Clinical trials: Healthy Normal Weight
Intra-Abdominal Fat
The Healthy Diet and Lifestyle Study II
Intermittent energy restriction (IER) may have important advantages over daily energy restriction (DER) in producing sustained weight loss and reducing cancer risk.
- Trial name
- (HDLS2) (NCT05132686)
- Testing
- IER+MED, MED/DER
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Obesity, Type 2 Diabetes
Cold Stress Stimulate the Browing of Subcutaneous White Adipose in Healthy Adults
Adipose tissues, which include white adipose tissue (WAT) and brown adipose tissue (BAT), play an essential role in regulating whole-body energy homeostasis.
- Trial name
- NCT02159144
- Testing
- cold stress
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Xiang Guang-da
Obesity, Insulin Resistance
Ghrelin and Insulin Resistance
Ghrelin, a hormone produced in the stomach that stimulates hunger and food intake, declines immediately after weight loss surgery. Some studies suggest that ghrelin may worsen an individual's ability to respond to insulin.
- Conditions
- Obesity, Insulin Resistance, Normal Weight,Healthy Controls
- Trial name
- NCT00884494
- Testing
- Ghrelin infusion to assess effects on insulin sensitivity
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Obesity, Childhood, Cognition
NiPPeR Randomised Trial - Child Follow Up Study
There is an increasing focus on the need to optimise nutrition, lifestyle and metabolism of parents before and during pregnancy and of the infant after birth, but as yet there is limited understanding of the specific influences…
- Conditions
- Obesity, Childhood, Cognition, Neurobehavioral Manifestations, Metabolic Disturbance
- Trial name
- NiPPeR Child (NCT05934422)
- Testing
- Intervention (Study Nutritional Drink), Control (Standard Nutritional Drink)
- Where
- 3 sites in New Zealand, Singapore and 1 more
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Healthy, Obesity
Fat Tissue Microperfusion to Measure Leptin Secretion and Its Relations With Fat Breakdown in Humans
Leptin is a hormone that acts in the body as a chemical messenger. It is produced in fat cells and is believed to regulate body weight in humans. Leptin decreases appetite and influences the energy balance of the body.
- Trial name
- NCT00001722
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Obesity
Longitudinal Follow-up of Brown Adipose Tissue Function and Structure
In Turku PET Centre, there have been 3 positron emission tomography studies on brown adipose tissue (BAT) activity in healthy adults. BATPET was performed between 2008 and 2009.
- Trial name
- BATFollowUp (NCT01985503)
- Where
- Finland
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Dyslipidemia
Saturated Fatty Acids and HDL Metabolism
The purpose of this study is to determine whether palmitic acid (C16:0) and stearic acid (C18:0) have different effects on HDL metabolism during the fasted state.
- Trial name
- NCT02835651
- Testing
- Palmitic acid, Stearic acid
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Healthy
The Effect of Calorie Deprivation on Adipose Tissue Distribution
In this study, we will be studying the effects of acute calorie deprivation (a 10-day fast) on bone marrow fat, other fat stores and bone parameters.
- Trial name
- NCT01658397
- Testing
- Fasting
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Potential Abnormality of Glucose Tolerance, Appetitive Behavior
Effects of Bran Size on Glycemic Responses
This study investigated the effects of bran's particle size on glycemic responses
- Trial name
- NCT03314142
- Testing
- Glucose as reference food, White bread as reference food, Bread enriched with coarse wheat bran
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Agricultural University of Athens
Obese, Healthy
Investigating the Effect of Obesity on Eosinophil Recruitment in Human Adipose Tissue
Researchers are trying to better understand the relationship between inflammation in adipose tissue (AT) and insulin resistance.
- Trial name
- NCT04234295
- Testing
- Fat Tissue Biopsy
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Healthy, Obesity
Mitochondrial Function in Circulating Cells and Muscle Tissue
The main goal of this project is to determine whether mitochondrial function in circulating cells is related to that measured in the muscle fibers of the same subjects.
