Clinical trials: Hearing Loss, active
Hearing Loss
Natural History of Autosomal Dominant Hearing Loss
Background: Hereditary hearing loss is one of the most common sensory disabilities affecting newborns. The main options for people with hereditary hearing loss are hearing aids and cochlear implants.
- Trial name
- NCT04501081
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Cochlear Hearing Loss
Retrospective Analysis of Speech Performance Using the HiRes Ultra and HiRes Ultra 3D Cochlear Implant
This is a retrospective study designed to collect speech perception results for HiRes Ultra CI and HiRes Ultra 3D CI users as measured in the clinical routine and to confirm the performance of these devices.
- Trial name
- NCT06301581
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Advanced Bionics AG
Cochlear Implantation, Sensorineural Hearing Loss
Retrospectively Investigating Longitudinal Outcomes in MED-EL SONATA 2 Cochlear Implant Recipients.
MED-EL Cochlear Implants (CI) provide auditory sensations via electrical stimulation of the auditory pathways for severely to profoundly hearing-impaired individuals who obtain little or no benefit from acoustic amplification in…
- Trial name
- LORIS (NCT07697911)
- Testing
- Transfer of data of SONATA 2 cochlear implant recipients
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Hearing Impaired Children
Artificial Grammar Learning in Children Who Are Deaf or Hard-of-Hearing: Stimulus Length Effect
The goal of this basic experimental study involving humans (BESH) clinical trial is to examine how stimulus length affects grammar learning in children who are deaf or hard-of-hearing and who primarily use spoken language.
- Trial name
- NCT07782567
- Testing
- Short linguistic content, Long linguistic content
- Volunteers
- 30 people
- Sponsor
- University of Illinois Chicago
Unilateral Hearing Loss
Audiological Rehabilitation of Children With Unilateral Hearing Loss
The goal of this study is to examine the effects of hearing aids and early intervention on hearing, language, and neural development in children with hearing loss in one ear, known as unilateral hearing loss.
- Trial name
- SHINE (NCT07911852)
- Testing
- hearing aids
- Where
- 3 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Father Flanagan's Boys' Home
Vestibular Schwannoma
Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma
This trial will evaluate the safety and tolerability of a single unilateral administration of one of three dose levels of AAVAnc80-antiVEGF and will evaluate the Akouos delivery device to safely achieve the intended product…
- Trial name
- NCT06517888
- Testing
- AAVAnc80-antiVEGF via Akouos Delivery Device
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Eli Lilly and Company
Otoferlin Gene-mediated Hearing Loss
Long Term Follow-up Study of AAVAnc80-hOTOF Gene Therapy
This multi-center, observational, post-intervention long term follow-up (LTFU) study will monitor for safety and efficacy of AAVAnc80-hOTOF in individuals with sensorineural hearing loss due to otoferlin gene mutations who have…
- Trial name
- NCT06696456
- Where
- 5 sites in United States, Spain and 1 more
- Volunteers
- 30 people
- Sponsor
- Eli Lilly and Company
Vestibular Schwannoma
Long Term Follow-up Study of AAVAnc80-antiVEGF Gene Therapy
This multi-center, observational, post-intervention LTFU study will monitor for safety and efficacy of AAVAnc80- antiVEGF in individuals with vestibular schwannoma who have previously received an intracochlear administration of…
- Trial name
- NCT07503613
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Eli Lilly and Company
Conductive Hearing Loss, Mixed Hearing Loss
Post-Market Registry Study for Vibrant Hearing Solutions
This observational registry collects retrospective and prospective, data from children and adults who use CE-marked MED-EL implantable (PMEI, BCI, or AMEI) or non-implantable (BCD) hearing solutions as part of routine care.
- Conditions
- Conductive Hearing Loss, Mixed Hearing Loss, Sensorineural Hearing Loss, Single Sided Deafness
- Trial name
- NCT07906314
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Hearing Loss, Bilateral Sensorineural
Performance of a Remote Microphone Compared to Hearing Aids Alone
This study will compare speech understanding in noise using a remote microphone with hearing aids and compatible receivers with speech understanding in noise using hearing aids alone in a population of hearing impaired adults…
- Trial name
- NCT07913776
- Testing
- Commercially available Receiver in the Canal (RIC) hearing devices, Hearing Aids plus Remote Microphone System
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Sonova AG
Hearing Loss, Sensorineural, Presbycusis
Barriers and Facilitators to OTC Hearing Aids Success
Hearing aids can improve hearing, communication, and overall quality of life for people with hearing loss. However, not many people use hearing aids. A common reason is that hearing aids are expensive and hard to get.
- Trial name
- NCT06499805
- Testing
- Audiologist-based fitting, Over-the-counter fitting
- Where
- 2 sites in United States
- Volunteers
- 360 people
- Sponsor
- Yu-Hsiang Wu
Hearing Loss, Cognitive Impairment, Mild
ENACT Program on Auditory Perception and Function, Cognitive Function and Health-related Quality of Life
Although previous studies indicated that tackling hearing loss may have a secondary benefit in improving cognitive function and delaying the onset of dementia, a more integrated care approach to optimize both hearing and…
- Trial name
- NCT06955494
- Testing
- Empowerment Network for Auditory-Cognitive Training (ENACT) Program, Usual Care
- Where
- Hong Kong
- Volunteers
- 62 people
- Sponsor
- The University of Hong Kong
Hearing Loss, Hearing Aids
New Hearing Aid Users and Their Social Participation
Does first-ever hearing aid fitting change social participation? Using a mixed methods approach made up of audiological assessments (hearing test and examination of the ear canal and eardrum), questionnaires, semi-structured…
- Conditions
- Hearing Loss, Hearing Aids, Social Participation
- Trial name
- NCT07866586
- Testing
- Observation
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
Hearing Loss
Automated Text Message Reminders to Promote Hearing Aid Adoption
Many individuals with hearing loss do not receive adequate hearing healthcare. Only about 30 percent of people that are found to have hearing loss during a hearing test go on to use hearing aids.
- Trial name
- NCT07170423
- Testing
- Automated text message reminder
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Stanford University
Hearing Loss, Deafness
Collection of Clinical Data and Specimens for Research in Hearing, Balance, Taste, Smell, Voice, Speech, and Language Disorders.
Background: People with hearing, balance, and taste, smell, voice, speech, language, and other Ear, Nose, and Throat (ENT) disorders may seek treatment at the National Institute on Deafness and Other Communication Disorders…
- Trial name
- NCT05670496
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Hearing Loss, Binaural, Cochlear Implantation
Mi2000 TICI Follow-up
This Post-Market Clinical Follow-up (PMCF) investigation aims to further collect evidence on safety and performance of the Mi2000 TICI.
- Trial name
- M2FU (NCT07902414)
- Testing
- Cochlear Implantation
- Where
- 6 sites in Austria, Belgium and 2 more
- Volunteers
- 36 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Hearing Loss, Dizziness
Fall Risk Assessment and Speech Intelligibility Enhancement Using In-ear Device
The purpose of this study is to develop and validate methods to use hearing aids equipped with embedded sensors and artificial intelligence to assist in the assessment of fall risk and in the implementation of interventions aimed…
- Conditions
- Hearing Loss, Dizziness, Vertigo, Fall Related Injury Risk
- Trial name
- NCT05365646
- Testing
- Hearing aids equipped with motion sensing abilities
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Stanford University
Hearing Loss, Binaural, Cochlear Implantation
Mi2000 TICI - Post-market Implantation Study
This Post-Market Clinical Follow-up (PMCF) investigation aims to further collect evidence on safety and performance of the Mi2000 TICI.
- Trial name
- TUPIS (NCT07897318)
- Testing
- Cochlear Implantation
- Volunteers
- 22 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Bilateral Hearing Loss, Health Services Research
Assessing Pharmacy Technician Educational Training for the Provision of Over-the-Counter Hearing Aids in Rural Alabama and Mississippi Pharmacies
Hearing loss is a major public health concern due to its negative association with emotional well-being, cognition, and physical ailments, such as diabetes.
- Trial name
- NCT06864273
- Testing
- Pharmacy Technician Educational Training
- Where
- 2 sites in United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa