Clinical trials: Heart; Complications
Postoperative Cognitive Complications, Open Heart Surgery
Effect of a Cooling Helmet on Postoperative Cognitive Dysfunction in Adults Undergoing Open-Heart Surgery
Postoperative cognitive dysfunction, or POCD, is a decline in thinking, memory, attention, or executive function that may occur after surgery and anesthesia.
- Trial name
- HELMET-POCD (NCT07689500)
- Testing
- Cooling Helmet With Cold Water Circulation, Cooling Helmet With Room-Temperature Water Circulation
- Where
- Indonesia
- Volunteers
- 153 people
- Sponsor
- Universitas Indonesia
End-stage Heart Failure
Acute Reno-Cardiac Action of Dapagliflozin In Advanced Heart Failure Patients on Heart Transplant Waiting List
In the DAPA-HF trial, the use of dapagliflozin, an inhibitor of sodium-glucose cotransporter 2 (SGLT2), reduced significantly the risk of worsening heart failure or death from cardiovascular causes compared to placebo among…
- Trial name
- ARCADIA-HF (NCT04782245)
- Testing
- Dapagliflozin 10mg
- Where
- France
- Sponsor
- Hospices Civils de Lyon
Chronic Kidney Diseases, Eye Diseases
Smarter Care Virginia, Examining Low-Value Care in Virginia
Low-value care is defined as patient care that provides no net benefit to patients in specific clinical scenarios, and can cause patient harm.
- Conditions
- Chronic Kidney Diseases, Eye Diseases, Cardiac Disease, Surgery
- Trial name
- NCT04053335
- Testing
- Multicomponent Physician Performance Peer-Comparison Feedback Intervention
- Where
- United States
- Volunteers
- 5,000,000 people
- Sponsor
- University of California, Los Angeles
Coronary Artery Disease, Coronary Artery Bypass Graft Surgery
The Effect of Listening to Holy Quran Recital on the Incidence of Delirium Post-CABG
This study is planned to check the effect of holy Quran recital on the development of delirium after conronary artery bypass graft surgery (CABG).
- Conditions
- Coronary Artery Disease, Coronary Artery Bypass Graft Surgery, Delirium, Postoperative
- Trial name
- NCT06346990
- Testing
- Holy Quran Recital
- Volunteers
- 264 people
- Sponsor
- Applied Science Private University
Postoperative Hemorrhage, Postoperative Anemia
Autologous Whole Blood Management for Transfusion Reduction in Adult Cardiac Surgery Patients
The goal of this pilot trial is to test a protocol for a planned Canada-wide clinical trial looking at whether or not the use of a patients own blood works as good as the current standard of care using donated blood products to…
- Conditions
- Postoperative Hemorrhage, Postoperative Anemia, Postoperative Blood Loss
- Trial name
- NCT05889494
- Testing
- Autologous Whole Blood Management, Standard Care involving allogenic and/or derivative transfusion.
- Where
- Canada
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Heart Failure, Chronic Obstructive Pulmonary Disease (COPD)
Epidemiological Cluster Evaluation in Patients Admitted to Internal Medicine, With at Least One of the Following Diagnoses: Heart Failure, COPD, Renal Failure. The FADOI IN-CluDiMI Study
Improved medical care has led to an increase in both the age and clinical complexity of patients admitted to Internal Medicine wards, characterized by multiple chronic diseases.
- Conditions
- Heart Failure, Chronic Obstructive Pulmonary Disease (COPD), Chronic Kidney Disease (CKD)
- Trial name
- IN-CluDiMI (NCT07660757)
- Where
- Italy
- Volunteers
- 4,500 people
- Sponsor
- Fadoi Foundation, Italy
Cardiac Allograft Vasculopathy, Transplanted Heart Complication
Effect of Ivabradine on Exercise Capacity After Heart Transplantation
This study evaluates whether treatment with ivabradine compared to placebo can improve exercise capacity in long-term heart transplant recipients with cardiac allograft vasculopathy and elevated heart rate at rest.
- Trial name
- VANISH-CAV (NCT03405831)
- Testing
- Ivabradine
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Finn Gustafsson
Surgery-Complications
Crystalloid Fluids and Cardiac Surgery
All cardiac patients admitted to the intensive care unit after surgery received crystalloid fluids as standard care procedure. 3 crystalloid fluids can be used during their stay: Normal Saline, PlasmaLyte or Ringer's Lactate.
- Trial name
- NCT05834257
- Testing
- Normal Saline for fluid resuscitation, PlasmaLyte for fluid resuscitation, Ringer's Lacatate for fluid resusciation
- Where
- Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Diabetes Complications, Cardiovascular Diseases
Effects of Mediterranean Diet Intervention in Diabetic Heart Disease
Diabetes Mellitus (DM) is a global epidemic associated with inflammation, aggressive atherosclerosis and increased risk for, and severity of, coronary artery disease.
- Trial name
- NCT03757845
- Testing
- Mediterranean Diet
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- MaineHealth
Analgesia, Postoperative Pain
Multimodal Analgesic Treatment Versus Traditional Morphine Analgesia After Cardiac Surgery
To test if multimodal analgesia with different analgesic medication offer better pain relief, lesser side effects and is safe compared to conventionel opiod analgesia after cardiac surgery.
