Clinical trials: Healthy (Controls)
Coronary Artery Disease
Impact of Breathing Maneuvers on the Oxygenation Supply of the Heart Assessed With MRI in Patients With Coronary Artery Disease
Patients with an impaired blood supply of the heart routinely receive oxygen in order to improve or preserve the oxygen supply of the heart muscle in acute cardiac care.
- Trial name
- CADOS-CMR (NCT02233634)
- Testing
- Oxygen, Hyperventilation Breath-hold (HVBH), HVBH with Oxygen
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cerebrovascular Accident
Oxygen Consumption in Post-stroke Patients During Various Walking Activities Compared to Healthy Controls
Stroke is major public health issue. The investigators recommend post-stroke patients to practice physical activity. Nevertheless, the recommendations are not widely respected due to the intensity of exercises.
- Trial name
- STROXCO (NCT05477238)
- Testing
- walking tasks
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Diabetic Nephropathies
Nitric Oxide (NO) Activity and Diabetic Nephropathy
Experimental data suggest that oxidative stress and endothelial dysfunction are key players in the pathogenesis of diabetic nephropathy.
- Trial name
- NCT00136188
- Testing
- Folic Acid
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Congenital Heart Disease, Univentricular Heart
Effect of Muscle Strengthening Training in Adults with Fontan Circulation
Aim: to evaluate the effect of muscle strengthening exercise training in adults with Fontan circulation compared to healthy controls.
- Trial name
- NCT05454254
- Testing
- Individualised muscle strengthening exercise training protocol.
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Umeå University
Chronic Low Back Pain
Intra- And Inter-operator Reliability Of Isometric Back And Abdominal Muscle Strength Testing In Healthy Controls And Persons With Nonspecific Chronic Low Back Pain.
Low back pain (LBP) is currently the most common cause of functional impairment with regard to the musculoskeletal system1. LBP occurs in men and women in all age groups and has a peak incidence between 30 and 65 years.
- Trial name
- LBP-BIO-REL (NCT03571880)
- Testing
- Biodex-assisted isometric strength testing
- Where
- 2 sites in Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Parkinson Disease, Huntington Disease
Evaluation of [123I]MNI-420 and SPECT as a Marker of the Adenosine A2a Receptor in PD, HD and Healthy Subjects.
The underlying goal of this study is to assess [123I]MNI-420 SPECT imaging as a tool to detect A2aR density in the brain of PD and HD research participants to be compared with similarly aged healthy subjects.
- Trial name
- MNI-420 (NCT00970229)
- Testing
- [123I]MNI-420
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Institute for Neurodegenerative Disorders
SPG4
Studying Non-motor Symptoms in HSP
Comparing the non-motor symptoms of patients with hereditary spastic paraplegia (HSP) to healthy controls (spouses, relatives or other healthy controls) by using the a number of specific questionaires
- Trial name
- NCT03204773
- Testing
- EuroQol five dimensions questionaire (EQ-5D), Modified Fatigue Impact Scale (MFI), Brief Pain Inventory (BPI)
- Where
- Germany
- Volunteers
- 236 people
- Sponsor
- University Hospital Tuebingen
Hair Loss
For an Investigator-led Hair Study Comparing Between Healthy and Hair Loss Volunteers
This study is to evaluate differences in the gut and follicle/scalp microbiome signature in AGA compared to a non-AGA population.
- Trial name
- NCT07716748
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National Skin Centre
Healthy Controls, Delayed Sleep Phase
Circadian Phase Assessments at Home
An estimated 23 million Americans, including adolescents and the elderly, suffer from circadian rhythm sleep disorders, such as delayed sleep phase disorder, advanced sleep phase disorder and winter depression.
- Trial name
- NCT01487252
- Testing
- At home saliva sampling
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Depression, Involutional
Function of Catecholamines in the Brain During Depression
This study will explore brain function related to depressive symptoms and will examine DNA for genes that may be involved in depressive disorders, particularly genes that regulate synthesis and metabolism of the brain…
- Trial name
- NCT00082030
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy Volunteer
A Safety And Pharmacokinetic Study of Setrobuvir Alone and In Combination With Ritonavir-Boosted Danoprevir in Subjects With Mild Hepatic Impairment Compared to Healthy Controls
This multi-center, fixed-sequence, open-label, multiple-dose, 2-period study will evaluate the safety, tolerability and pharmacokinetics of setrobuvir alone or in combination with ritonavir-boosted danoprevir in subjects with…
- Trial name
- NCT01714154
- Testing
- danoprevir, ritonavir, setrobuvir
- Where
- 3 sites in Hungary, Poland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Attention Deficit Hyperactivity Disorder
Effect of Methylphenidate on Connectivity
The goal of the study is to use graph theory to examine how the organization of the functional brain network may be altered by the administration of methylphenidate.
