Clinical trials: Heart; Arrest, Newborn
Cardiovascular Diseases, Cerebral Anoxia
Infant Heart Surgery: Central Nervous System Sequelae of Circulatory Arrest
To compare the influence of two surgical anesthetic techniques, hypothermia with circulatory arrest or hypothermia with low-flow bypass perfusion, on neurologic functioning in infants undergoing heart surgery.
- Conditions
- Cardiovascular Diseases, Cerebral Anoxia, Cerebrovascular Disorders, Defect, Congenital Heart
- Trial name
- BCAS (NCT00000470)
- Testing
- cardiac surgical procedures, cardiopulmonary bypass
- Volunteers
- 171 people
- Sponsor
- Boston Children's Hospital
Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic Right Ventricular Dysplasia
South Asian Arrhythmogenic Cardiomyopathy Registry
Arrhythmogenic Cardiomyopathy (ACM) is increasingly identified as an important cause of cardiac morbidity and mortality, especially of SCD, in a younger population.
- Conditions
- Arrhythmogenic Right Ventricular Cardiomyopathy, Arrhythmogenic Right Ventricular Dysplasia, Arrhythmogenic Ventricular Cardiomyopathy, Arrhythmogenic Cardiomyopathy
- Trial name
- NCT04895540
- Testing
- ECG, Echocardiography, Cardiac MRI
- Where
- 3 sites in United States, India
- Volunteers
- 100 people
- Sponsor
- Sheri Kashmir Institute of Medical Sciences
Cardiogenic Shock, Malignant Arrhythmias
The Caribbean Registry of Extracorporeal Membrane Oxygenation (ECMO) From the University Hospital in Martinique
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing VV, VA or VAV ECMO implantation in the French West Indies and Guiana.
- Conditions
- Cardiogenic Shock, Malignant Arrhythmias, Ischemic or Valvular Heart Failure, Drepanocytosis and Thoracic Syndrome
- Trial name
- NCT07351435
- Volunteers
- 1,200 people
- Sponsor
- University of Genova
Newborn Morbidity
Efficacy of Direct CAtheterisation of the OMbilical Vein in Emergency Through Wharton's Jelly
The aim of this study is to demonstrate, with a good level of evidence, the efficacy, safety and feasibility of placing an umbilical route through Wharton's jelly, in the context of emergency situations in the delivery room.
- Trial name
- CaDOm (NCT06915467)
- Testing
- Umbilical vein catheterization through Wharton's jelly procedure
- Where
- 5 sites in France
- Volunteers
- 26 people
- Sponsor
- Hôpital NOVO
Congenital Heart Disease, Coronary Artery Anomaly
European Prospective Registry on Anomalous Aortic Origin of the Coronary Arteries
Anomalous aortic origin of a coronary artery (AAOCA) is a group of rare congenital heart defects with various clinical presentations.
- Conditions
- Congenital Heart Disease, Coronary Artery Anomaly, Sudden Cardiac Death, Surgical Procedure, Unspecified
- Trial name
- EUROAAOCA (NCT06089902)
- Testing
- unroofing or other surgery if needed
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Padova
Muscular Dystrophy, Arrhythmia
Arrhythmias in Myotonic Muscular Dystrophy
Adult myotonic muscular dystrophy (Steinert's disease) is the most common inherited neuromuscular disorder. Cardiac rhythm disturbances occur frequently in this disease state and may be responsible for up to one-third of deaths.
- Conditions
- Muscular Dystrophy, Arrhythmia, Sudden Cardiac Death
- Trial name
- DM1 (NCT00622453)
- Testing
- Screening
- Where
- United States
- Volunteers
- 448 people
- Sponsor
- Indiana University
Arrhythmogenic Cardiomyopathy, PKP2-ACM
Gene Therapy for ACM Due to a PKP2 Pathogenic Variant
This is a Phase 1/2, first-in-human, open-label, intravenous, dose-escalating, multicenter trial that is designed to assess the safety and tolerability of LX2020 in adult patients with PKP2-ACM
- Conditions
- Arrhythmogenic Cardiomyopathy, PKP2-ACM, PKP2-ARVC
- Trial name
- NCT06109181
- Testing
- LX2020
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- Lexeo Therapeutics
Out-Of-Hospital Cardiac Arrest, Myocardial Infarction, Acute
Benefit of Hypothermia in OHCA Complicating AMI
To determine the clinical effectiveness of hypothermia treatment in patients with out-of-hospital cardiac arrest complicating acute myocardial infarction.
