Clinical trials: Healthy Gut Microbiota
Obesity, Metabolic Disease
Xla1 Christensenella Minuta, Phase I, Randomized, Partially Placebo-controlled Double-blind Protocol, Evaluating Safety, Tolerability and Impact on the Gut Microbiota in Healthy Volunteers, Overweight and Obese Adults
Xla1 Christensenella minuta, phase I, randomized, placebo-controlled double-blind protocol, evaluating safety, tolerability and impact on the gut microbiota in healthy volunteers, overweight and obese adults.
- Trial name
- CAUSALITY (NCT04663139)
- Testing
- Xla1
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- YSOPIA Bioscience
Short Chain Fatty Acids Concentration in Stools, Gut Microbiota Diversity and Composition
The Effect of Vitamin C Supplementation on Gut Microbiota Composition and Function in Healthy Adults
The aim of this dietary intervention study is to explore how vitamin C affects the bacteria that live in our gut. Vitamins are essential nutrients found in fruits and vegetables.
- Trial name
- VitaGut (NCT07388121)
- Testing
- Moderate Vitamin C dose (200 mg), High-dose vitamin C supplementation (1000 mg), Habitual diet (run in period)
- Where
- United Kingdom
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Healthy Infants
Probiotic for Infants
The BABIES II study is a single-center, randomized, double-blinded, placebo-controlled study in newborns with an 8½ months intervention period from 14 days of age to 9 months of age followed by a 3-months short-term follow-up…
- Trial name
- BABIES II (NCT07054216)
- Testing
- Probiotic
- Where
- 2 sites in Denmark
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Health, Subjective, Healthy
RIGHTWHEY - Responders In Gut HealTh Markers Using Fermented WHEY
This 8-week intervention will investigate the effect of daily consumption of a fermented whey concentrate on the short-chain fatty acid profile of faeces in healthy individuals.
- Conditions
- Health, Subjective, Healthy, Microbial Colonization
- Trial name
- RIGHTWHEY (NCT03844152)
- Testing
- Fermented whey concentrate
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Hypercholesterolemia, Flatulence
Fabulous Fibre Study - Effect of Wheat Bran Extract on Gut and General Health in Healthy Aging Subjects (FFS)
This is a placebo controlled, cross-over, randomized, double blinded study. The intervention food products will be taken as diet prebiotic supplements: 1.
- Conditions
- Hypercholesterolemia, Flatulence, Intestinal Diseases
- Trial name
- FFS (NCT02693782)
- Testing
- Fibre supplement
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Gastrointestinal Microbiome
Effects of Vigiis 101-LAB on a Healthy Populations' Gut Microflora, Peristalsis, Immunity, and Anti-oxidative Capacity
Vigiis 101-LAB capsules I and II are produced from the fermentation of Lactobacillus paracasei subsp. paracasei NTU 101. Investigators have examined the effects of the Vigiis 101-LAB capsules I or II (5 or 10 billion CFU/day…
- Trial name
- Vigiis101 (NCT04046432)
- Testing
- Vigiis 101-LAB
- Where
- Taiwan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- SunWay Biotech Co., LTD.
Parkinson Disease, Diet, Healthy
Microbiome and Diet in Parkinson's Disease
The goal of this pilot study is to examine the feasibility and effects of an 18-month intervention diet compared to an active control diet (standard diet) in those living with Parkinson's Disease (PD), without dementia.
- Conditions
- Parkinson Disease, Diet, Healthy, Gut Microbiome, Gastrointestinal Microbiome
- Trial name
- PD-Diet (NCT06207136)
- Testing
- Mediterranean-style diet
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Healthy
ProbGut: Probiotics on the Healthy Gut Microbiota
In adults, probiotics have been shown to have no effect on the microbial composition and the beneficial effects are only transient. However, the gut microbiota of young children is less stable and more impressionable.
- Trial name
- NCT03430726
- Testing
- Probiotic yogurt drink
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- McMaster University
Healthy
The Roles of Gut Microbiome in UTI Susceptible Women
Clinical trials on cranberry juice and UTI prevention yielded both positive and negative results for unknown reason. Gut microbiome in women affect the absorption and metabolism of cranberry bioactives.
