Clinical trials: Healthy Participant Study
Hepatitis B, Healthy
First in Human Study of ChAdOx1-HBV in Healthy Participants and Participants With Chronic hepB Infection
This is a Phase 1, first in human study of ChAdOx1-HBV. The study will be conducted in 40 healthy participants and 12 participants with CHB and virally suppressed with oral antiviral medication.
- Trial name
- NCT04297917
- Testing
- ChAdOx1-HBV
- Where
- 4 sites in United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Barinthus Biotherapeutics
Healthy Volunteers
A Study to Assess Absolute Bioavailability of Aducanumab in Healthy Volunteers
The primary objective of this study is to evaluate the absolute bioavailability of a single, fixed subcutaneous (SC) dose of aducanumab compared with a single weight-based intravenous (IV) dose of aducanumab in healthy…
- Trial name
- NCT04924140
- Testing
- Aducanumab
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Biogen
Healthy
A Study to Test How Different Doses of BI 3731579 Are Tolerated by Healthy People
The main objectives of this trial are to investigate safety, tolerability and pharmacokinetics and pharmacodynamics of BI 3731579 in healthy volunteers following administration of multiple rising doses per day over 15 days.
- Trial name
- NCT06716190
- Testing
- Mid-dose bid BI 3731579, Midazolam, Low-dose bid BI 3731579
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
A Study of LY3819253 (LY-CoV555) in Healthy Participants
The purpose of this study is to test the safety and tolerability of LY3819253 when it is given by injection just under the skin to healthy participants.
- Trial name
- NCT04537910
- Testing
- LY3819253
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Healthy, Obesity
A Study in Healthy People or Otherwise Healthy With Overweight or Obesity to Compare 2 Formulations of Survodutide Given in Different Ways, Either as a Pre-filled Syringe or a Pen-like Injector
The goal of this study is to find out whether different formulations of survodutide given by different delivery methods is taken up in the body in a similar way. Participants visit the study site regularly.
- Trial name
- NCT07413913
- Testing
- Survodutide formulation A, Survodutide formulation B2
- Where
- Germany
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Relative Bioavailability of 2 Fixed Dose Combinations of Empagliflozin/Metformin Extended Release (XR) Compared With Single Tablets
The purpose of this trial is to demonstrate the relative bioavailability of 2 newly developed fixed dose combinations (FDC) tablets containing empagliflozin \& metformin XR and the single tablets of empagliflozin and metformin XR…
- Trial name
- NCT02106923
- Testing
- 1 tablet Empagliflozin/2 tablets Metformin XR, 10 mg Empagliflozin/1000 mg Metformin XR, 1 tablet 10 mg Empagliflozin/3 tablets Metformin XR
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Infection, Human Immunodeficiency Virus
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Repeat Dose Administration of Long-Acting GSK1265744 and Long-Acting TMC278 Intramuscular and Subcutaneous Injections in Healthy Adult Subjects
LAI115428 is a Phase I, randomized, repeat dose escalation study to determine the safety, tolerability, and PK profile of intramuscular and subcutaneous injections of GSK1265744 in a long acting parenteral (LAP) formulation in…
- Trial name
- NCT01593046
- Testing
- GSK1265744 Oral, GSK1265744 LAP 800mg intramuscular injection, GSK1265744 LAP 200mg subcutaneous injection
- Where
- 2 sites in United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Healthy Volunteers
A Phase 1 Single-Dose Escalation Study of PF-04308515 in Healthy Volunteers
The purpose of this study is to determine the safety, tolerability, pharmacokinetics (understanding how a drug is absorbed and moves through the body) and pharmacodynamics (understanding the effects of a drug on certain target…
- Trial name
- NCT00990015
- Testing
- PF-04308515
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Pfizer
Thermogenesis by Different-dosage Ginger Flour Footbaths
Dose-Response Relationship of Ginger Flour Footbaths in Healthy Volunteers
A study to explore whether different dosages of ginger flour in footbaths cause different effects on warmth development as well as on general well-being and the autonomic nervous system.
