Clinical trials: Healthy Weight Management
Obesity, Healthy Volunteers
Effect of Administration of Itraconazole on the Pharmacokinetics of S-309309 in Healthy Participants
The primary purpose of this study is to determine the effect of repeated administration of itraconazole on the pharmacokinetic (PK) profile of S-309309; and the PK of S-309309 following administration of S-309309 alone and…
- Trial name
- NCT06106334
- Testing
- S309309, Itraconazole
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Shionogi
Obese and Metabolic Disorders
Safety and Pharmacokinetics of HRS-1597 Tablets in Healthy and Obese Participants: A Phase 1 Study
This is a Phase 1, single-center, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, and pharmacokinetics of HRS-1597 tablets following single-dose administration in healthy participants and…
- Trial name
- NCT07808918
- Testing
- HRS-1597
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Overweight, Obese
iStart Smart for Teens for Healthy Weight Management
The emerging epidemic of type 2 diabetes mellitus (T2DM) in children is coupled with the increased prevalence of childhood obesity in the last two decades.
- Trial name
- NCT01693250
- Testing
- fitbit Ultra, Pedometer
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy, Diabetes
Meta-analysis of Oats for Diabetes Prevention and Management
Oats are a commonly consumed source of viscous soluble fibre, which has an established role in cardiovascular disease risk management including in cholesterol and glycemic control.
- Conditions
- Healthy, Diabetes, Metabolic Syndrome, Overweight and Obesity
- Trial name
- NCT04631913
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy Participants
Assess the Safety, Tolerability, and Pharmacokinetics of AZD6234 Following Single Ascending Dose Administration to Healthy Subjects Who Are Overweight or Obese
A study in healthy male and female participants of non-childbearing potential who are overweight or obese.
- Trial name
- NCT05511025
- Testing
- AZD6234, Acetaminophen
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Overweight (BMI > 25)
To Evaluate Efficacy and Safety of Proprietary Healthy Diet Combinations for Weight Management in Overweight Volunteers
This is an open-label, four-arm, randomized, controlled clinical study designed to evaluate the efficacy and safety of a structured Weight Management Program (WMP) in overweight and obese adults with a body mass index (BMI) ≥ 23…
- Trial name
- NCT07452757
- Testing
- Arm II, Arm III, Arm IV
- Where
- India
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bioagile Therapeutics Pvt. Ltd.
Obesity
A Study to Learn How the Study Medicine Danuglipron is Taken Up Into the Blood and If Danuglipron Changes How the Body Processes Other Study Medicines (Atorvastatin and Rosuvastatin) in Healthy Adults Who Are Overweight or Obese
The purpose of this study is to learn the following about the study medicine, danuglipron, after multiple days of dosing in healthy adults who are overweight or obese: how the study medicine, danuglipron, is taken up into the…
- Trial name
- NCT06567327
- Testing
- Danuglipron, Atorvastatin, Rosuvastatin
- Where
- 3 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Pfizer
Nausea and Vomiting, Obesity
A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use
The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one…
- Trial name
- NCT07446439
- Testing
- Tradipitant
- Where
- 10 sites in United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Satiety, Appetite Regulation
A Placebo-Controlled Study Evaluating the Effects of Arrabina on Satiety in Healthy Adults
This study is being conducted to assess the effects of a prebiotic product, Arrabina, on appetite in healthy adults. The goal is to see if this product can help with appetite regulation, support gut health, and support weight…
- Conditions
- Satiety, Appetite Regulation, Weight Control
- Trial name
- NCT06884449
- Testing
- Arrabina Prebiotic 5.0 g, Arrabina Prebiotic 3.5 g
- Where
- 3 sites in United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Comet Bio Inc.
Weight Loss
Effect of Transform Burn on Weight Loss
This study was undertaken to explore the effects of a Thermogenic Composition (TC) composed of dihydrocapsiate, red pepper (Capsicum annuum) fruit extract, citrus (Citrus spp) peel extract, coleus (Coleus forskholi) root extract…
- Trial name
- Transform (NCT06092840)
- Testing
- Transform Burn
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- 4Life Research, LLC
Overweight, Obese
AZD7687 Multiple Ascending Dose Study
The aim of the study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD7687 following multiple ascending dose administrations in in overweight to obese but otherwise healthy male subjects
- Trial name
- NCT01119352
- Testing
- AZD7687
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Obesity
The Added Value of Telephone Follow Up and Home Visits in Helping Children to Grow Up Healthy
Leading medical organizations have called on primary care pediatricians to take a central role in the prevention of childhood obesity.