- Trial name
- NCT05065008
- Testing
- Cranberry juice, Apple juice
- Where
- United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- University of Florida
Healthy Subjects
The Effects of Fermented Brown Seaweed Intake on Glucose Metabolism and Gut Health
The aim of this randomised, controlled, cross-over study is to investigate whether the intake of fermented brown seaweed can lower postprandial blood glucose levels and influence the composition of the gut microbiota in 25…
- Trial name
- SEAPRO01 (NCT06418763)
- Testing
- Baobab spread mixed with fermented brown seaweed, Baobab spread
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Aventure AB
Gastrointestinal Microbiome, Nutrition, Healthy
The Effects of a Novel Nutritional Product on Nutrient Status and Digestive Health
This study is a randomized, double-blind, placebo-controlled study of N=30 apparently healthy men and women. This is an exploratory study to assess the effect of a novel dietary supplement on blood markers of nutrient status and…
- Conditions
- Gastrointestinal Microbiome, Nutrition, Healthy, Healthy Aging
- Trial name
- NCT06181214
- Testing
- AG1 - Nutritional Supplement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Athletic Greens International
Healthy Subjects
Effect of Proton Pump Inhibitors on Gut Microbiota Composition and Metabolites in Healthy Subjects Using CapScan
This study is designed to evaluate the effect of proton pump inhibitors on the regional composition of the gut microbiota and metabolic profiles of health volunteers using the CapScan collection capsule.
- Trial name
- NCT07054593
- Testing
- CapScan
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Envivo Bio Inc
Healthy Diet
Impact of Whole Grain Rye Bread on Health
This randomized controlled trial aims to study how a high intake of a fibre-rich bread affects the composition and functioning of the gut microbiota in healthy subjects, and how this, in turn, impacts on the release of gut…
- Trial name
- FBS (NCT06333717)
- Testing
- Whole grain bread, Control bread
- Where
- Sweden
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Human Microbiome
A Clinical Study to Assess the Effect of Change of Bile Acid on the PD and Safety of Metformin and Microbiome Profiles
This clinical trial is intended to evaluate the effect of change of bile acid pool with cholestyramine on the pharmacodynamics and safety of metformin and intestinal microbiome profiles in healthy volunteers
- Trial name
- NCT04335526
- Testing
- Cholestyramine Resin
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy
Lacticaseibacillus Rhamnosus GG Pili Study
The aim of this study was to investigate the host-microbe interaction effects of various Lacticaseibacillus rhamnosus GG strains, with different binding capacities to the mucus in the small intestine, in healthy individuals
- Trial name
- NCT05461443
- Testing
- Probiotic
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Healthy Participants, Healthy Adult Subject
Satiety, Microbiome, Appetite Regulation, and Tracking Energy Across Targeted Snacks: Chronic Study
The goal of this clinical trial is to learn how eating different snack foods affects long term hunger and gut health in healthy adults. The study will be conducted remotely over 7 weeks.
- Conditions
- Healthy Participants, Healthy Adult Subject, Healthy Subjects, Healthy Adult Volunteer
- Trial name
- SMARTEATS-RCT (NCT07782593)
- Testing
- High-fibre plant-based snack bar, Control snack bars
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zoe Global Limited
Colorectal Adenomas, Colorectal Cancers
Effects of Berberine on the Human Gut Microbiome
Berberine hydrochloride is a conventional component in Chinese medicine. In recent years, anticancer activity of berberine hydrochloride have been explored.
- Trial name
- NCT07519681
- Testing
- Berberine Hydrochloride
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jing-yuan Fang, MD, Ph. D
Quality of Life
Effect of Colon Delivered Vitamin C on Gut Microbiota and Related Health Biomarkers in Healthy Older Adults
Recent studies have shown that many vitamins, if consumed in high daily dosages or delivered to the colon, can modulate the gut microbiota and their metabolites.
- Trial name
- NCT05598619
- Testing
- Vitamin C
- Where
- Ireland
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Gut Microbiota and Sleep in Infants
Infant Sleep Behaviour and Gut Microbacteria
The overarching study aim is to evaluate the development of sleep behavior and gut microbiota (GMB), and their potential interaction, during the vulnerable period of the first year of life.
- Trial name
- SDEGU (NCT02836119)
- Where
- Switzerland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
A Study to Evaluate the Influence of Diet on GI Health
The purpose of this study is to understand the potential of protein and psyllium fiber to manipulate gut microbial densities, intestinal permeability, and inflammation in humans.
- Trial name
- NCT04783142
- Testing
- High-fiber, low-protein diet, Low-fiber, high-protein diet
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic