Clinical trials: Healthy Longevity
Aging
aKLmRNA-mediated Protein Replacement Therapy
This is a Phase 1b randomized, double-blind, placebo-controlled study to assess the safety and tolerability of a proprietary aKLmRNA formulated in lipid nanoparticles. Approximately 21 subjects will be enrolled.
- Trial name
- NCT07544420
- Testing
- aKLmRNA (AKL003)
- Where
- Honduras
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Klothea Bio Inc
Healthy Subjects
A Recovery and Lifespan Study Using INTERCEPT Red Blood Cells Prepared Using the INTERCEPT Blood System for RBCs With AS-1
The objective of this trial is to assess the post-infusion viability of INTERCEPT RBCs by measuring the 24-hour post-infusion recovery and lifespan of autologous RBCs prepared with the INTERCEPT Blood System for RBC with AS-1…
- Trial name
- NCT07015437
- Testing
- INTERCEPT Blood System for RBCs, Infusion of autologous radiolabeled RBCs
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cerus Corporation
Healthy Aging
Vitamin D3 - Omega3 - Home Exercise - HeALTHy Aging and Longevity Cohort
The DO-HEALTH trial will be extended into the cohort including the collection on life style factors such as diet, quality of life and physical activity, as well as health-related data on co-morbid conditions as well as a…
- Trial name
- DO-HEALTH-C (NCT05062018)
- Where
- Switzerland
- Volunteers
- 534 people, healthy volunteers welcome
- Sponsor
- Heike Bischoff-Ferrari
Improve Healthy Ageing in Seniors; Prevent Disease at Older Age
DO-HEALTH / Vitamin D3 - Omega3 - Home Exercise - Healthy Ageing and Longevity Trial
The European population is aging rapidly which poses a challenge on the individual, the European societies, and health care systems.
- Trial name
- DO-HEALTH (NCT01745263)
- Testing
- Vitamin D3, Omega 3 fatty acids, Strength Home Exercise
- Where
- 7 sites in Austria, France and 3 more
- Volunteers
- 2,157 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy
Metabolomics of Aging: Sub-study of the Healthy Elderly Active Longevity (HEAL) Study
This research is being done to learn more about healthy aging. We hope to learn which bodily processes or functions are important for the elderly to maintain good health.
- Trial name
- Metabolomics (NCT01209884)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Healthy Control Subjects, Schizophrenia Diagnosis
Understanding Lifespan Trajectories of Social Cognition, Brain Microstructure and Iron Dysregulation in Schizophrenia
This study aims to better understand how schizophrenia may affect social thinking, emotion regulation, brain function, and biological processes over time. Two groups will take part in the study: 1.
- Trial name
- NCT07856381
- Where
- Austria
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Longevity, Healthy Aging
Collagen Peptides and Cellular Aging
The goal of this clinical trial is to learn if daily collagen peptide supplementation can stabilize or lengthen telomeres and improve related markers of cellular aging in adults aged 50-70 years with overweight and…
- Conditions
- Longevity, Healthy Aging, Biological Ageing
- Trial name
- NCT07456449
- Testing
- Collagen peptides
- Where
- Austria
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Healthy
The Healthy Elderly Longevity Cohort
With the completion of the human genome project, investigators can now explore new questions in human biology. Previously human genetics focused on highly penetrant, Mendelian traits; however, now rare and common variants can be…
- Trial name
- Wellderly (NCT01004133)
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Healthy Volunteers
Quality of Life and Behavioral Change of Retired Persons
Researchers have found that the first phase of aging, called "frailty", is insidious, silent and slowly progressive. It begins well before the first signs of aging and possibly before retirement age with physiological reserves…
- Trial name
- R-FORM' (NCT06432010)
- Testing
- Group nutrition and physical activity coaching, Group cognition coaching
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Aging
Safety & Efficacy of Extended Longevity Protocol
The purpose of this study is to quantifiably determine if the Extended Longevity Protocol has a significant clinical effect on epigenetic age.
- Trial name
- NCT05296993
- Testing
- Extracts found in the Extended Longevity supplements
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic
Aging
Participatory Evaluation (of) Aging (With) Rapamycin (for) Longevity Study
This is a randomized, placebo-controlled trial into the safety and efficacy in reducing clinical measures of aging in an older adult population.
