Clinical trials: Healthy Blood Donors
Granulocyte Colony-Stimulating Factor (G-CSF) Mobilization
CHRONO-MOBILIZE: Chronotherapy of G-CSF for CD34+ Mobilization in Healthy Donors
Healthy donors are commonly mobilized with granulocyte colony-stimulating factor (G-CSF) to collect peripheral blood stem cells for allogeneic hematopoietic stem cell transplantation (allo-HSCT).
- Trial name
- CHRONO-MOBILIZ (NCT07423728)
- Testing
- G-CSF (Granulocyte colony-stimulating factor)
- Where
- 3 sites in China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Healthy
Safety and Efficacy of POL6326 for Mobilization of Hematopoietic Stem Cells in Healthy Volunteers
Phase I study to determine and compare the safety/tolerability of single ascending doses of POL6326 by intravenous infusion.
- Trial name
- NCT01841476
- Testing
- POL6326
- Where
- Germany
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Polyphor Ltd.
Blood Donors, Apheresis
Collection and Distribution of Blood Components From Healthy Donors for In Vitro Research Use
Background: Many different research projects need a steady supply of human blood. Blood donated by screened, healthy people may be used to test new drugs, for example, or to learn how blood cells work.
- Trial name
- NCT07877259
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Tuberculosis, Immunologic Activity Alteration
The Role of a Mycobacterium Growth Inhibition Assay to Quantify Host Immune Control of M. Tuberculosis
The goal of this observational study is to learn about how the blood leucocytes from patients with and without exposure or disease from tuberculosis (TB) are able to kill live mycobacteria (M. tuberculosis).
- Trial name
- MGIA (NCT06580639)
- Testing
- No intervention.
- Where
- 2 sites in Sweden
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Hematopoietic Stem Cell Mobilization
Non-interventional, Long-term Safety Data Collection of Zarzio® / Filgrastim HEXAL® in Stem Cell Donors
Data collection on the safety and efficacy of Zarzio® / Filgrastim HEXAL® in adult healthy unrelated stem cell donors undergoing peripheral blood progenitor cell mobilization.
- Trial name
- SMART (NCT01766934)
- Where
- 2 sites in Germany
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Sandoz
Cytomegalovirus Infections
Accelerated Immunization to Induce Cytomegalovirus Immunity in Stem Cell Donors
This study will evaluate the safety and effectiveness of a new vaccine, ALVAC-pp65, in boosting immunity to cytomegalovirus (CMV) infection in stem cell transplant donors.
- Trial name
- NCT00353977
- Testing
- ALVAC-CMV (vCP260)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Leukemia, Lymphoma
A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation From Related or Matched Unrelated Donors in Pediatric Patients With Solid Tumors and Leukemias
Background: Bone marrow stem cells, which are found in the bone marrow and blood stream, can be collected and transplanted to treat a variety of types of cancer in a process known as hematopoietic stem cell transplantation…
- Trial name
- NCT01287104
- Testing
- Natural Killer (NK) Cell Infusion, Stem Cell Infusion
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Healthy Blood Donor
Comparison of the Impact of Different Suspension Mediums on ABO Antibody Titres.
Accurate estimation of ABO antibody titres is vital in Transfusion Medicine due to their involvement in hemolytic transfusion reactions, hemolytic disease of the fetus and newborn, and solid-organ transplant rejection.
- Trial name
- NCT07054372
- Testing
- Titres on conventional test tube method with different diluent
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Blood Donors, Research Subjects
COLLECT BLOOD/RESEARCH USE
This protocol is designed to provide a mechanism for the Department of Transfusion Medicine, Clinical Center to collect and process blood components from paid, healthy volunteer donors for distribution to NIH intramural…
- Conditions
- Blood Donors, Research Subjects, Apheresis
- Trial name
- NCT00001846
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Iron Deficiency
Iron Replacement in Blood Donors
Blood donors who have a low fingerstick hemoglobin level are usually deferred from donating. A possible solution to the problem of repeated deferrals might be for Blood Banks to offer donors with low hemoglobin levels oral iron…
- Trial name
- NCT00327067
- Where
- United States
- Volunteers
- 1,820 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy Donors
Impact of Leukoreduction Timing on Plasma Citrullinated Histone H3 (H3cit) Dynamics and Red Blood Cell Storage Lesions
Impact of Leukoreduction Timing on Plasma Citrullinated Histone H3 (H3cit) Dynamics and Red Blood Cell Storage Lesions To measure H3cit levels immediately after filtration on Days 0, 1, 3, and 5.
- Trial name
- NCT07821736
- Testing
- H3Cit
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Malignant Lymphoma, Stem Cell Type
Healthy Donor Study II - Comparing Plerixafor With G-CSF and Plerixafor
Stem cells can be transplanted from a healthy donor to a patient to combat blood cancers and other disorders. This process is called stem cell transplantation. Stem cells normally live in the bone marrow.
- Trial name
- NCT01403896
- Testing
- Plerixafor (Mozobil), Plerixafor + G-CSF
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stephen Couban
Healthy Volunteers
Transfusion of Biotin-Labeled Red Blood Cells
The purpose of this research is to evaluate the impact of genetic and biologic factors in blood donors on red blood cell storage stability after autologous transfusion over the different range of storage period of 5-7 days and…
- Trial name
- NCT03364686
- Testing
- Biotin-Labeled Red Blood Cells
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Gladwin, Mark, MD
HIV Infections
An Open Trial Combining Zidovudine, Interferon-alfa, and Recombinant CD4-IgG With Transplantation of Syngeneic Bone Marrow and Peripheral Blood Lymphocytes From Healthy gp160-Immunized Donors in the Treatment of Patients With HIV Infection
To restore immunologic function and virus-free state in HIV-infected patients. Based on previous studies showing temporary improvement in immune function in HIV-infected patients using peripheral lymphocyte transfers and bone…
- Trial name
- NCT00000647
- Testing
- CD4-IgG, Zidovudine, Interferon alfa-n1
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
Filgrastim-Mobilized Stem Cells for Transplantation Using Unrelated Donors
The purpose of the study is to: Establish and evaluate a system for collection of filgrastim-mobilized peripheral blood stem cells from National Marrow Donor Program donors (NMDP) donors Assess the safety among NMDP donors of…
- Trial name
- NCT00785525
- Testing
- Filgrastim
- Where
- 4 sites in United States
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Center for International Blood and Marrow Transplant Research
Hepatitis E
Seroprevalence Hepatitis E Infection in Healthy Blood Donors
This is a HEV seroprevalence in the health donors in the Canton Ticino study. The pre-donation sampling pouch of each blood donor coming form the Cantone Ticino region will be collected and tested for HEV serology (IgM and IgG).
- Trial name
- NCT03601221
- Testing
- Sample collection
- Where
- Switzerland
- Volunteers
- 1,447 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Healthy Volunteers
Trima Accel® System Post Count Algorithm Study
The purpose of this study is to optimize collected platelet yields in single and double platelet collections, while maintaining donor postplatelet count of >100,000/µL.
- Trial name
- NCT02684630
- Testing
- Trima Accel System
- Where
- 2 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Terumo BCT
Thrombocytopenia
Identification of Donors of CD36-Deficient Platelets Among Japanese Individuals on the NIH Campus
Plasma histidine-rich glycoprotein (HRG) binds to platelets in the presence of zinc (1). This binding is totally blocked by a monoclonal antibody directed against platelet membrane CD36.
- Trial name
- NCT00015639
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Healthy Volunteers
Recruiting Blood Donor With Allogeneic Natural Killer Cell
This study on manufacture of MG4101 (allogeneic natural killer cell) to use for Hepatocellular carcinoma(HCC) after Transarterial Chemoembolization(TACE) will be harvested WBC(white blood cell) and plasma from healthy donors, or…
- Trial name
- NCT02716571
- Testing
- Leukapheresis or Plasmapheresis
- Where
- South Korea
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Allogeneic Granulocyte Donation
Improving White Blood Cell Collection From Healthy Donors
Background: White blood cells called granulocytes help the body fight infection. People who have had chemotherapy or bone marrow transplants may have very low numbers of these cells.
- Trial name
- NCT01553214
- Testing
- Filgrastim, Dexamethasone
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)