- Trial name
- NCT01764672
- Testing
- Methylphenidate
- Where
- Netherlands
- Volunteers
- healthy volunteers welcome
- Sponsor
- Iris Sommer
Cervicogenic Headache, Chronic Neck Pain
Physical Profile of Cervicogenic Headache: Comparison With Neck Pain and Healthy Controls
The goal of this observational study is to compare physical findings across three adult groups. Cervicogenic headache (CGH) is a headache linked to a problem in the neck.
- Trial name
- NCT07776275
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Nocturnal Enuresis, Polysomnography
Sleep and Nocturnal Enuresis: Ambulatory Polysomnographic Study
Full ambulatory polysomnography at home performed two nights in 30 healthy children and one night in 30 children with mono-symptomatic nocturnal enuresis (15 with polyuria and 15 without polyuria).
- Trial name
- NCT03477812
- Testing
- Polysomnography (Full sleep registration)
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Healthy, Alzheimer Disease
Tau Tracer Comparison in Healthy Controls and Alzheimer's Disease Patients
The primary objective of this study is to identify a new radioligand for imaging of tauopathy in Alzheimer's disease through direct comparisons of two potential candidates, [18F]RO-948 (formerly known as [18F]6958948) and…
- Trial name
- NCT03939780
- Testing
- [F18]RO-948, [F18]MK-6240, [F18]AV1451
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Glaucoma Patients and Healthy Controls
Reproducibility of Nerve Fiber Layer Thickness Measurements in Patients With Glaucoma and Healthy Controls Using Spectral-Domain and Time-Domain OCT
To assess the reproducibility of Spectral-Domain-OCT (SD-OCT) retinal nerve fiber layer thickness (RNFL) thickness measurements in healthy volunteers and patients with glaucoma and to compare these results to conventional…
- Trial name
- NCT01273285
- Testing
- Spectralis® SD-OCT, Heidelberg Engineering GmbH, H
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University of Zurich
Juvenile Idiopathic Arthritis, Familial Mediterranean Fever
Assessment of Cardiorespiratory Fitness Using the PACER in Patients With Juvenile Idiopathic Arthritis and Familial Mediterranean Fever
Juvenile Idiopathic Arthritis (JIA) and Familial Mediterranean Fever (FMF) are the most common autoimmune and autoinflammatory rheumatic diseases in childhood.
- Conditions
- Juvenile Idiopathic Arthritis, Familial Mediterranean Fever, Healty Controls
- Trial name
- NCT06697028
- Testing
- Usability and Comparison
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Hepatic Impairment (Mild and Moderate, Child-Pugh Class A and B), Hepatic Insufficiency (MeSH ID: D048550)
Pharmacokinetics and Safety of MDR-001 in Mild and Moderate Hepatic Impairment
This is a Phase I, single-center, open-label, parallel-group study. A single oral dose of MDR-001, a GLP-1 receptor agonist, will be administered to participants with mild (Child-Pugh A) or moderate (Child-Pugh B) hepatic…
- Trial name
- NCT07550634
- Testing
- MDR-001
- Where
- China
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- MindRank AI Ltd
Healthy Individuals (Controls), Vascular Surgery Patients With Acute Thrombosis
Haemodialysis Alters Hypercoagulability of Blood in Dialysis Patients
Primary Objective: To develop a thrombotic event risk assessment model integrating serum biomarkers (TM, TAT, t-PAIC, PIC) with clinical data, systematically compare its predictive performance across healthy populations, vascular…
- Conditions
- Healthy Individuals (Controls), Vascular Surgery Patients With Acute Thrombosis, Dialysis Patients
- Trial name
- TAT-t-PAIC (NCT07098676)
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Ai Peng
Healthy (Controls)
Visa-versa! Breaking Instead of Pushing the Pedals-D
Eccentric muscle work is defined as lengthening of a muscle while applying force. It was shown that with eccentric work, muscles are able to perform four times as much power compared to usual concentric work, which results in…
- Trial name
- NCT05185895
- Testing
- 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich