Clinical trials: Heart; Complications
Brain Excitability, Postoperative Delirium
Association Between the Brain Excitability and Postoperative Delirium in Patients Undergoing Heart Valve Replacement Surgery With Cardiopulmonary Bypass
The purpose of this study is to explorethe brain excitability in patients undergoing heart valve replacement surgery with cardiopulmonary bypass and the correlation with postoperative delirium
- Conditions
- Brain Excitability, Postoperative Delirium, Cardiac Surgery
- Trial name
- NCT05001425
- Where
- China
- Volunteers
- 90 people
- Sponsor
- General Hospital of Ningxia Medical University
Myocardial Infarction, Diabetes Mellitus
A Randomized, Pharmacodynamic Comparison of Low Dose Ticagrelor to Clopidogrel in Patients With Prior Myocardial Infarction
Taken together the results from CHARISMA and PEGASUS-TIMI54, it appears that physicians may consider extending beyond 1 year or reinitiating treatment with clopidogrel 75 mg od or ticagrelor 60mg bid in patients with a prior MI…
- Conditions
- Myocardial Infarction, Diabetes Mellitus, Renal Disease, Coronary Artery Disease
- Trial name
- ALTIC (NCT02663713)
- Testing
- Ticagrelor, Clopidogrel
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- University of Patras
Premature Baby, Pulmonary Hypertension of Newborn
Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography
This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle…
- Conditions
- Premature Baby, Pulmonary Hypertension of Newborn, Hypoxic Ischaemic Encephalopathy (HIE), Congenital Diaphragmatic Hernia
- Trial name
- NCT07364682
- Where
- United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Birmingham Women's NHS Foundation Trust
Surgery, Post Operative Complications
Enhanced Vitals Monitoring After Major Surgery Trial
The aim of this clinical trial is to examine the feasibility of an enhanced vital sign monitoring solution in-hospital and at-home. This study includes adult patients undergoing inpatient major vascular or abdominal surgery.
- Conditions
- Surgery, Post Operative Complications, Quality of Recovery, General Surgery
- Trial name
- NCT06584825
- Testing
- Enhanced Vitals Monitoring
- Where
- 2 sites in Canada
- Volunteers
- 110 people
- Sponsor
- University of British Columbia
Acute Heart Failure, Acute Kidney Injury
Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled Study
This study aims to demonstrate the efficacy of sequential nephron blockade by adding hydrochlorothiazide or spironolactone on intravenous furosemide compared to intravenous furosemide alone in the treatments of volume overload in…
- Trial name
- NEB-HF (NCT04465123)
- Testing
- Spironolactone or hydrochlorothiazide
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Chiang Mai University
Cardiac Output, Surgery
Personalized Hemodynamic Management in High-risk Major Abdominal Surgery
Postoperative mortality within 30 days after surgery is around 2% in patients having major noncardiac surgery in Europe and the USA.
- Conditions
- Cardiac Output, Surgery, Postoperative Complications, Anesthesia
- Trial name
- PELICAN (NCT05648279)
- Testing
- Personalized hemodynamic management
- Where
- 12 sites in Austria, Czechia and 3 more
- Volunteers
- 1,128 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Radiographic Contrast Agent Nephropathy, Renal Failure
Prevention of Contrast Nephropathy During Diagnostic Coronary Angiogram or PCI With Hydratation Based on LEVDP
The goal is to determine if prehydration based on LEVDP is superior to a standard hydratation with NaCl 0.9% or NaHCO3 for the prevention of contrast nephropathy related to a diagnostic coronary angiogram or to PCI.
- Conditions
- Radiographic Contrast Agent Nephropathy, Renal Failure, Coronary Heart Disease
- Trial name
- NEPHRON (NCT00584350)
- Testing
- Hydratation according LVEDP + NaHCO3, normal saline, Sodium bicarbonate
- Where
- Canada
- Volunteers
- 330 people
- Sponsor
- Université de Sherbrooke
Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome
Prediction of Inflammatory Response and Hypotensive Syndrome After Cardiac Surgery by Preoperative Copeptin Level
The purpose of this study is to find a preoperative biomarker before cardiac surgery with cardiopulmonary bypass related to severe postoperative inflammatory response and circulatory complications.
- Conditions
- Systemic Inflammatory Response Syndrome (SIRS), Postoperative Vasodilation Syndrome, Stress Response, Cardiac Surgery Prognosis
- Trial name
- MicorSIRS (NCT03288610)
- Testing
- Preoperative copeptin level
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Nephropathy
Effect of Intravenous Acetadote on Incidence of Contrast Induced Nephropathy
In patients undergoing coronary angiography, the incidence of contrast induced nephropathy(CIN)varies widely and ranges from < 5% in the lowest risk patients, to nearly 50% in the highest risk patients.
- Trial name
- NAC (NCT00939913)
- Testing
- intravenous NAC
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Ochsner Health System
Postoperative Delirium (POD), Cerebral Small Vessel Diseases
Prospective Randomized Controlled Trial of VR Cognitive Training in Reducing Postoperative Delirium in Elderly Patients With Cerebral Small Vessel Disease Undergoing Non-Cardiac Surgery
This clinical study investigates whether virtual reality (VR)-based cognitive training can help prevent postoperative delirium (POD) in elderly non-cardiac patients with pre-existing cerebral small vessel disease (CSVD).
- Trial name
- NCT06999668
- Testing
- Virtual reality cognitive function training, Virtual scene intervention
- Where
- 2 sites in China
- Volunteers
- 416 people
- Sponsor
- Peking University Third Hospital
Infective Endocarditis, End Stage Renal Disease
Incidence of Infective Endocarditis in End Stage Renal Disease Patients on Hemodialysis by Transesophageal Echocardiography in Assuit University Hospital
1. To detect in more detail the incidence of infective endocarditis in patients with end stage renal disease (ESRD) on hemodialysis. 2.
- Trial name
- NCT05692089
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Cardiovascular Risk, Chronic Kidney Disease
A Research Study Looking at Kidney and Heart Health in Adults With Type 2 Diabetes and Chronic Kidney Disease Treated With Semaglutide in China
The purpose of this clinical study is to find out what happens to kidney and heart health during treatment with a medicine called semaglutide, which is given as an injection under the skin.
- Trial name
- NCT07900438
- Testing
- Semaglutide
- Where
- 26 sites in China
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
Chronic Kidney Diseases, Coronary Artery Disease
Clinical Impact of Orsiro™ Stent in Patient With Chronic Kidney Disease
Orsiro™ or Orsiro_Mission™ stents have the biodegradable polymer and the thinnest stent strut (60㎛) in commercially available stents, which could minimize chronic inflammation and incomplete endothelialization.
- Trial name
- OKAY (NCT06475625)
- Testing
- Percutaneous coronary intervention, Orsiro™ or Orsiro_Mission™ stent
- Where
- South Korea
- Volunteers
- 3,113 people
- Sponsor
- The Catholic University of Korea
Chronic Heart Failure, Cardio-Renal Syndrome
Renal Denervation in Patients With Chronic Heart Failure
The purpose of the trial is to investigate the safety and effectiveness of renal denervation for the treatment of chronic heart failure (CHF).
- Trial name
- NCT02085668
- Testing
- Renal denervation (Symplicity™)
- Where
- 11 sites in Austria, Germany and 2 more
- Sponsor
- University Hospital, Saarland
Postoperative Pain, Sternotomy
Effect of Elastic Therapeutic Taping on Post-Sternotomy Pain in Coronary Artery Bypass Graft Surgery
This research study aims to find out whether elastic therapeutic taping can help reduce pain after heart surgery, specifically coronary artery bypass grafting (CABG), which is done using a surgical cut through the breastbone…
- Conditions
- Postoperative Pain, Sternotomy, Pain Management, Coronary Artery Bypass
- Trial name
- NCT06910215
- Testing
- Elastic therapeutic taping, Therapeutic Taping on Non-Surgical Areas
- Where
- Turkey (Türkiye)
- Volunteers
- 195 people
- Sponsor
- Abant Izzet Baysal University
Coronary Artery Disease
Clinical Trial of Kryptonite for Prevention of Sternal Complications in High Risk Patients Undergoing Cardiac Surgery
Kryptonite is a non-toxic biologic polymer, that has previously been used in orthopedic surgery. The objective of our study is to demonstrate the benefits of Kryptonite in cardiac surgery patients at high risk for sternal wound…
- Trial name
- Kryptonite (NCT01368991)
- Testing
- Kryptonite, Conventional closure
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- Cardiology Research UBC
Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1
Baby Detect : Genomic Newborn Screening
Newborn screening (NBS) is a global initiative of systematic testing at birth to identify babies with pre-defined severe but treatable conditions.
- Conditions
- Congenital Adrenal Hyperplasia, Familial Hyperinsulinemic Hypoglycemia 1, Phosphoglucomutase 1 Deficiency, Maturity Onset Diabetes of the Young
- Trial name
- BabyDetect (NCT05687474)
- Where
- Belgium
- Volunteers
- 6,824 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Liege
Systemic Inflammatory Response Syndrome, Acute Kidney Injury
Platelets as Regulators of Inflammation in Cardiac Surgery
Platelets are increasingly recognized as a potent and ubiquitously present source of inflammatory activation. Importantly, antiplatelet therapy has been shown to significantly reduce major adverse events such as renal injury in…
- Trial name
- PRICS (NCT02568410)
- Testing
- coronary artery bypass grafting using cardiopulmonary bypass
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Duke University
Cardiac Valve Disease, Aortic Valve Stenosis
Remote ECG Monitoring of TAVI Patients
After surgery, patients who undergo transcatheter aortic valve implantation (TAVI) are at risk of developing cardiac arrhythmias such as heart blocks and atrial fibrillation.
- Trial name
- NCT03810820
- Testing
- mobile Cardiac Arrhythmia Diagnostics Service (m-CARDS)
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Population Health Research Institute
Chronic Kidney Failure, Inflammation
Vascular Calcification's Risk Factors in Haemodialysis Patients
A not randomized , cross sectional study will be done to determine the possible association of coronary artery calcification (CAC) score assessed by multirow spiral computed tomography (MSCT) with specific and non specific uremic…
- Conditions
- Chronic Kidney Failure, Inflammation, Vascular Calcification
- Trial name
- NCT00694824
- Where
- Italy
- Volunteers
- 253 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
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