Clinical trials: Healthy Controls
Bulimia Nervosa, Eating Disorders
Neural Response to Catecholamine Depletion in Subjects Suffering From Bulimia Nervosa in Their Past and Healthy Controls
Bulimia nervosa is a severe psychiatric disorder characterized by recurrent binge eating episodes followed by inappropriate compensatory behavior to prevent weight gain such as self-induced vomiting.
- Conditions
- Bulimia Nervosa, Eating Disorders, Dopamine, Reward
- Trial name
- NCT02179814
- Testing
- AMPT/ Demser, Diphenhydramine
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bern
Circadian Rhythm Disorders, Intestinal Flora
An Observational Clinical Study on the Intestinal Flora in Circadian Rhythm Disorder and Healthy Controls
An observational clinical study on the changes of intestinal flora between people with circadian rhythm disorders and healthy controls was conducted to explore the relationship between circadian rhythm disorders and human…
- Trial name
- NCT05694481
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
PCD
NIOX VERO Nasal Application in Primary Ciliary Dyskinesia
This is a multi-centre, single visit clinical investigation involving patients with known PCD vs. age matched healthy volunteers. This study involves 1 visit which will last one (1) to two (2) hours.
- Trial name
- NCT02622061
- Where
- 5 sites in United States, Denmark and 2 more
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- Aerocrine AB
Healthy
Genotype and Phenotype Registry: Enrollment of Normal Control Subjects for Current and Future Research
Registry program for volunteers who are willing to serve as control subjects in future research studies.
- Trial name
- NCT00926042
- Where
- United States
- Volunteers
- 4,511 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Schizophrenia, Healthy (Controls)
Exploring the Genetics of Schizophrenia in Manitoba
Schizophrenia is a serious mental illness that affects about 1 in 100 Canadians, shortens life expectancy, and places a large burden on individuals, families, and the healthcare system.
- Trial name
- GENES-MB (NCT07656870)
- Where
- Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Cancer, Tumors
Detection of Tumor DNA in Blood Samples From Cancer Patients
The aim of this study is to employ genomic detection methodologies to measure the relative amount of tumor nucleic acids in the blood of a cancer patient with diagnosed metastatic disease that is either commencing, currently…
- Trial name
- NCT02288754
- Testing
- Blood test
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Lexent Bio, Inc.
Alzheimer Disease, Frontotemporal Dementia
First-in-Human Evaluation of an Astrocytic Glutamate Transporter (EAAT2) PET Tracer in Dementia
This is a first in human study that will assess the safety and diagnostic performance of [18F]RP-115 (fluorine-18 labeled RP115), a positron emission tomography (PET) agent.
- Conditions
- Alzheimer Disease, Frontotemporal Dementia, Dementia
- Trial name
- NCT05374278
- Testing
- [18F]RP-115 PET/MRI or PET/CT and MRI
- Where
- United States
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- David Wilson
Hypertension
Effects of Inhibition of NO-Synthesis on Renal Hemodynamics and Sodium Excretion in Patients With Essential Hypertension and Healthy Controls
The study tests the hypothesis that systemic and renal nitric oxide synthesis is changed in essential hypertension by investigating the effects of a non selective nitric oxide inhibitor on renal hemodynamics and sodium excretion…
- Trial name
- NCT00345150
- Testing
- Ng-monomethyl-L-arginine (drug)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Regional Hospital Holstebro
Periodontitis
IL-6, IL-17 and IL-35 Levels in the Gingival Crevicular Fluid of Patients With Periodontitis and Healthy Controls
Periodontitis is an inflammatory disease characterized by periodontal tissue destruction caused by bacterial infection. The immune response plays an important role in the progression of periodontitis.
- Trial name
- NCT05306860
- Testing
- No intervention was applied to the groups the samples will be collected in terms of the diagnosis (periodontitis, healthy)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Anorexia Nervosa
Characteristics of Intensity and Dependence to Physical Activity in Anorexia Nervosa
Etude d'épidémiologie clinique multicentrique (IMM), naturalistique, comparant un échantillon clinique à un échantillon de témoins issus de la population générale.
- Trial name
- HAP-AM (NCT02165982)
- Where
- France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Institut Mutualiste Montsouris
Healthy Subjects
Effect of Clemastine Fumarate on Color Vision in Healthy Controls
In a1972 study in the French Annals of Pharmaceuticals, Laroche and Laroche reported that the drug clemastine has a negative effect on patients' color discrimination, which is the ability to distinguish different hues and arrange…
- Trial name
- NCT02613091
- Testing
- Clemastine fumarate
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Epilepsies
Role of High-Frequency Oscillations on Scalp EEG in Identifying Epileptogenic Activity in Patients With Epilepsy and Healthy Controls
This observational case-control study aims to evaluate whether high-frequency oscillations (HFOs) detected on scalp electroencephalography (EEG) can differentiate patients with epilepsy from healthy controls.
- Trial name
- NCT07470931
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Respiratory Syncytial Virus Infections
A Study on the Immune Response and Safety of an RSV Vaccine When Given to Adults 18 Years of Age and Above Who Received Lung or Kidney Transplant and Are at an Increased Risk of Respiratory Syncytial Virus Lower Respiratory Tract Disease and Compared to Healthy Adults 50 Years of Age and Above
The purpose of this study is to evaluate the immunogenicity, safety, and reactogenicity of the RSVPreF3 OA investigational vaccine in an immunocompromised (lung and renal transplant recipients) population and assess whether a…
- Trial name
- RSV OA=ADJ-023 (NCT05921903)
- Testing
- RSVPreF3 OA Investigational Vaccine
- Where
- 46 sites in United States, Australia and 6 more
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Major Depressive Disorder, Healthy Controls
Effects of Treatment on Decision-making in Major Depression
In this trial, fifty participants with current major depressive disorder who are not receiving an antidepressant medication and fifty healthy controls will complete questionnaires and computerized tasks to assess their…
- Trial name
- NCT01916824
- Testing
- Any FDA Approved Antidepressant
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Emory University
FTD, AD
Metabolic Characterization of Alzheimer's Disease and Frontotemporal Dementia by 23Na-MRI and FDG-PET
Alzheimer's disease (AD) and frontotemporal dementia (FTD) are the most common forms of neurodegenerative dementia. However, their differential and timely diagnosis can be challenging for clinicians, therefore often closing the…
- Conditions
- FTD, AD, Healthy Controls
- Trial name
- MetaAD_FTD (NCT07100470)
- Testing
- Sodium MRI
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Healthy (Controls)
Visa-versa! Breaking Instead of Pushing the Pedals-D
Eccentric muscle work is defined as lengthening of a muscle while applying force. It was shown that with eccentric work, muscles are able to perform four times as much power compared to usual concentric work, which results in…
- Trial name
- NCT05185895
- Testing
- 15 minutes eccentric cycling, 15 minutes concentric (normal) cycling
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Renal Impairment
Investigation of the Effects of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of Opemalirsen (AZD2373)
This study is being conducted to investigate the PK, safety, and tolerability of opemalirsen in participants with renal impairment, compared to participants with normal renal function.
- Trial name
- NCT07154901
- Testing
- Opemalirsen (AZD2373)
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Anxiety, Distress, Emotional
Effect of (TaVNS) on Anxiety and Brain Function in Distressed Health Care Workers
The purpose of this research is to measure alterations in anxiety and brain activity associated with the use of an approved health device called Transauricular Vagal Nerve Stimulation (TaVNS) in distressed persons who work in a…
- Conditions
- Anxiety, Distress, Emotional, Effects of Vibration, Healthy
- Trial name
- fMRIVNS (NCT05132881)
- Testing
- Neuvana 2.0 Transcutaneous Auricular Vagal Nerve Stimulation (TaVNS), Waitlist Control, Healthy Controls: Substudy Group III
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Schizophrenia / Schizoaffective Disorder, SCHIZOPHRENIA 1 (Disorder)
Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 3
In Study 3, all tasks and models from Aim 1 will be evaluated in a large community sample of online participants recruited through Prolific.
- Conditions
- Schizophrenia / Schizoaffective Disorder, SCHIZOPHRENIA 1 (Disorder), Healthy Adult
- Trial name
- CNTRACS (NCT07900893)
- Testing
- Motion Perception Task, Sine Wave Speech Task, Volatility Task
- Where
- 2 sites in United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Chronic Low Back Pain (CLBP), Chronic Neck Pain
Comparative Analysis of Heart Rate Variability in Patients with Cervical Pain, Lumbar Pain, and Healthy Controls
This is a cross-sectional study designed to evaluate potential differences in heart rate variability (HRV) indices based on the affected body region (cervical vs lumbar) in individuals with chronic pain.
- Conditions
- Chronic Low Back Pain (CLBP), Chronic Neck Pain, Heart Rate Variability, Autonomic Nervous System Dysfunction
- Trial name
- NCT06890793
- Where
- Spain
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Universidad de Extremadura