Clinical trials: Healthy Patients
Multiple Sclerosis
A Longitudinal Study of Effect of Copaxone in RRMS Over 24 Months
To explore whether treatment with glatiramer acetate (GA) may decrease iron deposition in subcortical deep GM, as detected by SWI-filtered phase imaging, in patients with RRMS over 24 months and compared to a reference population…
- Trial name
- GASWI (NCT01695434)
- Testing
- MRI
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Healthy, Hyperlipoproteinemia
Lipoprotein Metabolism in Normal Volunteers and Patients With Abnormal Levels of Lipoproteins
Researchers plan to study the fat-rich particles, called lipoproteins, which circulate in the blood. This study is designed to improve understanding of normal, as well as abnormal, lipoprotein metabolism and the role it plays in…
- Trial name
- NCT00001226
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Mellitus, Type 2
A Study of the Safety, Pharmacokinetics, and Pharmacodynamics of CNTO 3649 in Healthy Adults and Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the safety, pharmacokinetics, and pharmacodynamics of CNTO 3649 following a single dose in healthy adults and following multiple doses in patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT00882726
- Testing
- CNTO 3649 IV (Healthy participants), CNTO 3649 SC (Healthy participants), CNTO 3649 SC (Diabetic patients)
- Where
- 3 sites in United States
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Centocor, Inc.
Type 2 Diabetes Mellitus
Postprandial Dysmetabolism
Type 2 diabetes (T2D) is a common disease associated with multiple complications and an increased risk of cardiovascular morbidity and mortality. Also, it is a heavy economical burden on society.
- Trial name
- PPDysMet (NCT00813215)
- Testing
- Meal challenge
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Hypertension
Yoga for a Healthy Heart
The Yoga for a Healthy Heart study will address various barriers to both medication management and blood pressure regulation for African American patients with hypertension.
- Trial name
- YHH (NCT06155240)
- Testing
- Therapeutic yoga
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- The Cleveland Clinic
Health Care Utilization, Healthy Aging
Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue
The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age.
- Trial name
- NCT05596474
- Testing
- Beet-root juice, red-light therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Bronchodilators in Mild Chronic Obstructive Pulmonary Disease (COPD)
In people with mild COPD, the ability to exhale air from the lungs is partly limited because of narrowing and collapse of the airways.
- Trial name
- NCT00202176
- Testing
- Ipratropium Bromide
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Queen's University
Diabetes, Diabetes Mellitus, Type 2
Safety and Tolerability of Liraglutide in Healthy Volunteers and Subjects With Type 2 Diabetes
This trial is conducted in Europe. The aim of this trial is to assess the safety and tolerability (maximum tolerated dose) after single and multiple doses of NNC 90-1170 (liraglutide) in healthy volunteers and in subjects with…
- Conditions
- Diabetes, Diabetes Mellitus, Type 2, Healthy
- Trial name
- NCT01507285
- Testing
- liraglutide
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Healthy Volunteers, Hypertension, Essential
Effects of TENS and IES on the Autonomous Balance of Normotens Volunteers and Hypertensive Patients
Hypertension is considered a serious public health problem. The imbalance in autonomic nervous system (ANS) activity is one of the main triggers in the development and maintenance of hypertension.
- Trial name
- NCT03258489
- Testing
- Transcutaneous nervous electric stimulation (TENS), Interferential electrical stimulation (IES)
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Asthma, COPD Exacerbation
Study to Explore the Relationship Between the Level of Exhaled Breath Condensate Hydrogen Peroxide (EBC H2O2) as Measured Using a New Device Against Existing Measures of Lung Disease
A cross-sectional, observational study of EBC H2O2 levels, as measured by a novel device, 'Inflammacheck™', and other markers of disease severity and symptom control in patients with Asthma and COPD and volunteers with no history…
- Trial name
- EXHALE 1A (NCT04061291)
- Where
- United Kingdom
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Schizophrenia
Evaluating Safety, Tolerability and Pharmacokinetic of Multiple Ascending Doses of VV119
This study will consist of 2 parts: Part Ⅰ-in healthy adult subjects, Part Ⅱ-in adult patients with schizophrenia
- Trial name
- NCT06504290
- Testing
- VV119 （in healthy adult subjects）, VV119(in adult patients with schizophrenia)
- Where
- 4 sites in China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vigonvita Life Sciences
Asthma, COPD
The Natural History of Small Airways Physiology in Diseased and Healthy States
Spirometry is a useful clinical tool for the assessment and monitoring of lung disease, however, it does not provide information on peripheral airways resistance.
