Clinical trials: Heart; Disease, Functional
Heart Failure
Evaluation of Systolic Function in Heart Failure With Middle Ejection Fraction by 3D Speckle Tracking Imaging
In 2016, the European Heart Association defined the median ejection fraction heart failure for the first time. More research is needed to improve our understanding of this population, so as to make the best clinical decision and…
- Trial name
- NCT04949997
- Testing
- diagnose
- Where
- China
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Left Bundle-Branch Block, Heart Failure
The Left Bundle Cardiac Resynchronization Therapy Trial
Cardiac resynchronization therapy (CRT) via biventricular (BiV) pacing significantly reduces morbidity and mortality in patients with left bundle branch block (LBBB), impaired LV function and heart failure in spite of optimal…
- Conditions
- Left Bundle-Branch Block, Heart Failure, Impaired Left Ventricular Function
- Trial name
- NCT05434962
- Testing
- Cardiac resynchronization therapy
- Where
- 10 sites in Spain
- Volunteers
- 176 people
- Sponsor
- Óscar Cano Pérez
Permanent Atrial Fibrillation
Rate Control Therapy Evaluation in Permanent Atrial Fibrillation (RATE-AF)
Atrial fibrillation is a common heart rhythm disturbance, causing important discomfort for patients, a high risk of stroke, frequent hospital admissions and a two-fold increase in death.
- Trial name
- RATE-AF (NCT02391337)
- Testing
- Bisoprolol, Digoxin
- Where
- 2 sites in United Kingdom
- Volunteers
- 161 people
- Sponsor
- University of Birmingham
Heart Failure
Change of NLRP3 Inflammasome Expression Level, Symptoms, and Functional Status in HFpEF Patients Treated With ARNI
Underlying inflammation has been increasingly recognized in heart failure with a preserved ejection fraction(HFpEF). But there is no study reported the relationship between NLRP3 inflammasome and HFpEF.
- Trial name
- NCT04269057
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Chongqing Medical University
Heart Failure, Diastolic, Coronary Artery Disease
Assessment of Functional Capacity and Inflammatory Markers in Women With Heart Failure With Preserved Ejection Fraction
This study assesses the impact of diastolic heart failure on exercise capacity in women who have a previous coronary condition. All the participants will go through the same evaluation.
- Conditions
- Heart Failure, Diastolic, Coronary Artery Disease, Inflammation
- Trial name
- NCT02649400
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Federal University of São Paulo
Heart Failure, Congestive
PROTECT-1: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
The study is being conducted to examine whether KW-3902IV will result in greater improvement in signs and symptoms of heart failure, with less treatment failure than standard therapy, when it is added to IV loop diuretics in…
- Trial name
- NCT00328692
- Testing
- rolofylline
- Volunteers
- 932 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Heart Failure
Erythropoietin Treatment in Patients With Systolic Left Ventricular Dysfunction, Mild Anemia and Normal Renal Function
Erythropoietin Treatment in Patients with systolic left ventricular dysfunction, mild anemia and normal renal function
- Trial name
- NCT00418119
- Testing
- erythropoietin
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Aortic Valve Stenosis
Cardiovascular Rehabilitation in Patients With Severe Aortic Stenosis Submitted to Valvar Correction
This study will be evaluate the autonomic, endothelial and hemodynamic functions, inspiratory muscle strength, peripheral tissue oxygenation, peripheral and respiratory muscle architecture, and inflammatory profile of severe AS…
- Trial name
- CARE-AS-MOTION (NCT02468219)
- Testing
- cardiovascular rehabilitation program
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Irmandade Santa Casa de Misericórdia de Porto Alegre
Congenital Heart Disease
Brain Function in Children With Congenital Heart Disease (CHD)
The purpose of the study is to determine whether the neurodevelopmental outcome and in particular executive functions in 9 to 14 year old school children with congenital heart disease who underwent cardiopulmonary bypass surgery…
- Trial name
- NCT02814539
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bea Latal
Heart Failure
A Research Study Comparing CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Reduced/Mildly Reduced Ejection Fraction and Left Ventricular Hypertrophy
This study will look into how CDR132L (a potential new medicine) works on the structure and function of the heart in people living with heart failure.
- Trial name
- 8282-Reduced (NCT06979375)
- Testing
- CDR132L
- Where
- 92 sites in Australia, Czechia and 8 more
- Volunteers
- 200 people
- Sponsor
- Novo Nordisk A/S
Coronary Heart Disease, Image
Research on the Relationship Between Cognitive Function Changes and Cerebrovascular Health in Patients With Coronary Heart Disease
The purpose of this study is to elucidate the imaging mechanisms of cognitive function changes in patients with coronary heart disease before and after surgery or conservative treatment, and to evaluate and predict the…
- Trial name
- NCT05848934
- Testing
- magnetic resonance image, Neuropsychological scale
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nanjing University of Traditional Chinese Medicine
Post Traumatic Stress Disorder
Neural Control and Cardiac-Vascular Function in Women With PTSD (VA Psychological Assessment)
The purpose of this research is 1) to investigate the role of the sympathetic nervous system and cardiac-vascular function in women with PTSD; and 2) to determine whether lifestyle modifications (exercise training and healthy…
- Trial name
- NCT03929939
- Testing
- Exercise training and healthy eating (overseen by IEEM research team)
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- North Texas Veterans Healthcare System
ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD)
Invasive Evaluation and Phenotype-Guided Treatment of ANOCA in Women
This prospective single-center interventional study will include women with angina and non-obstructive coronary arteries. Participants will undergo a standardized invasive coronary assessment combining coronary physiology…
- Conditions
- ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD), Vasospastic Angina
- Trial name
- ANOCA-UY (NCT07593157)
- Testing
- Invasive Coronary Functional and Morphological Assessment, Pharmacological treatment will be individualized according to the invasive coronary phenotype identified. Treatment may include antianginal therapy, vasodilator therapy, endothelial function-targeted
- Where
- Uruguay
- Volunteers
- 50 people
- Sponsor
- Hospital de Clínicas Dr. Manuel Quintela
Schizophrenia, Insight Impaired
The Effects of Bimodal tDCS on Illness Severity, Insight, Functional Outcomes, Neurocognition and HRV in Schizophrenia
The study aimed to investigate the effects of bimodal anodal transcranial direct current stimulation (tDCS) over bilateral dorsolateral prefrontal cortex (DLPFC) on psychopathological symptoms, insight, psychosocial functioning…
- Conditions
- Schizophrenia, Insight Impaired, Psychotic Symptoms, Schizoaffective Disorder
- Trial name
- NCT03701100
- Testing
- tDCS
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Obesity and Type 2 Diabetes
Effects of Enavogliflozin on Coronary Microvascular and Cardiac Function in Obesity
The goal of this study is to analyze the effects of enavogliflozin on heart function and coronary microvascular function in obese patients compared to a placebo, and to evaluate the improvement in cardiopulmonary exercise…
- Trial name
- ENVY (NCT06782139)
- Testing
- Enavogliflozin
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Korea University Anam Hospital
Obstetric Labor, Premature
Impact of Threatened Preterm Labour in Fetal Cardiovascular and Metabolic Programming (SHs)
The goal of this observational study is to learn about cardiac function and remodelling and metabolomic profiles in fetuses and infants who were exposed to a threatened preterm labor (TPL) during pregnancy.
- Trial name
- SHs (NCT05670665)
- Testing
- Threatened preterm labor
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Coarctation of the Aorta
Statins and Endothelial Function in Patients With Coarctation of the Aorta
Coarctation of the aorta (CoA) accounts for approximately 8% of all congenital heart problems. Patients with CoA are well known to have an increased rates of early heart disease, high blood pressure, heart failure and stroke.
- Trial name
- NCT00767572
- Testing
- atorvastatin, Sugar pill
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of California, San Francisco
Heart Failure
A Trial of Thiamin Supplementation in Patients With Heart Failure
Background: Patients with heart failure (HF) are at increased risk of developing thiamin deficiency (TD). Thiamin (vitamin B1) is required for the production of energy and therefore TD may contribute to the energy depletion…
- Trial name
- NCT00959075
- Testing
- Vitamin B1
- Where
- Canada
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Heart Diseases, Left Ventricular Dysfunction
InterventiOn of Biventricular Pacemaker Function on ventrIcular Function Among Patients With LVAD's
The primary reason the investigators are doing this study are to understand how the right side of the heart functions in heart failure patients with left ventricular assist devices (LVADs, or "mechanical hearts").
- Trial name
- ROBIN (NCT03232736)
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome)
Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients
This study evaluates the safety and effectiveness of Ciprofol, a new sedative, in critically ill patients receiving Extracorporeal Membrane Oxygenation (ECMO), a life-support system for heart or lung failure.
- Conditions
- ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome), ECMO and Acute MI, Respiratory Failure Patients Treated With ECMO
- Trial name
- CIP-OXY (NCT06934811)
- Testing
- Ciprofol, Midazolam
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College