Clinical trials: Healthy Humans
Human Volunteers
Drug-Drug Interaction Study Of Effect Of PF-03882845 On Simvastatin Pharmacokinetics
The purpose of this study is to estimate the effect of multiple oral doses of PF-03882845 on the pharmacokinetics of simvastatin and simvastatin acid in healthy, adult subjects.
- Trial name
- NCT01445860
- Testing
- Simvastatin/PF-03882845
- Where
- Singapore
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy
Losartan and Emotion Processing
The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear
- Trial name
- NCT03396523
- Testing
- Losartan
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Hiv, Healthy
Mapping the Human HIV Chronobiome
Individuals infected with HIV have a high risk of developing metabolic comorbidities not traditionally associated with the immune dysregulation and deficiency associated with HIV infection and AIDS.
- Trial name
- HCB (NCT03133559)
- Testing
- Observational
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Healthy
Singe Dose, First in Human Study of PF- 06946860 in Healthy Adult Subjects
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of PF-06946860 in healthy adult subjects following single ascending doses This is the first clinical study of PF-06946860.
- Trial name
- NCT03599063
- Testing
- PF-06946860
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Pfizer
Norovirus
Recombinant, Bivalent, Norovirus Vaccine Study
This clinical study will evaluate the vaccine candidate rNV-2v, which is under development to prevent disease triggered by noroviruses. Noroviruses are one of the leading causes of gastrointestinal diseases in the world.
- Trial name
- NCT05508178
- Testing
- Norovirus GI.4 / GII.4 Bivalent VLP Vaccine (100 µg), Norovirus GI.4 / GII.4 Bivalent VLP Vaccine (300 µg)
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Icon Genetics GmbH
Healthy
Neural Adaptations to a Single Session of Metronome-Paced Strength Training
The aim of the study is to investigate the effects of incorporating variability within a single session of Resistance Training (RT) methods on the neural adaptations along the corticospinal tract and on neuromuscular function.
- Trial name
- NCT06539650
- Testing
- Fractal Paced, Isochronus Paced, Self Paced
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Healthy
Recombinant Human Alkaline Phosphatase in Healthy Japanese Subjects
Clinical Phase 1 study to investigate the pharmacokinetics and to assess the safety and tolerability of recAP after single and multiple intravenous doses in healthy Japanese subjects.
- Trial name
- NCT04923282
- Testing
- single 1-hour IV infusion of 0.8 mg/kg recAP, single 1-hour IV infusion of 1.6 mg/kg recAP, single 1-hour IV infusion of 3.2 mg/kg recAP
- Where
- Japan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- AM-Pharma
Healthy Volunteer
Safety, Tolerability, and Pharmacokinetics of DD-S052P in Healthy Volunteers
This is a Phase 1, randomized, double-blind, placebo-controlled, first-in-human study designed to evaluate the safety, tolerability, and pharmacokinetics of DD-S052P in healthy adult volunteers.
- Trial name
- NCT07347223
- Testing
- DD-S052P
- Where
- South Korea
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- HLB Science
Healthy Adult Participants
Overcoming the Barriers to Effective Transcranial Temporal Interference Stimulation in Humans
Transcranial temporal interference stimulation (TIS) is an emerging novel tool for non-invasive transcranial brain stimulation that holds the potential for focal and steerable neuromodulation, and the possibility to stimulate…
- Trial name
- NCT07593859
- Testing
- transcranial Temporal Interference Stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Cholera, Cholera Vaccine Toxicity
First in Human Phase 1 Ascending Dose Study of PanChol in Healthy Volunteers
This study is a first-in-human, Phase 1 study of the safety, tolerability, and immunogenicity of PanChol in healthy volunteers. There will be three modules in this clinical trial assessing dosing, safety, and immunogenicity: 1.
- Trial name
- NCT05657782
- Testing
- PanChol
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Healthy
The Glucagonotropic Effect of Amino Acids in Humans
The objective of the study is to delineate the glucagonotropic signal exerted by selected amino acids in human subjects as well as the metabolic clearance rate of these amino acids after intravenous infusion
- Trial name
- STAMINA (NCT05954923)
- Testing
- Amino acid bolus infusion
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Overweight, Healthy
Effects of High Protein Diet on the Large Intestine in Overweight Humans
This study aims at evaluating the consequences of a 3 weeks high protein diet on the large intestine ecosystem (microbiota, metabolites and gene expression in rectal mucosa).
- Trial name
- NCT02351297
- Testing
- casein supplementation, soy protein supplementation, maltodextrin supplementation
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Avicenne
Healthy Subjects
First-in-man Study of Single and Multiple Ascending Doses of a New Drug for Neurological Disorders
The primary purpose of this first-in-man study is to investigate whether a new drug for neurological disorders is safe and well-tolerated when administered orally to healthy adults
- Trial name
- NCT02702648
- Testing
- AC-082
- Where
- Germany
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Cerebral Infarction
A Spinal Functional Magnetic Resonance Imagine (fMRI) Study of Resting-State, Motor Task and Acupoint Stimulation
The spinal cord is a very important part of the central nervous system. fMRI can be applied to observe functional status of the human spinal cord.
- Trial name
- NCT00629655
- Testing
- motor task, sensory stimulation
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- China Rehabilitation Research Center
Healthy
Food Reward Processing in the Human Brain
The aim of this study is to investigate the influence of different metabolic states and hormonal satiety signalling on responses in neural reward networks.
- Trial name
- NCT03081585
- Testing
- Satiety State
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Heidelberg Medical Center
Type 2 Diabetes Mellitus (T2DM)
Bioequivalence Study to Compare Empagliflozin / Metformin 25 mg/ 1000 mg Extended-Release Tablet Versus Synjardy XR Tablets 25mg/1000mg in Fast Condition
Bioequivalence Study to Compare Empagliflozin / Metformin 25 mg/ 1000 mg Extended-Release Tablet Versus Synjardy XR Tablets 25mg/1000mg in fast condition.
- Trial name
- NCT07372118
- Testing
- Empagliflozin / Metformin HCl XR Tablets, Synjardy® XR (empagliflozin and metformin hydrochloride extended-release Tablets)
- Where
- India
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Bioavailability
CreNeuroS™️CNS Fish Oil Plus Softgels Compared to Vascepa® Capsules and Deplin® Capsules in a Pharmacokinetic, Single Dose Evaluation on Healthy Adult Human Subjects Under Fasting Conditions
The objective of this study is to evaluate the oral bioavailability of 'CreNeuroS CNS Fish Oil Plus Softgels [Eicosapentaenoic Acid (as Ethyl Ester) 342 mg; L-5-methyltetrahydrofolate 1.875 mg; other Vitamins and Minerals] (Test…
- Trial name
- BE-001-2024 (NCT06758778)
- Testing
- CreNeuroS CNS Fish Oil Plus Softgel [380 mg of fish oil contains Eicosapentaenoic Acid (EPA) （as EE）342 mg; L-5- Methyltetrahydrofolate 1.875 mg; other Vitamins and Minerals], Vascepa® (Icosapent ethyl) 1000 mg Capsules, Deplin® (L-methylfolate Calcium) 7.5 mg Capsules
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Sichuan Credit Pharmaceutical Co., Ltd.
Healthy
Effect of Antioxidants on Oxygen Induced Vasoconstriction in Lipopolysaccharide (LPS) Induced Inflammatory Model in Humans
Oxidative stress has been implicated in playing a pathogenic role in many disease processes, especially in age-related disorders.
- Trial name
- NCT00914576
- Testing
- Vitamin and mineral supplement, 100% Oxygen, Escherichia coli Endotoxin
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hepatitis C
Cross-Over Study to Assess the Cardiovascular Effects of GSK2336805
This is a single-center, randomized, two part, double-blind, crossover study in healthy adult subjects to assess the effect of a single dose of GSK2336805 150mg on cardiac function comparing with placebo using echocardiography as…
- Trial name
- NCT01424540
- Testing
- GSK2336805 150mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy Ageing
Effect of Polyphenol-rich Cocoa Products on Cognitive Function
This project aims to investigate whether consumption of cocoa polyphenols has an impact on cognitive function in individuals aged 50 to 60 years of age and if such an improvement is a result of an improvement in risk factors…
- Trial name
- NCT02996578
- Testing
- polyphenol rich chocolate bar, polyphenol rich cocoa powder, low polyphenol content chocolate bar
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
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