Clinical trials: Healthy Adult Volunteers
Diabetes Mellitus
The Study Aims to Show Bioequivalence of the Test Product and the Reference Reference Product in a Crossover Design Study Healthy Volunteers. Additionally, the Safeyt Profile of Test Product Compared to Reference Product Will be Assessed.
To evaluate and compare the relative bioavailability and therefore the bioequivalence of Vildagliptin Tablets 50 mg of AET Laboratories Private Limited, India, with GALVUS® 50 mg Tablets of Novartis Europharm Limited, United…
- Trial name
- NCT05329844
- Testing
- Vildagliptin 50 MG
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- AET Laboratories Private Limited
Healthy Volunteers
Single Dose Escalation Study of P1101 in Healthy Adult Male Subjects
This was a single-center, double-blind, randomized, active control, single dose escalation study to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) profiles of P1101 in 48 healthy volunteers.
- Trial name
- NCT05129644
- Testing
- P1101 (24 mcg), P1101 (48 mcg), P1101 (90 mcg)
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- PharmaEssentia
Healthy
Study In Healthy Adult Volunteers To Evaluate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of PF-04427429
The purpose is to study the safety, tolerability, pharmacokinetics and pharmacodynamics of PF-04427429 administered intravenously to healthy adult volunteers
- Trial name
- NCT01117233
- Testing
- PF-04427429
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pfizer
Natural Blood and Blood Product Toxicity
A Randomized, Double-blinded, Active Controlled Crossover Clinical Trial to Investigate PK, PD and Safety of GBPD002
Erythropoietin (EPO) biosimilarity for GBPD002 (test candidate) and Eprex® (comparator) has been evaluated by comparing the pharmacokinetic (PK) and pharmacodynamic (PD) properties following subcutaneous injection in human…
- Trial name
- NCT05585658
- Testing
- Erythropoietin alpha
- Where
- 2 sites in Bangladesh
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Globe Biotech Limited
Healthy
A Single and Multiple Ascending Dose Study of Niclosamide in Healthy Volunteers
A single and multiple ascending dose study of ANA001 in healthy adults to assess the safety and pharmacokinetics
- Trial name
- NCT04705415
- Testing
- Niclosamide
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- NeuroBo Pharmaceuticals Inc.
Healthy
Bioequivalence Study of Metformin Hydrochloride Liquid 500mg/ 5 mL Under Fed Conditions
The objective of this study was to compare the single-dose oral bioavailability of metformin hydrochloride (HCI) liquid 500 mg/5 mL of Ranbaxy with GlucophageA® 1000 mg tablets of Bristol-Myers, USA following administration of a…
- Trial name
- NCT00780013
- Testing
- metformin hydrochloride liquid 500 mg per 5 mL
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Healthy Volunteers
A Positron Emission Tomography Study to Assess the Occupancy of M4 Muscarinic Acetylcholine Receptors by BMS-986521 in Healthy Adult Participants
The purpose of this study is to Assess the Occupancy of M4 Muscarinic Acetylcholine Receptors by BMS-986521 in Healthy Adult Participants
- Trial name
- NCT07655518
- Testing
- BMS-986521
- Where
- Belgium
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Cognition
Acute Effects of Supplemental Oxygen on Memory Testing in Healthy Adult Volunteers
Forty healthy adults (i.e., not recruited with respect to any particular diagnosis) are each alternately provided with supplemental oxygen and air via nasal cannula at about 6 Liters per Minute (LPM), while completing memory…
- Trial name
- NCT06555484
- Testing
- Cross Over Assignment Supplemental Oxygen and Supplemental Air
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Inogen Inc.
Healthy
Ultrasound Guided Local Anesthetic Block: Thoracolumbar Interfascial Plane
The purpose of the study is to determine the effectiveness of a new approach to numbing (anesthetizing) nerves in the back and to measure how far the area of anesthesia extends on the skin of the back.
- Trial name
- TLIP (NCT02297191)
- Testing
- Thoracolumbar Interfascial Plane Block, Ropivicaine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy Volunteers
A Study to Compare the Relative Bioavailability of Two Iberdomide (CC-220) Formulations and to Assess The Effect Of Food on the Drug Levels of Iberdomide in Healthy Adult Participants
The purpose of this study is to evaluate the relative bioavailability for the new iberdomide powder for reconstitution formulation relative to the reference capsule formulation and to assess the effect of food on the…
- Trial name
- NCT05899738
- Testing
- Iberdomide
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Hemophilia A, Healthy Adult Participants
A First-in Human Study of ARD001 in Healthy Volunteers and People With Hemophilia A
This study is evaluating ARD001, an investigational medicine being developed for the treatment of hemophilia A. In Phase 1, healthy adult participants will receive a single dose of ARD001 or placebo to assess its safety and…
- Trial name
- NCT07787091
- Testing
- ARD001
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Arditus Pte Ltd
PTSD, Alzheimer Disease
First-In-Human (FIH), Single Ascending Dose (SAD) Study of FluoroEthylNorMemantine (FENM)
The goal of this First-In-Human (FIH) trial is to learn about safety and PharmacoKinetics (PK) in healthy adult volunteers. The main questions it aims to answer are: What is the safety of single ascending doses of the…
- Conditions
- PTSD, Alzheimer Disease, Brain Diseases, Neuro-Degenerative Disease
- Trial name
- NCT05921929
- Testing
- Fluoroethylnormemantine (FENM)
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- ReST Therapeutics
Healthy
Hyperpolarized Xenon-129 Lung and/or Brain Magnetic Resonance Imaging: Healthy Adult Volunteer Pilot Study
In this pilot study, MRI of the lungs and/or brain of healthy adult volunteers will be performed at 3Tesla to assess image quality using a prototype chest coil and pulse sequence following inhalation of hyperpolarized 129Xe…
- Trial name
- NCT02195206
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Hypertension, Diabete Type 2
Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of HL1113-R1 and HL1113-R2 in Healthy Adult Volunteers
This clinical trial is a two-arm, open-label, single-sequence, multiple oral dosings, cross-over design clinical trial to evaluate the safety and pharmacokinetic characteristics of HL1113-R1 and HL1113-R2 in healthy adult…
- Trial name
- NCT07598968
- Testing
- Test group 1, Test group 2
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Hanlim Pharm. Co., Ltd.
Kidney Failure, Chronic
Comparing Absorption of Dietary Phosphorus When Administering FOSRENOL® or RENVELA® in Healthy Adult Volunteers
The purpose of this study is to compare the absorption of dietary phosphorus following a single dose with lanthanum carbonate (1000mg) and a single dose of sevelamer carbonate (2400mg).
- Trial name
- NCT00875017
- Testing
- Lanthanum Carbonate, Sevelamer
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Shire
Healthy Volunteers
A Study to Assess the Relative Bioavailability of BMS-986435 and Food Effect on the BMS-986435 in Healthy Adult Participants
This study is designed to evaluate the relative bioavailability (rBA) of multiple test tablet formulations of BMS-986435 compared to an equal dose of the BMS-986435 reference tablet formulation.
- Trial name
- NCT07226817
- Testing
- BMS-986435
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Ulcerative Colitis
First-In-Human Study of BBT-401-1S Following Single and Multiple Ascending Doses in Healthy Volunteers
This clinical trial is the first-in-human study of BBT-401-1S. The purpose of this phase 1 study is to assess the safety and tolerability of single and multiple ascending oral doses of BBT-401-1S in healthy adult subjects.
- Trial name
- NCT03482648
- Testing
- BBT-401-1S, Single dose, BBT-401-1S, Multiple doses
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bridge Biotherapeutics, Inc.
Healthy
A Healthy Volunteer Safety Study of Pyronaridine Tetraphosphate Taken in Combination With Piperaquine Tetraphosphate
The study is a clinical trial involving two medicines called piperaquine (PQP) and pyronaridine (PYR) which, in combination with dihydroartemisinin (DHA) and with artesunate (ART) respectively, have been in clinical use for over…
- Trial name
- NCT05160363
- Testing
- Pyronaridine Tetraphosphate, Piperaquine tetraphosphate
- Where
- United Kingdom
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Medicines for Malaria Venture
Healthy
A Comparative Bioavailability/Food Effect Study of Immediate-Release and Extended-Release Tramadol HCl/Acetaminophen Combination Products Following Single-Dose and Multiple-Dose Administration in Healthy Adult Volunteers
The objectives of this two-part study were to compare the single-dose and multiple-dose pharmacokinetics of extended release and immediate-release fixed combination formulations containing tramadol-HCl/acetaminophen and to…
- Trial name
- NCT00973232
- Testing
- DDS-06C (650 mg acetaminophen and 75 mg tramadol HCl), DDS-06C (650 mg acetaminophen and 75 mg tramadol), Zaldiar®
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Labopharm Inc.
Sarcopenia, Sarcopenia in Elderly
The Effect of Volunteer-Engaged Lifestyle Optimisation Via ICOPE on Sarcopenia in Older Adults (VELO-S)
Sarcopenia prevention and management are highly prioritised goals in the Healthy Ageing agenda. The study aims to: 1) evaluate the effects of the digital-enhanced, volunteer-engaged collaborative care pathway to improve…
- Conditions
- Sarcopenia, Sarcopenia in Elderly, Fall Prevention in Healthy Aging, Frailty Syndrome
- Trial name
- NCT07345832
- Testing
- Volunteer-Engaged Lifestyle Optimisation via ICOPE for Sarcopenia program (VELO-S), Attention control
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
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