- Trial name
- NCT01966172
- Testing
- Ibuprofen, Gabapentin, Morphine
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sleep, Atrial Fibrillation
Impact of Sleep Quality on Outcomes After Cardiac Surgery
Sleep is a basic human need and is essential for good quality of life, good health. In fact, humans spend one third of their life time in sleeping or attempting to do so.
- Conditions
- Sleep, Atrial Fibrillation, Delirium, Postoperative, Complications, Postoperative
- Trial name
- NCT06527105
- Testing
- Eye masks and ear plugs
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amrita Institute of Medical Sciences & Research Center
Acute Kidney Injury
Remote Ischemic Preconditioning to Prevent Contrast Nephropathy
Contrast-medium induced nephropathy (CIN) is a frequent and devastating complication of coronary angiography, occurring in 10-50% of cases.
- Trial name
- RIPC-CIN (NCT02674451)
- Testing
- Remote ischemic preconditioning
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Johns Hopkins University
Arterial Calcification, Kidney Diseases
Aortic Calcification and Central Blood Pressure in Patients With Chronic Kidney Disease
Aim and background: This study will seek to identify physiological and biochemical factors explaining and predicting a higher than expected central (aortic) blood pressure (BP) in patients with chronic kidney disease (CKD).
- Conditions
- Arterial Calcification, Kidney Diseases, Coronary Artery Disease, Aortic Calcification
- Trial name
- ACCEPT (NCT04114695)
- Where
- Denmark
- Volunteers
- 185 people
- Sponsor
- Central Jutland Regional Hospital
Chronic Kidney Diseases, Cardiomyopathies
The Interrogation of the Cardiomyopathy of Chronic Kidney Disease With advancEd caRdiac Imaging
Patients with kidney failure have a much higher risk of heart disease compared to people of the same age without kidney failure. The reason for this is not fully understood.
- Conditions
- Chronic Kidney Diseases, Cardiomyopathies, Cardiovascular Diseases, Cardiac Disease
- Trial name
- TICKER (NCT03704701)
- Testing
- Cardiac MRI and contrast-enhanced cardiac CT
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- NHS Greater Glasgow and Clyde
Reperfusion Injury, Myocardial Ischemia
Tolerance of Myocardium to Ischemia Injury
This study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery.
- Trial name
- TOMIS (NCT02812901)
- Testing
- cardiac surgery scheduled in the morning, cardiac surgery scheduled in the afternoon
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Lille
Atrial Fibrillation
Temporary Autonomic Blockade to Prevent Atrial Fibrillation After Cardiac Surgery
In this study, the investigators aim to determine whether injecting botulinum toxin into epicardial fat pads is efficacious and safe for decreasing postoperative atrial fibrillation (POAF) after cardiac surgery.
- Trial name
- NCT02498769
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Joseph Mathew, M.D.
Polycystic Ovary Syndrome
The Effects of Fish Oils on Blood Pressure, Heart Rate Variability and Liver Fat in the Polycystic Ovary Syndrome
We hypothesise that fish oils will have a beneficial effect on cardiometabolic parameters in women with PCOS. The purpose of this study therefore is to examine the effects of fish oils on blood pressure, heart rate variability…
- Trial name
- fops (NCT00620529)
- Testing
- Ocean Nutrition 2050, Olive oil capsules
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- Keogh Institute for Medical Research
Preoperative Sleep Disorder, Preoperative Anxiety
Relationship Between Perioperative Related Factors and Inflammatory Markers and Postoperative Delirium in Elderly Patients With Non-cardiac Major Surgery
Perioperative neurocognitive impairment, including postoperative delirium (POD), is common in older patients after anesthesia and surgery and is associated with poorer short- and long-term outcomes, including worsening cognitive…
- Conditions
- Preoperative Sleep Disorder, Preoperative Anxiety, Inflammatory Reaction, Postoperative Delirium
- Trial name
- NCT05341531
- Testing
- elderly patients undergoing non-cardiac surgery
- Volunteers
- 400 people
- Sponsor
- Beijing Friendship Hospital
Coronary Arterial Disease (CAD), Coronary Artery Bypass Graft (CABG)
Comparison of Oxygen Reserve Index and Spirometry in Predicting Respiratory Complications After Coronary Artery Bypass Surgery
Coronary artery disease (CAD) is one of the most common cardiac conditions, primarily caused by atherosclerosis. Studies have shown that environmental factors such as lifestyle, diet, genetics, and air pollution contribute to the…
- Conditions
- Coronary Arterial Disease (CAD), Coronary Artery Bypass Graft (CABG), Postoperative Pulmonary Complication
- Trial name
- NCT07063277
- Testing
- Preoperative Evaluation with ORI and Spirometry
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Ankara Bilkent Sehir Hastanesi
Delirium in Old Age, Delirium, Postoperative
Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)
Delirium is an acutely occurred neurocognitive disorder characterized by fluctuating symptoms of inattention, altered consciousness and cognitive dysfunction.
- Conditions
- Delirium in Old Age, Delirium, Postoperative, Anesthesia, Cognitive Dysfunction
- Trial name
- NCT06817239
- Testing
- Esketamine, Normal saline
- Where
- 6 sites in China
- Volunteers
- 1,670 people
- Sponsor
- Nanfang Hospital, Southern Medical University
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