Clinical trials: Healthy Smokers
Pharmacokinetics, Bioavailability
An Investigation Of The Effects Of Food On The Absorption Of A Varenicline Controlled Release Formulation
1. To estimate the absorption of a single oral dose of a controlled release varenicline tablet under fed and fasted conditions. 2.
- Conditions
- Pharmacokinetics, Bioavailability, Smoking Cessation
- Trial name
- NCT00731562
- Testing
- Varenicline Tartrate Controlled Release
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Healthy Volunteers, Smoking
A Nicotine Pharmacokinetics and Smoking Behaviour Study Examining Cigarette Ingredients
This study will compare nicotine delivery and smoking behaviour in healthy subjects using several combustible cigarette prototypes containing different ingredients which are commonly used in the European Union.
- Trial name
- NCT03272295
- Testing
- Reference cigarette, Cigarette with carob bean extract, Cigarette with cocoa powder
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- British American Tobacco (Investments) Limited
Smoking Cessation
A Pharmacokinetic and Pharmacodynamic Evaluation of Cytisine in Healthy Smokers
The primary objectives of this study are: To evaluate the pharmacokinetic (PK) parameters during repeat dosing of 1.5 mg or 3.0 mg cytisine when administered as the commercial 25-day schedule.
- Trial name
- NCT03303911
- Testing
- Cytisine
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Achieve Life Sciences
Nicotine Dependence, Nicotine Dependence, Cigarettes
Comparing the Pharmacokinetics of Nicotine Salt Based ENDS in Healthy Smokers
A Ten Sequence, Open Label, Randomized Crossover Study Comparing Nicotine Pharmacokinetics of JUUL 1.7% and JUUL 5% Nicotine Salt Based ENDS Products, in Healthy Adult Smokers.
- Conditions
- Nicotine Dependence, Nicotine Dependence, Cigarettes, Tobacco Use, Tobacco Smoking
- Trial name
- NCT03593239
- Testing
- Tobacco flavored JUUL 1.7% ENDS, Tobacco flavored JUUL 5% ENDS, Mint flavored JUUL 1.7% ENDS
- Where
- New Zealand
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Juul Labs, Inc.
Smoking, Vaccines
A Study to Assess the Safety and Tolerability of Different Doses of PF-05402536 and PF-06413367 in Healthy Adult Smokers.
The purpose of this study is to determine the safety and tolerability of multiple doses of PF-05402536 and PF-06413367 in healthy adult smokers.
- Trial name
- NCT01672645
- Testing
- NIC7-001, NIC7-003, Saline
- Where
- 3 sites in Canada
- Volunteers
- 277 people, healthy volunteers welcome
- Sponsor
- Pfizer
Smoking
Airway and Pulmonary Vascular Endothelial Function in Healthy Smokers: Effect of Inhaled Glucocorticosteroid Treatment
The purposes of the present proposal are to 1) compare inhaled albuterol-induced changes in airway blood flow (Qaw), and in CO and Ppas in healthy current smokers and lifetime non-smokers as an index of endothelial function in…
- Trial name
- smoker3 (NCT02141633)
- Testing
- echocardiogram plus albuterol, airway blood flow plus albuterol, Fluticasone propionate
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Miami
Respiratory Disorders
A Study to Assess Immunity to Specific Microbial Antigens in Healthy Smokers and Non-smokers and in Subjects With Stable COPD
The present study aims to assess the natural immunity to specific microbial antigens in healthy subjects and in subjects with stable COPD aged between 45-75 years.
- Trial name
- NCT01516437
- Testing
- Blood collection, Swab collection, Sputum collection
- Where
- 3 sites in Belgium
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Chronic Obstructive Pulmonary Disease, Asthma
Novel Endpoints in Cough Challenge Testing
The sensitivity of a person's cough reflex can be measured by getting them to breathe in (inhale) irritant chemicals. There are different methods by which subjects are asked to inhale these chemicals, either by taking one deep…
- Conditions
- Chronic Obstructive Pulmonary Disease, Asthma, Healthy, Chronic Cough
- Trial name
- NEAT (NCT01566968)
- Testing
- Cough challenge test, 24 hour ambulatory cough recording, Cough quality of life questionnaire
- Where
- United Kingdom
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Healthy Volunteer Smokers
Oral Tolerability Of Two Nicotine Dosage Forms
This study is to evaluate the oral tolerability of a nicotine prototype
- Trial name
- NCT00682461
- Testing
- Nicotine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tobacco Use Disorder
A Bioequivalence Study of 21 Milligram (mg) Nicotine Transdermal Patches (NicoDerm CQ, GlaxoSmithKline [GSK] Dungarvan) Compared to the Current Marketed 21 mg Nicotine Transdermal Patches (NicoDerm CQ, Alza) in Healthy Adult Smokers
The purpose of this study is to assess the bioequivalence of the 21mg nicotine transdermal patch from GSK Dungarvan (Test) compared to the 21mg nicotine transdermal patch currently manufactured by Alza (Reference).
- Trial name
- NCT05024747
- Testing
- NicoDerm CQ patch (GSK Dungarvan), NicoDerm CQ (Alza)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- HALEON
Smoking Cessation
Effects of EVT 302 With or Without NRT on Craving and Withdrawal in Healthy Male Smokers Deprived of Cigarettes
This randomised, placebo-controlled study is designed to explore the effects of EVT 302 both with and without concomitant nicotine replacement therapy (NRT) on craving and withdrawal in smokers after short term deprivation of…
- Trial name
- NCT00622752
- Testing
- EVT 302, 10 mg, Nicotine replacement therapy (NRT)
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- Evotec Neurosciences GmbH
Tobacco Dependence
Nicotine Pharmacodynamics With a New Oral Nicotine Replacement Therapy and Nicotine Gum
A comparison of two products for oral nicotine replacement with respect to relief of urges to smoke after single doses of nicotine.
- Trial name
- NCT01368016
- Testing
- Nicotine
- Where
- 2 sites in Sweden
- Volunteers
- 346 people
- Sponsor
- McNeil AB
Chronic Obstructive Pulmonary Disease (COPD)
Effect of Supplementary Vitamins on Oxidant Gene Expression in the Lungs of Healthy Smokers
Smoking damages the airway epithelium. The major mechanism by which this is done is by molecules called free radicals. Our body attempts to deal with these damaging molecules in two ways.
- Trial name
- NCT00565214
- Testing
- Group 1, Group 2
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Healthy, Healthy Volunteer
Avocado and Postprandial Responses
The purpose of this study is to see how adding avocado to a breakfast meal affects blood sugar control and signals of hunger and fullness after eating.
- Conditions
- Healthy, Healthy Volunteer, Healthy Volunteers, Healthy Adult
- Trial name
- NCT06818032
- Testing
- Negative control, Avocado, Fat and fiber addition
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Nicotine Addiction
Quantitation of Human Cerebral Nicotinie Receptors With 2[18F]FA-85380 and PET Healthy Non-smokers and Ex-Smokers and in Heavy and Light Situational Smokers
Background: Central nicotinic acetylcholine receptors (nAChRs) are primary targets for the action of nicotine. In addition to being involved in tobacco dependence, they are also involved in a variety of brain disorders, including…
- Trial name
- NCT01038245
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, Healthy Volenteers
Evaluation of GCF MMP-1, -8 and Growth Factor Levels in Smokers With Periodontal Health
Increased levels of cytokines in GCF have been demonstrated in smoker subjects with chronic periodontitis. It is not surprising that increased levels of inflammation associated molecules in GCF has been observed in smokers with…
- Trial name
- NCT02014857
- Testing
- Gingival Crevicular Fluid Sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ege University
COPD, Asthma
Biomarker Assay Validation in Healthy Smokers and COPD Smokers and Ex-smokers
This study will collect sputum samples from healthy smokers, COPD smokers and COPD ex-smokers to analyse biomarkers of inflammation
- Trial name
- NCT02490358
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Respivert Ltd
Current Smoker, Healthy Subject
Physical Activity in Promoting Smoking Cessation in African Americans
This randomized pilot clinical trial studies the use of physical activity in promoting the discontinuation of the habit of smoking (smoking cessation) in African Americans.
- Trial name
- NCT01915810
- Testing
- Exercise Intervention, Laboratory Biomarker Analysis, Nicotine Patch
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Asthma, COPD
ATP/AMP Challenge in Healthy Non-smokers, Smokers, Patients With Asthma, and Patients With Chronic Obstructive Pulmonary Disease (COPD)
In this randomised, cross-over, controlled study, a total of 84 subjects will be included: 12 healthy non-smoking volunteers; 12 current smokers; 30 patients with mild steroid-naïve asthma; and 30 patients with mild-moderate…
- Conditions
- Asthma, COPD, Smoking
- Trial name
- NCT00159315
- Testing
- Inhalation Challenge with ATP, Inhalation Challenge with AMP
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Smokers, Vaping
Persistence of Oral DNA Adducts in Smokers and Vapers
This study aims to better understand what damage caused to oral cells from smoking and vaping might be important in the formation of oral cancers.
- Conditions
- Smokers, Vaping, Healthy Volunteers
- Trial name
- NCT06983392
- Testing
- Abstain from smoking/vaping
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Minnesota