Clinical trials: Healthy Patients
Bone Marrow Diseases, Healthy Volunteers
Collection of Blood and Bone Marrow From Healthy Volunteers and Patients for Research Purposes
This study is designed to provide bone marrow and/or blood cells for other research studies. Patients participating in this study will be asked to provide small amounts of medical information and undergo a limited physical…
- Trial name
- NCT00001627
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Parkinson Disease (PD), MSA - Multiple System Atrophy
Test-retest Trial With [11C]MODAG-005 in PD or MSA and AMHC - Pilot Phase
This is an open-label, single-center Phase 1 study evaluating the safety, tolerability, and test-retest characteristics of [11C]MODAG-005, an investigational positron emission tomography/computed tomography (PET/CT) radioligand…
- Conditions
- Parkinson Disease (PD), MSA - Multiple System Atrophy, Healthy Adult Participants
- Trial name
- PIOSA (NCT07640542)
- Testing
- [11C]MODAG-005
- Where
- Germany
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- MODAG GmbH
Sepsis, Septic Shock
IL-40 and IL-41 Levels in Sepsis, Septic Shock, and Healthy Individuals
This study aims to investigate the blood levels of two recently identified immune-related proteins, Interleukin-40 (IL-40) and Interleukin-41 (IL-41), in patients with sepsis and its more severe form, septic shock.
- Conditions
- Sepsis, Septic Shock, Inflammation, Biomarkers
- Trial name
- NCT06963541
- Testing
- No intervention; Observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Melahat Yalcin Solak
Intermittent Claudication, Vascular Diseases
Secondary Prevention and Application-based Lifestyle Support for Patients With Intermittent Claudication
A randomized controlled pilot trial will be used to test Lifepod®PAD as secondary prevention support system. Approximately 60 patients with intermittent claudication at the Department of vascular diseases at Skåne University…
- Trial name
- PRESIC (NCT04390282)
- Testing
- Application-based support system
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Malmö University
Inflammatory Bowel Disease
Healthy Normal Single Ascending Dose and Crohn's Patient Multiple Ascending Dose
Healthy Normal Single Ascending Dose and Crohn's patient Multiple Ascending Dose
- Trial name
- NCT00868660
- Testing
- ZP1848
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Zealand Pharma
Parkinson's Disease With LRRK2 Mutation, Healthy Controls
Measure of Microglial Activation in the Brain of Parkinson Disease Patients With PET
There is accumulating evidence suggesting that inflammatory processes, through microglial activation, would play a key role in the neurodegenerative process of Parkinson's disease (PD).
- Conditions
- Parkinson's Disease With LRRK2 Mutation, Healthy Controls, Parkinson's Disease Without LRRK2 Mutation
- Trial name
- INFLAPARK (NCT02319382)
- Testing
- PET with the tracer 18F-DPA-714, PET with the tracer 11C-PE2I, MRI
- Where
- France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Melanoma
Tracing Dissemination of Melanoma Cells in Healthy Tissues
The objective of this project is to evaluate the presence of melanoma quiescent or initiating clonal cells in peritumoral healthy tissue displaying the same molecular signature than those of the tumor/metastasis and to correlate…
- Trial name
- DISSEMELA (NCT02854124)
- Testing
- Melanoma and peritumoral skin excision
- Where
- France
- Volunteers
- 226 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Psoriasis, Healthy Subjects
A Study to Investigate the Safety, Tolerability and Pharmacokinetics of ABY-035
The purpose of this first-in-human study is to investigate the safety and tolerability of ABY-035 when administered intravenously and subcutaneously, to healthy volunteers and to psoriasis patients.
- Trial name
- NCT02690142
- Testing
- ABY-035 i.v., ABY-035 s.c.
- Where
- 4 sites in United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Affibody
Itch
Role of Interleukin-13 Pathways on Pain and Itch Sensitivity
Atopic dermatitis (AD) is as chronic, inflammatory skin disorder affecting 20% of the world's population. Intense itch and skin pain are the main symptoms.
- Trial name
- IL-13 (NCT06503510)
- Testing
- Histamine, Cowhage, bovine adrenal medulla (BAM8-22)
- Where
- 3 sites in Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Hemorrhagic Stroke, Ischemic Stroke
Early Feasibility Study of the SENSE Device
A single site, study of the SENSE device in up to 20 study subjects, (five healthy controls and five each with ICH, AIS with LVO and AIS without LVO) in whom SENSE can be applied within 24 hours of stroke symptom onset.
- Trial name
- NCT03827720
- Testing
- SENSE Device
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sense Diagnostics, LLC
Healthy
(18)F-FDG PET Database of Adult Healthy Individuals
Epilepsy is the most common chronic neurological disorder in the world, affecting more than 50 million people worldwide. Approximately 35% of patients with epilepsy are refractory to all available antiepileptic drugs.
- Trial name
- BDD-FDG (NCT03100227)
- Testing
- PET [18F] FDG, Anatomical MRI
- Where
- France
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Heart Failure Patients
Physical Impairments in Heart Failure Patients With Pacemakers
Despite major breakthroughs that have recently been made in pacemakers implanted in heart failure (HF) patients, it is clear that functional impairments and symptoms often remain.
- Trial name
- NCT03701854
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Gazi University
Colorectal Cancer, Healthy Lifestyle
Personalized Health Self-Management Training for Colorectal Cancer Survivors
This is a Phase 2 prospective, randomized, controlled, double-arm study to assess personalized self-management training (PSMT) intervention efficacy and patient experiences compared to standardized self-management training…
- Conditions
- Colorectal Cancer, Healthy Lifestyle, Behavior, Health, Health Behavior
- Trial name
- NCT05984589
- Testing
- RISE Personalized Self-Management Training (PSMT), Standardized Self-Management Training (SSMT)
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Southern California
Rheumatoid Arthritis, Renal Impairment
A Study of Fostamatinib in Subjects With Impaired Kidney Function
A 2 stage study to evaluate the amount of fostamatinib in the blood and urine in subjects with impaired kidney (renal) function compared with healthy volunteers with normal renal function.
- Trial name
- NCT01245790
- Testing
- fostamatinib
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Whiplash, Whiplash Injury
Changes of Pain Sensitivity During Rehabilitation of Patients Suffering From Whiplash Associated Disorders
This study investigates the sensory profile of people suffering from whiplash associated disorders (WAD) during rehabilitation.
- Conditions
- Whiplash, Whiplash Injury, Neck Pain, Healthy
- Trial name
- NCT03784196
- Testing
- Conservative rehabilitation
- Where
- Spain
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Universidad San Jorge
Spondylitis, Ankylosing
Analysis of the Peripheral Blood Mononuclear Cells of Patients With Ankylosing Spondylitis During Infliximab Treatment (Study P04465)(COMPLETED)
This is an open-label, controlled sub-study to the parent protocol (P04041, NCT00779935) to examine the expression profile of genes in patients in the active stage of ankylosing spondylitis (AS) compared to the healthy population…
- Trial name
- NCT00778869
- Testing
- Remicade
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Dystonia, Focal Dystonia
Brain Changes in Blepharospasm
This study will examine the role of certain areas of the brain in blepharospasm, a type of dystonia (abnormality of movement and muscle tone) that causes unwanted or uncontrollable blinking or closing of the eyelids.
- Conditions
- Dystonia, Focal Dystonia, Cerebellar Disease
- Trial name
- NCT00487383
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
Clinical Relevance of the HD sEMG Signals in the Post-stroke Rehabilitation
The goal of this clinical trial is to learn about the WPM-SEMG-V2 device (Wireless Portable and Multi-Channel, WPM) designated to acquire high-density (HD) surface electromyography (sEMG) signals in healthy volunteers and…
- Trial name
- NCT05849896
- Testing
- Acquisition of HD sEMG signals using the WPM-SEMG device
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alain Kaelin
HIV Infections, Fatigue
Relationship Between Fatigue and Mitochondrial Damage in Patients With HIV/AIDS
This study will examine abnormalities in mitochondria (energy-producing machinery of cells) and in genes related to mitochondria in the blood cells, muscle, and fat of HIV-positive patients who are taking nucleoside reverse…
- Conditions
- HIV Infections, Fatigue, HIV Positive, AIDS
- Trial name
- NCT00106795
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy, Caregiver Burden
Effects of Breathing Therapy and Benson Relaxation Technique on Caregivers of Alzheimer's Patients
This randomized controlled trial aims to investigate the effects of respiratory therapy and the Benson Relaxation Technique on caregiver burden, perceived stress, and self-efficacy among caregivers of individuals with Alzheimer's…
- Conditions
- Healthy, Caregiver Burden, Caregiver Stress, Caregiver
- Trial name
- NCT06997523
- Testing
- Breath Therapy and Benson Relaxation Technique
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hülya Nuray Bayraktar