- Trial name
- NCT04051476
- Testing
- 3-g footbath, 6-g footbath, 12-g footbath
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- ARCIM Institute Academic Research in Complementary and Integrative Medicine
Healthy
Safety and Tolerability of SYNB1934 in Healthy Adult Volunteers
This Phase 1, first-in-human, multiple dose-escalation, randomized, double-blinded, placebo-controlled study is evaluating SYNB1934 in healthy volunteers (HV).
- Trial name
- NCT04984525
- Testing
- SYNB1934, SYNB1618
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Synlogic
Healthy
Open-label, Normal Healthy Volunteer Clinical Trial of a Novel Ondansetron Formulation
The goals of this open-label Phase Ia study are to evaluate the Pharmacokinetics (PK) profiles of new novel single-dose Ondansetron Pulsatile Release (Ond-PR) formulations in normal healthy volunteers.
- Trial name
- NCT01290276
- Testing
- Ond-PR1, Ond-PR1 + MPh-IR, Ond-PR2
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Tong Lee
Type 2 Diabetes Mellitus
Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects
The purpose of this study is determine that Dapagliflozin has no effect on the pharmacokinetics (PK) or pharmacodynamics (PD) of warfarin when dapagliflozin is coadministered with warfarin.
- Trial name
- NCT00904176
- Testing
- Dapagliflozin, Warfarin, Digoxin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Asthma,, Pharmacokinetics,
Phase I Study to Assess the Effect on Healthy Male Volunteers of Ketoconazole on the Pharmacokinetics of a Single Dose of AZD5069 Administered Orally.
The main purpose of the study is to compare the change of the AZD5069 Pharmacokinetic profile when administered with ketoconazole.
- Conditions
- Asthma,, Pharmacokinetics,, Cmax,, Tmax,
- Trial name
- NCT01735240
- Testing
- AZD5069, Ketoconazole
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy Volunteers
Bioequivalence Evaluation of a New and Current Tablet of ASP015K
The objective of this study is to evaluate the bioequivalence of a new tablet versus a current tablet of ASP015K under fasting conditions after single oral administration in healthy male subjects.
- Trial name
- NCT02531191
- Testing
- peficitinib
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy Volunteer
Study to Assess the Adverse Events, Tolerability, and How Oral Doses of ABBV-932 Moves Through the Body in Healthy Adult Chinese Participants
This study will assess the adverse events, tolerability, and how oral doses of ABBV-932 moves through the body in healthy adult Chinese participants.
- Trial name
- NCT07024797
- Testing
- ABBV-932
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AbbVie
Schizophrenia
Safety, Blood Levels and Effects of AUT00206
The study medicine is a potential future treatment for schizophrenia, an illness that affects the way that people think, feel or behave.
- Trial name
- NCT02589262
- Testing
- AUT00206
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Autifony Therapeutics Limited
Healthy Subjects
Study of TAVO101 in Healthy Volunteers
This is a Phase 1, single ascending dose study designed to investigate TAVO101, administered as an IV infusion in healthy subjects.
- Trial name
- NCT05298046
- Testing
- Experimental: TAVO101
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tavotek Biotherapeutics
Healthy Participants
A Single and Multiple Ascending Dose Study of CK-3828136 in Healthy Adult Participants
1. Learn about the safety and tolerability of CK-3828136 after a single dose and multiple doses in healthy subjects. 2. Find out how much CK-3828136 is in the blood after a single dose and multiple doses. 3.
- Trial name
- NCT05662215
- Testing
- CK-3828136
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cytokinetics
Progressive Supranuclear Palsy (PSP), Healthy Participants
First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain
This clinical study is being conducted to learn more about two new imaging drugs, called [18F]ABBV-964i and [18F]ABBV-965i, which are designed to help doctors see changes in the brain related to a condition called Progressive…
- Trial name
- NCT07348276
- Testing
- [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Invicro
Healthy Volunteers, Alzheimer Disease
I2PETHV - Imidazoline2 Binding Site in Healthy Volunteers
The imdazoline2 binding site (I2BS) is known to reside inside astrocytes. Changes in the numbers of I2BS in post mortem tissue has implicated them in a range of psychiatric conditions such as depression and addiction, along with…
- Conditions
- Healthy Volunteers, Alzheimer Disease, Molecular Imaging
- Trial name
- I2PETHV (NCT02323217)
- Testing
- [11C]BU99008, Idazoxan, Isocarboxazid
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Imperial College London