Clinical trials: Healthy Gut Microbiota
Hiv, Atherosclerosis
Effectiveness of Gut Microbiota-targeted Diatery Intervention Among Older People Living With HIV
The goal of this clinical trial is to conduct a dietary intervention targeting HIV specific gut microbiota alterations for primary atherosclerotic cardiovascular disease (ASCVD) prevention and evaluate its effectiveness in…
- Conditions
- Hiv, Atherosclerosis, Diet, Healthy
- Trial name
- NCT06560840
- Testing
- dietary intervention
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Fudan University
Healthy
Dietary Fiber and Gut Microbiome Study
The purpose of this dietary intervention is to study the effects of several dietary fibers on the gut microbiota at the personal level.
- Trial name
- NCT05424640
- Testing
- Dietary fiber 1, Dietary fiber 2, Dietary fiber 3
- Where
- Estonia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Center of Food and Fermentation Technologies
Healthy
ButyraGen™, Short Chain Fatty Acids and Gut Microbiome
This study is being conducted to demonstrate short chain fatty acid (SCFA), specifically butyrate, generation in stool, blood and urine in response to oral intake of ButyraGen™.
- Trial name
- BG (NCT05601635)
- Testing
- ButyraGen™
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Circadian Rhythm Disorders, Intestinal Flora
An Observational Clinical Study on the Intestinal Flora in Circadian Rhythm Disorder and Healthy Controls
An observational clinical study on the changes of intestinal flora between people with circadian rhythm disorders and healthy controls was conducted to explore the relationship between circadian rhythm disorders and human…
- Trial name
- NCT05694481
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
Healthy Adults
Adult HMO Supplementation and the Gut Microbiome
The goal of this study is to assess the impact of Layer Origin's SuperHMO prebiotic formulation on the healthy adult gut microbiome.
- Trial name
- NCT06570330
- Testing
- SuperHMO, Non-GMO corn Maltodextrin, Rapid Absorption
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seeding Inc
Dietary Fiber, Gastrointestinal Microbiome
Luxembourgish Fiber Cohort
Many human populations across the world are deficient in the intake of dietary fiber. This decline in fiber consumption parallels an increase in prevalence of a multitude of diseases (e.g. colorectal cancer, multiple sclerosis).
- Conditions
- Dietary Fiber, Gastrointestinal Microbiome, Healthy Volunteers
- Trial name
- Lux-FiCo (NCT04352231)
- Testing
- High Fiber Diet Intervention, Low Fiber Diet Intervention
- Where
- 2 sites in Luxembourg
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Luxembourg Institute of Health
Dysbiosis
Effect of Lentils and Chickpeas on Gut Microbiome and Metabolic Health
The primary goal of this research is to evaluate the effect of daily whole-cooked chickpea and lentil consumption for 8-weeks on gut health, including microbiome-metabolome arrays and gut epithelial/barrier function, in healthy…
- Trial name
- NCT06914375
- Testing
- Goya Foods - Canned Chickpeas, Goya Foods - Canned Lentils, Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Appetitive Behavior
Focus on Fibre Study
The investigators present a diet intervention study, to be conducted as a within-subject design, with all food and beverages provided, to allow ad libitum feeding to assess impact of diet change on appetite response.
- Trial name
- NCT05449665
- Testing
- Phase 1 - Control, Phase 2 - High Fibre, Phase 3 - Low Fibre
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Colorectal Cancer; Gut Microbiota Dysbiosis
Intestinal Flora Differences Between Colorectal Cancer Patients and Healthy Individuals
This observational case-control study aims to compare the composition of intestinal microbiota between colorectal cancer (CRC) patients and healthy individuals.
- Trial name
- NCT06875648
- Testing
- Not applicable (observational study)
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hansung University
Healthy
Physical Activity and Gut Microbiota in Children (PA-Microbiome Kids)
This study evaluates the effect of a 16-week moderate-to-vigorous physical activity (MVPA) program on physical fitness and gut microbiota in healthy school-aged children.
- Trial name
- PA-Microbiome (NCT07310654)
- Testing
- 16-week Structured MVPA Program, Attention Control Sedentary Activities
- Where
- China
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Aiyoudong Children and Youth Sports Health Research Institute
Obsessive-Compulsive Disorder
The Gut Microbiota in Obsessive-Compulsive Disorder
This study will examine the gut microbiota and serum inflammatory markers in patients with Obsessive-Compulsive Disorder vs. healthy controls.
- Trial name
- NCT02285699
- Testing
- SSRIs
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy Volunteers
Effects of S. Boulardii and Amoxicillin/Clavulanate on Gut Microbiota
The purpose of this study is to compare and contrast the effects of the probiotic Saccharomyces boulardii, the antibiotic amoxicillin/clavulanate and the combination on the gut microbiota of healthy volunteers.
- Trial name
- NCT01473368
- Testing
- Saccharomyces boulardii, Amoxicillin Clavulanate
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy, Overweight (BMI > 25)
Effect of Probiotics on Appetite Regulation in Adults With Overweight/Obesity
The goal of this 16-week randomised, placebo-controlled parallel study is to investigate the effect of a newly formed probiotic supplement on satiety and gut microbiota composition in healthy men and women with overweight or…
- Conditions
- Healthy, Overweight (BMI > 25), Overweight , Obesity, Male
- Trial name
- ProBiSat (NCT07715955)
- Testing
- Probiotic supplementation
- Where
- Netherlands
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Human Microbiome
A Clinical Trial for Analysis of Intestinal Microbiome Affecting PK, PD, and Safety of Metformin
This clinical trial is intended to evaluate the effects of the changes in intestinal microbiome by antibiotics (PO vancomycin) on the pharmacokinetic /pharmacodynamic and safety profiles of metformin in healthy male volunteers.
- Trial name
- NCT03809260
- Testing
- Metformin (part 1), Vancomycin, Metformin (part 2)
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Less Than 3 Months Old, Healthy Infants
An Intervention Study in Healthy Infants Aged 0-6 Months With Probiotics Lacticaseibacillus Rhamnosus LRa05 (LRa05) and Bifidobacterium Animalis Subsp. Lactis BLa80 (BLa80) vs. Placebo, for Promoting Gut Microbiome Development.
The probiotics Bifidobacterium animalis subsp. lactis BLa80 and Lacticaseibacillus rhamnosus LRa05 have potential to enhance infant health and development based on previous research conducted on human infants.
- Trial name
- SMILE (NCT07505329)
- Testing
- Probiotic
- Where
- Ireland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University College Cork
Overweight or Obesity, Healthy
Anti-inflammatory Effect and Associated Mechanisms of Mango Consumption
The primary objective of this project is to provide new knowledge through a comprehensive set of analyses that investigate the complex interplay between regular mango intake, gut microbial structure/ function, mechanisms of…
- Trial name
- MG2 (NCT04726293)
- Testing
- Mango, Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Healthy Volunteers
The Role of Gut Microbiome on Cardiovascular Health Benefits of Dietary Lignans (CardioFlax Study).
The aim of this study is to investigate the effects of gut microbial metabolism of flaxseed lignans on cardiovascular health. Enterolactone is the main gut microbial metabolite of lignans.
- Trial name
- NCT04179136
- Testing
- lignan capsules contain 300 mg flaxseed (SDG) extract
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- King's College London
Healthy Volunteer, Terminal Ileostomy
Behavior of Various Galenic Forms of a Probiotic in the Digestive Tract.
The aim of this study is to assess the behavior of a model probiotic strain, Lactobacillus salivarius, in the digestive tract of healthy volunteers and of ileostomized patients, depending on its galenic form.
- Trial name
- PROBIOSIN (NCT03143400)
- Testing
- Lactobacillus salivarius BL 3123
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Healthy Lifestyle, Home Environment Related Disease
HomeStyles-Adults of Chinese Heritage
Individuals of Chinese heritage are the largest and fastest growing segment of the US Asian population. US Chinese have sociodemographic characteristics and culture that differ substantially from other US Asians, and therefore…
- Conditions
- Healthy Lifestyle, Home Environment Related Disease, Cardiometabolic Disease, Systemic Inflammatory Response
- Trial name
- NCT06136793
- Testing
- HomeStyles-China
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Healthy
SwissGut - The Healthy Swiss Microbiome
Objective: This study is designed to address the complex interplay between the gut microbiome, environmental factors, and inflammatory diseases, with a specific emphasis on serving as a healthy cohort for several related…
- Trial name
- SwissGut (NCT06191224)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Benjamin Misselwitz