Clinical trials: Hearing Preservation
Hearing Loss
Hearing Preservation Using Dexamethasone and Hyaluronic Acid for Cochlear Implantation
The objective of the present study is to investigate the effect dexamethasone and hyaluronic acid have on hearing preservation
- Trial name
- NCT01588925
- Testing
- Cochlear Implantation, Cochlear Implantation+dexamethasone, Cochlear Implantation+dexamethasone+hyaluronic acid
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- University of Sao Paulo General Hospital
Cochlear Implants, Cochlear Implantation
Investigation of a Device to Deliver Intra-Operative Therapeutic Hypothermia for Hearing Preservation in Cochlear Implantation
The goal of this interventional clinical study is to investigate the use of mild therapeutic hypothermia for preservation of residual hearing in cochlear implant surgery. The main questions the trial aims to answer are: 1.
- Conditions
- Cochlear Implants, Cochlear Implantation, Hearing Loss
- Trial name
- NCT06375278
- Testing
- Intra-Ear Canal Cooling Catheter
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Restorear Devices LLC
Hearing Loss, High-Frequency
Hybrid Cochlear Implants in Severe to Profound Adults, Children, and Adolescents
The purpose of this study is to determine if adults and children with residual low-pitch hearing in the severe hearing loss range can develop improved speech perception by combining their residual acoustic hearing with electrical…
- Trial name
- NCT01975571
- Testing
- Cochlear® Nucleus™ Hybrid L24, Cochlear® Nucleus™ Hybrid S12
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bruce J Gantz
Cochlear Implant
Hearing Preservation and Electro-acoustic Stimulation With EVO® Electrode Lead and Zebra® Sound Processor
Some candidates to cochlear implantation can have residual low frequencies hearing. The EVO electrode lead has been specifically designed to preserve this residual hearing through surgery.
- Trial name
- NCT02966379
- Testing
- cochlear implantation
- Where
- 8 sites in France
- Volunteers
- 17 people
- Sponsor
- Oticon Medical
Deafness, Kidney Diseases
Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors
The von Hippel Lindau (VHL) gene has recently been identified as the genetic defect resulting in a syndrome of multiple neoplasias.
- Conditions
- Deafness, Kidney Diseases, Kidney Neoplasms, Neoplasms
- Trial name
- NCT00001668
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Hearing Loss
Neuroplastic Changes Seen in Cochlear Implants With Preserved Hearing
Investigators hope to study patients with 1 cochlear implant and who have had hearing preservation surgery and compare the changes in the brain of these patients with normal hearing patients by doing a scan of the brain when…
- Trial name
- NCT02407587
- Testing
- cochlear implants
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Manchester University NHS Foundation Trust
Hearing Loss, Sensorineural, Severe-to-profound Hearing Loss
Hearing and Structure Preservation Via ECochG
The goal of the study is to determine the benefit of using an ECochG-based corrective action guide during cochlear implant surgery compared to the traditional surgical approach without ECochG surveillance and guidance.
- Trial name
- PRESERVE (NCT06268340)
- Testing
- ECochG monitored CI surgery incl. corrective action guide, Routine CI surgery without ECochG monitoring
- Where
- 7 sites in Belgium, France and 5 more
- Volunteers
- 102 people
- Sponsor
- Advanced Bionics AG
Hearing Loss, Sensorineural, Hearing Loss, Cochlear
Usability of the Intracochlear Catheter INCAT - a Feasibility Study
This is a feasibility study for a inner ear catheter which will be used to apply steroids to the inner ear. It will be used on nearly deaf patients during their surgery, when they receive an implant that will restore the hearing.
- Trial name
- INCAT (NCT06218966)
- Testing
- intracochlear catheter
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cochlear Implants, Hearing Preservation
Exploring the Use of ECochG Testing During Electrode Insertion in Cochlear Implant Surgery
Investigation of a new ECoChG system (Electrocochleography) during the surgical insertion of cochlear implants, for patients with Advanced Bionics devices.
- Trial name
- NCT03807830
- Testing
- Electrocochlography
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Vestibular Schwannoma
Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study
The effect of Gamma knife radiosurgery (GKRS) on hearing loss, in patients with vestibular schwannoma (VS) and preserved hearing is still unclear.
- Trial name
- NCT01938677
- Testing
- Initial Gamma knife radiosurgery
- Where
- Sweden
- Volunteers
- 67 people
- Sponsor
- Karolinska Institutet
Retinitis Pigmentosa (RP), Usher Syndrome
A 24-Month Trial of NPI-001 for the Preservation of Photoreceptors in Retinitis Pigmentosa Associated With Usher Syndrome
The goal of this clinical trial is to learn if NPI-001 works to prevent progression of retinitis pigmentosa in adults diagnosed with Usher syndrome. It will also provide information about the safety of NPI-001.
