Clinical trials: Healthy Gut Microbiota
Healthy
A Study to Evaluate the Influence of Diet on GI Health
The purpose of this study is to understand the potential of protein and psyllium fiber to manipulate gut microbial densities, intestinal permeability, and inflammation in humans.
- Trial name
- NCT04783142
- Testing
- High-fiber, low-protein diet, Low-fiber, high-protein diet
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Wellbeing, Healthy
PROMOTE: The Effect of a Six Week Prebiotic Supplementation on Wellbeing of Young Adults.
The study will investigate whether taking a prebiotic for six weeks helps to reduce morning cortisol levels in healthy young adults with mild to moderate stress compared to a placebo.
- Conditions
- Wellbeing, Healthy, Mental Health
- Trial name
- PROMOTE (NCT06566157)
- Testing
- Prebiotic, Maltodextrin (Corn)
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southampton
Cognitive Performance, Inflammation
Peanut Consumption on Cognitive, Weight, and Inflammation
A multi-school, two-arm parallel cluster-randomized controlled trial will be conducted in 200 healthy young adolescents from Barcelona (Spain) to evaluate the effect of peanut consumption on cognitive performance, weight…
- Conditions
- Cognitive Performance, Inflammation, Weight Change, Body, Adolescents
- Trial name
- PEANUTY (NCT06127511)
- Testing
- Food (peanut)
- Where
- Spain
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
Metabolic Syndrome, Insulin Resistance
An Antiinflammatory Diet as Modulator of Cardiometabolic Risk and Body Weight in Healthy Subjects
Main scientific question: A previous intervention with an anti-inflammatory multifunctional dietary portfolio (MFD) showed remarkable reductions in cardiometabolic (CM) risk markers compared with a well-designed control diet.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Overweight
- Trial name
- NCT02148653
- Testing
- Multifunctional diet (MFD), Control diet
- Where
- Sweden
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Lund University
Crohn's Disease, Genetic Predisposition
Abnormal Fecal Microbiota in Healthy Subjects at High Risk for Crohn's Disease
Transversal multicentric French study on the microbiota in patients with Crohn's disease and their first degree healthy relatives The primary objective is the comparison of microbiota between patients with CD, healthy controls…
- Trial name
- MAGIC (NCT02826330)
- Testing
- biomarkers
- Where
- 10 sites in France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
NAFLD, Fecal Microbiota
Dietary Counseling Coupled With FMT in the Treatment of Obesity and NAFLD - the DIFTOB Study
There are several studies performed to reveal the linkage between diet, fecal microbiota, and obesity. Human fecal microbiota transplantations in this asset are still scarce.
- Conditions
- NAFLD, Fecal Microbiota, Gut Microbiota, Obesity
- Trial name
- DIFTOB (NCT05607745)
- Where
- 3 sites in Finland
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Quality of Life, Health, Subjective
Resistant Starch Blend Gastrointestinal Impact
This study aims to test the hypothesis that a unique blend of resistant starches and fiber will promote gastrointestinal health, as measured by an increase in short-chain fatty acids and improvement in quality of life measures in…
- Trial name
- NCT03983772
- Testing
- RS blend
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Healthy Adult
Effect of Bifidobacterium Animalis Subsp. Lactis Bi66 Supplementation on Gut Function in Healthy Adults
The goal of this clinical trial is to learn the effect of Bifidobacterium animalis subsp. lactis Bi66 supplementation on gut function in healthy adults. The main questions it aims to answer are: 1.
- Trial name
- NCT06740500
- Testing
- Probiotic
- Where
- China
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Healthy
Characterization of the Gut Microbiota Signature According to Physical Fitness and Its Implications for Intestinal Health.
The gut microbiota comprises all microorganisms inhabiting the digestive tract, evolving throughout life under the influence of various intrinsic and extrinsic factors.
- Trial name
- MICROPEPS (NCT07276464)
- Testing
- Maximal incremental exercise test, Submaximal exercise test, Fecal sampling
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Rennes 2
Gut Microbiota
Temporal Changes in the Gut Microbiota Before and After Migrating to High Altitude
This prospective observational cohort study aims to learn about temporal changes in the gut microbiota before and after migrating to high altitudes in healthy participants.
