Clinical trials: Healthy Gut Microbiota
Nutritional and Metabolic Diseases
Saskatoon Berry on Metabolism and Gut Microbiota in Healthy Subjects
Diabetes becomes epidemic in worldwide countries. Nine out of ten diabetic patients are type 2 diabetes (T2D). T2D is characterized by insulin resistance and obesity.
- Trial name
- NCT04809688
- Testing
- Saskatoon berry, Dried Saskatoon berry
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Gut Microbiota, Bowel Function
A Study of a Prebiotic, a Probiotic and a Synbiotic Upon the Gut Microbiota and Immune Response of Healthy Volunteers
Healthy volunteers will be recruited to a study where they will be given four different treatments over a 28 week period. These treatments include: a prebiotic, a probiotic, a synbiotic (prebiotic + probiotic) and a placebo.
- Conditions
- Gut Microbiota, Bowel Function, Immune Function, Plasma Lipids
- Trial name
- XOS (NCT01545219)
- Testing
- Prebiotic, Bi-07, Synbiotic
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Reading
Colorectal Cancer
Vitamin D Intervention and Associated Changes in the Gut Microbiome and Vitamin D Levels in Healthy Adults
Although dietary vitamin D supplementation has been used in the clinical setting for decades, the effect of supplementary vitamin D consumption on the structure of the microbiome has not been studied in humans in fine scale or…
- Trial name
- VDMT (NCT05387876)
- Testing
- Vitamin D intervention
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Baylor University
Overweight, Healthy
Effects of High Protein Diet on the Large Intestine in Overweight Humans
This study aims at evaluating the consequences of a 3 weeks high protein diet on the large intestine ecosystem (microbiota, metabolites and gene expression in rectal mucosa).
- Trial name
- NCT02351297
- Testing
- casein supplementation, soy protein supplementation, maltodextrin supplementation
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Avicenne
Healthy
The Roles of Gut Microbiome in UTI Susceptible Women
Clinical trials on cranberry juice and UTI prevention yielded both positive and negative results for unknown reason. Gut microbiome in women affect the absorption and metabolism of cranberry bioactives.
- Trial name
- NCT05065008
- Testing
- Cranberry juice, Apple juice
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy Volunteers
Pediatric Microbiome Study With Children Now Approximately 8-10 Years Old.
Single site study involving Biological Mothers and their children approximately 8-10 years old to assess the predominant microflora and skin physiology.
- Trial name
- NCT03485755
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Healthy Volunteer, Terminal Ileostomy
Behavior of Various Galenic Forms of a Probiotic in the Digestive Tract.
The aim of this study is to assess the behavior of a model probiotic strain, Lactobacillus salivarius, in the digestive tract of healthy volunteers and of ileostomized patients, depending on its galenic form.
- Trial name
- PROBIOSIN (NCT03143400)
- Testing
- Lactobacillus salivarius BL 3123
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Overweight, Healthy Subjects
Measuring the Impact of Dietary Supplementation With a High Fiber, High Antioxidant Aleurone on Biomarkers of Cardiovascular Disease and Gut Microbiota in Adults With High Body Mass Index
Study hypothesis Aleurone-rich food supplementation modifies cardiovascular and metabolic risk profiles and gut microbiota in subjects with high BMI Primary objectives of the trial are to evaluate whether wheat Aleurone-rich food…
- Trial name
- NCT02067026
- Testing
- Aleurone
- Where
- 2 sites in Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Fondazione Edmund Mach
Healthy Subjects
The Effects of Fermented Brown Seaweed Intake on Glucose Metabolism and Gut Health
The aim of this randomised, controlled, cross-over study is to investigate whether the intake of fermented brown seaweed can lower postprandial blood glucose levels and influence the composition of the gut microbiota in 25…
- Trial name
- SEAPRO01 (NCT06418763)
- Testing
- Baobab spread mixed with fermented brown seaweed, Baobab spread
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Aventure AB
Multidrug Resistant Bacterial Infection
Antibiotics Resistance Gene in Healthcare Workers
Multidrug resistant bacteria (MDR) pose a threat to the safety of patients worldwide. Drug resistant bacteria are commonly present in hospital environments and can cause infections, often leading to outbreaks within hospitals.
- Trial name
- ARGH (NCT06228248)
- Testing
- metagenomics
- Where
- 8 sites in China
- Volunteers
- 250 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Parkinson Disease, Diet, Healthy
Microbiome and Diet in Parkinson's Disease
The goal of this pilot study is to examine the feasibility and effects of an 18-month intervention diet compared to an active control diet (standard diet) in those living with Parkinson's Disease (PD), without dementia.
- Conditions
- Parkinson Disease, Diet, Healthy, Gut Microbiome, Gastrointestinal Microbiome
- Trial name
- PD-Diet (NCT06207136)
- Testing
- Mediterranean-style diet
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Healthy
Almonds: Digestive Health and Immune Function of Adults and Children
The purpose of this study is to determine whether incorporating almonds into the diets of families with young children will induce beneficial changes in gastrointestinal function, the fecal microbiota profile, and immune and…
- Trial name
- NCT01973595
- Testing
- Almonds, Then no almonds, No Almonds, Then almonds
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Florida
Microbial Colonization, Gut Microbiota
Diet Supplementation With Prebiotics to Improve Gut Health in Egyptian Children
The study described herein seeks to assess the extent to which diet supplementation of young Egyptian children, one of the most vulnerable groups to the risk of diarrhea, with prebiotic fiber can improve their gut health.
- Trial name
- NCT06561724
- Testing
- Biscuits maltodextrin, Biscuits includes prebiotics tartoufa inulin, Biscuits includes prebiotics chicory inulin
- Where
- Egypt
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Centre, Egypt
Microbial Colonization, Small Intestinal Bacterial Overgrowth
High-fat Diet (HFD) and Small Intestinal Microbiome
The investigators aim to characterize the upper small intestinal microbiome in healthy conditions in dependency on feeding condition (starved vs.
- Trial name
- FATBOM (NCT07019142)
- Testing
- HFD
- Where
- Switzerland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Colorectal Cancer Metastatic, Fecal Microbiota Transplantation
Using Healthy Gut Bacteria to Boost Immune Treatment for Advanced Bowel Cancer
This research protocol outlines an exploratory study on the combination of early-life fecal microbiota transplantation (yFMT) with immunotherapy and chemotherapy in patients with microsatellite stable metastatic colorectal cancer…
- Trial name
- NCT07486492
- Testing
- yFMT
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Sarcopenia
Trial in Elderly With Musculoskeletal Problems Due to Underlying Sarcopenia - Faeces to Unravel Gut and Inflammation Translationally
The overall aim of the TEMPUS-FUGIT study is to assess gut microbiota composition in older persons without sarcopenia and to determine the relationship with and between intestinal and systemic inflammation and with…
- Trial name
- TEMPUS-FUGIT (NCT05008770)
- Testing
- No intervention
- Where
- Belgium
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Thinness, Health Behavior
Phenotypic Characteristics of Superlean Individuals Including Gut Microbiome
The goal of this observational study is to build on our previous work to further characterise the phenotype of superlean individuals (BMI < 18.5) when compared to normal BMI people (BMI 21.5 to 25).
- Trial name
- NCT05804929
- Testing
- Observation without intervention
- Where
- China
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Healthy
Effects of Seaweeds Combined With Probiotics on Intestinal Function of Healthy Subjects
The aims of this study are to investigate the effect of seaweeds which is one of the main ingredients of Korean traditional food 'Kimchi' and probiotics on intestinal function of healthy subjects.
- Trial name
- NCT01651741
- Testing
- Seaweed and Duolac7S, Seaweed and Duolac7S-P
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Korea Institute of Planning & Evalution for Technology of Food, Agriculture, Forestry & Fisherie
Gut -Microbiota, Older People
Probiotics and Active Aging: Enhancing Gut Health
The general objective of this clinical trial is to assess the physical fitness and gut microbiota of older adults, thereby highlighting the importance of focusing on health maintenance.
- Conditions
- Gut -Microbiota, Older People, Physical Activity, Physical Fitness
- Trial name
- PAAEGH (NCT07033637)
- Testing
- Dietary Supplement, Structured Physical Activity Program
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Jose Luis Felipe
Beneficial Bacteria in Gut
Color Synbiotics Study
This study is initiated to investigate the effect of infant formula with added specific synbiotics mixture on proportion of beneficial bacteria.
- Trial name
- NCT01813175
- Testing
- Regular non-hydrolysed cow's milk I, Regular non-hydrolysed cow's milk II, Regular non-hydrolysed cow's milk - control
- Where
- 3 sites in Thailand
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.