Clinical trials: Healthy Controls
Hypoxia, Mental Disorder
Going to Altitude With Anxious-depressive Symptoms
Introduction: Currently, there is a lack of international guidelines or clinical recommendations for individuals with mental illnesses (i.e., bipolar disorder, posttraumatic stress disorder) going on high altitude sojourns.
- Trial name
- Psychoxie (NCT05323864)
- Testing
- Hypoxia
- Where
- Austria
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universitaet Innsbruck
Takayasu Arteritis, Behçet's Disease
Physical and Psychosocial Parameters in Takayasu Arteritis and Behçet's Disease: A Comparative Study With Healthy Controls
Systemic vasculitis refers to a group of rare diseases characterized by inflammation of blood vessel walls, which may cause ischemia and structural damage in various organs.
- Conditions
- Takayasu Arteritis, Behçet's Disease, Healthy Controls
- Trial name
- NCT07276087
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ÖZLEM NUR TOK YAMAN
Infections, Meningococcal
Combined Study - Phase 3b MenB Long Term Persistence in Adolescents
The purpose/aim of this study is to assess 1) the long-term persistence (4 to 7.5 years after the last dose) of bactericidal activity following primary vaccination with rMenB+OMV NZ in adolescents [who previously participated in…
- Trial name
- NCT02446743
- Testing
- rMenB+OMV NZ (Meningococcal (Group B) multi component recombinant adsorbed vaccine)
- Where
- 12 sites in Australia, Canada and 1 more
- Volunteers
- 531 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy (Controls), Healthy Volunteers
Ultralow Dose PET Imaging of SSTR2 Radiotracer Uptake
The goal of this clinical trial is to evaluate an investigational ultralow dose positron emission tomography (PET) imaging technique for neuroendocrine tumor detection and monitoring.
- Conditions
- Healthy (Controls), Healthy Volunteers, Neuroendocrine (NE) Tumors
- Trial name
- NCT07284589
- Testing
- 68Ga-Dotatate
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Akiva Mintz
HIV Infections, Opioid Use
Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls
The purpose of this research is to measure the extent of inflammation in the brain between different groups of participants using a radioactive tracer called [18F]NOS.
- Trial name
- NCT04401917
- Testing
- [18F]NOS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy, Healthy Adult
Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Healthy Individuals H
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in healthy individuals, who live permanently >2600m.
- Conditions
- Healthy, Healthy Adult, High Altitude Effects, High Altitude
- Trial name
- NCT07801950
- Testing
- Descent from 2850m to sea level and re-ascent back to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Healthy Individuals (Controls), Vascular Surgery Patients With Acute Thrombosis
Haemodialysis Alters Hypercoagulability of Blood in Dialysis Patients
Primary Objective: To develop a thrombotic event risk assessment model integrating serum biomarkers (TM, TAT, t-PAIC, PIC) with clinical data, systematically compare its predictive performance across healthy populations, vascular…
- Conditions
- Healthy Individuals (Controls), Vascular Surgery Patients With Acute Thrombosis, Dialysis Patients
- Trial name
- TAT-t-PAIC (NCT07098676)
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Ai Peng
Psychosis; Schizophrenia-Like, Healthy Controls
Mechanisms of Response to Therapeutic Intervention in Clinical High Risk (CHR) for Psychosis
This study, "Psychobiological Follow-up Study of Transition from Prodrome to Early Psychosis", will be conducted in collaboration with the Shanghai Mental Health Center (SMHC) and several data processing sites in the United…
- Trial name
- NCT06542640
- Testing
- Mb-rt-fMRI-NFB, rTMS
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
HIV Infections, Malaria
Drug Interaction Study Between Antimalarial and Anti-HIV Medications
The purpose of this study is to find out whether taking certain anti-HIV medicines with certain antimalarial medicines affects the amount of the medicines in the blood.
- Trial name
- NCT00266058
- Testing
- Lopinavir/Ritonavir, Efavirenz, Artemether/lumefantrine
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Multiple Sclerosis, Healthy Controls Group - Age and Sex-matched
Measurement Properties of the Walking Adaptability Ladder Test and Foot Tap Test in Multiple Sclerosis
Walking and motor control impairments are among the most common manifestations experienced by people with multiple sclerosis (pwMS) and may already be present in individuals with mild disability.
- Trial name
- NCT07505355
- Where
- 4 sites in Belgium, Italy and 1 more
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Familial Hemiplegic Migraine, Migraine With Aura
Calcitonin Gene-related Peptide in Familial Hemiplegic Migraine (FHM) and Migraine With Aura (MA)
The aim of the present study is to explore the importance of migraine phenotype on the headache/migraine responses after CGRP in FHM-patients, MA-patients and healthy volunteers.