- Conditions
- Asthma, COPD, Interstitial Lung Disease, Cystic Fibrosis
- Trial name
- NCT00677560
- Where
- United Kingdom
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Immunosuppression, Periodontal Disease
Oral Bacteria and Immune System Problems Involved in Gum Disease (Periodontitis)
Background: Gum disease is a condition in which the tissue around the tooth root becomes swollen and infected. This condition can cause tooth loss if it is not treated.
- Conditions
- Immunosuppression, Periodontal Disease, Healthy Subjects, Healthy Volunteer
- Trial name
- NCT01568697
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Diabetes Mellitus, Type 2, Surgery
Piezosurgical vs Conventional Exodontia Surgery in Healthy and Patients With Diabetes Mellitus Type 2
This study will evaluateand compare intraoperative and postoperative clinical parameters related to discomfort and wound heeling, as well as laboratory wound healing parameters after piezosurgical and conventional surgery…
- Conditions
- Diabetes Mellitus, Type 2, Surgery, Tooth Extraction Status Nos
- Trial name
- PCSDMT2 (NCT06046976)
- Testing
- piesosurgical extraction, conventional extraction
- Where
- Serbia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Inflammatory Diseases
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics (PK) of Oral AZD6793 in Healthy and Chronic Obstructive Pulmonary Disease Participants, to Assess the Relative Oral Bioavailability Between Two Formulations, and the Food Effect on the PK of AZD6793 Compared to Fasting State.
The purpose of the study is to assess the safety and tolerability of AZD6793 suspension following oral administration of Single Ascending Dose (SAD) [Part 1] and Multiple Ascending Dose (MAD) [Part 2] in healthy participants.
- Trial name
- NCT05662033
- Testing
- AZD6793
- Where
- 2 sites in United Kingdom
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Assessing Interest in a Platform for Early Phase Clinical Trial Recruitment
Assessing Interest in Web/App Platforms for Early Phase Clinical Trial Recruitment
Study objective: To assess whether the different stakeholders (volunteers, patients, doctors and industry) involved in early phase trials would be interested in using a platform to facilitate recruitment and engagement in this…
- Trial name
- NCT06302647
- Testing
- Questionnaires
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Patients With Heart Failure and Preserved Ejection Fraction - HFpEF, Patients With Heart Failure With Reduced Ejection Fraction - HFrEF
Developing Imaging And plasMa biOmarkers iN Describing Heart Failure With Preserved Ejection Fraction (DIAMONDHFpEF)
The investigators wish to test a hypothesis that patients with HFpEF have different characteristics on echo, cardiac MRI and plasma protein \& chemical profiles compared to HFrEF and healthy volunteers.
- Conditions
- Patients With Heart Failure and Preserved Ejection Fraction - HFpEF, Patients With Heart Failure With Reduced Ejection Fraction - HFrEF, Healthy Controls Group - Age and Sex-matched
- Trial name
- DIAMONDHFpEF (NCT03050593)
- Testing
- MRI scan, Echo scan
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Healthy, Liver Diseases
A Study to (1) Compare How BI 456906 is Taken up in the Body of Healthy People and People With Liver Problems and (2) Find Out How People With Overweight and Obesity, With and Without Liver Problems, Tolerate Different Doses of BI 456906
This study is open to adults who have different levels of liver problems and adults who are healthy. People with or without overweight or obesity can take part. This study has 2 parts.
- Conditions
- Healthy, Liver Diseases, Obesity
- Trial name
- NCT05296733
- Testing
- BI 456906
- Where
- 13 sites in United States, Germany and 4 more
- Volunteers
- 82 people
- Sponsor
- Boehringer Ingelheim
Healthy, Late Onset Pompe Disease
Study to Assess the Safety, Tolerability, PK and PD of ABX1100
Study ABX1100-1001 is a first-in-human (FIH), phase 1 study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of a single ascending dose (SAD) and multiple doses (MD) of ABX1100 administered intravenously…
- Trial name
- NCT06109948
- Testing
- ABX1100 injection for IV infusion
- Where
- 5 sites in United States, Canada
- Volunteers
- 46 people
- Sponsor
- Aro Biotherapeutics
Healthy
Effectiveness of a Multifactorial Intervention to Improve Diet and Physical Activity in Diabetics From Primary Care
This is a randomized, clinical trial aimed at diabetics between 25-70 years (with no cardiovascular disease) selected at urban primary care health clinics in Salamanca (Spain).
- Trial name
- NCT02991079
- Testing
- Intervention group, Control: Lifestyle counseling
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
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