- Conditions
- Healthy, Obesity, Insulin Sensitivity, Women
- Trial name
- MitoWomen (NCT02700698)
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Obesity, Insulin Resistance
Small Extracellular Vesicles and Insulin Action
The goals of this research study are to: 1) understand why some people with obesity are protected from developing conditions such as type 2 diabetes and cardiovascular disease while others are more likely to develop…
- Conditions
- Obesity, Insulin Resistance, Metabolically Healthy Obesity, Obesity, Metabolically Benign
- Trial name
- SEV (NCT05933707)
- Testing
- People with Metabolically Unhealthy Obesity - Low Calorie Diet
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Overweight and Obesity, Healthy
Bioavailability of Blackberry Juice Anthocyanins
The main aim of this study is to evaluate the bioavailability of blackberry juice anthocyanins, with or without ethanol, in normal weight and overweight/obese adults.
- Trial name
- NCT02613715
- Testing
- Blackberry juice with 12% ethanol, Blackberry juice
- Where
- Portugal
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Metabolically Healthy Obesity
Brown Fat Tissue Related Hormone Levels in Metabolically Healthy and Unhealthy Obese Individuals
There are two types of adipose tissue in humans, white and brown adipose tissue. While the main task of white adipose tissue is energy storage, the main task of brown adipose tissue is energy expenditure.
- Trial name
- NCT05232695
- Testing
- metabolically healthy obese
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Breast Cancer, Overweight and Obesity
Acceptance and Usability of an App Promoting Healthy Behaviours Amongst Young Women at Increased Risk of Breast Cancer
It is estimated that around 20% of breast cancers (BC) in the UK are preventable through adherence to appropriate health behaviours, i.e., healthy diet, physical activity, limited alcohol, not smoking, and that women at increased…
- Conditions
- Breast Cancer, Overweight and Obesity, Diet, Healthy, Weight Gain
- Trial name
- NCT05460650
- Testing
- App Promoting Healthy Behaviours
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Healthy
Bioenergetic Alterations After Exenatide Administration
The purpose of this study is to find out how exenatide causes weight loss. Specifically, the study is assessing how exenatide may change how people take in energy (energy intake), as well as how it may effect how people use…
- Trial name
- NCT00623545
- Testing
- Exenatide
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
ROSAH Syndrome, Anhidrosis
A Method Characterization Study to Evaluate Thermoregulatory Sweat Production in Healthy Volunteers and Patients With ROSAH Syndrome)
This study is designed to characterize a new quantitative method for measuring sweat production induced by controlled heat exposure. Approximately 20 healthy volunteers and up to 10 patients with ROSAH syndrome will be enrolled.
- Conditions
- ROSAH Syndrome, Anhidrosis, Hypohidrosis
- Trial name
- NCT07814209
- Testing
- Standardized Controlled Heat Exposure With Gravimetric Sweat Collection
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Obesity
Exenatide and Brown Adipose Tissue
The obesity epidemic has led to a enormous increase in the prevalence of type 2 diabetes mellitus (T2D), dyslipidemia and cardiovascular events.
- Trial name
- exe01 (NCT03002675)
- Testing
- Bydureon
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ingrid Jazet
Obesity, Insulin Resistance
Effects of Oral Glucosamine on Insulin and Blood Vessel Activity in Normal and Obese People
This study will examine whether glucosamine affects the way the body responds to insulin. Insulin is a hormone that causes the body to use glucose (sugar).
- Trial name
- NCT00065377
- Testing
- Glucosamine Hydrochloride
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Normal Healthy Adults
A Research Study to Evaluate BLX-0871 in Healthy Adults
This study will test an oral medicine called BLX-0871, which is being developed to improve metabolic health by activating AMP-activated protein kinase (AMPK), a key regulator of energy balance.
- Trial name
- NCT07140081
- Testing
- BLX-0871
- Where
- Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Biolexis Therapeutics