- Conditions
- Familial Hemiplegic Migraine, Migraine With Aura, Healthy
- Trial name
- CGRP-2008 (NCT00687947)
- Testing
- CGRP
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Healthy Controls
The Effect of Short-term Atorvastatin Treatment on Immune Responses to Pneumovax 23
The purpose of this research study is to: Improve the effectiveness of vaccinations by identifying the effect of cholesterol medication, statins, on immune responses.
- Trial name
- StatVax (NCT02097589)
- Testing
- Atorvastatin, Pneumovax 23
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Florida
Diabetes Mellitus, Peripheral Neuropathy
Diabetes Peripheral Neuropathy and Small-fibre Nerve Damage: A Comparative Study
The purpose of this study is to investigate whether patients with diabetes-related peripheral neuropathic pain also have non-recognized damage to the intestine caused by autonomic neuropathy.
- Conditions
- Diabetes Mellitus, Peripheral Neuropathy, Small Fibre Neuropathy, Autonomic Neuropathy
- Trial name
- NCT01160887
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Healthy
Phenytoin as a Neuroprotective Agent Against Corticosteroid-induced Functional Imaging Changes
The purpose of this research is to determine if patients who receive phenytoin (also commonly known as Dilantin) before taking corticosteroids will show less memory impairment and hypomanic symptoms (feelings of agitation…
- Trial name
- NCT00591006
- Testing
- Phenytoin (brand name Dilantin), Hydrocortisone
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Obstructive Pulmonary Disease
Follow-up-study of COPD Patients and Healthy Controls for Evaluation of Predictive Non-coding RNA Biomarkers
Between 2012 and 2014, a cohort of 90 COPD subjects of disease severity grades GOLD I-IV as well as 60 healthy control subjects (30 smokers and 30 non-smokers) have been examined regarding different clinical and blood/ sputum…
- Trial name
- Ribo2 (NCT02522026)
- Where
- Germany
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Patients With Heart Failure and Preserved Ejection Fraction - HFpEF, Patients With Heart Failure With Reduced Ejection Fraction - HFrEF
Developing Imaging And plasMa biOmarkers iN Describing Heart Failure With Preserved Ejection Fraction (DIAMONDHFpEF)
The investigators wish to test a hypothesis that patients with HFpEF have different characteristics on echo, cardiac MRI and plasma protein \& chemical profiles compared to HFrEF and healthy volunteers.
- Conditions
- Patients With Heart Failure and Preserved Ejection Fraction - HFpEF, Patients With Heart Failure With Reduced Ejection Fraction - HFrEF, Healthy Controls Group - Age and Sex-matched
- Trial name
- DIAMONDHFpEF (NCT03050593)
- Testing
- MRI scan, Echo scan
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Systemic Lupus Erthematosus, Sjogren's Syndrome
Mass Spectrometry-based Immune Profiling in Autoimmune Diseases
Based on mass spectrometry flow method, this study analyzed the typing of new T, B, NK and DC cell subsets in peripheral blood of common autoimmune diseases and their correlation with disease activity, aiming at establishing an…
- Conditions
- Systemic Lupus Erthematosus, Sjogren's Syndrome, Inflammatory Myopathies, Systemic Sclerosis (SSc)
- Trial name
- NCT07188285
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Pulmonary Fibrosis, Healthy
Pulmonary Fibrosis Lung Sounds Study
The goal of this observational study is to test whether it is possible to detect particular lung sounds that are unique to patients with the lung disease pulmonary fibrosis and whether any such sounds could be analysed using…
- Trial name
- NCT05771740
- Testing
- Stemoscope (bluetooth sound amplifier)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Multiple Sclerosis, Healthy
Effects of Gilenya (Fingolimod) on Thalamus Pathology and Cognitive Impairment in Patients With Relapsing Forms of Multiple Sclerosis
This study aims to assess the effect of Gilenya on brain pathology and cognitive impairment over 6, 12, and 24 months in patients with relapsing MS using MRI, clinical data, and neurological assessments.
- Trial name
- GLT (NCT02021162)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Postural Tachycardia Syndrome
Alterations of Attention in POTS Depending on Body Position and Hydration
The Postural Tachycardia-Syndrome (POTS) is a form of autonomic dysregulation, typically accompanied by symptoms of orthostatic intolerance (OI).
- Trial name
- NCT03253120
- Testing
- Water
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern