Clinical trials: Healthy Older Adults
Infections, Rotavirus
Evaluate Protective Efficacy of Diff Strengths of Human Rotavirus Vaccine After Admn of 2 Doses to Infants Aged 2 Months
The purpose of this study is to test how infants respond to different strengths of the human rotavirus vaccine.
- Trial name
- NCT00385320
- Testing
- HRV vaccine
- Volunteers
- 2,640 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of JNJ-54861911 in Healthy Elderly Participants
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple-ascending dose JNJ-54861911 which is currently being developed for the treatment of Alzheimer's disease.
- Trial name
- NCT01887535
- Testing
- JNJ-54861911 3 mg, JNJ-54861911 10 mg, JNJ-54861911 30 mg
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Stroke, Healthy
The Effect of a Walking Assist Robot on Gait Function and Brain Activity in Stroke Patients and Elderly Adults
The purpose of this study was to investigate the effects of the new wearable hip assist robot, gait enhancing and motivating system (GEMS) developed by Samsung Advanced Institute of Technology (Samsung Electronics Co, Ltd.…
- Trial name
- NCT03048968
- Testing
- Gait, sit-to-stand movement, stair climbing and treadmill gait, Sit-to-stand movement and treadmill gait, gait enhancing mechatronic system (GEMS)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Samsung Medical Center
Elderly
Salutogenic Healthy Aging Program Embracement (SHAPE) for Elderly-only Households
Elderly residing in elderly-only households are more vulnerable as they are socially isolated, suffer from poorer health outcomes, and are less likely to adopt health-promoting behaviors.
- Trial name
- SHAPE (NCT03147625)
- Testing
- SHAPE Intervention
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Motor Activity
The Influence of Laterality on the Performance of Healthy Women in Selected Standardized Tests
The aim of the research study is to find out how the results of healthy women aged 20-24 years (inclusive) differ in the Nine Peg Test, the Purdue Pegboard Test and the Box and Block Test, depending on the laterality of the…
- Trial name
- NCT05661617
- Testing
- Nine Hole Peg Test, Purdue Pegboard Test, Box and Block Test
- Where
- Czechia
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Contraception
A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012)
The primary objective of this trial was to identify at least one next generation ring (NGR) that demonstrates inhibition of ovulation (which was considered confirmed if in the subset of participants ovulation was observed in less…
- Trial name
- NCT01709318
- Testing
- Nomegestrol acetate (NOMAC), Etonogestrel (ENG), Ethinyl estradiol (EE)
- Volunteers
- 666 people, healthy volunteers welcome
- Sponsor
- Organon and Co
H5N1 Influenza
H5N1 Vaccine Study in Japanese Adults
The purpose of this study is to obtain immunogenicity and safety data of two different dose levels of an H5N1 pandemic influenza vaccine in a healthy Japanese adult population aged 18 to 59 years.
- Trial name
- NCT01382329
- Testing
- H5N1 (pre-)pandemic influenza vaccine (whole virion, Vero Cell derived, inactivated)
- Where
- 3 sites in Japan
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Alachua Government Services, Inc.
Influenza, Healthy Volunteers
Study of Influenza Vaccines Containing an Additional H3 Antigen in Healthy Adult Participants 18 to 49 Years of Age and 60 Years of Age and Older
Study FBP00005 is planned to be a translational Phase I, randomized, modified double-blind, active-controlled, multi-center study to be conducted in 2 stages in approximately 400 adults, 18 to 49 years of age and ≥ 60 years of…
- Trial name
- NCT06507553
- Testing
- Trivalent-Darwin influenza vaccine, Augment-Tasmania influenza vaccine, TIV-2X Darwin influenza vaccine
- Where
- 10 sites in Australia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Aging, Parkinson's Disease (PD)
Impact of Force Control of Hip Abductor Muscles in Healthy Adults and Individuals With Parkinson's Disease
Both aging and Parkinson's disease (PD) negatively affect postural control and increase the risk of falls, with frontal plane balance being particularly challenging for these populations.
- Trial name
- NCT07568951
- Testing
- Age, Parkinson's disease (PD)
- Where
- 2 sites in Taiwan
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
CNS
2-Part Multiple Ascending Dose Study for Safety and Pharmacokinetics in Healthy and Elderly Subjects
This is a single-center, randomized, double-blind, placebo-controlled, sequential, multiple-dose study. The study will be conducted in two parts: Part A (6 cohorts of healthy adults receiving evening dosing) and Part B (one…
- Trial name
- NCT01673451
- Testing
- E2006
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Clostridium Difficile Associated Disease
Clostridium Difficile Vaccine Safety, Tolerability, and Immunogenicity Study in Japanese Adults
The first-in-Japanese study B5091010 has been designed to evaluate the safety, tolerability, and immunogenicity of 2 antigen dose levels of C difficile vaccine when administered as one of two 3-dose regimens to healthy Japanese…
- Trial name
- NCT02725437
- Testing
- Clostridium difficile Vaccine
- Where
- 2 sites in Japan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pfizer
Aging, Older Adults
Aging Mastery Program® (AMP) Evaluation
The Aging Mastery Program® (AMP) is designed to inform, encourage, and support older adults as they take steps to improve their lives and stay engaged in their communities.
