Clinical trials: Healthy Adult Participants
Healthy Adult Participants, Healthy Participants
Location- and Frequency-Dependent Effects of Thalamic Temporal Interference Stimulation During Sleep
This study is to find out whether a type of non-invasive electrical brain stimulation called temporal interference transcranial electrical stimulation (TI-TES) can temporarily change brain activity during sleep, especially sleep…
- Trial name
- CAP-TI (NCT07498270)
- Testing
- Magnetic Resonance Imaging (MRI), Broad thalamic stimulation (TI-TES), Anterior thalamic stimulation (TI-TES)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Healthy Adult Male and Female Volunteers
A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years
Characterize the safety, tolerability and pharmacokinetics of ORX489 following single and multiple doses.
- Trial name
- NCT07413666
- Testing
- ORX489 Tablets
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Centessa Pharmaceuticals (UK) Limited
HIV Infections
Safety and Immunogenicity of Clade C ALVAC and gp120 HIV Vaccine
The purpose of this study is to evaluate the safety and immune response to an HIV clade C vaccine and to an MF59- or alum-adjuvanted clade C Env protein in healthy, HIV-uninfected adults.
- Trial name
- HVTN107 (NCT03284710)
- Testing
- ALVAC-HIV (vCP2438), Bivalent Subtype C gp120/MF59, Bivalent Subtype C gp120 admixed with Al(OH)3 Suspension
- Where
- 6 sites in Mozambique, South Africa and 1 more
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy Adult Participants
Apple Intake Effect on Faecal Metabolome
This pilot dietary intervention study aimed to investigate whether short-term consumption of apples influences the human faecal metabolomic profile.
- Trial name
- AppleNMR (NCT07499960)
- Testing
- Apple consumption
- Where
- Czechia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Czech University of Life Sciences Prague
Healthy Adult Participants
Physiological Responses to Upper Limb NMES
The primary objective of this study is to explore the application of the Firefly® device for delivering NMES to anatomically defined regions of the upper limb and to observe associated physiological changes.
- Trial name
- NCT07635979
- Testing
- Firefly NMES device
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Kieron.Day
Cancer
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer and from healthy participants may help doctors learn more about cancer.
- Trial name
- NCT00899496
- Testing
- immunological diagnostic method, physiologic testing
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Healthy
A Study to Learn if the Study Medicine Called Itraconazole and if Food Changes How the Body Processes the Other Study Medicine Called PF 07258669 in Older Adults or Healthy Adults
The purpose of this study is to learn how the medicine called itraconazole and food changes how the body processes another study medicine called PF-07258669 in older adults or healthy adults.
- Trial name
- NCT06706869
- Testing
- PF-07258669, Itraconazole
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Pfizer
Lyme Disease
A Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1982 to Prevent Lyme Disease in Healthy Participants (18 to 70 Years of Age)
This clinical study will evaluate the safety, reactogenicity, and immunogenicity of monovalent mRNA-1982, a messenger ribonucleic acid (mRNA) vaccine to prevent Lyme disease in healthy adults aged 18 to 70 years old.
- Trial name
- NCT07561294
- Testing
- mRNA-1982
- Where
- 8 sites in Canada
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
Healthy
A Study to Learn More About the Study Medicine PF-07275315 in Healthy Chinese Adult Participants
The purpose of this study is to learn if the study medicine (called PF-07275315) is safe and how it is processed in healthy Chinese participants. This study is seeking participants who: Are between 18 to 65 years of age.
- Trial name
- NCT06675188
- Testing
- PF-07275315
- Where
- China
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Pfizer
Obesity
A Study to Evaluate the Effect of the Experimental GLP-1 Drug PF-07081532 on Blood Levels of Common Birth Control Pills, and Drugs Omeprazole and Midazolam, and Effect of GLP-1 Drug Semaglutide on Midazolam Blood Levels in Healthy Adults With Weight in the Obesity Range
Two different groups of healthy volunteers will be chronically treated with GLP-1 drugs PF-07081532 or alternatively Semaglutide.
- Trial name
- NCT05671653
- Testing
- PF-07081532, Semaglutide
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Adult Participants, Exercise Training
The Effect of Olive Leaf Extract Supplementation on Training-induced Skeletal Muscle Functional and Molecular Adaptations in Healthy Volunteers
The goal of this study is to investigate the effect of combining olive leaf extract supplementation with endurance training (moderate intensity continuous training or sprint interval training).
- Conditions
- Healthy Adult Participants, Exercise Training, Neuromuscular Adaptations, Nutritional Intervention
- Trial name
- OLE_Training_1 (NCT07729072)
- Testing
- Olive leaf extract
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Obesity and Overweight
A Study of MET233 in Individuals With Obesity or Overweight
The goal of this clinical trial is to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of once-weekly subcutaneous injections of MET233 in otherwise healthy adults with overweight or obesity.
- Trial name
- NCT07022977
- Testing
- MET233
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pain Thresholds, Healthy Adult Participants
Evaluation of Psychophysical Responses After Mechanical Stimulation.
This study evaluates the test-retest reliability of psychophysical responses to non-injurious sharp stimuli applied via a robotic system.
- Trial name
- NCT07774429
- Testing
- Robot-controlled non-injurious mechanical stimulation
- Where
- Argentina
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Healthy Adult Participants
Understanding Oral Nicotine Pouch Use in Healthy Volunteers
The goal of this clinical trial is to understand how using oral nicotine pouches effects the body in healthy volunteers. The main questions it aims to answer are: 1.
- Trial name
- NCT07829939
- Testing
- 0 mg oral nicotine pouches, 3 mg oral nicotine pouches, 6 mg oral nicotine pouches
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cicatrix, Scar Prevention
A Study of Single Ascending Dose of LEM-S401 in Healthy Participants
The primary objective of the study is to assess the safety and tolerability of single dose of LEM-S401 in healthy adult subjects.
- Trial name
- NCT04707131
- Testing
- LEM-S401
- Where
- South Korea
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Lemonex Inc.
Healthy Participants
Safety, Tolerability, and Pharmacokinetics of a Single Intravenous Infusion of XTMAB-16 in Healthy Adult Participants
This is a single-center, randomized, double-blind, placebo-controlled, first-in-human, single intravenous (IV) infusion of XTMAB-16 (formerly referred to as KBMAB-16) in normal healthy male and female participants.
- Trial name
- NCT04971395
- Testing
- XTMAB-16 2 mg/kg, XTMAB-16 4mg/kg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Xentria, Inc.
Healthy Volunteers
A Study to Evaluate Single Doses of Alpha-0261 in Healthy Adult Volunteers
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of Alpha-0261 tablets after single oral administration in healthy adult volunteers.
- Trial name
- NCT07279636
- Testing
- Alpha-0261
- Where
- China
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- AlphaMol Science Ltd. (Shanghai)
Healthy Male Participants
A Single Intravenous Dose of E3112 in Japanese Healthy Adult Male Participants
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics after a single intravenous dose of E3112 in Japanese healthy adult male participants.
- Trial name
- NCT03922633
- Testing
- E3112
- Where
- Japan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- EA Pharma Co., Ltd.
Cryptosporidiosis
Study Testing the Efficacy, Safety, and Tolerability of EDI048 in Cryptosporidium Infection Model in Healthy Adults
This study has the purpose to demonstrate prospect of benefit of EDI048 on clinical signs and symptoms of cryptosporidiosis to facilitate trial in target population, pediatric patients.
- Trial name
- CRYPTONITE (NCT07249463)
- Testing
- Cryptosporidium parvum oocysts (ABO809), EDI048
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals
Healthy
A Clinical Study of Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-025)
The purpose of this study is to learn what happens to the amount of enlicitide decanoate in the blood when enlicitide decanoate is given in different formulations.
- Trial name
- NCT06691906
- Testing
- Enlicitide decanoate
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC