Therapy
Multiple Sclerosis (MS) is the most common chronic inflammatory neurological disorder in young adults. Due to heterogeneous symptoms, MS patients are often more inactive than healthy controls, resulting in an inactivity related…
- Trial name
- NCT02466165
- Testing
- Physical exercise
- Where
- 2 sites in Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bert Op't Eijnde
Irritable Bowel Syndrome, Visceral Hypersensitivity
Evaluation of Bowel Sensitivity Threshold in IBS Patients Versus in Healthy Controls Using the Novel Rapid Barostat Bag
BACKGROUND \& AIMS: Bowel hypersensitivity (lower threshold for discomfort in response to distention of a balloon in the rectum compared to healthy controls) is a key documented feature in Irritable Bowel Syndrome (IBS)…
- Trial name
- NCT03224494
- Testing
- Rapid Barostat Bag, IBS severity scoring system questionnaire (IBS-SSS), HAD scale questionnaire
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Queen's University
Epilepsy, Dravet Syndrome
A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome
Dravet Syndrome (DS) is a severe neurodevelopmental disease, which is predominantly caused by mutations of SCN1A, the gene coding for Nav1.1 voltage-gated sodium channels.
- Conditions
- Epilepsy, Dravet Syndrome, Drug Resistant Epilepsy, Healthy Controls
- Trial name
- DRAPETONINE (NCT07013331)
- Testing
- [18F]MPPF PET-MRI
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Irritable Bowel Syndrome, Food Sensitivity
Confocal Laser Endomicroscopy to Determine Influence of Food Antigens on Mucosal Integrity
Irritable bowel syndrome (IBS) is mainly associated with food intolerance and presents a particular challenge in gastrointestinal practice.
- Conditions
- Irritable Bowel Syndrome, Food Sensitivity, Healthy Controls
- Trial name
- RDS_CLE (NCT05056610)
- Testing
- food antigens on duodenal mucosa
- Where
- Germany
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Alzheimer Disease (AD), Healthy Controls Group - Age and Sex-matched
MIND Diet in Relation to Malnutrition and Depression in AD
The aim of this study was to examine the association between depression, malnutrition, and the Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay (MIND) diet in Alzheimer's disease…
- Trial name
- NCT07163923
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Parkinson's Disease (PD)
Novel Shoe Device NUSHU to Measure Gait Analysis in Parkinson's Patients
Gait changes in Parkinson's disease are complex, variable, and difficult to detect during short clinic assessments. The aim of this study is to collect gait measurements in Parkinson's patients through sensors in a novel shoe…
- Trial name
- NCT06975059
- Testing
- NUSHU shoe
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Healthy, Mild Cognitive Impairment
Supporting Episodic Memory With Transcranial Direct Current Stimulation in Healthy Controls and Dementia Patients
Previous studies showed that anodal tDCS applied over the dorsolateral prefrontal cortex (DLPFC) improved episodic memory performance, indicating a possible use as an intervention for patients suffering from memory impairments.
- Conditions
- Healthy, Mild Cognitive Impairment, Alzheimer Disease
- Trial name
- NCT03227185
- Testing
- real anodal transcranial direct current stimulation (tDCS)
- Where
- Switzerland
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Bern
Rheumatoid Arthritis, Healthy Controls
Subunit Vaccine Against Herpes Zoster in RA Patients Treated With JAK-inhibitors (VACCIMIL-ZOSTER)
Background. A new subunit vaccine against herpes zoster (HZ) has recently been approved for vaccination of adults i in Sweden. This vaccine (Shingrix) elicits a strong cellular and humoral immune response in healthy adults…
- Trial name
- NCT03886038
- Testing
- Shingrix
- Where
- Sweden
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Region Skane
Healthy Controls
Intranasal Insulin and Olanzapine Study in Healthy Volunteers
Antipsychotic (AP) medications are considered to be the gold standard treatment for psychotic disorders including schizophrenia.
- Trial name
- INI/OLA (NCT03741478)
- Testing
- OLANZapine 2.5 MG, Insulin Lispro 100 UNT/ML, Saline
- Where
- 2 sites in Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Patients With Cardiovascular Disease, Healthy Participants
OCTA in Cardiovascular Disease and Healthy Controls
This prospective clinical study will involve the non-invasive assessment of retinal vessels using OCTA (Cirrus OCT 6000 AngioPlex) and scanning laser Doppler flowmetry (SLDF) in patients with cardiovascular disease and healthy…
- Trial name
- NCT07359664
- Testing
- Retinal vascular assessment using OCTA and SLDF
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Duchenne Muscular Dystrophy
DART Electrical Impedance Myography (EIM) Trial in Duchenne Muscular Dystrophy (DMD) and Healthy Controls
Physicians seek a method to assess neuromuscular disease that is both non-invasive and quantifiable. Many patients do not tolerate standard current day assessment tools (such as needle electromyogram), and Electrical Impedance…
- Trial name
- NCT01523964
- Testing
- Testing with EIM
- Where
- 6 sites in United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Dart Therapeutics. LLC
Glaucoma Patients and Healthy Controls
Reproducibility of RNFL Circle Scans With ART-Function of Heidelberg Spectralis SD-OCT Software Version 5.3
To assess the improvement in reproducibility of 100 vs. 16 averaged images by Automatic Real Time (ART) using Spectralis™ Spectral Domain-Optical Coherence Tomography (SD-OCT, Heidelberg Engineering GmbH, Heidelberg, Germany) in…
- Trial name
- NCT01299233
- Testing
- Spectralis® SD-OCT, Heidelberg Engineering GmbH, H
- Where
- Switzerland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Paget's Disease of Bone
Pathophysiology of Paget's Disease of Bone
Paget's disease of the bone is a skeletal disorder which results in increased and disorganized bone remodeling, leading to dense but fragile and expanding bones.
- Trial name
- NCT02802384
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University