- Trial name
- SLORP Preserve (NCT07710196)
- Testing
- NPI-001
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Nacuity Pharmaceuticals, Inc.
Sensorineural Hearing Loss, Tinnitus
ACEMg Hearing Preservation, Tinnitus and Hyperacusis Relief
ACEMg (Soundbites) is a neuroprotectant supplement designed to block the initiating biological events in the inner ear leading to inner ear hearing loss, sensorineural hearing loss, SNHL, which accounts for more than 90% of all…
- Conditions
- Sensorineural Hearing Loss, Tinnitus, SNHL, Inner Ear Hearing Loss
- Trial name
- OTISRWD (NCT06477354)
- Testing
- ACEMg
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Keep Hearing, Inc.
Hearing Loss, Cochlear Implant
Cochlear Trauma, Functional and Structural Preservation in Cochlear Implant Surgery
Prospective 2-arm cohort consisting of a preoperative visit and visits at the time of implantation (Day 0) and follow-up in patients for whom their treating physician indicated a perimodiolar or straight cochlear implant.
- Conditions
- Hearing Loss, Cochlear Implant, Cochlear Microphonics, Electrocochleography
- Trial name
- NCT05079867
- Testing
- Cochlear implantation
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- Hospital Italiano de Buenos Aires
Hearing Impairment, Sensorineural
Cochlear Response Telemetry and Hearing Preservation
The main purpose of this study is to monitor the response from the cochlea as the electrode is inserted during the operation to receive a cochlear implant.
- Trial name
- CREST (NCT03134989)
- Testing
- Cochlear implant
- Where
- Argentina
- Volunteers
- 80 people
- Sponsor
- Cochlear
Cochlear Implantation, Robotics
Robotic-Assisted Versus Manual Electrode Array Insertion
Robotics-assisted electrode insertion overcomes many surgeon-related kinetic limitations such as insertion speed, tremor, drift, and lack of accurate force control.
- Trial name
- NCT06951594
- Testing
- Robotic
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Bruce J Gantz
Hearing Loss, Deafness
Evaluation of Hearing Preservation in Adults With Partial Low-Frequency Hearing Implanted With the HiFocus™ Mid-Scala Electrode
The purpose of this study is to determine the feasibility of preserving low-frequency acoustic hearing in adults with a moderate degree of hearing loss in the low frequencies and severe-to-profound hearing loss in the mid-to-high…
- Conditions
- Hearing Loss, Deafness, Hearing Disorders, Ear Diseases
- Trial name
- NCT01959152
- Testing
- HiRes™ 90K Advantage implant with HiFocus™ Mid-Scala electrode
- Where
- 3 sites in Canada
- Volunteers
- 1 people
- Sponsor
- Advanced Bionics
Heart Failure
Impact of Hear Failure on Lungs in Patients With Heart Failure
Heart failure (HF) is a common disease, which impacts on other organs. Despite an ongoing progress in knowledge about HF, there are still some uncharted aspects of impact of HF on respiratory system.
- Trial name
- NCT05191459
- Where
- Poland
- Volunteers
- 61 people
- Sponsor
- Medical University of Warsaw
Sporadic Acoustic Neuromas, Useful Hearing
Cyberknife Radiosurgery for Patients With Neurinomas
Most vestibular schwannomas are benign and slow-growing. Based on that fact, conservative management with serial imaging is a viable alternative.
- Trial name
- ACOUNEU (NCT02055859)
- Testing
- Radiosurgery
- Where
- Italy
- Volunteers
- 108 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Hearing Loss
Scalar Localization Cochlear Electrode Array Using 64 Slice CT
Insertion of electrode array in scala vestibuli, rather than the preferred location within scala tympani, leads to loss of native hearing in those patients with isolated high-frequency hearing loss undergoing cochlear…
- Trial name
- NCT00587262
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Mayo Clinic
Hearing Loss, Sensorineural, Hearing Loss, Bilateral
Characterisation of Low Frequency Hearing and Vestibular Function in Patients Undergoing Cochlear Implantation
The study will follow a cohort of CI-candidates becoming CI-user, till two years postoperative. A through-out assessment of both their audiological and vestibular status will be carried out at multiple fixed timepoints over 2…
- Trial name
- NCT06021132
- Testing
- cochlear implant
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Aalborg University Hospital