- Trial name
- PEARL (NCT04488601)
- Testing
- Rapamycin
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- AgelessRx
Healthy Longevity
A Randomized Controlled Trial of a Multi-domain Smartphone Intervention Incorporating Generative AI for Healthy Older Adults
This study evaluates the efficacy of a smartphone-based multi-domain intervention designed to promote healthy aging and prevent cognitive decline in older adults.
- Trial name
- NCT07524478
- Testing
- Multidomain intervention, Control
- Where
- Japan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tatsuhiro Hisatsune
Healthy
Self-Directed Biological Transformation Initiative
It is becoming increasingly recognized in the literature that ancient practices for wellbeing, including meditation, yoga, and specific herbs, can improve health and promote longevity.
- Trial name
- SBTI (NCT02241226)
- Testing
- Perfect Health Course
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Skin Ageing, Healthy Ageing
Effects of a Multi-Targeted Oral Supplement on Skin, Hair, Sleep, Energy, Cognition, Libido and Epigenetic Biological Clock Age
This study evaluated the effects of a daily oral supplement regimen (Advanced ID Brain, Heart and Eye Omega Gel Capsules taken with Advanced ID Longevity and Collagen Complex Powder) on measures of skin condition, hair, sleep…
- Conditions
- Skin Ageing, Healthy Ageing, Effect of Oral Nutritional Supplementation on Skin, Hair, Sleep, Energy, Cognition and Sexual Wellbeing in Healthy Adults, Longevity
- Trial name
- IDF-AID-1 (NCT07827651)
- Testing
- Advanced ID
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- IDI Skincare Limited
Cognitive Decline, Sarcopenia
Holistic Integration for Healthy Longevity and Aging in Place
Background: Taiwan is experiencing rapid population aging, with a growing prevalence of chronic diseases and functional impairments among older adults.
- Conditions
- Cognitive Decline, Sarcopenia, Depression Disorders, Nutrition Disorder
- Trial name
- HIHOPE (NCT06882434)
- Testing
- Local intervention program, Referral Process, Telehealth Education & Digital Integration
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
No Disease, Mitochondria Health
Kaempferol Absorption and Pharmacokinetics Evaluation
This study is a multi-site clinical trial designed to evaluate how the body absorbs and processes Kaempferol, a naturally occurring compound found in many plant-based foods.
- Conditions
- No Disease, Mitochondria Health, Longevity, Pharmacokinetics and Biological Absorption of Kaempferol in Healthy Adult
- Trial name
- KAPE (NCT07322406)
- Testing
- Kaempferol
- Where
- 3 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Diabetes Mellitus, Healthy
Exhaled Carbon Monoxide and Red Blood Cell Turnover
Hemoglobin A1C (HbA1c) is the cornerstone of blood sugar monitoring. As HbA1c is formed by the covalent reaction of glucose with hemoglobin throughout the lifespan of the red blood cell (RBC), it is used as a surrogate marker for…
- Trial name
- NCT03288233
- Testing
- Breath carbon monoxide measurement
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Aging, Longevity
Psilocybin Effects on Healthy Aging Biomarkers and Purpose in Life
The LONG-LIFE study is a randomized Phase I, dose-ranging trial designed to evaluate whether psilocybin impacts aging-related biomarkers, cognitive function, and purpose/meaning in life in medically stable older adults.
- Conditions
- Aging, Longevity, Biomarkers of Aging
- Trial name
- LONG-LIFE (NCT07719088)
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Charles Raison
Healthy Volunteers
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide
Background: Proteins are essential to the health and structure of the cells that make up body tissues. Most proteins become damaged over time and are replaced with new ones.
- Trial name
- NCT06269653
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Dentin Sensitivity
Longevity and Effectiveness of Bleaching in Healthy and Smokers Patients
The main objective of this study is to evaluate the effectiveness and longevity of color and Tooth sensitivity of patients undergoing home whitening peroxide 10% carbamide ( Whiteness Perfect , FGM , Joinville , Santa Catarina …
- Trial name
- BLESMOK (NCT02017873)
- Testing
- Peroxide Carbamide 10% - Dental bleaching treatment
- Where
- 2 sites in Brazil, Chile
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Chile