- Conditions
- Out-Of-Hospital Cardiac Arrest, Myocardial Infarction, Acute, Hypothermia Neonatal
- Trial name
- Hypothermia (NCT06141252)
- Testing
- Hypothermia
- Where
- South Korea
- Volunteers
- 2,925 people
- Sponsor
- Yonsei University
Ischemic Cardiomyopathy, Dilated Cardiomyopathy
Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden Death
Despite pharmacologic advances for the treatment of congestive heart failure (HF), sudden cardiac death (SCD) and pump failure remain the leading causes of mortality in patients with HF.
- Conditions
- Ischemic Cardiomyopathy, Dilated Cardiomyopathy, Inflammation, Sudden Cardiac Death
- Trial name
- NCT01919983
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Johns Hopkins University
Lymphocytic Myocarditis (Disorder), Heart Failure
Micophenolate Mofetil Versus Azathioprine in Myocarditis
The study is aimed at studying the direct efficacy of mycophenolate mofetil (mycophenolate mofetil, CellCept, Genentech, N015393/02, 12.08.2009) (in combination with corticosteroids (methylprednisolone, Metypred, Orion, 003467…
- Conditions
- Lymphocytic Myocarditis (Disorder), Heart Failure, Dilated Cardiomyopathy, Cardiomyopathies
- Trial name
- NCT05237323
- Testing
- mycophenolate mofetil 2 g per day, azathioprine of 150 [75; 150] mg per day
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Coronary Artery Disease, Myocardial Infarction
Comparative Effectiveness Research to Assess the Use of Primary ProphylacTic Implantable Cardioverter Defibrillators in Europe
The "EUropean Comparative Effectiveness Research to assess the use of primary prophylacTic Implantable Cardioverter Defibrillators (EU-CERT-ICD)" is a modular research project to study the effectiveness of prophylactic ICDs in a…
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Dilated Cardiomyopathy, Implantable Defibrillator User
- Trial name
- EU-CERT-ICD (NCT02064192)
- Where
- 42 sites in Belgium, Bulgaria and 14 more
- Volunteers
- 2,285 people
- Sponsor
- University Medical Center Goettingen
Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE)
Intranasal AAV9-PHP.eB Gene Therapy in Cerebral Palsy (CP) & Hypoxic Ischemic Encephalopathy (HIE)
This international study, organized by Healing Hope International, is an observational registry designed to collect real-world data on participants living with chronic hypoxic ischemic encephalopathy (HIE) who receive an emerging…
- Conditions
- Hypoxic Brain Damage, Hypoxic Ischaemic Encephalopathy (HIE), Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest, Hypoxic Ischemic Encephalopathy of Newborn
- Trial name
- GEN-HOPE (NCT07264166)
- Where
- Mexico
- Volunteers
- 25 people
- Sponsor
- Healing Hope International
Brugada Syndrome
Ablation in Brugada Syndrome for the Prevention of VF
This trial aims to develop evidence based curative treatment with optimal net benefit for patients with Brugada syndrome.
- Trial name
- BRAVE (NCT02704416)
- Testing
- Catheter Ablation
- Where
- 6 sites in Netherlands, Thailand
- Volunteers
- 200 people
- Sponsor
- Pacific Rim Electrophysiology Research Institute
Spinocerebellar Ataxia
Functional and Structural Imaging and Motor Control in Spinocerebellar Ataxia
The purpose of this research study is to investigate how the brain and motor behavior changes both in individuals with spinocerebellar ataxia and healthy individuals, and to assess whether a therapeutic intervention reduces…
- Trial name
- SCA (NCT02488031)
- Testing
- Error-reduction, International Cooperative Ataxia Rating Scale, Scale for the Assessment and Rating of Ataxia
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Cardiac Arrest, Long QT Syndrome
Registry of Unexplained Cardiac Arrest
The CASPER will collect systematic clinical assessments of patients and families within the multicenter Canadian Inherited Heart Rhythm Research Network.
- Conditions
- Cardiac Arrest, Long QT Syndrome, Brugada Syndrome, Catecholaminergi Polymorphic Ventricular Tachycardia
- Trial name
- NCT00292032
- Where
- Canada
- Volunteers
- 1,529 people
- Sponsor
- University of British Columbia
Wolff-Parkinson-White Syndrome, Sudden Cardiac Death
Stress ECG Test for the Evaluation of the Risk of Sudden Cardiac Death in a Paediatric Cohort With WPW Pattern
Patients with preexcitation are at risk for sudden cardiac death. The pathogenesis is a rapid antegrade conduction of atrial fibrillation over the accessory pathway to the ventricle resulting in ventricular fibrillation.
- Conditions
- Wolff-Parkinson-White Syndrome, Sudden Cardiac Death, Risk Stratification
- Trial name
- NCT03207373
- Testing
- Stress test (ECG)
- Where
- Switzerland
- Volunteers
- 3 people
- Sponsor
- Christian Balmer