- Trial name
- NCT01973153
- Testing
- Brief Motivational Counseling (BMC), Brief Motivational Counseling Plus Phone Calls (BMC + Phone), Brief Motivational Counseling Plus Home Visits (BMC + Home)
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Connecticut Children's Medical Center
Kisspeptin Action on Insulin in Healthy Normal Men, Kisspeptin Action on Insulin in Obese Diabetic Men
KP-10 and Insulin Secretion in Men
Induction of insulin secretion by kisspeptin is observed in mouse, pig, rat, and human islets in vitro and in rats, mice and monkeys in vivo, but its mechanism is not fully clear.
- Trial name
- NCT03771326
- Testing
- Kisspeptin-10
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Quaid-e-Azam University
Breastfeeding, Breastfeeding, Exclusive
Using the Electronic Health Record to Guide Management of Newborn Weight Loss
Weight loss is normal for healthy newborns in the first few days, especially for those exclusively breastfed, who may have low enteral intake for several days.
- Conditions
- Breastfeeding, Breastfeeding, Exclusive, Morbidity;Perinatal, Feeding, Bottle
- Trial name
- NCT03655314
- Testing
- NEWT, Usual care
- Where
- United States
- Volunteers
- 2,682 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity, Diabetes
Gelesis Glycemic Index Study
A study to determine glucose and insulin responses to 50g and 100 g of carbohydrate with and without Gelesis200.
- Conditions
- Obesity, Diabetes, PreDiabetes
- Trial name
- GLIDE (NCT03124134)
- Testing
- Gelesis200
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gelesis, Inc.
Metabolic Syndrome, Obesity
Pharmacodynamics and Pharmacokinetics of 3 New Developed Coated Glucose Beads in 20 Obese Healthy Subjects
This single-dose, randomized, open label, five-treatment, five-period, five-sequence crossover study was performed to assess pharmacodynamics (PD) and pharmacokinetics (PK) of three new developed coated Glucose beads formulations…
- Trial name
- NCT05713773
- Testing
- coated beads glucose (8 g) and caffeine anhydrous, coated beads glucose (8 g), uncoated beads glucose (8 g) and caffeine anhydrous
- Where
- Romania
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Aphaia Pharma US LLC
Chronic Weight Management
A Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC47 in Healthy and Obese Subjects
This will be a phase I, randomized, double-blind, placebo-controlled, single dose escalation study. This study will be conducted in three periods: the screening period, the treatment period, and the follow-up period.
- Trial name
- NCT06427590
- Testing
- ASC47
- Where
- Australia
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharma (China) Co., Limited
Healthy Volunteers, Overweight
A Two-Part First-In-Human Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GUB014295
This is a two-part, single centre, double-blind (within cohorts), randomised, placebo-controlled, single (Part 1) and multiple (Part 2) ascending subcutaneous dose study in lean to overweight or obese but otherwise healthy men…
- Trial name
- NCT06144684
- Testing
- GUB014295
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- AbbVie
Childhood Obesity
Mountain West Prevention Research Center Core Research Project
This hybrid type 3 effectiveness-implementation sequential multiple assignment randomized trial will assess the impact of integrating population health management (PHM) strategies-text messaging and enrollment in Building Healthy…
- Trial name
- MW-PRCCRP (NCT07479498)
- Testing
- Text Message-based recruitment, Active outreach follow-up
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Paul Estabrooks
Obesity
Healthy Weight Management Project for Overweight and Obesity Children
Childhood obesity is a significant public health concern worldwide. In China, childhood obesity has dramatically increased as the economy has grown quickly over the past decades.
- Trial name
- NCT05482191
- Testing
- Lifestyle intervention
- Where
- China
- Volunteers
- 331 people, healthy volunteers welcome
- Sponsor
- Ningbo No. 1 Hospital