- Conditions
- Aging, Older Adults, Healthy
- Trial name
- AMP (NCT03342729)
- Testing
- Intervention, Control
- Where
- 5 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy
Study to Evaluate the Safety, Tolerability, PK and PD of PB2452 in Healthy Younger, Older and Elderly Subjects
This is a Phase 2A, randomized, double-blind, placebo-controlled, single dose, sequential group study to evaluate the safety, tolerability, PK, and PD of PB2452 vs matching placebo with ticagrelor (with or without acetylsalicylic…
- Trial name
- NCT03928353
- Testing
- PB2452 Infusion, Ticagrelor Oral Tablet - Pre-Treatment, Ticagrelor Oral Tablet - Pre-Treatment and Post-Treatment
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- SFJ Pharmaceuticals, Inc.
Cognitive Impairment, Elderly People
Effects of Nintendo Switch on Rehabilitation Programs for Elderly People With Cognitive Impairment
Purpose: Healthy aging is the process of optimizing opportunities for health, participation and safety in order to improve quality of life as people age.
- Conditions
- Cognitive Impairment, Elderly People, Healthy Aging, Occupational Therapy
- Trial name
- NCT06129630
- Testing
- Conventional occupational therapy sessions., Conventional occupational therapy sessions + Nintendo Switch
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universidad Rey Juan Carlos
Parkinson Disease (PD)
Synthetic Vasomotion for Glymphatic Enhancement
The goal of this pilot clinical trial is to learn whether a week-long study combining controlled breathing procedures, intermittent exposure to a low-concentration carbon dioxide gas mixture, and noninvasive vagus nerve…
- Trial name
- NCT07814534
- Testing
- Active noninvasive vagus nerve stimulation, Active intermittent hypercapnia, Guided breathing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Healthy
Single and Multiple Ascending Dose and Food Effect PK Study in Healthy Adult and Elderly Subjects
A three (3) part study to evaluate the safety, tolerability and PK of RDN-929
- Trial name
- NCT03668314
- Testing
- RDN-929, RDN-929 TBD dose
- Where
- Netherlands
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Alkermes, Inc.
Virus Diseases, Pneumonia
Universal Anti-Viral Vaccine for Healthy Elderly Adults
This protocol tests the safety and efficacy of a novel universal vaccine concept called "allo-priming" which is designed to protect elderly adults from progression of any type of viral infection, including possible protection…
- Conditions
- Virus Diseases, Pneumonia, COVID-19 Respiratory Infection, RSV Pneumonia
- Trial name
- ALLOPRIME (NCT04441047)
- Testing
- AlloStim
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mirror Biologics, Inc.
COVID-19
A FIRST IN HUMAN TO EVALUATE THE SAFETY AND IMMUNOGENICITY OF SARS-CoV-2 UQSC2 VACCINE IN HEALTHY ADULTS.
This will be a single centre, Phase 1, First-In-Human , Randomized, Active-controlled (2- arm) Double-blind, single dose, parallel design study.
- Trial name
- NCT05775887
- Testing
- UQSC2 Vaccine, NVX-CoV2373 vaccine
- Where
- Australia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Infections, Meningococcal, Meningococcal Vaccines
Non-Inferiority of Meningococcal Vaccine GSK134612 Versus Mencevax™ in 2-10 Year Old Subjects
The purpose of this study is to demonstrate, in 2-10 year old subjects, the non-inferiority of meningococcal vaccine GSK134612 compared to licensed meningococcal vaccine Mencevax™.
- Trial name
- NCT00514904
- Testing
- Nimenrix, Mencevax
- Where
- 7 sites in India, Lebanon and 2 more
- Volunteers
- 1,504 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Geriatrics, Healthy
Elafibranor Pharmacokinetic Parameters in Elderly Healthy Volunteers
In the elderly, pharmacokinetics is altered. Gastric juice pH is elevated which influences drug solubility and absorption. Drug distribution is decreased in the elderly because of decreased cardiac output, increased peripheral…
- Trial name
- NCT04171752
- Testing
- elafibranor
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Genfit
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