- Trial name
- NCT05901896
- Testing
- there are no intervention
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Liaocheng People's Hospital
Healthy
SwissGut - The Healthy Swiss Microbiome
Objective: This study is designed to address the complex interplay between the gut microbiome, environmental factors, and inflammatory diseases, with a specific emphasis on serving as a healthy cohort for several related…
- Trial name
- SwissGut (NCT06191224)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Benjamin Misselwitz
Gastroesophageal Reflux Disease With Esophagitis
Evaluate the Intestinal Microbiome in Patients With Erosive Gastroesophageal Reflux Disease and in Asymptomatic Healthy Controls
. In this study, we investigated intestinal microbiomes, in individuals with Gastroesophageal Reflux Disease and healthy individuals, using metagenomic techniques.
- Trial name
- NCT04248296
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Healthy Infants
Study on the Effects of Probiotic on Infant Gut Microbiota and Immune Regulation
This is a probiotic intervention study in healthy infants aged 0 - 6 months. The primary objective is to evaluate the effects of Lacticaseibacillus paracasei LPB27 (also known as Lacticaseibacillus paracasei 207-27)…
- Trial name
- NCT07896083
- Testing
- Probiotic, Maltodextrin
- Where
- China
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- BYHEALTH Co., LTD
Healthy
Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults
The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota.
- Trial name
- NCT06873204
- Testing
- Soluble Arabinoxylan, Rice Bran
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Purdue University
Morbid Obesity, Metabolically Healthy Obesity
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Obesity
This is a prospective, clinical, multicentre study aimed to collect biological samples and study microbiota from subjects with morbid obesity, metabolically healthy obesity and from healthy volunteers.
- Trial name
- BIOMIS-Endo (NCT04698135)
- Testing
- Biological samples collection, Questionnaire, Medical/laboratory examinations
- Where
- Italy
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Healthy Males
Effect of a 4-week Post-exercise Sauna Bathing on Targeted Gut Microbiota
Body temperature fluctuations induced by acute exercise bouts may influence the intestinal barrier with related effects on epithelial permeability, immune responses, and release of metabolites produced by the gut microbiota.
- Trial name
- NCT05277597
- Testing
- The exercise 60 minutes, 3 times per week, on a bicycle ergometer followed by a 30-minute dry Finish sauna treatment., The same exercise training program without the sauna treatments
- Where
- Poland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Healthy
Infant Microbiota and Probiotic Intake Study
The purpose of this study is to determine if supplementing healthy term infants delivered by C-section or vaginal delivery who only consume breastmilk with a probiotic for 21 consecutive days increases levels of bacteria in…
- Trial name
- IMPRINT (NCT02457338)
- Testing
- Bifidobacterium
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Endometriosis, Bacterial Vaginosis
Effects of a Multi-strain Oral Probiotic on the Vaginal Microbiota Composition in Healthy Women and Women with Endometriosis
Endometriosis is a chronic inflammatory disease affecting approximately 10-15% of reproductive age women, and, in recent years, an association between this pathology and dysbiosis, either involving the gut or the genital…
- Conditions
- Endometriosis, Bacterial Vaginosis, Healthy Volunteer
- Trial name
- NCT06592976
- Testing
- Multi-strain Oral Probiotic (CDS22-formula)
- Where
- Italy
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Healthy Subjects
Effects of Barley Based Food Products on Metabolism and Gut Microflora
The main objective is to investigate gut microflora composition in relation to cardiometabolic risk markers, and to investigate the effects of 3 days intervention with a barley kernel based product on these variables.
- Trial name
- NCT02427555
- Testing
- Barley kernel bread, white wheat bread
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lund University
Inflammatory Bowel Disease
Gut Microbiota in the Healthy Population, Inflammatory Bowel Disease Patients, and Their Relatives
The aim of this study is to compare the gut microbiota in Chinese patients with Inflammatory Bowel Disease (IBD) in Hong Kong with that of healthy controls, compare the gut microbiota in IBD patients in a developing country (low…
- Trial name
- NCT01140802
- Where
- Hong Kong
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong